Parthenolide induces autophagy via the depletion of 4E-BP1

Biochemical and Biophysical Research Communications

Volumn 456, Issue 1, 2015, Pages 434-439

  Lan, Bei ^a   Wan, Ya Juan ^a   Pan, Shuang ^a   Wang, Yu ^a   Yang, Yin ^a   Leng, Qian Li ^a   Jia, Huiyan ^a   Liu, Yao Hui ^a   Zhang, Cui Zhu ^a   Cao, Youjia ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

4E BP1; Apoptosis; Autophagy; Parthenolide; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; INITIATION FACTOR 4E BINDING PROTEIN 1; PARTHENOLIDE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; CARRIER PROTEIN; EIF4EBP1 PROTEIN, HUMAN; EIF4EBP1 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOPROTEIN; SESQUITERPENE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA;

APOPTOSIS ASSAY; ARTICLE; AUTOPHAGY; DRUG EFFICACY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; LENTIVIRINAE; OXIDATIVE STRESS; PROMYELOCYTIC LEUKEMIA; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; WILD TYPE MOUSE; ANIMAL; APOPTOSIS; DRUG EFFECTS; FIBROBLAST; HEK293 CELL LINE; HELA CELL LINE; HL 60 CELL LINE; METABOLISM; MOUSE; PHAGOSOME; PHOSPHORYLATION; PLASMID; SIGNAL TRANSDUCTION;

TANACETUM PARTHENIUM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CARRIER PROTEINS; FIBROBLASTS; HEK293 CELLS; HELA CELLS; HL-60 CELLS; HUMANS; MICE; PHAGOSOMES; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMIDS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84919703416     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.11.102     Document Type: Article

References (33)

1. D.W. Knight Feverfew: chemistry and biological activity Nat. Prod. Rep. 12 1995 271 276
2. J.H. Kim, L. Liu, and S.O. Lee Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis Cancer Res. 65 2005 6312 6320
3. M.L. Guzman, R.M. Rossi, and L. Karnischky The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells Blood 105 2005 4163 4169
4. J. Wen, K.R. You, and S.Y. Lee Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide J. Biol. Chem. 277 2002 38954 38964
5. S. Zhang, C.N. Ong, and H.M. Shen Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis Cancer Lett. 211 2004 175 188
6. A.J. Garcia-Pineres, V. Castro, and G. Mora Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones J. Biol. Chem. 276 2001 39713 39720
7. M.T. Yip-Schneider, H. Nakshatri, and C.J. Sweeney Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells Mol. Cancer Ther. 4 2005 587 594
8. Z. Yang, and D.J. Klionsky An overview of the molecular mechanism of autophagy Curr. Top. Microbiol. Immunol. 335 2009 1 32
9. G. Marino, M. Niso-Santano, and E.H. Baehrecke Self-consumption: the interplay of autophagy and apoptosis Nat. Rev. Mol. Cell Biol. 15 2014 81 94
10. L. Dubois, M.G. Magagnin, and A.H. Cleven Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance Int. J. Radiat. Oncol. Biol. Phys. 73 2009 1219 1227
11. A.J. Steele, D.T. Jones, and K. Ganeshaguru The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro Leukemia 20 2006 1073 1079
12. T. Schmelzle, and M.N. Hall TOR, a central controller of cell growth Cell 103 2000 253 262
13. C. Hu, S. Pang, and X. Kong Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors Proc. Natl. Acad. Sci. U.S.A. 91 1994 3730 3734
14. A. Haghighat, S. Mader, and A. Pause Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E EMBO J. 14 1995 5701 5709
15. N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev. 18 2004 1926 1945
16. I. Mothe-Satney, D. Yang, and P. Fadden Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression Mol. Cell. Biol. 20 2000 3558 3567
17. S. Mader, H. Lee, and A. Pause The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins Mol. Cell. Biol. 15 1995 4990 4997
18. S.S. Schalm, D.C. Fingar, and D.M. Sabatini TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function Curr. Biol. 13 2003 797 806
19. S. Zhang, C.N. Ong, and H.M. Shen Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells Cancer Lett. 208 2004 143 153
20. M.B. Azad, Y. Chen, and S.B. Gibson Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment Antioxid. Redox Signal. 11 2009 777 790
21. J.A. McCubrey, M.M. Lahair, and R.A. Franklin Reactive oxygen species-induced activation of the MAP kinase signaling pathways Antioxid. Redox Signal. 8 2006 1775 1789
22. A. D'Anneo, D. Carlisi, and M. Lauricella Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer Cell Death Dis. 4 2013 e891
23. C. Lu, W. Wang, and Y. Jia Inhibition of AMPK/autophagy potentiates parthenolide-induced apoptosis in human breast cancer cells J. Cell. Biochem. 115 2014 1458 1466
24. J. Sun, C. Zhang, and Y.L. Bao Parthenolide-induced apoptosis, autophagy and suppression of proliferation in HepG2 cells Asian Pac. J. Cancer Prev. 15 2014 4897 4902
25. C.B. Lim, P.Y. Fu, and N. Ky NF-kappaB p65 repression by the sesquiterpene lactone. Helenalin, contributes to the induction of autophagy cell death BMC Complement. Altern. Med. 12 2012 93
26. T. Itoh, K. Ohguchi, and Y. Nozawa Intracellular glutathione regulates sesquiterpene lactone-induced conversion of autophagy to apoptosis in human leukemia HL60 cells Anticancer Res. 29 2009 1449 1457
27. K. Moreau, S. Luo, and D.C. Rubinsztein Cytoprotective roles for autophagy Curr. Opin. Cell Biol. 22 2010 206 211
28. Y.J. Chen, W.P. Huang, and Y.C. Yang Platonin induces autophagy-associated cell death in human leukemia cells Autophagy 5 2009 173 183
29. H.C. Yu, D.R. Hou, and C.Y. Liu Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome PLoS One 8 2013 e55705
30. C.Y. Lai, S.L. Pan, and X.M. Yang Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects Carcinogenesis 34 2013 2050 2060
31. B.S. Balakumaran, A. Porrello, and D.S. Hsu MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy Cancer Res. 69 2009 7803 7810
32. A. Ertmer, V. Huber, and S. Gilch The anticancer drug imatinib induces cellular autophagy Leukemia 21 2007 936 942
33. Available at: < http://www.druglib.com/trial/09/NCT00136409.html > (2014-10-31).