-
1
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, et al: Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305, 2005.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
-
2
-
-
78649302320
-
Metformin and cancer risk in diabetic patients: A systematic review and meta-analysis
-
Decensi A, Puntoni M, Goodwin P, et al: Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 3: 1451-1461, 2010.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1451-1461
-
-
Decensi, A.1
Puntoni, M.2
Goodwin, P.3
-
3
-
-
84858695046
-
Cancer risk in diabetic patients treated with metformin: A systematic review and meta-analysis
-
Noto H, Goto A, Tsujimoto T and Noda M: Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PLoS One 7: e33411, 2012.
-
(2012)
PLoS One
, vol.7
, pp. e33411
-
-
Noto, H.1
Goto, A.2
Tsujimoto, T.3
Noda, M.4
-
4
-
-
77953527360
-
Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena
-
Martin-Castillo B, Vazquez-Martin A, Oliveras-Ferraros C and Menendez JA: Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena. Cell Cycle 9: 1057-1064, 2010.
-
(2010)
Cell Cycle
, vol.9
, pp. 1057-1064
-
-
Martin-Castillo, B.1
Vazquez-Martin, A.2
Oliveras-Ferraros, C.3
Menendez, J.A.4
-
5
-
-
84883165443
-
Repositioning metformin for cancer prevention and treatment
-
Quinn BJ, Kitagawa H, Memmott RM, et al: Repositioning metformin for cancer prevention and treatment. Trends Endocrinol Metab 24: 469-480, 2013.
-
(2013)
Trends Endocrinol Metab
, vol.24
, pp. 469-480
-
-
Quinn, B.J.1
Kitagawa, H.2
Memmott, R.M.3
-
6
-
-
84858745832
-
Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
-
Hanna RK, Zhou C, Malloy KM, et al: Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. Gynecol Oncol 125: 458-469, 2012.
-
(2012)
Gynecol Oncol
, vol.125
, pp. 458-469
-
-
Hanna, R.K.1
Zhou, C.2
Malloy, K.M.3
-
7
-
-
84864619407
-
Metformin sensitizes endo-metrial cancer cells to chemotherapy by repressing glyoxalase i expression
-
Dong L, Zhou Q, Zhang Z, et al: Metformin sensitizes endo-metrial cancer cells to chemotherapy by repressing glyoxalase I expression. J Obstet Gynaecol Res 38: 1077-1085, 2012.
-
(2012)
J Obstet Gynaecol Res
, vol.38
, pp. 1077-1085
-
-
Dong, L.1
Zhou, Q.2
Zhang, Z.3
-
8
-
-
84867405520
-
Metformin targets ovarian cancer stem cells in vitro and in vivo
-
Shank JJ, Yang K, Ghannam J, et al: Metformin targets ovarian cancer stem cells in vitro and in vivo. Gynecol Oncol 127: 390-397, 2012.
-
(2012)
Gynecol Oncol
, vol.127
, pp. 390-397
-
-
Shank, J.J.1
Yang, K.2
Ghannam, J.3
-
9
-
-
84861487778
-
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro
-
Liu H, Scholz C, Zang C, et al: Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro. Anticancer Res 32: 1627-1637, 2012.
-
(2012)
Anticancer Res
, vol.32
, pp. 1627-1637
-
-
Liu, H.1
Scholz, C.2
Zang, C.3
-
10
-
-
84861540166
-
Antiproliferative action of metformin in human lung cancer cell lines
-
Ashinuma H, Takiguchi Y, Kitazono S, et al: Antiproliferative action of metformin in human lung cancer cell lines. Oncol Rep 28: 8-14, 2012.
-
(2012)
Oncol Rep
, vol.28
, pp. 8-14
-
-
Ashinuma, H.1
Takiguchi, Y.2
Kitazono, S.3
-
11
-
-
79955834631
-
Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo
-
Rattan R, Graham RP, Maguire JL, et al: Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 13: 483-491, 2011.
-
(2011)
Neoplasia
, vol.13
, pp. 483-491
-
-
Rattan, R.1
Graham, R.P.2
Maguire, J.L.3
-
12
-
-
79551489371
-
Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE tran-scriptional activity through AMPK activation
-
Kim HG, Hien TT, Han EH, et al: Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE tran-scriptional activity through AMPK activation. Br J Pharmacol 162: 1096-1108, 2011.
-
(2011)
Br J Pharmacol
, vol.162
, pp. 1096-1108
-
-
Kim, H.G.1
Hien, T.T.2
Han, E.H.3
-
13
-
-
79959207505
-
Metformin amplifes chemotherapy-induced AMPK activation and antitumoral growth
-
Rocha GZ, Dias MM, Ropelle ER, et al: Metformin amplifes chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res 17: 3993-4005, 2011.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3993-4005
-
-
Rocha, G.Z.1
Dias, M.M.2
Ropelle, E.R.3
-
14
-
-
79952246410
-
MevaloNate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells
-
Nilsson S, Huelsenbeck J and Fritz G: MevaloNate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. Cancer Lett 304: 60-69, 2011.
-
(2011)
Cancer Lett
, vol.304
, pp. 60-69
-
-
Nilsson, S.1
Huelsenbeck, J.2
Fritz, G.3
-
15
-
-
79955490053
-
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
-
Iliopoulos D, Hirsch HA and Struhl K: Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res 71: 3196-3201, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 3196-3201
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
16
-
-
78650677585
-
Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
-
Janjetovic K, Vucicevic L, Misirkic M, et al: Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur J Pharmacol 651: 41-50, 2011.
-
(2011)
Eur J Pharmacol
, vol.651
, pp. 41-50
-
-
Janjetovic, K.1
Vucicevic, L.2
Misirkic, M.3
-
17
-
-
79957438835
-
Induction of Apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins
-
Yasmeen A, Beauchamp MC, Piura E, et al: Induction of Apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins. Gynecol Oncol 121: 492-498, 2011.
-
(2011)
Gynecol Oncol
, vol.121
, pp. 492-498
-
-
Yasmeen, A.1
Beauchamp, M.C.2
Piura, E.3
-
18
-
-
69949126976
-
AMPK-mediated autophagy inhibits Apoptosis in cisplatin-treated tumour cells
-
Harhaji-Trajkovic L, Vilimanovich U, Kravic-Stevovic T, et al: AMPK-mediated autophagy inhibits Apoptosis in cisplatin-treated tumour cells. J Cell Mol Med 13: 3644-3654, 2009.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 3644-3654
-
-
Harhaji-Trajkovic, L.1
Vilimanovich, U.2
Kravic-Stevovic, T.3
-
19
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN and Struhl K: Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69: 7507-7511, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
20
-
-
47249088612
-
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
-
Gotlieb WH, Saumet J, Beauchamp MC, et al: In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecol Oncol 110: 246-250, 2008.
-
(2008)
Gynecol Oncol
, vol.110
, pp. 246-250
-
-
Gotlieb, W.H.1
Saumet, J.2
Beauchamp, M.C.3
-
22
-
-
0029044687
-
Role of metformin accumulation in metformin-associated lactic acidosis
-
Lalau JD, Lacroix C, Compagnon P, et al: Role of metformin accumulation in metformin-associated lactic acidosis. Diabetes Care 18: 779-784, 1995.
-
(1995)
Diabetes Care
, vol.18
, pp. 779-784
-
-
Lalau, J.D.1
Lacroix, C.2
Compagnon, P.3
-
23
-
-
84864059240
-
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A
-
Martin MJ, Hayward R, Viros A and Marais R: Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. Cancer Discov 2: 344-355, 2012.
-
(2012)
Cancer Discov
, vol.2
, pp. 344-355
-
-
Martin, M.J.1
Hayward, R.2
Viros, A.3
Marais, R.4
-
24
-
-
27144488205
-
Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction
-
Berridge MV, Herst PM and Tan AS: Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev 11: 127-152, 2005.
-
(2005)
Biotechnol Annu Rev
, vol.11
, pp. 127-152
-
-
Berridge, M.V.1
Herst, P.M.2
Tan, A.S.3
-
25
-
-
0030978319
-
A highly water-soluble disulfoNated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability
-
Ishiyama M, Miyazono Y, Sasamoto K, et al: A highly water-soluble disulfoNated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Talanta 44: 1299-1305, 1997.
-
(1997)
Talanta
, vol.44
, pp. 1299-1305
-
-
Ishiyama, M.1
Miyazono, Y.2
Sasamoto, K.3
-
26
-
-
0038433339
-
The mitochondrial uncoupler dicumarol disrupts the MTT assay
-
Collier AC and Pritsos CA: The mitochondrial uncoupler dicumarol disrupts the MTT assay. Biochem Pharmacol 66: 281-287, 2003.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 281-287
-
-
Collier, A.C.1
Pritsos, C.A.2
-
27
-
-
0027179465
-
Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: A further pitfall in the use of the MTT assay for evaluating cell growth and survival
-
Pagliacci MC, Spinozzi F, Migliorati G, et al: Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur J Cancer 29A: 1573-1577, 1993.
-
(1993)
Eur J Cancer
, vol.29 A
, pp. 1573-1577
-
-
Pagliacci, M.C.1
Spinozzi, F.2
Migliorati, G.3
-
28
-
-
79953277302
-
Prospective evaluation of insulin resistance among endometrial cancer patients
-
Burzawa JK, Schmeler KM, Soliman PT, et al: Prospective evaluation of insulin resistance among endometrial cancer patients. Am J Obstet Gynecol 204: 355.e1-7, 2011.
-
(2011)
Am J Obstet Gynecol
, vol.204
, pp. 355e1-3557
-
-
Burzawa, J.K.1
Schmeler, K.M.2
Soliman, P.T.3
-
29
-
-
33646874133
-
Association between adiponectin, insulin resistance, and endometrial cancer
-
Soliman PT, Wu D, Tortolero-Luna G, et al: Association between adiponectin, insulin resistance, and endometrial cancer. Cancer 106: 2376-2381, 2006.
-
(2006)
Cancer
, vol.106
, pp. 2376-2381
-
-
Soliman, P.T.1
Wu, D.2
Tortolero-Luna, G.3
-
30
-
-
84861184739
-
Insulin resistance: A signifcant risk factor of endometrial cancer
-
Mu N, Zhu Y, Wang Y, et al: Insulin resistance: a signifcant risk factor of endometrial cancer. Gynecol Oncol 125: 751-757, 2012.
-
(2012)
Gynecol Oncol
, vol.125
, pp. 751-757
-
-
Mu, N.1
Zhu, Y.2
Wang, Y.3
-
31
-
-
80155143528
-
Adjuvant chemotherapy for endometrial cancer after hysterectomy
-
Johnson N, Bryant A, Miles T, et al: Adjuvant chemotherapy for endometrial cancer after hysterectomy. Cochrane Database Syst Rev 10: CD003175, 2011.
-
(2011)
Cochrane Database Syst Rev
, vol.10
, pp. CD003175
-
-
Johnson, N.1
Bryant, A.2
Miles, T.3
-
32
-
-
84866769698
-
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma
-
Vale CL, Tierney J, Bull SJ and Symonds PR: Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma. Cochrane Database Syst Rev 8: CD003915, 2012.
-
(2012)
Cochrane Database Syst Rev
, vol.8
, pp. CD003915
-
-
Vale, C.L.1
Tierney, J.2
Bull, S.J.3
Symonds, P.R.4
-
33
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
-
El-Mir M Y, Nogueira V, Fontaine E, et al: Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 275: 223-228, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 223-228
-
-
El-Mir, M.Y.1
Nogueira, V.2
Fontaine, E.3
-
34
-
-
0034659785
-
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
-
Owen MR, Doran E and Halestrap AP: Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348: 607-614, 2000.
-
(2000)
Biochem J
, vol.348
, pp. 607-614
-
-
Owen, M.R.1
Doran, E.2
Halestrap, A.P.3
-
35
-
-
0028158709
-
Accumulation of metformin by tissues of the normal and diabetic mouse
-
Wilcock C and Bailey CJ: Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica 24: 49-57, 1994.
-
(1994)
Xenobiotica
, vol.24
, pp. 49-57
-
-
Wilcock, C.1
Bailey, C.J.2
-
36
-
-
84875496902
-
Fatal metformin intoxication with markedly elevated Blood and liver concentrations
-
Cantrell LF, Nelson CL, Gary RD and McIntyre IM: Fatal metformin intoxication with markedly elevated Blood and liver concentrations. J Anal Toxicol 36: 657-659, 2012.
-
(2012)
J Anal Toxicol
, vol.36
, pp. 657-659
-
-
Cantrell, L.F.1
Nelson, C.L.2
Gary, R.D.3
McIntyre, I.M.4
-
37
-
-
84872326962
-
Mitochondrial dysfunction in breast cancer cells prevents tumor growth: Understanding chemoprevention with metformin
-
Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, et al: Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle 12: 172-182, 2013.
-
(2013)
Cell Cycle
, vol.12
, pp. 172-182
-
-
Sanchez-Alvarez, R.1
Martinez-Outschoorn, U.E.2
Lamb, R.3
-
38
-
-
3242842321
-
Analysis of mitochondrial morphology and function with novel fxable fuorescent stains
-
Poot M, Zhang YZ, Krämer JA, et al: Analysis of mitochondrial morphology and function with novel fxable fuorescent stains. J Histochem Cytochem 44: 1363-1372, 1996.
-
(1996)
J Histochem Cytochem
, vol.44
, pp. 1363-1372
-
-
Poot, M.1
Zhang, Y.Z.2
Krämer, J.A.3
-
39
-
-
38949108241
-
Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
-
Renehan AG, Tyson M, Egger M, et al: Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371: 569-578, 2008.
-
(2008)
Lancet
, vol.371
, pp. 569-578
-
-
Renehan, A.G.1
Tyson, M.2
Egger, M.3
-
40
-
-
67749144226
-
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
-
Jiralerspong S, Palla SL, Giordano SH, et al: Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 27: 3297-3302, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3297-3302
-
-
Jiralerspong, S.1
Palla, S.L.2
Giordano, S.H.3
-
41
-
-
60549102941
-
Insulin-lowering effects of metformin in women with early breast cancer
-
Goodwin PJ, Pritchard KI, Ennis M, et al: Insulin-lowering effects of metformin in women with early breast cancer. Clin Breast Cancer 8: 501-505, 2008.
-
(2008)
Clin Breast Cancer
, vol.8
, pp. 501-505
-
-
Goodwin, P.J.1
Pritchard, K.I.2
Ennis, M.3
|