Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats

Phytomedicine

Volumn 20, Issue 3-4, 2013, Pages 202-212

  Huang, Xiao Yan ^a   Chen, Chang Xun ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Gene overexpression; Oxymatrine; Radix Sophorae flavescentis (Kushen); SHR; Signaling pathway; Ventricular remodeling

Indexed keywords

ANGIOTENSIN II; CAPTOPRIL; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DIPEPTIDYL CARBOXYPEPTIDASE; DRINKING WATER; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NORADRENALIN; OXYMATRINE; PICRIC ACID; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEART MUSCLE; HEART MUSCLE FIBROSIS; HEART RATE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HEART WEIGHT; HEART WEIGHT INDEX; HYPERTENSION; LEFT VENTRICULAR WEIGHT INDEX; MEAN ARTERIAL PRESSURE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOPHORAE FLAVESCENTIS; WESTERN BLOTTING;

ALKALOIDS; ANGIOTENSIN II; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; COLLAGEN; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; HEART; HEART RATE; HYPERTENSION; MALE; MAP KINASE SIGNALING SYSTEM; MYOCARDIUM; NOREPINEPHRINE; ORGAN SIZE; PEPTIDYL-DIPEPTIDASE A; PHYTOTHERAPY; QUINOLIZINES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR REMODELING;

RATTUS;

EID: 84873715806     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.10.012     Document Type: Article

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