메뉴 건너뛰기




Volumn 125, Issue 3, 2012, Pages 751-757

Insulin resistance: A significant risk factor of endometrial cancer

Author keywords

Adipokine; Endometrial cancer; Insulin resistance; Obesity; PI3K Akt; Ras MAPK

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR; AROMATASE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; ESTROGEN; INSULIN; INSULIN SENSITIZING AGENT; INTERLEUKIN 6; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84861184739     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.03.032     Document Type: Conference Paper
Times cited : (139)

References (107)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • R. Siegel, E. Ward, O. Brawley, and A. Jemal Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J Clin 61 2011 212 236
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 3
    • 0023857383 scopus 로고
    • The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: Its central role in explaining and predicting endometrial cancer risk
    • T.J. Key, and M.C. Pike The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk Br J Cancer 57 1988 205 212
    • (1988) Br J Cancer , vol.57 , pp. 205-212
    • Key, T.J.1    Pike, M.C.2
  • 4
    • 40049088464 scopus 로고    scopus 로고
    • Diabetes and endometrial cancer: An evaluation of the modifying effects of other known risk factors
    • B.S. Saltzman, J.A. Doherty, and D.A. Hill Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors Am J Epidemiol 167 2008 607 614
    • (2008) Am J Epidemiol , vol.167 , pp. 607-614
    • Saltzman, B.S.1    Doherty, J.A.2    Hill, D.A.3
  • 5
    • 0033851421 scopus 로고    scopus 로고
    • Long-term consequences of polycystic ovary syndrome: Results of a 31 year follow-up study
    • S. Wild, T. Pierpoint, H. Jacobs, and P. McKeigue Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study Hum Fertil (Camb) 3 2000 101 105
    • (2000) Hum Fertil (Camb) , vol.3 , pp. 101-105
    • Wild, S.1    Pierpoint, T.2    Jacobs, H.3    McKeigue, P.4
  • 6
    • 71449120059 scopus 로고    scopus 로고
    • Insulin resistance and hyperinsulinaemia in the development and progression of cancer
    • I.F. Godsland Insulin resistance and hyperinsulinaemia in the development and progression of cancer Clin Sci (Lond) 118 2010 315 332
    • (2010) Clin Sci (Lond) , vol.118 , pp. 315-332
    • Godsland, I.F.1
  • 7
    • 42149124307 scopus 로고    scopus 로고
    • A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer
    • M.J. Gunter, D.R. Hoover, and H. Yu A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer Cancer Epidemiol Biomarkers Prev 17 2008 921 929
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 921-929
    • Gunter, M.J.1    Hoover, D.R.2    Yu, H.3
  • 8
    • 79953277302 scopus 로고    scopus 로고
    • Prospective evaluation of insulin resistance among endometrial cancer patients
    • J.K. Burzawa, K.M. Schmeler, and P.T. Soliman Prospective evaluation of insulin resistance among endometrial cancer patients Am J Obstet Gynecol 204 355 2011 e1 e7
    • (2011) Am J Obstet Gynecol , vol.204 , Issue.355
    • Burzawa, J.K.1    Schmeler, K.M.2    Soliman, P.T.3
  • 9
    • 8644259131 scopus 로고    scopus 로고
    • Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer
    • L.M. Berstein, J.O. Kvatchevskaya, and T.E. Poroshina Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer J Cancer Res Clin Oncol 130 2004 687 693
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 687-693
    • Berstein, L.M.1    Kvatchevskaya, J.O.2    Poroshina, T.E.3
  • 10
    • 0348012945 scopus 로고    scopus 로고
    • Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer
    • A. Lukanova, A. Zeleniuch-Jacquotte, and E. Lundin Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer Int J Cancer 108 2004 262 268
    • (2004) Int J Cancer , vol.108 , pp. 262-268
    • Lukanova, A.1    Zeleniuch-Jacquotte, A.2    Lundin, E.3
  • 11
    • 45849133110 scopus 로고    scopus 로고
    • Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • N.E. Allen, T.J. Key, and L. Dossus Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC) Endocr Relat Cancer 15 2008 485 497
    • (2008) Endocr Relat Cancer , vol.15 , pp. 485-497
    • Allen, N.E.1    Key, T.J.2    Dossus, L.3
  • 12
    • 18544387769 scopus 로고    scopus 로고
    • Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women
    • W.H. Xu, C.E. Matthews, and Y.B. Xiang Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women Am J Epidemiol 161 2005 939 947
    • (2005) Am J Epidemiol , vol.161 , pp. 939-947
    • Xu, W.H.1    Matthews, C.E.2    Xiang, Y.B.3
  • 13
    • 32144440774 scopus 로고    scopus 로고
    • Weight history and risk of endometrial cancer among Chinese women
    • W.H. Xu, Y.B. Xiang, and W. Zheng Weight history and risk of endometrial cancer among Chinese women Int J Epidemiol 35 2006 159 166
    • (2006) Int J Epidemiol , vol.35 , pp. 159-166
    • Xu, W.H.1    Xiang, Y.B.2    Zheng, W.3
  • 14
    • 33947195839 scopus 로고    scopus 로고
    • Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis
    • V.M. Chia, P.A. Newcomb, A. Trentham-Dietz, and J.M. Hampton Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis Int J Gynecol Cancer 17 2007 441 446
    • (2007) Int J Gynecol Cancer , vol.17 , pp. 441-446
    • Chia, V.M.1    Newcomb, P.A.2    Trentham-Dietz, A.3    Hampton, J.M.4
  • 15
    • 34249948987 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of endometrial cancer: A meta-analysis
    • E. Friberg, N. Orsini, C.S. Mantzoros, and A. Wolk Diabetes mellitus and risk of endometrial cancer: a meta-analysis Diabetologia 50 2007 1365 1374
    • (2007) Diabetologia , vol.50 , pp. 1365-1374
    • Friberg, E.1    Orsini, N.2    Mantzoros, C.S.3    Wolk, A.4
  • 16
    • 78751570990 scopus 로고    scopus 로고
    • Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: An Australian case-control study
    • E.J. Fearnley, L. Marquart, A.B. Spurdle, P. Weinstein, and P.M. Webb Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study Cancer Causes Control 21 2010 2303 2308
    • (2010) Cancer Causes Control , vol.21 , pp. 2303-2308
    • Fearnley, E.J.1    Marquart, L.2    Spurdle, A.B.3    Weinstein, P.4    Webb, P.M.5
  • 17
    • 77950848588 scopus 로고    scopus 로고
    • Metabolic syndrome and endometrial carcinoma
    • T. Bjorge, T. Stocks, and A. Lukanova Metabolic syndrome and endometrial carcinoma Am J Epidemiol 171 2010 892 902
    • (2010) Am J Epidemiol , vol.171 , pp. 892-902
    • Bjorge, T.1    Stocks, T.2    Lukanova, A.3
  • 18
    • 77949299792 scopus 로고    scopus 로고
    • The association between metabolic abnormality and endometrial cancer: A large case-control study in China
    • Y. Zhang, Z. Liu, and X. Yu The association between metabolic abnormality and endometrial cancer: a large case-control study in China Gynecol Oncol 117 2010 41 46
    • (2010) Gynecol Oncol , vol.117 , pp. 41-46
    • Zhang, Y.1    Liu, Z.2    Yu, X.3
  • 19
    • 77956792321 scopus 로고    scopus 로고
    • Risk factors in women 40 years of age and younger with endometrial carcinoma
    • D. Haidopoulos, M. Simou, and N. Akrivos Risk factors in women 40 years of age and younger with endometrial carcinoma Acta Obstet Gynecol Scand 89 2010 1326 1330
    • (2010) Acta Obstet Gynecol Scand , vol.89 , pp. 1326-1330
    • Haidopoulos, D.1    Simou, M.2    Akrivos, N.3
  • 20
    • 13944263263 scopus 로고    scopus 로고
    • Risk factors for young premenopausal women with endometrial cancer
    • P.T. Soliman, J.C. Oh, and K.M. Schmeler Risk factors for young premenopausal women with endometrial cancer Obstet Gynecol 105 2005 575 580
    • (2005) Obstet Gynecol , vol.105 , pp. 575-580
    • Soliman, P.T.1    Oh, J.C.2    Schmeler, K.M.3
  • 22
    • 67651017976 scopus 로고    scopus 로고
    • Clinicopathological features in endometrial carcinoma associated with Lynch syndrome in China
    • Y. Wang, F. Xue, R.R. Broaddus, X. Tao, S.S. Xie, and Y. Zhu Clinicopathological features in endometrial carcinoma associated with Lynch syndrome in China Int J Gynecol Cancer 19 2009 651 656
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 651-656
    • Wang, Y.1    Xue, F.2    Broaddus, R.R.3    Tao, X.4    Xie, S.S.5    Zhu, Y.6
  • 23
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • H. Xu, G.T. Barnes, and Q. Yang Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 2003 1821 1830
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 24
    • 34047119110 scopus 로고    scopus 로고
    • Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
    • N. Hosogai, A. Fukuhara, and K. Oshima Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation Diabetes 56 2007 901 911
    • (2007) Diabetes , vol.56 , pp. 901-911
    • Hosogai, N.1    Fukuhara, A.2    Oshima, K.3
  • 25
    • 0346880504 scopus 로고    scopus 로고
    • Inflammatory pathways and insulin action
    • G.S. Hotamisligil Inflammatory pathways and insulin action Int J Obes Relat Metab Disord 27 Suppl. 3 2003 S53 S55
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.SUPPL. 3
    • Hotamisligil, G.S.1
  • 26
    • 0041568670 scopus 로고    scopus 로고
    • TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes
    • S.C. Souza, H.J. Palmer, and Y.H. Kang TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes J Cell Biochem 89 2003 1077 1086
    • (2003) J Cell Biochem , vol.89 , pp. 1077-1086
    • Souza, S.C.1    Palmer, H.J.2    Kang, Y.H.3
  • 27
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • G.I. Shulman Cellular mechanisms of insulin resistance J Clin Invest 106 2000 171 176
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 28
    • 33846407051 scopus 로고    scopus 로고
    • Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications
    • T. Nishikawa, and E. Araki Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications Antioxid Redox Signal 9 2007 343 353
    • (2007) Antioxid Redox Signal , vol.9 , pp. 343-353
    • Nishikawa, T.1    Araki, E.2
  • 29
    • 33845566268 scopus 로고    scopus 로고
    • The metabolic syndrome: Metabolic changes with vascular consequences
    • A.M. Wassink, J.K. Olijhoek, and F.L. Visseren The metabolic syndrome: metabolic changes with vascular consequences Eur J Clin Invest 37 2007 8 17
    • (2007) Eur J Clin Invest , vol.37 , pp. 8-17
    • Wassink, A.M.1    Olijhoek, J.K.2    Visseren, F.L.3
  • 30
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • J.M. Olefsky, and C.K. Glass Macrophages, inflammation, and insulin resistance Annu Rev Physiol 72 2010 219 246
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 31
    • 0036130293 scopus 로고    scopus 로고
    • The role of cytokines in regulating estrogen synthesis: Implications for the etiology of breast cancer
    • A. Purohit, S.P. Newman, and M.J. Reed The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer Breast Cancer Res 4 2002 65 69
    • (2002) Breast Cancer Res , vol.4 , pp. 65-69
    • Purohit, A.1    Newman, S.P.2    Reed, M.J.3
  • 32
    • 79955758193 scopus 로고    scopus 로고
    • A prospective study of inflammation markers and endometrial cancer risk in postmenopausal hormone nonusers
    • T. Wang, T.E. Rohan, and M.J. Gunter A prospective study of inflammation markers and endometrial cancer risk in postmenopausal hormone nonusers Cancer Epidemiol Biomarkers Prev 20 2011 971 977
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 971-977
    • Wang, T.1    Rohan, T.E.2    Gunter, M.J.3
  • 33
    • 0022637802 scopus 로고
    • Androgen and estrogen metabolism: Relationship to obesity
    • C. Longcope, R. Baker Jr., and C.C. Johnston Androgen and estrogen metabolism: relationship to obesity Metabolism 35 1986 235 237
    • (1986) Metabolism , vol.35 , pp. 235-237
    • Longcope, C.1    Baker, Jr.R.2    Johnston, C.C.3
  • 34
    • 33846619697 scopus 로고    scopus 로고
    • Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase
    • Y. Hong, B. Yu, M. Sherman, Y.C. Yuan, D. Zhou, and S. Chen Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase Mol Endocrinol 21 2007 401 414
    • (2007) Mol Endocrinol , vol.21 , pp. 401-414
    • Hong, Y.1    Yu, B.2    Sherman, M.3    Yuan, Y.C.4    Zhou, D.5    Chen, S.6
  • 35
    • 33847733103 scopus 로고    scopus 로고
    • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
    • T. Yamauchi, Y. Nio, and T. Maki Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13 2007 332 339
    • (2007) Nat Med , vol.13 , pp. 332-339
    • Yamauchi, T.1    Nio, Y.2    Maki, T.3
  • 36
    • 33644664433 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: Comparison of activation of PPARalpha, PPARgamma, and their combination
    • A. Tsuchida, T. Yamauchi, and S. Takekawa Peroxisome proliferator- activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination Diabetes 54 2005 3358 3370
    • (2005) Diabetes , vol.54 , pp. 3358-3370
    • Tsuchida, A.1    Yamauchi, T.2    Takekawa, S.3
  • 37
    • 56749116073 scopus 로고    scopus 로고
    • Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women
    • I. Rzepka-Gorska, R. Bedner, A. Cymbaluk-Ploska, and A. Chudecka-Glaz Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women Eur J Gynaecol Oncol 29 2008 594 597
    • (2008) Eur J Gynaecol Oncol , vol.29 , pp. 594-597
    • Rzepka-Gorska, I.1    Bedner, R.2    Cymbaluk-Ploska, A.3    Chudecka-Glaz, A.4
  • 38
    • 33846103488 scopus 로고    scopus 로고
    • Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women
    • A.E. Cust, R. Kaaks, and C. Friedenreich Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women J Clin Endocrinol Metab 92 2007 255 263
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 255-263
    • Cust, A.E.1    Kaaks, R.2    Friedenreich, C.3
  • 39
    • 33745177371 scopus 로고    scopus 로고
    • Expression of adiponectin receptors and its possible implication in the human endometrium
    • Y. Takemura, Y. Osuga, and T. Yamauchi Expression of adiponectin receptors and its possible implication in the human endometrium Endocrinology 147 2006 3203 3210
    • (2006) Endocrinology , vol.147 , pp. 3203-3210
    • Takemura, Y.1    Osuga, Y.2    Yamauchi, T.3
  • 40
    • 35949000153 scopus 로고    scopus 로고
    • Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2
    • L. Cong, J. Gasser, J. Zhao, B. Yang, F. Li, and A.Z. Zhao Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2 Endocr Relat Cancer 14 2007 713 720
    • (2007) Endocr Relat Cancer , vol.14 , pp. 713-720
    • Cong, L.1    Gasser, J.2    Zhao, J.3    Yang, B.4    Li, F.5    Zhao, A.Z.6
  • 41
    • 0031775895 scopus 로고    scopus 로고
    • Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk
    • F. Leyva, I.F. Godsland, and M. Ghatei Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk Arterioscler Thromb Vasc Biol 18 1998 928 933
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 928-933
    • Leyva, F.1    Godsland, I.F.2    Ghatei, M.3
  • 42
    • 79952559571 scopus 로고    scopus 로고
    • Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3
    • E. Burgos-Ramos, J.A. Chowen, E. Arilla-Ferreiro, S. Canelles, J. Argente, and V. Barrios Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3 J Neurochem 117 2011 175 185
    • (2011) J Neurochem , vol.117 , pp. 175-185
    • Burgos-Ramos, E.1    Chowen, J.A.2    Arilla-Ferreiro, E.3    Canelles, S.4    Argente, J.5    Barrios, V.6
  • 43
    • 78049439559 scopus 로고    scopus 로고
    • Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy participants
    • M. Sarigianni, E. Bekiari, A. Tsapas, M. Kaloyianni, G. Koliakos, and K. Paletas Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy participants Angiology 61 2010 768 774
    • (2010) Angiology , vol.61 , pp. 768-774
    • Sarigianni, M.1    Bekiari, E.2    Tsapas, A.3    Kaloyianni, M.4    Koliakos, G.5    Paletas, K.6
  • 45
    • 62849109985 scopus 로고    scopus 로고
    • Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells
    • J. Gao, J. Tian, and Y. Lv Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells Cancer Sci 100 2009 389 395
    • (2009) Cancer Sci , vol.100 , pp. 389-395
    • Gao, J.1    Tian, J.2    Lv, Y.3
  • 46
    • 33745108419 scopus 로고    scopus 로고
    • Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways
    • D. Sharma, N.K. Saxena, P.M. Vertino, and F.A. Anania Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways Endocr Relat Cancer 13 2006 629 640
    • (2006) Endocr Relat Cancer , vol.13 , pp. 629-640
    • Sharma, D.1    Saxena, N.K.2    Vertino, P.M.3    Anania, F.A.4
  • 47
    • 58149388704 scopus 로고    scopus 로고
    • Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation
    • S. Catalano, C. Giordano, and P. Rizza Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation J Cell Physiol 218 2009 490 500
    • (2009) J Cell Physiol , vol.218 , pp. 490-500
    • Catalano, S.1    Giordano, C.2    Rizza, P.3
  • 48
    • 77955790232 scopus 로고    scopus 로고
    • Relationship between resistin and aPAI-1 levels with insulin resistance in Saudi children
    • N.M. Al-Daghri, O.S. Al-Attas, M.S. Alokail, K.M. Alkharfy, and H.M. Draz Relationship between resistin and aPAI-1 levels with insulin resistance in Saudi children Pediatr Int 52 2010 551 556
    • (2010) Pediatr Int , vol.52 , pp. 551-556
    • Al-Daghri, N.M.1    Al-Attas, O.S.2    Alokail, M.S.3    Alkharfy, K.M.4    Draz, H.M.5
  • 49
    • 71849120421 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 (PAI-1) is a valuable biomarker for predicting the metabolic syndrome (MS) in institutionalized elderly residents in Taiwan
    • Y.Y. Chou, W.H. Sheu, and Y.J. Tang Plasminogen activator inhibitor type 1 (PAI-1) is a valuable biomarker for predicting the metabolic syndrome (MS) in institutionalized elderly residents in Taiwan Arch Gerontol Geriatr 49 Suppl. 2 2009 S41 S45
    • (2009) Arch Gerontol Geriatr , vol.49 , Issue.SUPPL. 2
    • Chou, Y.Y.1    Sheu, W.H.2    Tang, Y.J.3
  • 50
    • 0035167384 scopus 로고    scopus 로고
    • Clinical relevance of urokinase-type plasminogen activator, its receptor, and its inhibitor type 1 in endometrial cancer
    • C. Tecimer, D.L. Doering, L.J. Goldsmith, J.S. Meyer, G. Abdulhay, and J.L. Wittliff Clinical relevance of urokinase-type plasminogen activator, its receptor, and its inhibitor type 1 in endometrial cancer Gynecol Oncol 80 2001 48 55
    • (2001) Gynecol Oncol , vol.80 , pp. 48-55
    • Tecimer, C.1    Doering, D.L.2    Goldsmith, L.J.3    Meyer, J.S.4    Abdulhay, G.5    Wittliff, J.L.6
  • 51
    • 0035200775 scopus 로고    scopus 로고
    • Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer
    • M. Fredstorp-Lidebring, P.O. Bendahl, and N. Brunner Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer Eur J Cancer 37 2001 2339 2348
    • (2001) Eur J Cancer , vol.37 , pp. 2339-2348
    • Fredstorp-Lidebring, M.1    Bendahl, P.O.2    Brunner, N.3
  • 52
    • 84863466729 scopus 로고    scopus 로고
    • Interplay between insulin resistance and estrogen deficiency as co- activators in carcinogenesis
    • Z. Suba Interplay between insulin resistance and estrogen deficiency as co- activators in carcinogenesis Pathol Oncol Res 18 2011 123 133
    • (2011) Pathol Oncol Res , vol.18 , pp. 123-133
    • Suba, Z.1
  • 53
    • 77949366041 scopus 로고    scopus 로고
    • The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort
    • N.D. Freedman, J.J. Lacey, A.R. Hollenbeck, M.F. Leitzmann, A. Schatzkin, and C.C. Abnet The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort Cancer 116 2010 1572 1581
    • (2010) Cancer , vol.116 , pp. 1572-1581
    • Freedman, N.D.1    Lacey, J.J.2    Hollenbeck, A.R.3    Leitzmann, M.F.4    Schatzkin, A.5    Abnet, C.C.6
  • 55
    • 1842867053 scopus 로고    scopus 로고
    • Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial
    • G.L. Anderson, M. Limacher, and A.R. Assaf Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial JAMA 291 2004 1701 1712
    • (2004) JAMA , vol.291 , pp. 1701-1712
    • Anderson, G.L.1    Limacher, M.2    Assaf, A.R.3
  • 56
    • 36849096092 scopus 로고    scopus 로고
    • Gender-related hormonal risk factors for oral cancer
    • Z. Suba Gender-related hormonal risk factors for oral cancer Pathol Oncol Res 13 2007 195 202
    • (2007) Pathol Oncol Res , vol.13 , pp. 195-202
    • Suba, Z.1
  • 57
    • 12944276957 scopus 로고    scopus 로고
    • Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity
    • M.E. Jones, A.W. Thorburn, and K.L. Britt Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity Proc Natl Acad Sci USA 97 2000 12735 12740
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12735-12740
    • Jones, M.E.1    Thorburn, A.W.2    Britt, K.L.3
  • 58
    • 0035930060 scopus 로고    scopus 로고
    • Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
    • C.G. Solomon, F.B. Hu, and A. Dunaif Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus JAMA 286 2001 2421 2426
    • (2001) JAMA , vol.286 , pp. 2421-2426
    • Solomon, C.G.1    Hu, F.B.2    Dunaif, A.3
  • 59
    • 0026655766 scopus 로고
    • Ageing and the response of plasma insulin, glucose and C-peptide concentrations to intravenous glucose in postmenopausal women
    • A.J. Proudler, C.V. Felton, and J.C. Stevenson Ageing and the response of plasma insulin, glucose and C-peptide concentrations to intravenous glucose in postmenopausal women Clin Sci (Lond) 83 1992 489 494
    • (1992) Clin Sci (Lond) , vol.83 , pp. 489-494
    • Proudler, A.J.1    Felton, C.V.2    Stevenson, J.C.3
  • 60
    • 54049148644 scopus 로고    scopus 로고
    • Effects of insulin on proliferation and apoptosis of endometrial carcinoma cell
    • J. Zhao, F.X. Xue, S.F. Hua, and L.Z. Zhang Effects of insulin on proliferation and apoptosis of endometrial carcinoma cell Zhonghua Fu Chan Ke Za Zhi 42 2007 696 700
    • (2007) Zhonghua Fu Chan Ke Za Zhi , vol.42 , pp. 696-700
    • Zhao, J.1    Xue, F.X.2    Hua, S.F.3    Zhang, L.Z.4
  • 62
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathway
    • R.J. Davis The mitogen-activated protein kinase signal transduction pathway J Biol Chem 268 1993 14553 14556
    • (1993) J Biol Chem , vol.268 , pp. 14553-14556
    • Davis, R.J.1
  • 63
    • 77953681397 scopus 로고    scopus 로고
    • Insulin signal transduction in normal cells and its role in carcinogenesis
    • K. Mussig, and H.U. Haring Insulin signal transduction in normal cells and its role in carcinogenesis Exp Clin Endocrinol Diabetes 118 2010 356 359
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 356-359
    • Mussig, K.1    Haring, H.U.2
  • 64
    • 33644665451 scopus 로고    scopus 로고
    • Exploration of genetic alterations in human endometrial cancer and melanoma: Distinct tumorigenic pathways that share a frequent abnormal PI3K/AKT cascade
    • K. Ogawa, C. Sun, and A. Horii Exploration of genetic alterations in human endometrial cancer and melanoma: distinct tumorigenic pathways that share a frequent abnormal PI3K/AKT cascade Oncol Rep 14 2005 1481 1485
    • (2005) Oncol Rep , vol.14 , pp. 1481-1485
    • Ogawa, K.1    Sun, C.2    Horii, A.3
  • 65
    • 63849308483 scopus 로고    scopus 로고
    • Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
    • H.B. Salvesen, S.L. Carter, and M. Mannelqvist Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation Proc Natl Acad Sci USA 106 2009 4834 4839
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4834-4839
    • Salvesen, H.B.1    Carter, S.L.2    Mannelqvist, M.3
  • 66
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • M.A. Lawlor, and D.R. Alessi PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114 2001 2903 2910
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 67
    • 65249086248 scopus 로고    scopus 로고
    • Combined PTEN and p27kip1 protein expression patterns are associated with obesity and prognosis in endometrial carcinomas
    • A. Dellas, G. Jundt, G. Sartorius, M. Schneider, and H. Moch Combined PTEN and p27kip1 protein expression patterns are associated with obesity and prognosis in endometrial carcinomas Clin Cancer Res 15 2009 2456 2462
    • (2009) Clin Cancer Res , vol.15 , pp. 2456-2462
    • Dellas, A.1    Jundt, G.2    Sartorius, G.3    Schneider, M.4    Moch, H.5
  • 68
    • 33646828975 scopus 로고    scopus 로고
    • Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    • S. Horman, D. Vertommen, and R. Heath Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491 J Biol Chem 281 2006 5335 5340
    • (2006) J Biol Chem , vol.281 , pp. 5335-5340
    • Horman, S.1    Vertommen, D.2    Heath, R.3
  • 69
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • K. Inoki, T. Zhu, and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577 590
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 70
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • D.M. Gwinn, D.B. Shackelford, and D.F. Egan AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol Cell 30 2008 214 226
    • (2008) Mol Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 71
    • 49849087494 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    • K.H. Lu, W. Wu, and B. Dave Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma Clin Cancer Res 14 2008 2543 2550
    • (2008) Clin Cancer Res , vol.14 , pp. 2543-2550
    • Lu, K.H.1    Wu, W.2    Dave, B.3
  • 72
    • 65549133791 scopus 로고    scopus 로고
    • Autocrine stimulation of IGF1 in estrogen-induced growth of endometrial carcinoma cells: Involvement of the mitogen-activated protein kinase pathway followed by up-regulation of cyclin D1 and cyclin e
    • H. Kashima, T. Shiozawa, and T. Miyamoto Autocrine stimulation of IGF1 in estrogen-induced growth of endometrial carcinoma cells: involvement of the mitogen-activated protein kinase pathway followed by up-regulation of cyclin D1 and cyclin E Endocr Relat Cancer 16 2009 113 122
    • (2009) Endocr Relat Cancer , vol.16 , pp. 113-122
    • Kashima, H.1    Shiozawa, T.2    Miyamoto, T.3
  • 73
    • 33747161036 scopus 로고    scopus 로고
    • Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer
    • Z. Ai, L. Yin, and X. Zhou Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer Cancer 107 2006 746 756
    • (2006) Cancer , vol.107 , pp. 746-756
    • Ai, Z.1    Yin, L.2    Zhou, X.3
  • 74
    • 0030693249 scopus 로고    scopus 로고
    • Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting
    • E.M. Bailyes, B.T. Nave, M.A. Soos, S.R. Orr, A.C. Hayward, and K. Siddle Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting Biochem J 327 Pt 1 1997 209 215
    • (1997) Biochem J , vol.327 , Issue.PART 1 , pp. 209-215
    • Bailyes, E.M.1    Nave, B.T.2    Soos, M.A.3    Orr, S.R.4    Hayward, A.C.5    Siddle, K.6
  • 76
    • 0033886824 scopus 로고    scopus 로고
    • Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways
    • S. Kato, Y. Masuhiro, and M. Watanabe Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways Genes Cells 5 2000 593 601
    • (2000) Genes Cells , vol.5 , pp. 593-601
    • Kato, S.1    Masuhiro, Y.2    Watanabe, M.3
  • 77
    • 15944403593 scopus 로고    scopus 로고
    • Dose-dependent insulin regulation of insulin-like growth factor binding protein-1 in human endometrial stromal cells is mediated by distinct signaling pathways
    • R.B. Lathi, A.P. Hess, S. Tulac, N.R. Nayak, M. Conti, and L.C. Giudice Dose-dependent insulin regulation of insulin-like growth factor binding protein-1 in human endometrial stromal cells is mediated by distinct signaling pathways J Clin Endocrinol Metab 90 2005 1599 1606
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1599-1606
    • Lathi, R.B.1    Hess, A.P.2    Tulac, S.3    Nayak, N.R.4    Conti, M.5    Giudice, L.C.6
  • 78
    • 57149137029 scopus 로고    scopus 로고
    • Crosstalk between IGF1R and estrogen receptor signaling in breast cancer
    • D.H. Fagan, and D. Yee Crosstalk between IGF1R and estrogen receptor signaling in breast cancer J Mammary Gland Biol Neoplasia 13 2008 423 429
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 423-429
    • Fagan, D.H.1    Yee, D.2
  • 79
    • 77953536809 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: Pooled individual data analysis of 17 prospective studies
    • T.J. Key, P.N. Appleby, G.K. Reeves, and A.W. Roddam Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies Lancet Oncol 11 2010 530 542
    • (2010) Lancet Oncol , vol.11 , pp. 530-542
    • Key, T.J.1    Appleby, P.N.2    Reeves, G.K.3    Roddam, A.W.4
  • 80
    • 2942517650 scopus 로고    scopus 로고
    • Insulin-like growth factors, insulin-like growth factor-binding proteins, and endometrial cancer in postmenopausal women: Results from a U.S. case-control study
    • J.V. Lacey Jr., N. Potischman, and M.P. Madigan Insulin-like growth factors, insulin-like growth factor-binding proteins, and endometrial cancer in postmenopausal women: results from a U.S. case-control study Cancer Epidemiol Biomarkers Prev 13 2004 607 612
    • (2004) Cancer Epidemiol Biomarkers Prev , Issue.13 , pp. 607-612
    • Lacey, Jr.J.V.1    Potischman, N.2    Madigan, M.P.3
  • 82
    • 5644268978 scopus 로고    scopus 로고
    • Association between components of the insulin-like growth factor system and endometrial cancer risk
    • L.S. Augustin, L. Dal Maso, and S. Franceschi Association between components of the insulin-like growth factor system and endometrial cancer risk Oncology 67 2004 54 59
    • (2004) Oncology , vol.67 , pp. 54-59
    • Augustin, L.S.1    Dal Maso, L.2    Franceschi, S.3
  • 83
    • 0035753039 scopus 로고    scopus 로고
    • Function of insulin-like growth factor (IGF-I) and its binding protein (IGFBP-1) in pathological proliferation of endometrium
    • B. Waksmanski, J. Dudkiewicz, and S. Dabrowski Function of insulin-like growth factor (IGF-I) and its binding protein (IGFBP-1) in pathological proliferation of endometrium Wiad Lek 54 2001 656 661
    • (2001) Wiad Lek , vol.54 , pp. 656-661
    • Waksmanski, B.1    Dudkiewicz, J.2    Dabrowski, S.3
  • 84
    • 0023809454 scopus 로고
    • Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin
    • S.R. Plymate, L.A. Matej, R.E. Jones, and K.E. Friedl Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin J Clin Endocrinol Metab 67 1988 460 464
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 460-464
    • Plymate, S.R.1    Matej, L.A.2    Jones, R.E.3    Friedl, K.E.4
  • 85
    • 67349166619 scopus 로고    scopus 로고
    • Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition
    • L. Baglietto, D.R. English, and J.L. Hopper Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition Breast Cancer Res Treat 115 2009 171 179
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 171-179
    • Baglietto, L.1    English, D.R.2    Hopper, J.L.3
  • 86
    • 0018099658 scopus 로고
    • Sex hormone concentrations in post-menopausal women
    • A. Vermeulen, and L. Verdonck Sex hormone concentrations in post-menopausal women Clin Endocrinol (Oxf) 9 1978 59 66
    • (1978) Clin Endocrinol (Oxf) , vol.9 , pp. 59-66
    • Vermeulen, A.1    Verdonck, L.2
  • 87
    • 33645418021 scopus 로고    scopus 로고
    • Hyperandrogenemia: Pathophysiology and its role in ovulatory dysfunction in PCOS
    • E. Diamanti-Kandarakis, J. Papailiou, and S. Palimeri Hyperandrogenemia: pathophysiology and its role in ovulatory dysfunction in PCOS Pediatr Endocrinol Rev 3 Suppl. 1 2006 198 204
    • (2006) Pediatr Endocrinol Rev , vol.3 , Issue.SUPPL. 1 , pp. 198-204
    • Diamanti-Kandarakis, E.1    Papailiou, J.2    Palimeri, S.3
  • 89
    • 0031987433 scopus 로고    scopus 로고
    • Pathological and immunohistochemical study on estrogen and progesterone receptors in endometrium of polycystic ovarian syndrome
    • L. Li, C. Yang, and Qiaojie Pathological and immunohistochemical study on estrogen and progesterone receptors in endometrium of polycystic ovarian syndrome Zhonghua Fu Chan Ke Za Zhi 33 1998 89 91
    • (1998) Zhonghua Fu Chan Ke Za Zhi , vol.33 , pp. 89-91
    • Li, L.1    Yang, C.2    Qiaojie3
  • 90
    • 0028936283 scopus 로고
    • Reproductive health and polycystic ovary syndrome
    • M. Gibson Reproductive health and polycystic ovary syndrome Am J Med 98 1995 67S 75S
    • (1995) Am J Med , vol.98
    • Gibson, M.1
  • 91
    • 0029915085 scopus 로고    scopus 로고
    • The link between female infertility and cancer: Epidemiology and possible aetiologies
    • D. Meirow, and J.G. Schenker The link between female infertility and cancer: epidemiology and possible aetiologies Hum Reprod Update 2 1996 63 75
    • (1996) Hum Reprod Update , vol.2 , pp. 63-75
    • Meirow, D.1    Schenker, J.G.2
  • 92
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • C. Weyer, T. Funahashi, and S. Tanaka Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia J Clin Endocrinol Metab 86 2001 1930 1935
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3
  • 93
    • 77954482444 scopus 로고    scopus 로고
    • Serum levels of leptin, adiponectin, retinol binding protein 4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese
    • M. Tajtakova, D. Petrasova, A. Pidanicova, A. Gallovicova, C. Blanarova, and J. Petrovicova Serum levels of leptin, adiponectin, retinol binding protein 4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese Bratisl Lek Listy 111 2010 212 215
    • (2010) Bratisl Lek Listy , vol.111 , pp. 212-215
    • Tajtakova, M.1    Petrasova, D.2    Pidanicova, A.3    Gallovicova, A.4    Blanarova, C.5    Petrovicova, J.6
  • 94
    • 33646874133 scopus 로고    scopus 로고
    • Association between adiponectin, insulin resistance, and endometrial cancer
    • P.T. Soliman, D. Wu, and G. Tortolero-Luna Association between adiponectin, insulin resistance, and endometrial cancer Cancer 106 2006 2376 2381
    • (2006) Cancer , vol.106 , pp. 2376-2381
    • Soliman, P.T.1    Wu, D.2    Tortolero-Luna, G.3
  • 95
    • 0037339002 scopus 로고    scopus 로고
    • Plasma adiponectin concentrations in relation to endometrial cancer: A case-control study in Greece
    • E. Petridou, C. Mantzoros, and N. Dessypris Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece J Clin Endocrinol Metab 88 2003 993 997
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 993-997
    • Petridou, E.1    Mantzoros, C.2    Dessypris, N.3
  • 97
    • 34247530340 scopus 로고    scopus 로고
    • Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition
    • A.E. Cust, N.E. Allen, and S. Rinaldi Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; results from the European prospective investigation into cancer and nutrition Int J Cancer 120 2007 2656 2664
    • (2007) Int J Cancer , vol.120 , pp. 2656-2664
    • Cust, A.E.1    Allen, N.E.2    Rinaldi, S.3
  • 99
    • 33749479230 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Role in metabolism and therapeutic implications
    • G. Schimmack, R.A. Defronzo, and N. Musi AMP-activated protein kinase: role in metabolism and therapeutic implications Diabetes Obes Metab 8 2006 591 602
    • (2006) Diabetes Obes Metab , vol.8 , pp. 591-602
    • Schimmack, G.1    Defronzo, R.A.2    Musi, N.3
  • 100
    • 84869237080 scopus 로고    scopus 로고
    • Metformin and cancer: New applications for an old drug
    • [Epub ahead of print, PMID:21301998]
    • T.V. Kourelis, and R.D. Siegel Metformin and cancer: new applications for an old drug Med Oncol 2011 [Epub ahead of print, PMID:21301998]
    • (2011) Med Oncol
    • Kourelis, T.V.1    Siegel, R.D.2
  • 101
    • 77949703788 scopus 로고    scopus 로고
    • Metformin: A therapeutic opportunity in breast cancer
    • A.M. Gonzalez-Angulo, and F. Meric-Bernstam Metformin: a therapeutic opportunity in breast cancer Clin Cancer Res 16 2010 1695 1700
    • (2010) Clin Cancer Res , vol.16 , pp. 1695-1700
    • Gonzalez-Angulo, A.M.1    Meric-Bernstam, F.2
  • 102
    • 70749106139 scopus 로고    scopus 로고
    • Metformin is a potent inhibitor of endometrial cancer cell proliferation - Implications for a novel treatment strategy
    • L.A. Cantrell, C. Zhou, A. Mendivil, K.M. Malloy, P.A. Gehrig, and V.L. Bae-Jump Metformin is a potent inhibitor of endometrial cancer cell proliferation - implications for a novel treatment strategy Gynecol Oncol 116 2010 92 98
    • (2010) Gynecol Oncol , vol.116 , pp. 92-98
    • Cantrell, L.A.1    Zhou, C.2    Mendivil, A.3    Malloy, K.M.4    Gehrig, P.A.5    Bae-Jump, V.L.6
  • 104
    • 68849089020 scopus 로고    scopus 로고
    • An attempt at conservative treatment in selected cases of type i endometrial carcinoma (stage i a/G1) in young women
    • S. Stanosz An attempt at conservative treatment in selected cases of type I endometrial carcinoma (stage I a/G1) in young women Eur J Gynaecol Oncol 30 2009 365 369
    • (2009) Eur J Gynaecol Oncol , vol.30 , pp. 365-369
    • Stanosz, S.1
  • 105
    • 84863230219 scopus 로고    scopus 로고
    • Metformin: A potential novel endometrial cancer therapy
    • N. Mu, Y. Wang, and F. Xue Metformin: a potential novel endometrial cancer therapy Int J Gynecol Cancer 22 2012 181
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 181
    • Mu, N.1    Wang, Y.2    Xue, F.3
  • 106
    • 5144234027 scopus 로고    scopus 로고
    • Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
    • Y.X. Yang, S. Hennessy, and J.D. Lewis Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients Gastroenterology 127 2004 1044 1050
    • (2004) Gastroenterology , vol.127 , pp. 1044-1050
    • Yang, Y.X.1    Hennessy, S.2    Lewis, J.D.3
  • 107
    • 43049089327 scopus 로고    scopus 로고
    • Insulin therapy and colorectal adenoma risk among patients with type 2 diabetes mellitus: A case-control study in Korea
    • Y.W. Chung, D.S. Han, K.H. Park, C.S. Eun, K.S. Yoo, and C.K. Park Insulin therapy and colorectal adenoma risk among patients with type 2 diabetes mellitus: a case-control study in Korea Dis Colon Rectum 51 2008 593 597
    • (2008) Dis Colon Rectum , vol.51 , pp. 593-597
    • Chung, Y.W.1    Han, D.S.2    Park, K.H.3    Eun, C.S.4    Yoo, K.S.5    Park, C.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.