Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 299, Issue 4, 2010, Pages

  Ichimonji, Isao ^a,b   Tomura, Hideaki ^a   Mogi, Chihiro ^a   Sato, Koichi ^a   Aoki, Haruka ^b   Hisada, Takeshi ^b   Dobashi, Kunio ^a   Ishizuka, Tamotsu ^b   Mori, Masatomo ^b   Okajima, Fumikazu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Asthmatic airway; G proteins

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 16; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 7; INTERLEUKIN 8; LYMPHOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PROTEIN OGR1; RANTES; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; ACID; CALCIUM; CHEMOKINE; CYTOKINE; GPR68 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MESSENGER RNA; PROTON;

ACIDIFICATION; AIRWAY; AIRWAY SMOOTH MUSCLE CELL; ALLERGIC ASTHMA; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INHIBITION KINETICS; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; BRONCHUS; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; PH; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACIDS; BLOTTING, WESTERN; BRONCHI; CALCIUM; CELLS, CULTURED; CHEMOKINES; CYTOKINES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-6; MYOCYTES, SMOOTH MUSCLE; PROTONS; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 77957368768     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00415.2009     Document Type: Article

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