Aqueous two-phase extraction as a platform in the biomanufacturing industry: Economical and environmental sustainability

Biotechnology Advances

Volumn 29, Issue 6, 2011, Pages 559-567

  Rosa, P A J ^a   Azevedo, A M ^a   Sommerfeld, S ^b   Backer W ^b   Aires Barros, M R ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b BAYER AG   (Germany)

Author keywords

Aqueous two phase systems; Economical analysis; Environmental sustainability; Protein A affinity chromatography; Purification of antibodies

Indexed keywords

ALTERNATIVE PROCESS; AQUEOUS TWO PHASE SYSTEM; AQUEOUS TWO-PHASE EXTRACTION; BIOMANUFACTURING; BIOTECH INDUSTRY; DOWNSTREAM PROCESS; ECONOMICAL ANALYSIS; ENVIRONMENTAL SUSTAINABILITY; HIGH COSTS; HUMAN THERAPEUTICS; MONOCLONAL ANTIBODIES (MABS); PACKING PROBLEMS; PROCESS ECONOMICS; PRODUCTION BOTTLENECKS; PROTEIN A; PROTEIN A AFFINITY CHROMATOGRAPHY; PROTEOLYTIC STABILITY; PURIFICATION PROCESS; SUPERNATANTS; UPSTREAM PROCESS;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL CULTURE; BIOTECHNOLOGY; CHEMICAL STABILITY; ENVIRONMENTAL IMPACT; INDUSTRY; MONOCLONAL ANTIBODIES; OPERATING COSTS; PURIFICATION; SUSTAINABLE DEVELOPMENT;

SOLVENT EXTRACTION;

ANTIBODY; AQUEOUS SOLUTION; BIOTECHNOLOGY; CHROMATOGRAPHY; ECONOMIC ANALYSIS; ION CHROMATOGRAPHY; PHASE TRANSITION; PROTEIN; PURIFICATION; SUSTAINABLE DEVELOPMENT;

AFFINITY CHROMATOGRAPHY; BIOTECHNOLOGY; DRUG INDUSTRY; ECONOMICS; ENVIRONMENT; GREEN CHEMISTRY; HUMAN; LIQUID LIQUID EXTRACTION; METHODOLOGY; REVIEW;

BIOTECHNOLOGY; CHROMATOGRAPHY, AFFINITY; DRUG INDUSTRY; ENVIRONMENT; GREEN CHEMISTRY TECHNOLOGY; HUMANS; LIQUID-LIQUID EXTRACTION;

EID: 80053444906     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2011.03.006     Document Type: Review

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