Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin

Cancer Letters

Volumn 356, Issue 2, 2015, Pages 713-720

  Song, Jin ^a   Ge, Zhouhong ^a   Yang, Xinrong ^b   Luo, Qin ^a   Wang, Cun ^a   You, Haiyan ^a   Ge, Tianxiang ^a   Deng, Yun ^a   Lin, Hechun ^a   Cui, Yongqi ^a   Chu, Wei ^a   Yao, Ming ^a   Zhang, Zhigang ^a   Gu, Jianren ^a   Fan, Jia ^b   Qin, Wenxin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Acidic tumor microenvironment; Glycolysis; Hepatic stellate cells; Proton pump inhibitor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOPONTIN; ACID; CULTURE MEDIUM; MESSENGER RNA; TUMOR MARKER;

ACIDIFICATION; ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER TISSUE; CANCER TRANSPLANTATION; CELL ACTIVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; METASTASIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; STELLATE CELL; STEM CELL; STROMA CELL; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; CULTURE MEDIUM; DRUG SCREENING; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENETICS; LIVER TUMOR; METABOLISM; MORTALITY; NUDE MOUSE; PATHOLOGY; PH; PHARMACOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECONDARY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ACIDS; ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HEPATIC STELLATE CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MYOFIBROBLASTS; OSTEOPONTIN; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919442571     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.10.021     Document Type: Article

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