Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons

Stem Cells

Volumn 33, Issue 1, 2015, Pages 68-78

  Ren, Yong ^a   Jiang, Houbo ^a,b   Hu, Zhixing ^a,b   Fan, Kevin ^a   Wang, Jun ^a   Janoschka, Stephen ^c   Wang, Xiaomin ^d   Ge, Shaoyu ^c   Feng, Jian ^a,b,d  

^a UNIVERSITY AT BUFFALO   (United States)

^b VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

^c Stony Brook University   (United States)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Dopamine; Induced pluripotent stem cells; Microtubule; Parkin; Parkinson's disease

Indexed keywords

COLCHICINE; GREEN FLUORESCENT PROTEIN; PACLITAXEL; PARKIN; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MICROTUBULE; NERVE CELL; NERVE CELL CULTURE; NEURITE; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PROTEIN STABILITY; WESTERN BLOTTING; ENZYMOLOGY; GENETICS; MUTATION; PATHOLOGY; PHYSIOLOGY; ULTRASTRUCTURE;

MUS;

HUMANS; INDUCED PLURIPOTENT STEM CELLS; MUTATION; NEURONS; PARKINSON DISEASE; PLURIPOTENT STEM CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 84919430270     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1854     Document Type: Article

References (33)

1. Lang AE, Lozano AM,. Parkinson's disease. First of two parts. N Engl J Med 1998; 339: 1044-1053.
2. Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392: 605-608.
3. Nuytemans K, Theuns J, Cruts M, et al. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: A mutation update. Hum Mutat 2010; 31: 763-780.
4. Shimura H, Hattori N, Kubo S, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000; 25: 302-305.
5. Narendra D, Tanaka A, Suen DF, et al. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183: 795-803.
6. Kim KY, Stevens MV, Akter MH, et al. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest 2011; 121: 3701-3712.
7. Manzanillo PS, Ayres JS, Watson RO, et al. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature 2013; 501: 512-516.
8. Chen Y, Dorn GW,. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 2013; 340: 471-475.
9. Ren Y, Zhao JH, Feng J,. Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci 2003; 23: 3316-3324.
10. Yang F, Jiang Q, Zhao J, et al. parkin stabilizes microtubules through strong binding mediated by three independent domains. J Biol Chem 2005; 280: 17154-17162.
11. Ren Y, Liu W, Jiang H, et al. Selective vulnerability of dopaminergic neurons to microtubule depolymerization. J Biol Chem 2005; 280: 34105-34112.
12. Ren Y, Jiang H, Yang F, et al. Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation. J Biol Chem 2009; 284: 4009-4017.
13. Matsuda W, Furuta T, Nakamura KC, et al. Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum. J Neurosci 2009; 29: 444-453.
14. Pissadaki EK, Bolam JP,. The energy cost of action potential propagation in dopamine neurons: Clues to susceptibility in Parkinson's disease. Front Comput Neurosci 2013; 7: 13.
15. Bolam JP, Pissadaki EK,. Living on the edge with too many mouths to feed: Why dopamine neurons die. Mov Disord 2012; 27: 1478-1483.
16. Iseki E, Kato M, Marui W, et al. A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies. J Neurol Sci 2001; 185: 129-134.
17. Raff MC, Whitmore AV, Finn JT,. Axonal self-destruction and neurodegeneration. Science 2002; 296: 868-871.
18. Dawson TM, Ko HS, Dawson VL,. Genetic animal models of Parkinson's disease. Neuron 2010; 66: 646-661.
19. Perez FA, Palmiter RD,. Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci USA 2005; 102: 2174-2179.
20. Jiang H, Ren Y, Yuen EY, et al. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nat Commun 2012; 3: 668.
21. Meijering E, Jacob M, Sarria JC, et al. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry A 2004; 58: 167-176.
22. Kumamoto N, Gu Y, Wang J, et al. A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nat Neurosci 2012; 15: 399-405, S1.
23. Hirsch E, Graybiel AM, Agid YA,. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 1988; 334: 345-348.
24. Braak H, Braak E,. Pathoanatomy of Parkinson's disease. J Neurol 2000; 247 (suppl 2): II3-10.
25. Bellin M, Marchetto MC, Gage FH, et al. Induced pluripotent stem cells: The new patient? Nat Rev Mol Cell Biol 2012; 13: 713-726.
26. Pu J, Jiang H, Zhang B, et al. Redefining Parkinson's disease research using induced pluripotent stem cells. Curr Neurol Neurosci Rep 2012; 12: 392-398.
27. Badger JL, Cordero-Llana O, Hartfield EM, et al. Parkinson's disease in a dish-Using stem cells as a molecular tool. Neuropharmacology 2014; 76 Pt A: 88-96.
28. Feng J,. Microtubule: A common target for parkin and Parkinson's disease toxins. Neuroscientist 2006; 12: 469-476.
29. Dickson DW,. Parkinson's disease and parkinsonism: Neuropathology. Cold Spring Harb Perspect Med 2012; 2.
30. Law BM, Spain VA, Leinster VH, et al. A direct interaction between leucine-rich repeat kinase 2 and specific beta-tubulin isoforms regulates tubulin acetylation. J Biol Chem 2014; 289: 895-908.
31. Sheng C, Heng X, Zhang G, et al. DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth. Neurobiol Aging 2013; 34: 489-498.
32. Choi WS, Kruse SE, Palmiter RD, et al. Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci USA 2008; 105: 15136-15141.
33. Choi WS, Palmiter RD, Xia Z,. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model. J Cell Biol 2011; 192: 873-882.