TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells

Journal of Hepatology

Volumn 54, Issue 3, 2011, Pages 521-528

  Shimada, Hideaki ^a   Staten, Nicholas R ^a   Rajagopalan, Lakshman E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Endothelin 1; Hepatic stellate cells; Liver fibrosis; LX 2 cell line; Rho kinase; Transforming growth factor

Indexed keywords

ENDOTHELIN 1; RHO KINASE; RNA; SMAD PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENOMICS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; ENDOTHELIN-1; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 79951676653     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.07.026     Document Type: Article

References (49)

1. J. Jiao, S.L. Friedman, and C. Aloman Hepatic fibrosis Curr Opin Gastroenterol 25 2009 223 229
2. L. Atzori, G. Poli, and A. Perra Hepatic stellate cell: a star cell in the liver Int J Biochem Cell Biol 41 2009 1639 1642
3. H. Shen, G.J. Huang, and Y.W. Gong Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation World J Gastroenterol 9 2003 784 787 (Pubitemid 36531560)
4. G. Fibbi, M. Pucci, S. D'Alessio, C. Grappone, G. Pellegrini, and R. Salzano Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system Growth Factors 19 2001 87 100 (Pubitemid 33133367)
5. M. El-Youssef, Y. Mu, L. Huang, V. Stellmach, and S.E. Crawford Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell J Pediatr Gastroenterol Nutr 28 1999 386 392 (Pubitemid 30349247)
6. A. Marquez-Aguirre, A. Sandoval-Rodriguez, J. Gonzalez-Cuevas, M. Bueno-Topete, J. Navarro-Partida, and I. Arellano-Olivera Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats J Gene Med 11 2009 207 219
7. J. George, D. Roulot, V.E. Koteliansky, and D.M. Bissell In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis Proc Natl Acad Sci USA 96 1999 12719 12724 (Pubitemid 29513569)
8. S. Itoh, F. Itoh, M.J. Goumans, and P. Ten Dijke Signaling of transforming growth factor-beta family members through Smad proteins Eur J Biochem 267 2000 6954 6967 (Pubitemid 32009435)
9. X.L. Wu, W.Z. Zeng, M.D. Jiang, J.P. Qin, and H. Xu Effect of oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis World J Gastroenterol 14 2008 2100 2105 (Pubitemid 351795834)
10. I.J. Cho, S.H. Kim, and S.G. Kim Inhibition of TGFbeta1-mediated PAI-1 induction by oltipraz through selective interruption of Smad 3 activation Cytokine 35 2006 284 294 (Pubitemid 44827747)
11. R. Samarakoon, and P.J. Higgins Integration of non-SMAD and SMAD signaling in TGF-beta1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells Thromb Haemost 100 2008 976 983
12. A.K. Kamaraju, and A.B. Roberts Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo J Biol Chem 280 2005 1024 1036
13. M. Uemura, E.S. Swenson, M.D. Gaca, F.J. Giordano, M. Reiss, and R.G. Wells Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization Mol Biol Cell 16 2005 4214 4224 (Pubitemid 41262890)
14. K.K. Kharbanda, D.D. Rogers 2nd, T.A. Wyatt, M.F. Sorrell, and D.J. Tuma Transforming growth factor-beta induces contraction of activated hepatic stellate cells J Hepatol 41 2004 60 66 (Pubitemid 39005154)
15. D.C. Rockey Hepatic fibrosis, stellate cells and portal hypertension Clin Liver Dis 10 2006 459 479 vii-viii (Pubitemid 44879987)
16. N.G. Theodorakis, Y.N. Wang, J.M. Wu, M.A. Maluccio, J.V. Sitzmann, and N.J. Skill Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride induced liver fibrosis model Am J Physiol Gastrointest Liver Physiol 297 2009 G792 G799
17. N. Ohara, S. Futagawa, S. Watanabe, M. Fukasawa, and S. Takamori Clinical investigation of endothelin-1 and nitric oxide in patients with portal hypertension focusing on plasma levels and immunohistological staining of liver tissues Hepatol Res 21 2001 40 54 (Pubitemid 32725374)
18. S. Liu, R.T. Premont, C.D. Kontos, S. Zhu, and D.C. Rockey A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension Nat Med 11 2005 952 958 (Pubitemid 41294440)
19. G. Anegawa, H. Kawanaka, D. Yoshida, K. Konishi, S. Yamaguchi, and N. Kinjo Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis Hepatology 47 2008 966 977 (Pubitemid 351449688)
20. R.K. Soon Jr., and H.F. Yee Jr Stellate cell contraction: role, regulation, and potential therapeutic target Clin Liver Dis 12 2008 791 803 viii
21. N. Wettschureck, and S. Offermanns Rho/Rho-kinase mediated signaling in physiology and pathophysiology J Mol Med 80 2002 629 638 (Pubitemid 35471727)
22. K. Kitamura, S. Tada, N. Nakamoto, K. Toda, H. Horikawa, and S. Kurita Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis J Gastroenterol Hepatol 22 2007 2022 2033 (Pubitemid 47525076)
23. M.A. Sohail, A.Z. Hashmi, W. Hakim, A. Watanabe, A. Zipprich, and R.J. Groszmann Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition Hepatology 49 2009 185 194
24. T. Murata, S. Arii, T. Nakamura, A. Mori, T. Kaido, and H. Furuyama Inhibitory effect of Y-27,632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells J Hepatol 35 2001 474 481 (Pubitemid 32964446)
25. L. Xu, A.Y. Hui, E. Albanis, M.J. Arthur, S.M. O'Byrne, and W.S. Blaner Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Gut 54 2005 142 151 (Pubitemid 40007234)
26. H. Shimada, T. Ochi, A. Imasato, Y. Morizane, M. Hori, and H. Ozaki Gene expression profiling and functional assays of activated hepatic stellate cells suggest that myocardin has a role in activation Liver Int 30 2010 42 54
27. J. Kountouras, B.H. Billing, and P.J. Scheuer Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat Br J Exp Pathol 65 1984 305 311 (Pubitemid 14085298)
28. B.K. Mueller, H. Mack, and N. Teusch Rho kinase, a promising drug target for neurological disorders Nat Rev Drug Discov 4 2005 387 398 (Pubitemid 40704122)
29. O. Nakagawa, K. Fujisawa, T. Ishizaki, Y. Saito, K. Nakao, and Narumiya.S. ROCK-I Two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice FEBS Lett 392 1996 189 193 (Pubitemid 26276745)
30. S.L. Lin, A. Chiang, D. Chang, and S.Y. Ying Loss of mir-146a function in hormone-refractory prostate cancer RNA 14 2008 417 424 (Pubitemid 351397806)
31. J. Lane, T.A. Martin, G. Watkins, R.E. Mansel, and W.G. Jiang The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer Int J Oncol 33 2008 585 593
32. C.C. Wong, C.M. Wong, E.K. Tung, K. Man, and I.O. Ng Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion Hepatology 49 2009 1583 1594
33. Y. Kureishi, S. Kobayashi, M. Amano, K. Kimura, H. Kanaide, and T. Nakano Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation J Biol Chem 272 1997 12257 12260 (Pubitemid 27203307)
34. W. Gogarten, C.W. Emala, K.S. Lindeman, and C.A. Hirshman Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase Biol Reprod 65 2001 401 406 (Pubitemid 32702302)
35. S. Ai, M. Kuzuya, T. Koike, T. Asai, S. Kanda, and K. Maeda Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways Atherosclerosis 155 2001 321 327 (Pubitemid 32209302)
36. B. Hu, Z. Wu, and S.H. Phan Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression Am J Respir Cell Mol Biol 29 2003 397 404 (Pubitemid 37093999)
37. G.J. Inman, F.J. Nicolas, J.F. Callahan, J.D. Harling, L.M. Gaster, and A.D. Reith SB-431,542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 Mol Pharmacol 62 2002 65 74 (Pubitemid 34680517)
38. Y. Inagaki, M. Kushida, K. Higashi, J. Itoh, R. Higashiyama, and Y.Y. Hong Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice Gastroenterology 129 2005 259 268 (Pubitemid 41002059)
39. T. Morita, T. Mayanagi, and K. Sobue Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs) Exp Cell Res 313 2007 3432 3445 (Pubitemid 47407747)
40. F. Miralles, G. Posern, A.I. Zaromytidou, and R. Treisman Actin dynamics control SRF activity by regulation of its coactivator MAL Cell 113 2003 329 342 (Pubitemid 36556115)
41. R.P. Gao, and D.R. Brigstock Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function World J Gastroenterol 15 2009 3807 3813
42. S.Y. Lee, J.H. Chuang, C.C. Huang, M.H. Chou, C.L. Wu, and C.M. Chen Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia J Pediatr Surg 39 2004 702 708
43. C. Hill, A. Flyvbjerg, R. Rasch, M. Bak, and A. Logan Transforming growth factor-beta2 antibody attenuates fibrosis in the experimental diabetic rat kidney J Endocrinol 170 2001 647 651 (Pubitemid 32834331)
44. M. Prelog, P. Scheidegger, S. Peter, M.E. Gershwin, G. Wick, and R. Sgonc Diminished transforming growth factor beta2 production leads to increased expression of a profibrotic procollagen alpha2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis Arthritis Rheum 52 2005 1804 1811 (Pubitemid 40852889)
45. S. Ren, A. Babelova, K. Moreth, C. Xin, W. Eberhardt, and A. Doller Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression Kidney Int 76 2009 857 867
46. C. Breitenlechner, M. Gassel, H. Hidaka, V. Kinzel, R. Huber, and R.A. Engh Protein kinase A in complex with Rho-kinase inhibitors Y-27,632, Fasudil, and H-1152P: structural basis of selectivity Structure 11 2003 1595 1607 (Pubitemid 37510358)
47. S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem J 351 2000 95 105
48. M. Boerma, Q. Fu, J. Wang, D.S. Loose, A. Bartolozzi, and J.L. Ellis Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin Blood Coagul Fibrinolysis 19 2008 709 718
49. Hahmann C, Schroeter T. Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity. Cell Mol Life Sci, 2009.