A novel LC-MS/MS method for determination of tissue distribution and excretion of timosaponin B-II in rat biological matrices

Biomedical Chromatography

Volumn 28, Issue 7, 2014, Pages 1011-1016

  Xu, Zhongyuan ^a,b   Gao, Shouhong ^a   Cai, Fei ^c   Zhang, Feng ^a   Jiang, Wei ^a   Liu, Xiaowei ^a   Chen, Wansheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c Laser Plastic and Aesthetic Center   (China)

Author keywords

Excretion; LC MS MS; Rats; Timosaponin B II; Tissue distribution

Indexed keywords

BIOCHEMISTRY; BODY FLUIDS; CLINICAL RESEARCH; PHASE SEPARATION; PHYSIOLOGY; TISSUE;

ANEMARRHENA ASPHODELOIDES; BIOLOGICAL MATRIXES; CHINESE MEDICINAL HERBS; EXCRETION; LC-MS-MS; LC.MS/MS; NATURAL BIOACTIVES; TIMOSAPONIN; TIMOSAPONIN B-II; TISSUE DISTRIBUTIONS;

RATS;

GLYCOSIDE; STEROID; TIMOSAPONIN B 2; UNCLASSIFIED DRUG; SAPONIN; TIMOSAPONIN B-II;

ACCURACY; ANEMARRHENA ASPHODELOIDES; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BILE LEVEL; DRUG EXCRETION; DRUG FECES LEVEL; DRUG SELECTIVITY; DRUG TISSUE LEVEL; DRUG URINE LEVEL; IONIZATION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIVER HOMOGENATE; MALE; NONHUMAN; RAT; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; ANIMAL; BILE; CHEMISTRY; FECES; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

ANEMARRHENA ASPHODELOIDES; LILIACEAE; RATTUS;

ANIMALS; BILE; CHROMATOGRAPHY, LIQUID; FECES; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAPONINS; SENSITIVITY AND SPECIFICITY; STEROIDS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84902547863     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3109     Document Type: Article

References (11)

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