The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes

International Journal of Molecular Medicine

Volumn 35, Issue 2, 2015, Pages 325-332

  Yu, Seon Mi ^a   Kim, Song Ja ^a  

^a Kongju National University   (South Korea)

Author keywords

Chondrocytes; Dedifferentiation; Reactive oxygen species; Thymoquinone

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGEN TYPE 2; CYCLOOXYGENASE 2; DICHLOROFLUORESCEIN; FLUORESCENT DYE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEOCHONDROITIN SULFATE; REACTIVE OXYGEN METABOLITE; THYMOQUINONE; BENZOQUINONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CELL DEDIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; ARTICULAR CARTILAGE; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PATHOLOGY; RABBIT; SIGNAL TRANSDUCTION;

ANIMALS; BENZOQUINONES; CARTILAGE, ARTICULAR; CELL DEDIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; RABBITS; REACTIVE OXYGEN SPECIES;

EID: 84919625733     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.2014     Document Type: Article

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