-
1
-
-
84862664760
-
Unusual glucuronides
-
Argikar UA (2012) Unusual glucuronides. Drug Metab Dispos 40:1239-1251.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 1239-1251
-
-
Argikar, U.A.1
-
2
-
-
0026505255
-
Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I
-
Bosma PJ, Chowdhury NR, Goldhoorn BG, Hofker MH, Oude Elferink RPJ, Jansen PLM, and Chowdhury JR (1992) Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I. Hepatology 15:941-947.
-
(1992)
Hepatology
, vol.15
, pp. 941-947
-
-
Bosma, P.J.1
Chowdhury, N.R.2
Goldhoorn, B.G.3
Hofker, M.H.4
Oude Elferink, R.P.J.5
Jansen, P.L.M.6
Chowdhury, J.R.7
-
3
-
-
30144436526
-
Isoform-selective probe substrates for in vitro studies of human UDPglucuronosyltransferases
-
Court MH (2005) Isoform-selective probe substrates for in vitro studies of human UDPglucuronosyltransferases. Methods Enzymol 400 : 104-116.
-
(2005)
Methods Enzymol
, vol.400
, pp. 104-116
-
-
Court, M.H.1
-
4
-
-
48249102000
-
Phylogeny.Fr: Robust phylogenetic analysis for the non-specialist
-
Dereeper A, Guignon V, Blanc G, Audic S, Buffet S, Chevenet F, Dufayard JF, Guindon S, Lefort V, and Lescot M, et al. (2008) Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res 36(Web Server Issue):W465-W469.
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.WEB SERVER ISSUE
, pp. W465-W469
-
-
Dereeper, A.1
Guignon, V.2
Blanc, G.3
Audic, S.4
Buffet, S.5
Chevenet, F.6
Dufayard, J.F.7
Guindon, S.8
Lefort, V.9
Lescot, M.10
-
5
-
-
84893623513
-
Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys
-
Furukawa T, Naritomi Y, Tetsuka K, Nakamori F, Moriguchi H, Yamano K, Terashita S, Tabata K, and Teramura T (2014) Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys. Xenobiotica 44:205-216.
-
(2014)
Xenobiotica
, vol.44
, pp. 205-216
-
-
Furukawa, T.1
Naritomi, Y.2
Tetsuka, K.3
Nakamori, F.4
Moriguchi, H.5
Yamano, K.6
Terashita, S.7
Tabata, K.8
Teramura, T.9
-
6
-
-
84939871310
-
Quantitative ADME proteomics-CYP and UGT enzymes in the beagle dog liver and intestine
-
published ahead of print
-
Heikkinen AT, Friedlein A, Matondo M, Hatley OJ, Petsalo A, Juvonen R, Galetin A, Rostami-Hodjegan A, Aebersold R, and Lamerz J, et al. (2014) Quantitative ADME proteomics-CYP and UGT enzymes in the beagle dog liver and intestine. Pharm Res DOI: 10.1007/s11095-014-1446-8 [published ahead of print].
-
(2014)
Pharm Res
-
-
Heikkinen, A.T.1
Friedlein, A.2
Matondo, M.3
Hatley, O.J.4
Petsalo, A.5
Juvonen, R.6
Galetin, A.7
Rostami-Hodjegan, A.8
Aebersold, R.9
Lamerz, J.10
-
7
-
-
80053571497
-
Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens
-
Höglund C, Sneitz N, Radominska-Pandya A, Laakonen L, and Finel M (2011) Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens. Steroids 76:1465-1473.
-
(2011)
Steroids
, vol.76
, pp. 1465-1473
-
-
Höglund, C.1
Sneitz, N.2
Radominska-Pandya, A.3
Laakonen, L.4
Finel, M.5
-
8
-
-
77950270954
-
How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?
-
Itäaho K, Laakkonen L, and Finel M (2010) How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10? Drug Metab Dispos 38:687-696.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 687-696
-
-
Itäaho, K.1
Laakkonen, L.2
Finel, M.3
-
9
-
-
54349124543
-
The configuration of the 17-hydroxy group variably influences the glucuronidation of b-estradiol and epiestradiol by human UDP-glucuronosyltransferases
-
Itäaho K, Mackenzie PI, Ikushiro S, Miners JO, and Finel M (2008) The configuration of the 17-hydroxy group variably influences the glucuronidation of b-estradiol and epiestradiol by human UDP-glucuronosyltransferases. Drug Metab Dispos 36:2307-2315.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 2307-2315
-
-
Itäaho, K.1
Mackenzie, P.I.2
Ikushiro, S.3
Miners, J.O.4
Finel, M.5
-
10
-
-
79960140023
-
N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases
-
Kaivosaari S, Finel M, and Koskinen M (2011) N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases. Xenobiotica 41:652-669.
-
(2011)
Xenobiotica
, vol.41
, pp. 652-669
-
-
Kaivosaari, S.1
Finel, M.2
Koskinen, M.3
-
11
-
-
47949097984
-
Regioand stereospecific N-glucuronidation of medetomidine: The differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes
-
Kaivosaari S, Toivonen P, Aitio O, Sipilä J, Koskinen M, Salonen JS, and Finel M (2008) Regioand stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes. Drug Metab Dispos 36:1529-1537.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1529-1537
-
-
Kaivosaari, S.1
Toivonen, P.2
Aitio, O.3
Sipilä, J.4
Koskinen, M.5
Salonen, J.S.6
Finel, M.7
-
12
-
-
70349089346
-
Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDPglucuronosyltransferase1A1, 1A6, 1A9, 2B7, and 2B10
-
Kerdpin O, Mackenzie PI, Bowalgaha K, Finel M, and Miners JO (2009) Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDPglucuronosyltransferase1A1, 1A6, 1A9, 2B7, and 2B10. Drug Metab Dispos 37:1948-1955.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1948-1955
-
-
Kerdpin, O.1
Mackenzie, P.I.2
Bowalgaha, K.3
Finel, M.4
Miners, J.O.5
-
14
-
-
0141596080
-
The dog genome: Survey sequencing and comparative analysis
-
Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W, and Fraser CM, et al. (2003) The dog genome: survey sequencing and comparative analysis. Science 301:1898-1903.
-
(2003)
Science
, vol.301
, pp. 1898-1903
-
-
Kirkness, E.F.1
Bafna, V.2
Halpern, A.L.3
Levy, S.4
Remington, K.5
Rusch, D.B.6
Delcher, A.L.7
Pop, M.8
Wang, W.9
Fraser, C.M.10
-
15
-
-
0037423299
-
Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme
-
Kurkela M, García-Horsman JA, Luukkanen L, Mörsky S, Taskinen J, Baumann M, Kostiainen R, Hirvonen J, and Finel M (2003) Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme. J Biol Chem 278:3536-3544.
-
(2003)
J Biol Chem
, vol.278
, pp. 3536-3544
-
-
Kurkela, M.1
García-Horsman, J.A.2
Luukkanen, L.3
Mörsky, S.4
Taskinen, J.5
Baumann, M.6
Kostiainen, R.7
Hirvonen, J.8
Finel, M.9
-
16
-
-
0041856580
-
Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases
-
Kuuranne T, Kurkela M, Thevis M, Schänzer W, Finel M, and Kostiainen R (2003) Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos 31:1117-1124.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1117-1124
-
-
Kuuranne, T.1
Kurkela, M.2
Thevis, M.3
Schänzer, W.4
Finel, M.5
Kostiainen, R.6
-
17
-
-
0012142031
-
Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs
-
Kuusela E, Raekallio M, Anttila M, Falck I, Mölsä S, and Vainio O (2000) Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J Vet Pharmacol Ther 23: 15-20.
-
(2000)
J Vet Pharmacol Ther
, vol.23
, pp. 15-20
-
-
Kuusela, E.1
Raekallio, M.2
Anttila, M.3
Falck, I.4
Mölsä, S.5
Vainio, O.6
-
18
-
-
0033786733
-
The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases
-
Lautala P, Ethell BT, Taskinen J, and Burchell B (2000) The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos 28:1385-1389.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 1385-1389
-
-
Lautala, P.1
Ethell, B.T.2
Taskinen, J.3
Burchell, B.4
-
19
-
-
34249946792
-
Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes
-
Li C and Wu Q (2007) Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evol Biol 7:69.
-
(2007)
BMC Evol Biol
, vol.7
, pp. 69
-
-
Li, C.1
Wu, Q.2
-
20
-
-
28644447707
-
Genome sequence, comparative analysis and haplotype structure of the domestic dog
-
Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, 3rd, and Zody MC, et al. (2005) Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438:803-819.
-
(2005)
Nature
, vol.438
, pp. 803-819
-
-
Lindblad-Toh, K.1
Wade, C.M.2
Mikkelsen, T.S.3
Karlsson, E.K.4
Jaffe, D.B.5
Kamal, M.6
Clamp, M.7
Chang, J.L.8
Kulbokas, E.J.9
Zody, M.C.10
-
21
-
-
18144406492
-
Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases
-
Luukkanen L, Taskinen J, Kurkela M, Kostiainen R, Hirvonen J, and Finel M (2005) Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos 33:1017-1026.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1017-1026
-
-
Luukkanen, L.1
Taskinen, J.2
Kurkela, M.3
Kostiainen, R.4
Hirvonen, J.5
Finel, M.6
-
22
-
-
0344178210
-
Enzymeassisted synthesis and structural characterization of nitrocatechol glucuronides
-
Luukkanen L, Kilpeläinen I, Kangas H, Ottoila P, Elovaara E, and Taskinen J (1999) Enzymeassisted synthesis and structural characterization of nitrocatechol glucuronides. Bioconjug Chem 10:150-154.
-
(1999)
Bioconjug Chem
, vol.10
, pp. 150-154
-
-
Luukkanen, L.1
Kilpeläinen, I.2
Kangas, H.3
Ottoila, P.4
Elovaara, E.5
Taskinen, J.6
-
23
-
-
25144500468
-
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
-
Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, and Nebert DW (2005) Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 15:677-685.
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 677-685
-
-
Mackenzie, P.I.1
Bock, K.W.2
Burchell, B.3
Guillemette, C.4
Ikushiro, S.5
Iyanagi, T.6
Miners, J.O.7
Owens, I.S.8
Nebert, D.W.9
-
24
-
-
33745235041
-
Repeated glucuronidation at one hydroxyl group leads to structurally novel diglucuronides of steroid sex hormones
-
Murai T, Iwabuchi H, and Ikeda T (2005) Repeated glucuronidation at one hydroxyl group leads to structurally novel diglucuronides of steroid sex hormones. Drug Metab Pharmacokinet 20:282-293.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 282-293
-
-
Murai, T.1
Iwabuchi, H.2
Ikeda, T.3
-
25
-
-
84875924213
-
The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification
-
Rowland A, Miners JO, and Mackenzie PI (2013) The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification. Int J Biochem Cell Biol 45:1121-1132.
-
(2013)
Int J Biochem Cell Biol
, vol.45
, pp. 1121-1132
-
-
Rowland, A.1
Miners, J.O.2
Mackenzie, P.I.3
-
26
-
-
0035154231
-
Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney
-
Soars MG, Riley RJ, Findlay KAB, Coffey MJ, and Burchell B (2001a) Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney. Drug Metab Dispos 29:121-126.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 121-126
-
-
Soars, M.G.1
Riley, R.J.2
Findlay, K.A.B.3
Coffey, M.J.4
Burchell, B.5
-
28
-
-
0037446386
-
Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily
-
Soars MG, Fettes M, O'Sullivan AC, Riley RJ, Ethell BT, and Burchell B (2003) Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily. Biochem Pharmacol 65:1251-1259.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1251-1259
-
-
Soars, M.G.1
Fettes, M.2
O'Sullivan, A.C.3
Riley, R.J.4
Ethell, B.T.5
Burchell, B.6
-
29
-
-
59649084478
-
UDPglucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly
-
Sten T, Bichlmaier I, Kuuranne T, Leinonen A, Yli-Kauhaluoma J, and Finel M (2009) UDPglucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos 37:417-423.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 417-423
-
-
Sten, T.1
Bichlmaier, I.2
Kuuranne, T.3
Leinonen, A.4
Yli-Kauhaluoma, J.5
Finel, M.6
-
30
-
-
33747814457
-
Prominent but reverse stereoselectivity in propranolol glucuronidation by human UDP-glucuronosyltransferases 1A9 and1A10
-
Sten T, Qvisen S, Uutela P, Luukkanen L, Kostiainen R, and Finel M (2006) Prominent but reverse stereoselectivity in propranolol glucuronidation by human UDP-glucuronosyltransferases 1A9 and1A10. Drug Metab Dispos 34:1488-1494.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1488-1494
-
-
Sten, T.1
Qvisen, S.2
Uutela, P.3
Luukkanen, L.4
Kostiainen, R.5
Finel, M.6
-
31
-
-
0034128936
-
Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
-
Tukey RH and Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 581-616
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
32
-
-
84859899415
-
Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: Altered alamethicin concentration and utility to screen for UGT inhibitors
-
Walsky RL, Bauman JN, Bourcier K, Giddens G, Lapham K, Negahban A, Ryder TF, Obach RS, Hyland R, and Goosen TC (2012) Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metab Dispos 40:1051-1065.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 1051-1065
-
-
Walsky, R.L.1
Bauman, J.N.2
Bourcier, K.3
Giddens, G.4
Lapham, K.5
Negahban, A.6
Ryder, T.F.7
Obach, R.S.8
Hyland, R.9
Goosen, T.C.10
-
33
-
-
84866467905
-
Human UDPglucuronosyltransferase expression in insect cells: Ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics
-
Zhang H, Patana AS, Mackenzie PI, Ikushiro S, Goldman A, and Finel M (2012a) Human UDPglucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics. Drug Metab Dispos 40:1935-1944.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 1935-1944
-
-
Zhang, H.1
Patana, A.S.2
Mackenzie, P.I.3
Ikushiro, S.4
Goldman, A.5
Finel, M.6
-
34
-
-
84856247392
-
Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases
-
Zhang H, Soikkeli A, Tolonen A, Rousu T, Hirvonen J, and Finel M (2012b) Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases. Toxicol In Vitro 26:1286-1293.
-
(2012)
Toxicol In Vitro
, vol.26
, pp. 1286-1293
-
-
Zhang, H.1
Soikkeli, A.2
Tolonen, A.3
Rousu, T.4
Hirvonen, J.5
Finel, M.6
-
35
-
-
33846674113
-
Pharmacokinetic drug interactions involving 17a-ethinylestradiol: A new look at an old drug
-
Zhang H, Cui D, Wang B, Han YH, Balimane P, Yang Z, Sinz M, and Rodrigues AD (2007) Pharmacokinetic drug interactions involving 17a-ethinylestradiol: a new look at an old drug. Clin Pharmacokinet 46:133-157.
-
(2007)
Clin Pharmacokinet
, vol.46
, pp. 133-157
-
-
Zhang, H.1
Cui, D.2
Wang, B.3
Han, Y.H.4
Balimane, P.5
Yang, Z.6
Sinz, M.7
Rodrigues, A.D.8
-
36
-
-
78049358974
-
Bilirubin glucuronidation revisited: Proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1
-
Zhou J, Tracy TS, and Remmel RP (2010) Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1. Drug Metab Dispos 38:1907-1911.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 1907-1911
-
-
Zhou, J.1
Tracy, T.S.2
Remmel, R.P.3
-
37
-
-
84863180549
-
Characterization of hepatic and intestinal glucuronidation of magnolol: Application of the relative activity factor approach to decipher the contributions of multiple UDPglucuronosyltransferase isoforms
-
Zhu L, Ge G, Zhang H, Liu H, He G, Liang S, Zhang Y, Fang Z, Dong P, and Finel M, et al. (2012) Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDPglucuronosyltransferase isoforms. Drug Metab Dispos 40:529-538.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 529-538
-
-
Zhu, L.1
Ge, G.2
Zhang, H.3
Liu, H.4
He, G.5
Liang, S.6
Zhang, Y.7
Fang, Z.8
Dong, P.9
Finel, M.10
|