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Volumn 352, Issue 1, 2015, Pages 129-138

The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY TARTRATE; CISPLATIN; FOCAL ADHESION KINASE; MATRIGEL; PROTEIN TYROSINE KINASE; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANTIPARASITIC AGENT; PROTEIN KINASE; VASCULOTROPIN A;

EID: 84919705106     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.218644     Document Type: Article
Times cited : (26)

References (48)
  • 1
    • 0001445330 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. VI. The role of hypotension in the action of components of podophyllin on transplanted sarcomas
    • Algire GH, Legallais FY, and Anderson BF (1954) Vascular reactions of normal and malignant tissues in Vivo. VI. The role of hypotension in the action of components of podophyllin on transplanted sarcomas. J Natl Cancer Inst 14:879-893.
    • (1954) J Natl Cancer Inst , vol.14 , pp. 879-893
    • Algire, G.H.1    Legallais, F.Y.2    Anderson, B.F.3
  • 2
    • 0028827625 scopus 로고
    • Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo
    • Asahara T, Bauters C, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, and Isner JM (1995) Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 92 (Suppl)II365-II371.
    • (1995) Circulation , vol.92 , pp. II365-II371
    • Asahara, T.1    Bauters, C.2    Zheng, L.P.3    Takeshita, S.4    Bunting, S.5    Ferrara, N.6    Symes, J.F.7    Isner, J.M.8
  • 3
    • 34547770279 scopus 로고    scopus 로고
    • New uses for old drugs
    • Chong CR and Sullivan DJ, Jr (2007) New uses for old drugs. Nature 448:645-646.
    • (2007) Nature , vol.448 , pp. 645-646
    • Chong, C.R.1    Sullivan, D.J.2
  • 5
    • 77954668887 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Current strategies and future prospects
    • Cook KM and Figg WD (2010) Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 60:222-243.
    • (2010) CA Cancer J Clin , vol.60 , pp. 222-243
    • Cook, K.M.1    Figg, W.D.2
  • 7
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J (2003) Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3:11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 8
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, and Novotny W (2004) Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3:391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 9
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N and Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438:967-974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 10
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 13
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D and Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 15
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, and Tarnawski AS (1999) Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 5:1418-1423.
    • (1999) Nat Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3    Levin, E.4    Itani, R.M.5    Sarfeh, I.J.6    Tarnawski, A.S.7
  • 16
    • 34548065791 scopus 로고    scopus 로고
    • Non-receptor proteintyrosine kinases as molecular targets for antiangiogenic therapy (Review)
    • Kanda S, Miyata Y, Kanetake H, and Smithgall TE (2007) Non-receptor proteintyrosine kinases as molecular targets for antiangiogenic therapy (Review). Int J Mol Med 20:113-121.
    • (2007) Int J Mol Med , vol.20 , pp. 113-121
    • Kanda, S.1    Miyata, Y.2    Kanetake, H.3    Smithgall, T.E.4
  • 17
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358:2039-2049.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 18
    • 70349758510 scopus 로고    scopus 로고
    • Src kinases as therapeutic targets for cancer
    • Kim LC, Song L, and Haura EB (2009) Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6:587-595.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 587-595
    • Kim, L.C.1    Song, L.2    Haura, E.B.3
  • 19
    • 34147171490 scopus 로고    scopus 로고
    • Endothelial cell migration during angiogenesis
    • Lamalice L, Le Boeuf F, and Huot J (2007) Endothelial cell migration during angiogenesis. Circ Res 100:782-794.
    • (2007) Circ Res , vol.100 , pp. 782-794
    • Lamalice, L.1    Le Boeuf, F.2    Huot, J.3
  • 20
    • 0036584920 scopus 로고    scopus 로고
    • Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells
    • Lecureur V, Lagadic-Gossmann D, and Fardel O (2002a) Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells. Int J Oncol 20:1071-1076.
    • (2002) Int J Oncol , vol.20 , pp. 1071-1076
    • Lecureur, V.1    Lagadic-Gossmann, D.2    Fardel, O.3
  • 21
  • 22
    • 0033517823 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces angiogenesis: Its angiogenic action and signaling mechanism in human umbilical vein endothelial cells
    • Lee OH, Kim YM, Lee YM, Moon EJ, Lee DJ, Kim JH, Kim KW, and Kwon YG (1999) Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. Biochem Biophys Res Commun 264:743-750.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 743-750
    • Lee, O.H.1    Kim, Y.M.2    Lee, Y.M.3    Moon, E.J.4    Lee, D.J.5    Kim, J.H.6    Kim, K.W.7    Kwon, Y.G.8
  • 23
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA and Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141:1117-1134.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 24
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P, Cheng H, Roberts TM, and Zhao JJ (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8:627-644.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 26
    • 34249810645 scopus 로고    scopus 로고
    • KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Massarelli E, Varella-Garcia M, Tang X, Xavier AC, Ozburn NC, Liu DD, Bekele BN, Herbst RS, and Wistuba II (2007) KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. Clin Cancer Res 13:2890-2896.
    • (2007) Clin Cancer Res , vol.13 , pp. 2890-2896
    • Massarelli, E.1    Varella-Garcia, M.2    Tang, X.3    Xavier, A.C.4    Ozburn, N.C.5    Liu, D.D.6    Bekele, B.N.7    Herbst, R.S.8    Wistuba, I.I.9
  • 28
    • 84860540538 scopus 로고    scopus 로고
    • Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas
    • Migliardi G, Sassi F, Torti D, Galimi F, Zanella ER, Buscarino M, Ribero D, Muratore A, Massucco P, and Pisacane A, et al. (2012) Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas. Clin Cancer Res 18:2515-2525.
    • (2012) Clin Cancer Res , vol.18 , pp. 2515-2525
    • Migliardi, G.1    Sassi, F.2    Torti, D.3    Galimi, F.4    Zanella, E.R.5    Buscarino, M.6    Ribero, D.7    Muratore, A.8    Massucco, P.9    Pisacane, A.10
  • 29
    • 0021055582 scopus 로고
    • In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
    • Montesano R, Orci L, and Vassalli P (1983) In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J Cell Biol 97:1648-1652.
    • (1983) J Cell Biol , vol.97 , pp. 1648-1652
    • Montesano, R.1    Orci, L.2    Vassalli, P.3
  • 30
    • 83755162608 scopus 로고    scopus 로고
    • The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells
    • Nacev BA, Grassi P, Dell A, Haslam SM, and Liu JO (2011) The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286:44045-44056.
    • (2011) J Biol Chem , vol.286 , pp. 44045-44056
    • Nacev, B.A.1    Grassi, P.2    Dell, A.3    Haslam, S.M.4    Liu, J.O.5
  • 31
    • 0034093853 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma
    • Niki T, Iba S, Tokunou M, Yamada T, Matsuno Y, and Hirohashi S (2000) Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma. Clin Cancer Res 6:2431-2439.
    • (2000) Clin Cancer Res , vol.6 , pp. 2431-2439
    • Niki, T.1    Iba, S.2    Tokunou, M.3    Yamada, T.4    Matsuno, Y.5    Hirohashi, S.6
  • 32
    • 58349092759 scopus 로고    scopus 로고
    • Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways
    • Pang X, Yi T, Yi Z, Cho SG, Qu W, Pinkaew D, Fujise K, and Liu M (2009a) Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res 69 :518-525.
    • (2009) Cancer Res , vol.69 , pp. 518-525
    • Pang, X.1    Yi, T.2    Yi, Z.3    Cho, S.G.4    Qu, W.5    Pinkaew, D.6    Fujise, K.7    Liu, M.8
  • 33
    • 67651005688 scopus 로고    scopus 로고
    • Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
    • Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Aggarwal BB, and Liu M (2009b) Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res 69:5893-5900.
    • (2009) Cancer Res , vol.69 , pp. 5893-5900
    • Pang, X.1    Yi, Z.2    Zhang, X.3    Sung, B.4    Qu, W.5    Lian, X.6    Aggarwal, B.B.7    Liu, M.8
  • 34
    • 0032920883 scopus 로고    scopus 로고
    • Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity
    • Parman T, Wiley MJ, and Wells PG (1999) Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat Med 5:582-585.
    • (1999) Nat Med , vol.5 , pp. 582-585
    • Parman, T.1    Wiley, M.J.2    Wells, P.G.3
  • 35
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • Paz-Ares LG, Biesma B, Heigener D, von Pawel J, Eisen T, Bennouna J, Zhang L, Liao M, Sun Y, and Gans S, et al.; NSCLC [non-small-cell lung cancer] Research Experience Utilizing Sorafenib (NExUS) Investigators Study Group (2012) Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin Oncol 30:3084-3092.
    • (2012) J Clin Oncol , vol.30 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3    Von Pawel, J.4    Eisen, T.5    Bennouna, J.6    Zhang, L.7    Liao, M.8    Sun, Y.9    Gans, S.10
  • 37
    • 39149100314 scopus 로고    scopus 로고
    • Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity
    • Pyun BJ, Choi S, Lee Y, Kim TW, Min JK, Kim Y, Kim BD, Kim JH, Kim TY, and Kim YM, et al. (2008) Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res 68:227-235.
    • (2008) Cancer Res , vol.68 , pp. 227-235
    • Pyun, B.J.1    Choi, S.2    Lee, Y.3    Kim, T.W.4    Min, J.K.5    Kim, Y.6    Kim, B.D.7    Kim, J.H.8    Kim, T.Y.9    Kim, Y.M.10
  • 38
    • 84875420089 scopus 로고    scopus 로고
    • Lgr4-mediated Wnt/b-catenin signaling in peritubular myoid cells is essential for spermatogenesis
    • Qian Y, Liu S, Guan Y, Pan H, Guan X, Qiu Z, Li L, Gao N, Zhao Y, and Li X, et al. (2013) Lgr4-mediated Wnt/b-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development 140:1751-1761.
    • (2013) Development , vol.140 , pp. 1751-1761
    • Qian, Y.1    Liu, S.2    Guan, Y.3    Pan, H.4    Guan, X.5    Qiu, Z.6    Li, L.7    Gao, N.8    Zhao, Y.9    Li, X.10
  • 39
    • 79551520348 scopus 로고    scopus 로고
    • Treatment-related mortality with bevacizumab in cancer patients: A meta-analysis
    • Ranpura V, Hapani S, and Wu S (2011) Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. JAMA 305:487-494.
    • (2011) JAMA , vol.305 , pp. 487-494
    • Ranpura, V.1    Hapani, S.2    Wu, S.3
  • 40
    • 79960227968 scopus 로고    scopus 로고
    • VEGF and angiopoietin signaling in tumor angiogenesis and metastasis
    • Saharinen P, Eklund L, Pulkki K, Bono P, and Alitalo K (2011) VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med 17:347-362.
    • (2011) Trends Mol Med , vol.17 , pp. 347-362
    • Saharinen, P.1    Eklund, L.2    Pulkki, K.3    Bono, P.4    Alitalo, K.5
  • 42
    • 0013918579 scopus 로고
    • Biological disposition of antibilharzial antimony drugs. II. Antimony fate and uptake by Schistosoma haematobium eggs in man
    • Schulert AR, Rassoul AA, Mansour M, Girgis N, McConnell E, and Farid Z (1966) Biological disposition of antibilharzial antimony drugs. II. Antimony fate and uptake by Schistosoma haematobium eggs in man. Exp Parasitol 18:397-402.
    • (1966) Exp Parasitol , vol.18 , pp. 397-402
    • Schulert, A.R.1    Rassoul, A.A.2    Mansour, M.3    Girgis, N.4    McConnell, E.5    Farid, Z.6
  • 43
    • 84866693927 scopus 로고    scopus 로고
    • Controlling escape from angiogenesis inhibitors
    • Sennino B and McDonald DM (2012) Controlling escape from angiogenesis inhibitors. Nat Rev Cancer 12:699-709.
    • (2012) Nat Rev Cancer , vol.12 , pp. 699-709
    • Sennino, B.1    McDonald, D.M.2
  • 46
    • 0032884777 scopus 로고    scopus 로고
    • Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas
    • Takahama M, Tsutsumi M, Tsujiuchi T, Nezu K, Kushibe K, Taniguchi S, Kotake Y, and Konishi Y (1999) Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas. Clin Cancer Res 5:2506-2510.
    • (1999) Clin Cancer Res , vol.5 , pp. 2506-2510
    • Takahama, M.1    Tsutsumi, M.2    Tsujiuchi, T.3    Nezu, K.4    Kushibe, K.5    Taniguchi, S.6    Kotake, Y.7    Konishi, Y.8
  • 47
    • 84859426342 scopus 로고    scopus 로고
    • Challenges in the current antiangiogenic treatment paradigm for patients with non-small cell lung cancer
    • Wozniak A (2012) Challenges in the current antiangiogenic treatment paradigm for patients with non-small cell lung cancer. Crit Rev Oncol Hematol 82:200-212.
    • (2012) Crit Rev Oncol Hematol , vol.82 , pp. 200-212
    • Wozniak, A.1
  • 48
    • 79953745096 scopus 로고    scopus 로고
    • Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
    • Zhang S, Huang WC, Li P, Guo H, Poh SB, Brady SW, Xiong Y, Tseng LM, Li SH, and Ding Z, et al. (2011) Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med 17:461-469.
    • (2011) Nat Med , vol.17 , pp. 461-469
    • Zhang, S.1    Huang, W.C.2    Li, P.3    Guo, H.4    Poh, S.B.5    Brady, S.W.6    Xiong, Y.7    Tseng, L.M.8    Li, S.H.9    Ding, Z.10


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