The hepatobiliary disposition of timosaponin B2 is highly dependent on influx/efflux transporters but not metabolism

Drug Metabolism and Disposition

Volumn 43, Issue 1, 2015, Pages 63-72

  Sheng, Jingjing ^b   Tian, Xiaoting ^a   Xu, Guanglin ^b   Wu, Zhitao ^a   Chen, Chen ^c   Wang, Le ^a   Pan, Lili ^b   Huang, Chenggang ^a   Pan, Guoyu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b NANJING NORMAL UNIVERSITY   (China)

^c JIANGSU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; ROSUVASTATIN; SAPONIN DERIVATIVE; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; TIMOSAPONIN B2; UNCLASSIFIED DRUG; ABC TRANSPORTER; CARRIER PROTEIN; FLUOROBENZENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; ORGANIC ANION TRANSPORTER; PYRIMIDINE DERIVATIVE; SAPONIN; STEROID; SULFONAMIDE; TIMOSAPONIN B-II;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; DRUG POTENTIATION; DRUG TRANSPORT; DRUG UPTAKE; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; LIVER CELL; MALE; MEMBRANE VESICLE; NONHUMAN; RAT; ANIMAL; BILE; CELL LINE; DRUG INTERACTION; GENETIC TRANSFECTION; HEK293 CELL LINE; LIVER; METABOLISM; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CELL LINE; DRUG INTERACTIONS; FLUOROBENZENES; HEK293 CELLS; HEPATOCYTES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; STEROIDS; SULFONAMIDES; TRANSFECTION;

EID: 84919624740     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.059923     Document Type: Article

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