Simultaneous extraction and purification of alkaloids from Sophora flavescens Ait. by microwave-assisted aqueous two-phase extraction with ethanol/ammonia sulfate system

Separation and Purification Technology

Volumn 141, Issue , 2015, Pages 113-123

  Zhang, Wei ^a   Zhu, Dan ^a   Fan, Huajun ^a,b   Liu, Xiaoqin ^a   Wan, Qiang ^a   Wu, Xuehao ^a   Liu, Peng ^b   Tang, James Z ^b  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

Alkaloids; Aqueous two phase systems; Mechanisms; Microwave assisted aqueous two phase extraction; Sophora flavescens Ait.

Indexed keywords

ALKALOIDS; ETHANOL; IMPURITIES; LIQUIDS; MASS TRANSFER; MECHANISMS; METABOLITES; MICROWAVES; NITROGEN COMPOUNDS; PURIFICATION; SOLVENT EXTRACTION; SOLVENTS;

AQUEOUS TWO PHASE SYSTEM; AQUEOUS TWO-PHASE EXTRACTION; EXTRACTION AND PURIFICATIONS; MICROWAVE-ASSISTED AQUEOUS TWO-PHASE EXTRACTION; MICROWAVE-ASSISTED EXTRACTION; RESPONSE SURFACE METHODOLOGY; SINGLE-FACTOR EXPERIMENTS; SOPHORA FLAVESCENS;

ORGANIC SOLVENTS;

SOPHORA FLAVESCENS;

EID: 84919493223     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2014.11.014     Document Type: Article

References (60)

1. Chinese Pharmacopoeia Commission, Kushen (Sophorae Flavescentis Radix), Pharmacopoeia of the People's Republic of China, vol. 1, China Medicine Science and Technology Press, Beijing, 2010, pp. 188-189.
2. K.L. Miao, J.Z. Zhang, Y. Dong, Y.F. Xi, Research progress on the chemical compounds and pharmacology of Sophora flavescens, Nat. Prod. Res. Dev. 13 (2001) 69-73.
3. H.Z. Chen, H.Y. Bao, M. Nuo, Y. Ma, Summary of chemical composition and pharmacological effects and clinical study of Sophora flavescens, Ginseng Res. 22 (2010) 31-37.
4. H.J. Zhao, W.J. Sun, Research progress on the flavonoids in Sophora flavescens Ait. and their pharmacology, J. Chin. Med. Mater. 28 (2005) 247-251.
5. J.H. Jin, J.S. Kim, S.S. Kang, K.H. Son, H.W. Chang, H.P. Kim, Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens, J. Ethnopharmacol. 127 (2010) 589-595.
6. P.L. Ding, Z.X. Liao, H. Huang, P. Zhou, D.F. Chen, (+)-12a-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens, Bioorg. Med. Chem. Lett. 16 (2006) 1231-1235.
7. John W. Ho, Parry L Ngan. Hon, Wai O. Chim, Effects of oxymatrine from Ku Shen on cancer cells, Anticancer Agents Med. Chem. 9 (2009) 823-826.
8. Y.P. Yang, X.C. Shen, Research progress of pharmacological effects of oxymatrine, Chin. J. Hosp. Pharm. 29 (2009) 405-407.
9. M. Huang, Y.Y. Hu, X.Q. Dong, Q.P. Xu, W.H. Yu, Z.Y. Zhang, The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain, J. Ethnopharmacol. 143 (2012) 228-235.
10. X.Y. Huang, C.X. Chen, Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats, Phytomedicine 20 (2013) 202-212.
11. Y.H. Zhou, H.L. Shan, G.F. Qiao, X.H. Sui, Y.J. Lu, B.F. Yang, Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens Ait, Biol. Pharm. Bull. 31 (2008) 2057-2062.
12. L.H. Zhang, B.E. Chen, M.J. Pan, Research progress of pharmacological effects of matrine, Chin. Tradit. Herb. Drugs 40 (6) (2009) 1000-1003.
13. B. Zhang, Z.Y. Liu, Y.Y. Li, Y. Luo, M.L. Liu, H.Y. Dong, Y.X. Wang, Y. Liu, P.T. Zhao, F.G. Jin, Z.C. Li, Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice, Eur. J. Pharm. Sci. 44 (2011) 573-579.
14. C.Z. Liang, J.K. Zhang, Z.L. Shi, B. Liu, C.C.Q. Shen, H.M. Tao, Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2, Cancer Chemother. Pharmacol. 69 (2012) 317-331.
15. M. Xu, L. Yang, L.Z. Hong, X.Y. Zhao, H.L. Zhang, Direct protection of neurons and astrocytes by matrine via inhibition of the NF-κB signaling pathway contributes to neuroprotection against focal cerebral ischemia, Brain Res. 1454 (2012) 48-64.
16. H.F. Zhang, L.J. Shi, G.Y. Song, Z.G. Cai, C. Wang, R.J. An, Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation, Food Chem. Tox. 55 (2013) 70-77.
17. X. Chen, C.Q. Yi, X.Q. Yang, X.R. Wang, Liquid chromatography of active principles in Sophora flavescens root, J. Chromatogr. B 812 (2004) 149-163.
18. X.J. Liu, M.A. Cao, W.H. Li, C.S. Shen, S.Q. Yan, C.S. Yuan, Alkaloids from Sophora flavescens Aition, Fitoterapia 81 (2010) 524-527.
19. G.Q. Liu, J. Dong, H. Wang, Y.K. Hashi, S.Z. Chen, Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry, J. Pharm. Biomed. Anal. 54 (2011) 1065-1072.
20. H.Y. Wang, Y.C. Lu, J. Chen, J.C. Li, S.H. Liu, Subcritical water extraction of alkaloids in Sophora flavescens Ait. and determination by capillary electrophoresis with field-amplified sample stacking, J. Pharm. Biomed. Anal. 58 (2012) 146-151.
21. J.H. Ruan, J. Liu, D. Zhu, T. Gong, F.M. Yang, X.J. Hao, Z.R. Zhang, Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique, Int. J. Pharm. 386 (2010) 282-290.
22. S.W. Yang, L.X. Li, Advances in the research and preparation of matrine in pharmaceutics, Pract. Pharm. Clin. Rem. 15 (2012) 52-54.
23. F.L. Ma, Y. Cheng, Research progress of pharmacodynamics of matrine in various preparations, Chin. Tradit. Patent Med. 26 (2004) 420-422.
24. Y. Ma, Q.W. Zhang, Z.M. Wang, H.M. Gao, Advance in study on compound Kushen injection, Chin. J. Exp. Tradit. Med. Form. 18 (2012) 342-345.
25. L.N. Li, M.S. Ji, Z.Y. Su, Research advances in use of the agricultural fungicide Sophora flavescens, Agrochemicals 45 (2006) 581-583.
26. M.X. Lu, H.P. Zeng, X.J. Wang, Y. Xie, H. Wang, Recent progress in pesticidal alkaloids, Agrochemicals 43 (2004) 249-253.
27. X.M. Song, Z.S. Tang, The Extraction and Preparation of Chemical Components of Traditional Chinese Medicine, People's Medical Publishing House, Beijing, 2004. pp. 296-300.
28. W. Zhang, H.H. Chen, X.Q. Liu, H.J. Fan, X.H. She, S.J. Luo, Comparison of extraction of alkaloids from Sophora flavescens by different microwave assisted methods, Chin. J. Exp. Tradit. Med. Form. 18 (2012) 34-38.
29. J.Y. Ling, G.Y. Zhang, Z.J. Cui, C.K. Zhang, Supercritical fluid extraction of quinolizidine alkaloids from Sophora flavescens Ait. and purification by high-speed counter-current chromatography, J. Chromatogr. A 1145 (2007) 123-127.
30. W.T. Bi, M.L. Tian, K. Ho, Solid-phase extraction of matrine and oxymatrine from Sophora flavescens Ait using amino-imidazolium polymer, J. Sep. Sci. 33 (2010) 1739-1745.
31. C.H. Chan, R. Yusoff, G.C. Ngoh, F.W. Kung, Microwave-assisted extractions of active ingredients from plants, J. Chromatogr. A 1218 (2011) 6213-6225.
32. A. Delazar, L. Nahar, S. Hamedeyazdan, S.D. Sarker, Microwave-assisted extraction in natural products isolation, Methods Mol. Biol. 864 (2012) 89-115.
33. B.K. Tang, W.T. Bi, M.L. Tian, K.H. Row, Application of ionic liquid for extraction and separation of bioactive compounds from plants, J. Chromatogr. B 904 (2012) 1-21.
34. Z.F. Wei, Y.G. Zu, Y.J. Fu, W. Wang, M. Luo, C.J. Zhao, Y.Z. Pan, Ionic liquids-based microwave-assisted extraction of active components from pigeon pea leaves for quantitative analysis, Sep. Purif. Technol. 102 (2013) 75-81.
35. J.R.J. Paré, J.M.R. Bélanger, S.S. Stafford, Microwave-assisted process (MAP™): a new tool for the analytical laboratory, TrAC, Trends Anal. Chem. 13 (1994) 176-184.
36. C.S. Eskilsson, E. Björklund, Analytical-scale microwave-assisted extraction, J. Chromatogr. A 902 (2000) 227-250.
37. B. Kaufmann, P. Christen, Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction, Phytochem. Anal. 13 (2002) 105-113.
38. P.A. Albertson, Partition of cell particles and macromolecules, third ed., Wiley, New York, 1986.
39. M.R. Kula, Trends and future prospects of aqueous two-phase extraction, Bioseparation 1 (1990) 181-189.
40. A.D. Diamond, J.T. Hsu, Aqueous two-phase systems for biomolecule separation, Adv. Biochem. Eng. Biotechnol. 47 (1992) 89-135.
41. O. Aguilar, M. Rito-Palomares, Aqueous two-phase systems strategies for the recovery and characterization of biological products from plants, J. Sci. Food Agric. 90 (2010) 1385-1392.
42. P.A. Rosa, A.M. Azevedo, S. Sommerfeld, W. Bäcker, M.R. Aires-Barros, Aqueous two-phase extraction as a platform in the biomanufacturing industry: economical and environmental sustainability, Biotechnol. Adv. 29 (2011) 559-567.
43. F. Ruiz-Ruiz, J. Benavides, O. Aguilar, M. Rito-Palomares, Aqueous two-phase affinity partitioning systems: current applications and trends, J. Chromatogr. A 1244 (2012) 1-13.
44. Z.L. Xiu, A.P. Zeng, Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol, Appl. Microbiol. Biotechnol. 76 (2008) 917-926.
45. Z.G. Li, H. Teng, Z.L. Xiu, Aqueous two-phase extraction of 2,3-butanediol from fermentation broths using an ethanol/ammonium sulfate system, Proc. Biochem. 45 (2010) 731-737.
46. Z.G. Li, H. Teng, Z.L. Xiu, Extraction of 1,3-propanediol from glycerol-based fermentation broths with methanol/phosphate aqueous two-phase system, Proc. Biochem. 46 (2011) 586-591.
47. Y.X. Guo, J. Han, D.Y. Zhang, L.H. Wang, L.L. Zhou, An ammonium sulfate/ethanol aqueous two-phase system combined with ultrasonication for the separation and purification of lithospermic acid B from Salvia miltiorrhiza Bunge, Ultrason. Sonochem. 19 (2012) 719-724.
48. X. Liu, T. Mu, H. Sun, M. Zhang, J. Chen, Optimisation of aqueous two-phase extraction of anthocyanins from purple sweet potatoes by response surface methodology, Food Chem. 141 (2013) 3034-3041.
49. Z.J. Tan, F.F. Li, X.L. Xu, Extraction and purification of anthraquinones derivatives from Aloe vera L. using alcohol/salt aqueous two-phase system, Bioproc. Biosys. Eng. 36 (2013) 1105-1113.
50. Y.X. Guo, J. Han, D.Y. Zhang, L.H. Wang, L.L. Zhou, Aqueous two-phase system coupled with ultrasound for the extraction of lignans from seeds of Schisandra chinensis (turcz.) Baill, Ultrason. Sonochem. 20 (2013) 125-132.
51. X.Q. Liu, H.J. Fan, X.W. Huang, L.F. Zhang, HPLC determination of 5 alkaloids in Sophora flavescens Ait with microwave-assisted extraction, PTCA (Part B: Chem. Anal.) 48 (2012) 299-302.
52. X.Q. Liu, W. Zhang, H.J. Fan, L.P. Wang, X.W. Huang, Y. Feng, D. Zhu, Separation of alkaloids in Sophora flavescens Ait. by aqueous two-phase extraction, Chin. J. Proc. Eng. 12 (2012) 641-647.
53. H. Wang, Y.S. Dong, Z.L. Xiu, Microwave-assisted aqueous two-phase extraction of piceid, resveratrol and emodin from Polygonum cuspidatum by ethanol/ammonium sulphate systems, Biotechnol. Lett. 30 (2008) 2079-2084.
54. L. Liu, Y.S. Dong, Z.L. Xiu, Three-liquid-phase extraction of diosgenin and steroidal saponins from fermentation of Dioscorea zingibernsis CH Wright, Proc. Biochem. 45 (2010) 752-756.
55. X. Lin, Y.Z. Wang, X.J. Liu, S.Y. Huang, Q. Zeng, ILs-based microwave-assisted extraction coupled with aqueous two-phase for the extraction of useful compounds from Chinese medicine, Analyst 137 (2012) 4076-4085.
56. D.Y. Zhang, Y.G. Zu, Y.J. Fu, W. Wang, L. Zhang, M. Luo, F.S. Mu, X.H. Yao, M.H. Duan, Aqueous two-phase extraction and enrichment of two main flavonoids from pigeon pea roots and the antioxidant activity, Sep. Purif. Technol. 102 (2013) 26-33.
57. F.Y. Ma, C.B. Gu, C.Y. Li, M. Luo, W. Wang, Y.G. Zu, J. Li, Y.J. Fu, Microwave-assisted aqueous two-phase extraction of isoflavonoids from Dalbergia odorifera T. Chen leaves, Sep. Purif. Technol. 115 (2013) 136-144.
58. G.Z. Pan, F. Li, J. Li, Effect of converter of matrine and oxymatrine on extraction method of Radix Sophorae flavescentis, Res. Pract. Chin. Med. 2 (2008) 52-54.
59. H.J. Fan, G.X. Lin, X.X. Xiao, G.K. Li, Investigation of thermodynamic mechanism for extraction of active constituents in Lycoris radiata and Rhizma Polygoni Cuspidati using microwave-assisted extraction, Chem. J. Chin. Univ. 27 (2006) 2271-2276.
60. N. Nagaraj, A.V. Narayan, N.D. Srinivas, K.S.M.S. Raghavarao, Microwave-field-assisted enhanced demixing of aqueous two-phase systems, Anal. Biochem. 312 (2003) 134-140.