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Volumn 3, Issue 9, 2014, Pages

Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: Molecular mechanisms and clinical significance

Author keywords

Chronic hepatitis B; Covalently closed circular DNA; Hepatitis B virus; Interferon; Nucleos(t)ide analog

Indexed keywords

ANTIVIRUS AGENT; CIRCULAR DNA; COVALENTLY CLOSED CIRCULAR DNA; RELAXED CIRCULAR DNA; UNCLASSIFIED DRUG;

EID: 84919449705     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1038/emi.2014.64     Document Type: Review
Times cited : (113)

References (110)
  • 1
    • 84983726731 scopus 로고    scopus 로고
    • Recent advances in the research of hepatitis B virusrelated hepatocellular carcinoma: Epidemiologic and molecular biological aspects
    • Kao JH, Chen PJ, Chen DS. Recent advances in the research of hepatitis B virusrelated hepatocellular carcinoma: epidemiologic and molecular biological aspects. Adv Cancer Res 2010; 108: 21-72.
    • (2010) Adv Cancer Res , vol.108 , pp. 21-72
    • Kao, J.H.1    Chen, P.J.2    Chen, D.S.3
  • 2
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Dienstag JL. Hepatitis B virus infection. N Engl J Med 2008; 359: 1486-1500.
    • (2008) N Engl J Med , vol.359 , pp. 1486-1500
    • Dienstag, J.L.1
  • 3
    • 84879158955 scopus 로고    scopus 로고
    • Hepatitis B viral factors and treatment responses in chronic hepatitis B
    • Lin CL, Kao JH. Hepatitis B viral factors and treatment responses in chronic hepatitis B. J Formosan Med Assoc 2013; 112: 302-311.
    • (2013) J Formosan Med Assoc , vol.112 , pp. 302-311
    • Lin, C.L.1    Kao, J.H.2
  • 4
    • 84890886957 scopus 로고    scopus 로고
    • HBeAg-positive chronic hepatitis B: Why do i treat my patients with pegylated interferon?
    • Kao JH. HBeAg-positive chronic hepatitis B: why do I treat my patients with pegylated interferon? Liver Int 2014; 34 Suppl 1: 112-119.
    • (2014) Liver Int , vol.34 , pp. 112-119
    • Kao, J.H.1
  • 5
    • 84984538817 scopus 로고    scopus 로고
    • Chronic hepatitis B: Whom to treat and for how long? Propositions, challenges, and future directions
    • Ahn SH, Chan HL, Chen PJ et al. Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions. Hepatol Int 2010; 4: 386-395.
    • (2010) Hepatol Int , vol.4 , pp. 386-395
    • Ahn, S.H.1    Chan, H.L.2    Chen, P.J.3
  • 6
    • 79960013101 scopus 로고    scopus 로고
    • Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy
    • LiangY,JiangJ,SuMet al. Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy. Aliment Pharmacol Ther 2011; 34: 344-352.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 344-352
    • Liang, Y.1    Jiang, J.2    Sumet, Al.3
  • 7
    • 84890877852 scopus 로고    scopus 로고
    • New therapeutic perspectives in HBV: When to stop NAs
    • Perez-Cameo C, Pons M, Esteban R. New therapeutic perspectives in HBV: when to stop NAs. Liver Int 2014; 34 Suppl 1: 146-153.
    • (2014) Liver Int , vol.34 , pp. 146-153
    • Perez-Cameo, C.1    Pons, M.2    Esteban, R.3
  • 8
    • 13844250599 scopus 로고    scopus 로고
    • New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA
    • Zoulim F. New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA. J Hepatol 2005; 42: 302-308.
    • (2005) J Hepatol , vol.42 , pp. 302-308
    • Zoulim, F.1
  • 9
  • 10
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996; 2: 1104-1108.
    • (1996) Nat Med , vol.2 , pp. 1104-1108
    • Rehermann, B.1    Ferrari, C.2    Pasquinelli, C.3    Chisari, F.V.4
  • 11
    • 0030858894 scopus 로고    scopus 로고
    • Persistence of hepatitis B virus DNA in serum and liver from patients with chronic hepatitis B after loss of HBsAg
    • Loriot MA, Marcellin P, Walker F et al. Persistence of hepatitis B virus DNA in serum and liver from patients with chronic hepatitis B after loss of HBsAg. J Hepatol 1997; 27: 251-258.
    • (1997) J Hepatol , vol.27 , pp. 251-258
    • Loriot, M.A.1    Marcellin, P.2    Walker, F.3
  • 12
    • 0031778788 scopus 로고    scopus 로고
    • Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen
    • Mason AL, Xu L, Guo L, Kuhns M, Perrillo RP. Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen. Hepatology 1998; 27: 1736-1742.
    • (1998) Hepatology , vol.27 , pp. 1736-1742
    • Mason, A.L.1    Xu, L.2    Guo, L.3    Kuhns, M.4    Perrillo, R.P.5
  • 13
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers J, Mason WS. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 1982; 29: 403-415.
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 14
    • 43049117085 scopus 로고    scopus 로고
    • Hepatitis B viruses: Reverse transcription a different way
    • Nassal M. Hepatitis B viruses: reverse transcription a different way. Virus Res 2008; 134: 235-249.
    • (2008) Virus Res , vol.134 , pp. 235-249
    • Nassal, M.1
  • 16
    • 84879327902 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
    • Yan H, Zhong G, Xu G et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 2012; 1: e00049.
    • (2012) ELife , vol.1
    • Yan, H.1    Zhong, G.2    Xu, G.3
  • 17
    • 0036380904 scopus 로고    scopus 로고
    • Regulatory elements of hepatitis B virus transcription
    • Moolla N, Kew M, Arbuthnot P. Regulatory elements of hepatitis B virus transcription. J Viral Hepat 2002; 9: 323-331.
    • (2002) J Viral Hepat , vol.9 , pp. 323-331
    • Moolla, N.1    Kew, M.2    Arbuthnot, P.3
  • 18
    • 77954489756 scopus 로고    scopus 로고
    • Control of hepatitis B virus at the level of transcription
    • Quasdorff M, Protzer U. Control of hepatitis B virus at the level of transcription. J Viral Hepat 2010; 17: 527-536.
    • (2010) J Viral Hepat , vol.17 , pp. 527-536
    • Quasdorff, M.1    Protzer, U.2
  • 19
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells
    • Tuttleman JS, Pourcel C, Summers J. Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 1986; 47: 451-460.
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.S.1    Pourcel, C.2    Summers, J.3
  • 20
    • 0025329760 scopus 로고
    • In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway
    • Wu TT, Coates L, Aldrich CE, Summers J, Mason WS. In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway. Virology 1990; 175: 255-261.
    • (1990) Virology , vol.175 , pp. 255-261
    • Wu, T.T.1    Coates, L.2    Aldrich, C.E.3    Summers, J.4    Mason, W.S.5
  • 21
    • 0029037074 scopus 로고
    • The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes
    • Newbold JE, Xin H, Tencza M et al. The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes. J Virol 1995; 69: 3350-3357.
    • (1995) J Virol , vol.69 , pp. 3350-3357
    • Newbold, J.E.1    Xin, H.2    Tencza, M.3
  • 22
    • 0142027756 scopus 로고    scopus 로고
    • Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver
    • Zhang YY, Zhang BH, Theele D, Litwin S, Toll E, Summers J. Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver. Proc Natl Acad Sci USA 2003; 100: 12372-12377.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12372-12377
    • Zhang, Y.Y.1    Zhang, B.H.2    Theele, D.3    Litwin, S.4    Toll, E.5    Summers, J.6
  • 23
    • 34249945560 scopus 로고    scopus 로고
    • Formation of hepatitis B virus covalently closed circular DNA: Removal of genome-linked protein
    • Gao W, Hu J. Formation of hepatitis B virus covalently closed circular DNA: removal of genome-linked protein. J Virol 2007; 81: 6164-6174.
    • (2007) J Virol , vol.81 , pp. 6164-6174
    • Gao, W.1    Hu, J.2
  • 24
    • 36049013787 scopus 로고    scopus 로고
    • Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: An intermediate of covalently closed circular DNA formation
    • Guo H, Jiang D, Zhou T, Cuconati A, Block TM, Guo JT. Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation. J Virol 2007; 81: 12472-12484.
    • (2007) J Virol , vol.81 , pp. 12472-12484
    • Guo, H.1    Jiang, D.2    Zhou, T.3    Cuconati, A.4    Block, T.M.5    Guo, J.T.6
  • 25
    • 72849136702 scopus 로고    scopus 로고
    • Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses
    • Guo H, Mao R, Block TM, Guo JT. Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses. J Virol 2010; 84: 387-396.
    • (2010) J Virol , vol.84 , pp. 387-396
    • Guo, H.1    Mao, R.2    Block, T.M.3    Guo, J.T.4
  • 26
    • 84861321768 scopus 로고    scopus 로고
    • In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase
    • Jones SA, Boregowda R, Spratt TE, Hu J. In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase. J Virol 2012; 86: 5134-5150.
    • (2012) J Virol , vol.86 , pp. 5134-5150
    • Jones, S.A.1    Boregowda, R.2    Spratt, T.E.3    Hu, J.4
  • 27
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle B, Bowden S, Locarnini S et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 2004; 126: 1750-1758.
    • (2004) Gastroenterology , vol.126 , pp. 1750-1758
    • Werle-Lapostolle, B.1    Bowden, S.2    Locarnini, S.3
  • 28
    • 77950684115 scopus 로고    scopus 로고
    • Hepatitis B surface antigen seroclearance during chronic HBV infection
    • Chu CM, Liaw YF. Hepatitis B surface antigen seroclearance during chronic HBV infection. Antivir Ther 2010; 15: 133-143.
    • (2010) Antivir Ther , vol.15 , pp. 133-143
    • Chu, C.M.1    Liaw, Y.F.2
  • 29
    • 0033952115 scopus 로고    scopus 로고
    • Latent hepatitis B virus infection in healthy individuals with antibodies to hepatitis B core antigen
    • Marusawa H, Uemoto S, Hijikata M et al. Latent hepatitis B virus infection in healthy individuals with antibodies to hepatitis B core antigen. Hepatology 2000; 31: 488-495.
    • (2000) Hepatology , vol.31 , pp. 488-495
    • Marusawa, H.1    Uemoto, S.2    Hijikata, M.3
  • 30
    • 0034950571 scopus 로고    scopus 로고
    • Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: Clinically significant or purely "occult"?
    • Brechot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Brechot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"? Hepatology 2001; 34: 194-203.
    • (2001) Hepatology , vol.34 , pp. 194-203
    • Brechot, C.1    Thiers, V.2    Kremsdorf, D.3    Nalpas, B.4    Pol, S.5    Paterlini-Brechot, P.6
  • 32
    • 59149085061 scopus 로고    scopus 로고
    • Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab
    • Yeo W, Chan TC, Leung NW et al. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab. J Clin Oncol 2009; 27: 605-611.
    • (2009) J Clin Oncol , vol.27 , pp. 605-611
    • Yeo, W.1    Chan, T.C.2    Leung, N.W.3
  • 33
    • 84901591515 scopus 로고    scopus 로고
    • Chemotherapy-induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: A prospective study
    • Hsu C, Tsou HH, Lin SJ et al. Chemotherapy-induced hepatitis B reactivation in lymphoma patients with resolved HBV infection: a prospective study. Hepatology 2014; 59: 2092-2100.
    • (2014) Hepatology , vol.59 , pp. 2092-2100
    • Hsu, C.1    Tsou, H.H.2    Lin, S.J.3
  • 35
    • 0028024340 scopus 로고
    • The half-life of duck hepatitis B virus supercoiled DNA in congenitally infected primary hepatocyte cultures
    • Civitico GM, Locarnini SA. The half-life of duck hepatitis B virus supercoiled DNA in congenitally infected primary hepatocyte cultures. Virology 1994; 203: 81-89.
    • (1994) Virology , vol.203 , pp. 81-89
    • Civitico, G.M.1    Locarnini, S.A.2
  • 36
    • 0030776176 scopus 로고    scopus 로고
    • Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus
    • Moraleda G, Saputelli J, Aldrich CE, Averett D, Condreay L, Mason WS. Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus. J Virol 1997; 71: 9392-9399.
    • (1997) J Virol , vol.71 , pp. 9392-9399
    • Moraleda, G.1    Saputelli, J.2    Aldrich, C.E.3    Averett, D.4    Condreay, L.5    Mason, W.S.6
  • 37
    • 0034234540 scopus 로고    scopus 로고
    • Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA
    • DandriM, Burda MR, Will H, Petersen J. Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA. Hepatology 2000; 32: 139-146.
    • (2000) Hepatology , vol.32 , pp. 139-146
    • Dandri, M.1    Burda, M.R.2    Will, H.3    Petersen, J.4
  • 38
    • 59849105037 scopus 로고    scopus 로고
    • Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocytelike cells
    • Hantz O, Parent R, Durantel D, Gripon P, Guguen-Guillouzo C, Zoulim F. Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocytelike cells. J Gen Virol 2009; 90(Pt 1): 127-135.
    • (2009) J Gen Virol , vol.90 , pp. 127-135
    • Hantz, O.1    Parent, R.2    Durantel, D.3    Gripon, P.4    Guguen-Guillouzo, C.5    Zoulim, F.6
  • 39
    • 0034749753 scopus 로고    scopus 로고
    • Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis
    • Zhu Y, Yamamoto T, Cullen J et al. Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J Virol 2001; 75: 311-322.
    • (2001) J Virol , vol.75 , pp. 311-322
    • Zhu, Y.1    Yamamoto, T.2    Cullen, J.3
  • 40
    • 0036109092 scopus 로고    scopus 로고
    • Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication
    • Addison WR, Walters KA, Wong WW et al. Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication. J Virol 2002; 76: 6356-6363.
    • (2002) J Virol , vol.76 , pp. 6356-6363
    • Addison, W.R.1    Walters, K.A.2    Wong, W.W.3
  • 41
    • 0033988351 scopus 로고    scopus 로고
    • Characterization of the antiviral effect of 29,39-dideoxy-29, 39-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model
    • Le Guerhier F, Pichoud C, Guerret S et al. Characterization of the antiviral effect of 29,39-dideoxy-29, 39-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model. Antimicrob Agents Chemother 2000; 44: 111-122.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 111-122
    • Le Guerhier, F.1    Pichoud, C.2    Guerret, S.3
  • 42
    • 0035084728 scopus 로고    scopus 로고
    • Antiviral activity of beta-L-29,39-dideoxy- 29,39-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus
    • Le Guerhier F, Pichoud C, Jamard C et al. Antiviral activity of beta-L-29,39-dideoxy- 29,39-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus. Antimicrob Agents Chemother 2001; 45: 1065-1077.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1065-1077
    • Le Guerhier, F.1    Pichoud, C.2    Jamard, C.3
  • 43
    • 80052453168 scopus 로고    scopus 로고
    • The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesis
    • Reaiche GY, Le Mire MF, Mason WS, Jilbert AR. The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesis. Virology 2010; 406: 286-292.
    • (2010) Virology , vol.406 , pp. 286-292
    • Reaiche, G.Y.1    Le Mire, M.F.2    Mason, W.S.3    Jilbert, A.R.4
  • 44
    • 3543125970 scopus 로고    scopus 로고
    • A long-term latent reservoir forHIV-1: Discovery and clinical implications
    • Siliciano JD, Siliciano RF. A long-term latent reservoir forHIV-1: discovery and clinical implications. J Antimicrob Chemother 2004; 54: 6-9.
    • (2004) J Antimicrob Chemother , vol.54 , pp. 6-9
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 45
    • 0027272784 scopus 로고
    • Analysis of the earliest steps of hepadnavirus replication: Genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity
    • Kock J, Schlicht HJ. Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity. J Virol 1993; 67: 4867-4874.
    • (1993) J Virol , vol.67 , pp. 4867-4874
    • Kock, J.1    Schlicht, H.J.2
  • 46
    • 0036148731 scopus 로고    scopus 로고
    • Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro
    • Delmas J, Schorr O, Jamard C et al. Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro. Antimicrob Agents Chemother 2002; 46: 425-433.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 425-433
    • Delmas, J.1    Schorr, O.2    Jamard, C.3
  • 47
    • 17144440717 scopus 로고    scopus 로고
    • Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes
    • Kock J, Baumert TF, Delaney WE 4th, Blum HE, von Weizsacker F. Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes. Hepatology 2000; 38: 1410-1418.
    • (2000) Hepatology , vol.38 , pp. 1410-1418
    • Kock, J.1    Baumert, T.F.2    Delaney, I.V.W.E.3    Blum, H.E.4    Von Weizsacker, F.5
  • 48
    • 12444252951 scopus 로고    scopus 로고
    • Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
    • Boni C, Penna A, Bertoletti A et al. Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J Hepatol 2003; 39: 595-605.
    • (2003) J Hepatol , vol.39 , pp. 595-605
    • Boni, C.1    Penna, A.2    Bertoletti, A.3
  • 49
    • 84866705034 scopus 로고    scopus 로고
    • Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues
    • Boni C, Laccabue D, LamperticoP et al. Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues. Gastroenterology 2012; 143: 963-973.
    • (2012) Gastroenterology , vol.143 , pp. 963-973
    • Boni, C.1    Laccabue, D.2    Lampertico, P.3
  • 50
    • 20444505037 scopus 로고    scopus 로고
    • Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy
    • Sung JJ, Wong ML, Bowden S et al. Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy. Gastroenterology 2005; 128: 1890-1897.
    • (2005) Gastroenterology , vol.128 , pp. 1890-1897
    • Sung, J.J.1    Wong, M.L.2    Bowden, S.3
  • 51
    • 4644296081 scopus 로고    scopus 로고
    • Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients
    • Wong DK, Yuen MF, YuanHet al. Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients. Hepatology 2004; 40: 727-737.
    • (2004) Hepatology , vol.40 , pp. 727-737
    • Wong, D.K.1    Yuen, M.F.2    Yuanhet, Al.3
  • 52
    • 84902595106 scopus 로고    scopus 로고
    • Comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"
    • Chisari FV, Mason WS, Seeger C. Virology. Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA". Science 2014; 344: 1237.
    • (2014) Science , vol.344 , pp. 1237
    • Chisari, F.V.1    Mason, W.S.2    Virology, S.C.3
  • 53
    • 36549058611 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response
    • Chan HL, Wong VW, Tse AM et al. Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response. Clin Gastroenterol Hepatol 2007; 5: 1462-1468.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1462-1468
    • Chan, H.L.1    Wong, V.W.2    Tse, A.M.3
  • 54
    • 84984552614 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters
    • Tseng TC, Liu CJ, Su TH et al. Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters. Gastroenterology 2011; 141: 517-525.
    • (2011) Gastroenterology , vol.141 , pp. 517-525
    • Tseng, T.C.1    Liu, C.J.2    Su, T.H.3
  • 55
    • 84872498407 scopus 로고    scopus 로고
    • Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: New trick of old dog
    • Tseng TC, Kao JH. Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog. J Gastroenterol 2013; 48: 13-21.
    • (2013) J Gastroenterol , vol.48 , pp. 13-21
    • Tseng, T.C.1    Kao, J.H.2
  • 56
    • 33750964835 scopus 로고    scopus 로고
    • One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels
    • Wong DK, Yuen MF, Ngai VW, Fung J, Lai CL. One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels. Antivir Ther 2006; 11: 909-916.
    • (2006) Antivir Ther , vol.11 , pp. 909-916
    • Wong, D.K.1    Yuen, M.F.2    Ngai, V.W.3    Fung, J.4    Lai, C.L.5
  • 57
    • 66149162007 scopus 로고    scopus 로고
    • Benefits and risks of interferon therapy for hepatitis B
    • Perrillo R. Benefits and risks of interferon therapy for hepatitis B. Hepatology 2009; 49(5 Suppl): S103-S111.
    • (2009) Hepatology , vol.49 , Issue.5 , pp. S103-S111
    • Perrillo, R.1
  • 58
    • 84894064916 scopus 로고    scopus 로고
    • Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
    • Allweiss L, Volz T, Lutgehetmann M et al. Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration. J Hepatol 2014; 60: 500-507.
    • (2014) J Hepatol , vol.60 , pp. 500-507
    • Allweiss, L.1    Volz, T.2    Lutgehetmann, M.3
  • 59
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • Lucifora J, Xia Y, Reisinger F et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 2014: 343: 1221-1228.
    • (2014) Science , vol.343 , pp. 1221-1228
    • Lucifora, J.1    Xia, Y.2    Reisinger, F.3
  • 60
    • 33748929265 scopus 로고    scopus 로고
    • Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
    • Wursthorn K, Lutgehetmann M, Dandri M et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology 2006; 44: 675-684.
    • (2006) Hepatology , vol.44 , pp. 675-684
    • Wursthorn, K.1    Lutgehetmann, M.2    Dandri, M.3
  • 61
    • 84876356179 scopus 로고    scopus 로고
    • Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B
    • Hagiwara S, Kudo M, Osaki Y et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol 2013; 85: 987-995.
    • (2013) J Med Virol , vol.85 , pp. 987-995
    • Hagiwara, S.1    Kudo, M.2    Osaki, Y.3
  • 63
    • 0033029334 scopus 로고    scopus 로고
    • Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
    • Tsiang M, Rooney JF, Toole JJ, Gibbs CS. Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy. Hepatology 1999; 29: 1863-1869.
    • (1999) Hepatology , vol.29 , pp. 1863-1869
    • Tsiang, M.1    Rooney, J.F.2    Toole, J.J.3    Gibbs, C.S.4
  • 64
    • 0034756599 scopus 로고    scopus 로고
    • Analysis of hepatitis B viral load decline under potent therapy: Complex decay profiles observed
    • Lewin SR, Ribeiro RM, Walters T et al. Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed. Hepatology 2001; 34: 1012-1020.
    • (2001) Hepatology , vol.34 , pp. 1012-1020
    • Lewin, S.R.1    Ribeiro, R.M.2    Walters, T.3
  • 65
    • 0035991456 scopus 로고    scopus 로고
    • Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B
    • Wolters LM, Hansen BE, Niesters HG, DeHertogh D, de Man RA. Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B. J Hepatol 2002; 37: 137-144.
    • (2002) J Hepatol , vol.37 , pp. 137-144
    • Wolters, L.M.1    Hansen, B.E.2    Niesters, H.G.3    Dehertogh, D.4    De Man, R.A.5
  • 66
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293: 1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 67
    • 34249692514 scopus 로고    scopus 로고
    • Role of DNA methylation in stable gene repression
    • Lande-Diner L, Zhang J, Ben-Porath I et al. Role of DNA methylation in stable gene repression. J Biol Chem 2007; 282: 12194-12200.
    • (2007) J Biol Chem , vol.282 , pp. 12194-12200
    • Lande-Diner, L.1    Zhang, J.2    Ben-Porath, I.3
  • 68
    • 33847070442 scopus 로고    scopus 로고
    • The role of chromatin during transcription
    • Li B, Carey M, Workman JL. The role of chromatin during transcription. Cell 2007; 128: 707-719.
    • (2007) Cell , vol.128 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 69
    • 0028095561 scopus 로고
    • Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell
    • Bock CT, Schranz P, Schroder CH, Zentgraf H. Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell. Virus genes 1994; 8: 215-229.
    • (1994) Virus Genes , vol.8 , pp. 215-229
    • Bock, C.T.1    Schranz, P.2    Schroder, C.H.3    Zentgraf, H.4
  • 70
    • 0035896013 scopus 로고    scopus 로고
    • Structural organization of the hepatitis B virus minichromosome
    • Bock CT, Schwinn S, Locarnini S et al. Structural organization of the hepatitis B virus minichromosome. J Mol Biol 2001; 307: 183-196.
    • (2001) J Mol Biol , vol.307 , pp. 183-196
    • Bock, C.T.1    Schwinn, S.2    Locarnini, S.3
  • 72
    • 33644854241 scopus 로고    scopus 로고
    • Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones
    • Pollicino T, Belloni L, Raffa G et al. Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology 2006; 130: 823-837.
    • (2006) Gastroenterology , vol.130 , pp. 823-837
    • Pollicino, T.1    Belloni, L.2    Raffa, G.3
  • 73
    • 73949127893 scopus 로고    scopus 로고
    • Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
    • Belloni L, Pollicino T, de Nicola F et al. Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function. Proc Natl Acad Sci USA 2009; 106: 19975-19979.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19975-19979
    • Belloni, L.1    Pollicino, T.2    De Nicola, F.3
  • 74
    • 37649007673 scopus 로고    scopus 로고
    • Hepatitis B viral DNA is methylated in liver tissues
    • Vivekanandan P, Thomas D, Torbenson M. Hepatitis B viral DNA is methylated in liver tissues. J Viral Hepat 2008; 15: 103-107.
    • (2008) J Viral Hepat , vol.15 , pp. 103-107
    • Vivekanandan, P.1    Thomas, D.2    Torbenson, M.3
  • 75
    • 84874326995 scopus 로고    scopus 로고
    • Comparative analysis of CpG islands among HBV genotypes
    • Zhang Y, Li C, Zhang Y et al. Comparative analysis of CpG islands among HBV genotypes. PloS One 2013; 8: e56711.
    • (2013) PloS One , vol.8
    • Zhang, Y.1    Li, C.2    Zhang, Y.3
  • 76
    • 65649090562 scopus 로고    scopus 로고
    • Methylation regulates hepatitis B viral protein expression
    • Vivekanandan P, Thomas D, Torbenson M. Methylation regulates hepatitis B viral protein expression. J Infect Dis 2009; 199: 1286-1291.
    • (2009) J Infect Dis , vol.199 , pp. 1286-1291
    • Vivekanandan, P.1    Thomas, D.2    Torbenson, M.3
  • 77
    • 67649989072 scopus 로고    scopus 로고
    • Evidence that methylation of hepatitis B virus covalently closed circular DNA in liver tissues of patients with chronic hepatitis B modulates HBV replication
    • Guo Y, Li Y, Mu S, Zhang J, Yan Z. Evidence that methylation of hepatitis B virus covalently closed circular DNA in liver tissues of patients with chronic hepatitis B modulates HBV replication. J Med Virol 2009; 81: 1177-1183.
    • (2009) J Med Virol , vol.81 , pp. 1177-1183
    • Guo, Y.1    Li, Y.2    Mu, S.3    Zhang, J.4    Yan, Z.5
  • 78
    • 33748939050 scopus 로고    scopus 로고
    • Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients
    • Laras A, Koskinas J, Dimou E, Kostamena A, Hadziyannis SJ. Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients. Hepatology 2006; 44: 694-702.
    • (2006) Hepatology , vol.44 , pp. 694-702
    • Laras, A.1    Koskinas, J.2    Dimou, E.3    Kostamena, A.4    Hadziyannis, S.J.5
  • 79
    • 34548475512 scopus 로고    scopus 로고
    • Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients
    • Volz T, Lutgehetmann M, Wachtler P et al. Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients. Gastroenterology 2007; 133: 843-852.
    • (2007) Gastroenterology , vol.133 , pp. 843-852
    • Volz, T.1    Lutgehetmann, M.2    Wachtler, P.3
  • 80
    • 84856514985 scopus 로고    scopus 로고
    • IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNAminichromosome
    • Belloni L, Allweiss L, Guerrieri F et al. IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNAminichromosome. J Clin Invest 2012; 122: 529-537.
    • (2012) J Clin Invest , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3
  • 81
    • 84884692876 scopus 로고    scopus 로고
    • Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes
    • Liu F, Campagna M, Qi Y et al. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. PLoS Pathog 2013; 9: e1003613.
    • (2013) PLoS Pathog , vol.9
    • Liu, F.1    Campagna, M.2    Qi, Y.3
  • 82
    • 32944460932 scopus 로고    scopus 로고
    • Hepatitis B virus cccDNA clearance: Killing for curing?
    • Dandri M, Petersen J. Hepatitis B virus cccDNA clearance: killing for curing? Hepatology 2005; 42: 1453-1455.
    • (2005) Hepatology , vol.42 , pp. 1453-1455
    • Dandri, M.1    Petersen, J.2
  • 83
    • 0028348561 scopus 로고
    • Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice
    • Guidotti LG, Ando K, Hobbs MV et al. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci USA 1994; 91: 3764-3768.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3764-3768
    • Guidotti, L.G.1    Ando, K.2    Hobbs, M.V.3
  • 84
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • Guidotti LG. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999; 284: 825-829.
    • (1999) Science , vol.284 , pp. 825-829
    • Guidotti, L.G.1
  • 85
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolytic control of viral infections by the innate and adaptive immune response
    • Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001; 19: 65-91.
    • (2001) Annu Rev Immunol , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 86
    • 73949152609 scopus 로고    scopus 로고
    • CD81 T cell control of hepatitis B virus replication: Direct comparison between cytolytic and noncytolytic functions
    • Phillips S, Chokshi S, Riva A, Evans A, Williams R, Naoumov NV. CD81 T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functions. J Immunol 2010; 184: 287-295.
    • (2010) J Immunol , vol.184 , pp. 287-295
    • Phillips, S.1    Chokshi, S.2    Riva, A.3    Evans, A.4    Williams, R.5    Naoumov, N.V.6
  • 87
    • 0033951066 scopus 로고    scopus 로고
    • Relative sensitivity of hepatitisBvirus and other hepatotropic viruses to the antiviral effects of cytokines
    • McClaryH, Koch R, Chisari FV, Guidotti LG. Relative sensitivity of hepatitisBvirus and other hepatotropic viruses to the antiviral effects of cytokines. J Virol 2000; 74: 2255-2264.
    • (2000) J Virol , vol.74 , pp. 2255-2264
    • McClary, H.1    Koch, R.2    Chisari, F.V.3    Guidotti, L.G.4
  • 89
    • 3042533780 scopus 로고    scopus 로고
    • Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection
    • Jacquard AC, Nassal M, Pichoud C et al. Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother 2004; 48: 2683-2692.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2683-2692
    • Jacquard, A.C.1    Nassal, M.2    Pichoud, C.3
  • 90
    • 4344689368 scopus 로고    scopus 로고
    • Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus
    • Zhu Y, Cullen JM, Aldrich CE et al. Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus. Virology 2004; 327: 26-40.
    • (2004) Virology , vol.327 , pp. 26-40
    • Zhu, Y.1    Cullen, J.M.2    Aldrich, C.E.3
  • 91
    • 1642308939 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by APOBEC3G
    • Turelli P, Mangeat B, Jost S, Vianin S, Trono D. Inhibition of hepatitis B virus replication by APOBEC3G. Science 2004; 303: 1829.
    • (2004) Science , vol.303 , pp. 1829
    • Turelli, P.1    Mangeat, B.2    Jost, S.3    Vianin, S.4    Trono, D.5
  • 93
    • 84878489347 scopus 로고    scopus 로고
    • Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: Excision repair of covalently closed circular DNA
    • Kitamura K, Wang Z, Chowdhury S, Simadu M, Koura M, Muramatsu M. Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA. PLoS Pathog 2013; 9: e1003361.
    • (2013) PLoS Pathog , vol.9
    • Kitamura, K.1    Wang, Z.2    Chowdhury, S.3    Simadu, M.4    Koura, M.5    Muramatsu, M.6
  • 94
    • 0037213545 scopus 로고    scopus 로고
    • CD81 T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • Thimme R, Wieland S, Steiger C et al. CD81 T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003; 77: 68-76.
    • (2003) J Virol , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3
  • 95
    • 0028102990 scopus 로고
    • Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks
    • Fourel I, Cullen JM, Saputelli J et al. Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks. J Virol 1994; 68: 8321-8330.
    • (1994) J Virol , vol.68 , pp. 8321-8330
    • Fourel, I.1    Cullen, J.M.2    Saputelli, J.3
  • 96
    • 0033965482 scopus 로고    scopus 로고
    • Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections
    • Guo JT, Zhou H, Liu C et al. Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections. J Virol 2000; 74: 1495-1505.
    • (2000) J Virol , vol.74 , pp. 1495-1505
    • Guo, J.T.1    Zhou, H.2    Liu, C.3
  • 97
    • 0141593509 scopus 로고    scopus 로고
    • Hepatocyte turnover during resolution of a transient hepadnaviral infection
    • Summers J, Jilbert AR, Yang W et al. Hepatocyte turnover during resolution of a transient hepadnaviral infection. Proc Natl Acad Sci USA 2003; 100: 11652-11659.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11652-11659
    • Summers, J.1    Jilbert, A.R.2    Yang, W.3
  • 98
    • 0347635488 scopus 로고    scopus 로고
    • Residual integrated viralDNAafter hepadnavirus clearance by nucleoside analog therapy
    • Summers J, Mason WS. Residual integrated viralDNAafter hepadnavirus clearance by nucleoside analog therapy. Proc Natl Acad Sci USA 2004; 101: 638-640.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 638-640
    • Summers, J.1    Mason, W.S.2
  • 99
    • 12844283883 scopus 로고    scopus 로고
    • Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection
    • Mason WS, Jilbert AR, Summers J. Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection. Proc Natl Acad Sci USA 2005; 102: 1139-1144.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1139-1144
    • Mason, W.S.1    Jilbert, A.R.2    Summers, J.3
  • 100
    • 84880799657 scopus 로고    scopus 로고
    • Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: A mathematical modeling approach
    • Schiffer JT, Swan DA, Stone D, Jerome KR. Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: a mathematical modeling approach. PLoS Comput Biol 2013; 9: e1003131.
    • (2013) PLoS Comput Biol , vol.9
    • Schiffer, J.T.1    Swan, D.A.2    Stone, D.3    Jerome, K.R.4
  • 101
    • 77952011493 scopus 로고    scopus 로고
    • Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs
    • Cradick TJ, Keck K, Bradshaw S, Jamieson AC, McCaffrey AP. Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Mol Ther 2010; 18: 947-954.
    • (2010) Mol Ther , vol.18 , pp. 947-954
    • Cradick, T.J.1    Keck, K.2    Bradshaw, S.3    Jamieson, A.C.4    McCaffrey, A.P.5
  • 102
    • 84885023096 scopus 로고    scopus 로고
    • Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activatorlike effector nucleases
    • Bloom K, Ely A, Mussolino C, Cathomen T, Arbuthnot P. Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activatorlike effector nucleases. Mol Ther 2013; 21: 1889-1897.
    • (2013) Mol Ther , vol.21 , pp. 1889-1897
    • Bloom, K.1    Ely, A.2    Mussolino, C.3    Cathomen, T.4    Arbuthnot, P.5
  • 103
    • 84895908706 scopus 로고    scopus 로고
    • An efficient antiviral strategy for targeting hepatitis B virus genome using Transcription Activator-Like Effector Nucleases
    • Chen J, Zhang W, Lin J et al. An efficient antiviral strategy for targeting hepatitis B virus genome using Transcription Activator-Like Effector Nucleases. Mol Ther 2013: 22: 303-311.
    • (2013) Mol Ther , vol.22 , pp. 303-311
    • Chen, J.1    Zhang, W.2    Lin, J.3
  • 104
    • 84884856342 scopus 로고    scopus 로고
    • Cas9 as a versatile tool for engineering biology
    • Mali P, Esvelt KM, Church GM. Cas9 as a versatile tool for engineering biology. Nat Methods 2013; 10: 957-963.
    • (2013) Nat Methods , vol.10 , pp. 957-963
    • Mali, P.1    Esvelt, K.M.2    Church, G.M.3
  • 105
    • 0025719119 scopus 로고
    • Cytotoxic T lymphocytes recognize an HLA-A2- restricted epitope within the hepatitis B virus nucleocapsid antigen
    • Penna A, Chisari FV, Bertoletti A et al. Cytotoxic T lymphocytes recognize an HLA-A2- restricted epitope within the hepatitis B virus nucleocapsid antigen. J Exp Med 1991; 174: 1565-1570.
    • (1991) J Exp Med , vol.174 , pp. 1565-1570
    • Penna, A.1    Chisari, F.V.2    Bertoletti, A.3
  • 106
    • 0027297761 scopus 로고
    • HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection
    • Nayersina R, Fowler P, Guilhot S et al. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol 1993; 150: 4659-4671.
    • (1993) J Immunol , vol.150 , pp. 4659-4671
    • Nayersina, R.1    Fowler, P.2    Guilhot, S.3
  • 107
    • 0028925535 scopus 로고
    • The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis
    • Rehermann B, Fowler P, Sidney J et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995; 181: 1047-1058.
    • (1995) J Exp Med , vol.181 , pp. 1047-1058
    • Rehermann, B.1    Fowler, P.2    Sidney, J.3
  • 108
    • 35448951348 scopus 로고    scopus 로고
    • Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B
    • Bohne F, Protzer U. Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B. J Viral Hepat 2007; 14 Suppl 1: 45-50.
    • (2007) J Viral Hepat , vol.14 , pp. 45-50
    • Bohne, F.1    Protzer, U.2
  • 109
    • 84880582625 scopus 로고    scopus 로고
    • T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice
    • Krebs K, Bottinger N, Huang LR et al. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology 2013; 145: 456-465.
    • (2013) Gastroenterology , vol.145 , pp. 456-465
    • Krebs, K.1    Bottinger, N.2    Huang, L.R.3


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