Maslinic acid induces mitochondrial apoptosis and suppresses HIF-1α expression in A549 lung cancer cells under normoxic and hypoxic conditions

Molecules

Volumn 19, Issue 12, 2014, Pages 19892-19906

  Hsia, Te Chun ^a,b   Liu, Wen Hu ^c   Qiu, Wen Wei ^d   Luo, Jian ^d   Yin, Mei Chin ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d EAST CHINA NORMAL UNIVERSITY   (China)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Hif 1 ; Lung cancer; Maslinic acid; Mitochondrial apoptosis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); APOPTOSIS INDUCING FACTOR; BIRC5 PROTEIN, HUMAN; CASPASE 3; CASPASE 8; CYTOCHROME C; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INHIBITOR OF APOPTOSIS PROTEIN; MASLINIC ACID; NITRIC OXIDE; NOS2 PROTEIN, HUMAN; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TRITERPENE;

APOPTOSIS; BRONCHUS; CELL HYPOXIA; CELL SURVIVAL; CYTOSOL; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; HUMAN; LUNG TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; BRONCHI; CASPASE 3; CASPASE 8; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; CYTOSOL; EPITHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITOR OF APOPTOSIS PROTEINS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; TRITERPENES;

EID: 84919725789     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191219892     Document Type: Article

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