Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 11, 2008, Pages 2057-2062

  Zhou, Yuhong ^a   Shan, Hongli ^a   Qiao, Guofen ^a   Sui, Xiaohong ^a   Lu, Yanjie ^a,b   Yang, Baofen ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b State Province Key Laboratory of Biopharmaceutical Engineering   (China)

Author keywords

Calcium current; Intracellular calcium concentration; Matrine; Positive inotropic action

Indexed keywords

ACETIC ACID DERIVATIVE; ALKALOID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL L TYPE; ESTER; FLUO 3; ION CHANNEL; MATRINE; METHYL GROUP; POTASSIUM CHLORIDE; QUINOLIZIDINE DERIVATIVE; SOPHORA FLAVESCENS EXTRACT;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GUINEA PIG; HEART MUSCLE CELL; HEART PAPILLARY MUSCLE; HEART VENTRICLE; INOTROPISM; MUSCLE CONTRACTILITY; NONHUMAN; SOPHORA;

ACTION POTENTIALS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ALKALOIDS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; MUSCLE CELLS; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; QUINOLIZINES; SOPHORA;

EID: 55549111248     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.2057     Document Type: Article

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