Regulatory elements of hepatitis B virus transcription

Journal of Viral Hepatitis

Volumn 9, Issue 5, 2002, Pages 323-331

  Moolla, Naazneen ^a   Kew, Michael ^a   Arbuthnot, Patrick ^a  

^a UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

Author keywords

Core promoter; Enhancer I; Enhancer II; HBV; S1 promoter; S2 promoter; Transcription; X promoter

Indexed keywords

GENE PRODUCT; MEMBRANE ANTIGEN; TRANSCRIPTION FACTOR; VIRUS RNA;

ENHANCER REGION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SEQUENCE; GENETIC CODE; HEPATITIS B VIRUS; LIVER; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; REGULATORY MECHANISM; REVIEW; RNA SYNTHESIS; TATA BOX; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VIROGENESIS; VIRUS CORE; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

CARCINOMA, HEPATOCELLULAR; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, VIRAL; HEPATITIS B VIRUS; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 0036380904     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.2002.00381.x     Document Type: Review

References (62)

1. Nassal M, Schaller H. Hepatitis B virus replication - an update. J Viral Hepat 1996; 3: 217-226.
2. Nassal M, Schaller H. Hepatitis B virus replication. Trends Microbiol 1993; 1: 221-228.
3. Feitelson M. Hepatitis B virus infection and primary hepatocellular carcinoma. Clin Microbiol Rev 1992; 5: 275-301.
4. Yaginuma K, Koike K. Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein. J Virol 1989; 63: 2914-2920.
5. YuX, Mertz JE. Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated. J Virol 1996; 70: 8719-8726.
6. Yuh CH, Chang YL, Ting LP. Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J Virol 1992; 66: 4073-4084.
7. Chen IH, Huang CJ, Ting LP. Overlapping initiator and TATA box functions in the basal core promoter of hepatitis B virus. J Virol 1995; 69: 3647-3657.
8. Chen M, Ou JH. Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter. Virology 1995; 214: 198-206.
9. Li J, Ou JH. Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor. J Virol 2001; 75: 8400-8406.
10. Raney AK, Johnson JL, Palmer CN, McLachlan A. Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter. J Virol 1997; 71: 1058-1071.
11. Yu X, Mertz JE. Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily. J Virol 1997; 71: 9366-9374.
12. Baptista M, Kramvis A, Kew MC. High prevalence of. (T) 1764 (A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1762; 1999: 946-953.
13. Hsia CC, Yuwen H, Tabor E. Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinoma. Lancet 1996; 348: 625-626.
14. Li J, Xu Z, Zheng Y, Johnson DL, Ou JH. Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus x proteins. J Virol 2002; 76: 5875-5881.
15. Raney AK, McLachlan A. Characterization of the hepatitis B virus large surface antigen promoter Sp1 binding site. Virology 1995; 208: 399-404.
16. Siddiqui A, Jameel S, Mapoles J. Transcriptional control elements of hepatitis B surface antigen gene. Proc Natl Acad Sci USA 1986; 83: 566-570.
17. Raney AK, Easton AJ, McLachlan A. Characterization of the minimal elements of the hepatitis B virus large surface antigen promoter. J General Virol 1994; 75: 2671-2679.
18. Raney AK, Zhang P, McLachlan A. Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3. J Virol 1995; 69: 3265-3272.
19. Bulla GA, Siddiqui A. Negative regulation of the hepatitis B virus pre-S1 promoter by internal DNA sequences. Virology 1989; 170: 251-260.
20. Cattaneo R, Will H, Hernandez N, Schaller H. Signals regulating hepatitis B surface antigen transcription. Nature 1983; 305: 336-338.
21. Zhou DX, Yen TS. The hepatitis B virus S promoter comprises A CCAAT motif and two initiation regions. J Biol Chem 1991; 266: 23416-23421.
22. Lu CC, Chen M, Ou JH, Yen TS. Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology 1995; 206: 1155-1158.
23. Bock CT, Kubicka S, Manns MP, Trautwein C. Two control elements in the hepatitis B virus S-promoter are important for full promoter activity mediated by CCAAT-binding factor. Hepatology 1999; 29: 1236-1247.
24. Raney AK, Milich DR, McLachlan A. Complex regulation of transcription from the hepatitis B virus major surface antigen promoter in human hepatoma cell lines. J Virol 1991; 65: 4805-4811.
25. Raney AK, Le HB, McLachlan A. Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor. J Virol 1992; 66: 6912-6921.
26. Xu Z, Jensen G, Yen TS. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 1997; 71: 7387-7392.
27. Zheng YW, Riegler J, Wu J, Yen TS. Novel short transcripts of hepatitis B virus X gene derived from intragenic promoter. J Biol Chem 1994; 269: 22593-22598.
28. Zhang P, Raney AK, McLachlan A. Characterization of the hepatitis B virus X- and nucleocapsid gene transcriptional regulatory elements. Virology 1992; 191: 31-41.
29. Treinin M, Laub O. Identification of a promoter element located upstream from the hepatitis B virus X gene. Mol Cell Biol 1987; 7: 545-548.
30. Guo WT, Bell KD, Ou JH. Characterization of the hepatitis B virus EnhI enhancer and X promoter complex. J Virol 1991; 65: 6686-6692.
31. Fukai K, Takada S, Yokosuka O et al. Characterization of a specific region in the hepatitis B virus enhancer I for the efficient expression of X gene in the hepatic cell. Virology 1997; 236: 279-287.
32. Takada S, Kaneniwa N, Tsuchida N, Koike K. Hepatitis B virus X gene expression is activated by X protein but repressed by p53 tumor suppressor gene product in the transient expression system. Virology 1996; 216: 80-89.
33. Chen M, Hieng S, Qian X, Costa R, Ou JH. Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3. Virology 1994; 205: 127-132.
34. Bock CT, Malek NP, Tillmann HL, Manns MP, Trautwein C. The enhancer I core region contributes to the replication level of hepatitis B virus in vivo and in vitro. J Virol 2000; 74: 2193-2202.
35. Ori A, Shaul Y. Hepatitis B virus enhancer binds and is activated by the Hepatocyte nuclear factor 3. Virology 1995; 207: 98-106.
36. Bulla GA, Siddiqui A. The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location. J Virol 1988; 62: 1437-1441.
37. Antonucci TK, Rutter WJ. Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner. J Virol 1989; 63: 579-583.
38. Kosovsky MJ, Siddiqui A. Biochemical and functional properties of a palindromic sequence motif within the hepatitis B virus enhancer 1. Virology 1999; 259: 60-66.
39. Waris G, Siddiqui A. Interaction between STAT-3 and HNF-3 leads to the activation of liver- specific hepatitis B virus enhancer 1 function. J Virol 2002; 76: 2721-2729.
40. Cressman DE, Greenbaum LE, DeAngelis RA et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996; 274: 1379-1383.
41. Waris G, Huh KW, Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol 2001; 21: 7721-7730.
42. Hu KQ, Siddiqui A. Regulation of the hepatitis B virus gene expression by the enhancer element I. Virology 1991; 181: 721-726.
43. Yuh CH, Ting LP. The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function. J Virol 1990; 64: 4281-4287.
44. Li M, Xie Y, Wu X, Kong Y, Wang Y. HNF3 binds and activates the second enhancer, ENII, of hepatitis B virus. Virology 1995; 214: 371-378.
45. Ishida H, Ueda K, Ohkawa K et al. Identification of multiple transcription factors, HLF, FTF, and E4BP4, controlling hepatitis B virus enhancer II. J Virol 2000; 74: 1241-1251.
46. Lai CK, Ting LP. Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. J Virol 1999; 73: 3197-3209.
47. Nakatake H, Chisaka O, Yamamoto S, Matsubara K, Koshy R. Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication. Virology 1993; 195: 305-314.
48. Miller RH, Robinson WS. Common evolutionary origin of hepatitis B virus and retroviruses. Proc Natl Acad Sci USA 1986; 83: 2531-2535.
49. Arbuthnot P, Kew M. Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol 2001; 82: 77-100.
50. Barnabas S, Andrisani OM. Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression. J Virol 2000; 74: 83-90.
51. Haviv I, Shamay M, Doitsh G, Shaul Y. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol 1998; 18: 1562-1569.
52. Lin Y, Nomura T, Cheong J et al. Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J Biol Chem 1997; 272: 7132-7139.
53. Qadri I, Maguire HF, Siddiqui A. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc Natl Acad Sci USA 1995; 92: 1003-1007.
54. Maguire HF, Hoeffler JP, Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 1991; 252: 842-844.
55. Seto E, Mitchell PJ, Yen TS. Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 1990; 344: 72-74.
56. Cross JC, Wen P, Rutter WJ. Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc Natl Acad Sci USA 1993; 90: 8078-8082.
57. Benn J, Schneider RJ. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 1994; 91: 10350-10354.
58. Lee YH, Yun Y. HBx protein of hepatitis B virus activates Jak1-STAT signaling. J Biol Chem 1998; 273: 25510-25515.
59. Chen HS, Kaneko S, Girones R et al. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol 1993; 67: 1218-1226.
60. Zoulim F, Saputelli J, Seeger C. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 1994; 68: 2026-30.
61. Xu Z, Yen TS, Wu L et al. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol 2002; 76: 2579-2584.
62. Reifenberg K, Wilts H, Lohler J et al. The hepatitis B virus X protein transactivates viral core gene expression in vivo. J Virol 1999; 73: 10399-10405.