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Volumn 9, Issue 1, 2015, Pages 3-10

Mechanism of subclinical hypothyroidism accelerating endothelial dysfunction (Review)

Author keywords

Chronic inflammation; Endothelial dysfunction; L thyroxine replacement therapy; Lipid profile; Oxidative stress; Subclinical hypothyroidism; Thyroid stimulating hormone receptor

Indexed keywords

3 NITROTYROSINE; ASCORBIC ACID; C REACTIVE PROTEIN; CARBONYL DERIVATIVE; CAVEOLIN 1; DIMETHYLARGININASE; GLYCERYL TRINITRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LEVOTHYROXINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N (G), N (G) DIMETHYLARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITRIC OXIDE SYNTHASE; PROPYLTHIOURACIL; PROSTACYCLIN; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THYROTROPIN RECEPTOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84919429670     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.2037     Document Type: Review
Times cited : (51)

References (76)
  • 1
    • 9144238095 scopus 로고    scopus 로고
    • Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management
    • Surks MI, Ortiz E, Daniels GH, et al: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291: 228-238, 2004.
    • (2004) JAMA , vol.291 , pp. 228-238
    • Surks, M.I.1    Ortiz, E.2    Daniels, G.H.3
  • 2
    • 84859104026 scopus 로고    scopus 로고
    • Subclinical thyroid disease
    • Cooper DS and Biondi B: Subclinical thyroid disease. Lancet 379: 1142-1154, 2012.
    • (2012) Lancet , vol.379 , pp. 1142-1154
    • Cooper, D.S.1    Biondi, B.2
  • 3
    • 84875445390 scopus 로고    scopus 로고
    • Thyroid dysfunction in the elderly
    • Boelaert K: Thyroid dysfunction in the elderly. Nat Rev Endocrinol 9: 194-204, 2013.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 194-204
    • Boelaert, K.1
  • 4
    • 0034651789 scopus 로고    scopus 로고
    • Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: The Rotterdam study
    • Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A and Witteman JC: Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study. Ann Intern Med 132: 270-278, 2000.
    • (2000) Ann Intern Med , vol.132 , pp. 270-278
    • Hak, A.E.1    Pols, H.A.2    Visser, T.J.3    Drexhage, H.A.4    Hofman, A.5    Witteman, J.C.6
  • 5
    • 28344446835 scopus 로고    scopus 로고
    • Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death
    • Rodondi N, Newman AB, Vittinghoff E, et al: Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 165: 2460-2466, 2005.
    • (2005) Arch Intern Med , vol.165 , pp. 2460-2466
    • Rodondi, N.1    Newman, A.B.2    Vittinghoff, E.3
  • 6
    • 28344432759 scopus 로고    scopus 로고
    • Subclinical thyroid dysfunction as a risk factor for cardiovascular disease
    • Walsh JP, Bremner AP, Bulsara MK, et al: Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med 165: 2467-2472, 2005.
    • (2005) Arch Intern Med , vol.165 , pp. 2467-2472
    • Walsh, J.P.1    Bremner, A.P.2    Bulsara, M.K.3
  • 7
    • 77951640269 scopus 로고    scopus 로고
    • The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: Reanalysis of the Whickham Survey cohort
    • Razvi S, Weaver JU, Vanderpump MP and Pearce SH: The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. J Clin Endocrinol Metab 95: 1734-1740, 2010.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1734-1740
    • Razvi, S.1    Weaver, J.U.2    Vanderpump, M.P.3    Pearce, S.H.4
  • 8
    • 77956928569 scopus 로고    scopus 로고
    • Subclinical hypo-thyroidism and the risk of coronary heart disease and mortality
    • Rodondi N, den Elzen WP, Bauer DC, et al: Subclinical hypo-thyroidism and the risk of coronary heart disease and mortality. JAMA 304: 1365-1374, 2010.
    • (2010) JAMA , vol.304 , pp. 1365-1374
    • Rodondi, N.1    Den Elzen, W.P.2    Bauer, D.C.3
  • 9
    • 84865116104 scopus 로고    scopus 로고
    • Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults
    • Tseng FY, Lin WY, Lin CC, et al: Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol 60: 730-737, 2012.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 730-737
    • Tseng, F.Y.1    Lin, W.Y.2    Lin, C.C.3
  • 12
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis
    • Galkina E and Ley K: Immune and inflammatory mechanisms of atherosclerosis. Ann Rev Immunol 27: 165, 2009.
    • (2009) Ann Rev Immunol , vol.27 , pp. 165
    • Galkina, E.1    Ley, K.2
  • 13
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM and Hansson GK: Progress and challenges in translating the biology of atherosclerosis. Nature 473: 317-325, 2011.
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 15
    • 0031742598 scopus 로고    scopus 로고
    • Possible modulation by endothelin-1, nitric oxide, prostaglandin I2 and thromboxane A2 of vasoconstriction induced by an α-agonist in mesenteric arterial bed from diabetic rats
    • Makino A and Kamata K: Possible modulation by endothelin-1, nitric oxide, prostaglandin I2 and thromboxane A2 of vasoconstriction induced by an α-agonist in mesenteric arterial bed from diabetic rats. Diabetologia 41: 1410-1418, 1998.
    • (1998) Diabetologia , vol.41 , pp. 1410-1418
    • Makino, A.1    Kamata, K.2
  • 16
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
    • Beckman JS and Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 40: C1424, 1996.
    • (1996) Am J Physiol , vol.40 , pp. C1424
    • Beckman, J.S.1    Koppenol, W.H.2
  • 17
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton WK, Cooper CE and Knowles RG: Nitric oxide synthases: structure, function and inhibition. Biochem J 357: 593-615, 2001.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 18
    • 75549091472 scopus 로고    scopus 로고
    • Bench-to-bedside review: Nitric oxide in critical illness-update 2008
    • Hollenberg SM and Cinel I: Bench-to-bedside review: nitric oxide in critical illness-update 2008. Crit Care 13: 218, 2009.
    • (2009) Crit Care , vol.13 , pp. 218
    • Hollenberg, S.M.1    Cinel, I.2
  • 20
    • 84861323605 scopus 로고    scopus 로고
    • Endothelial dysfunction: The early predictor of atherosclerosis
    • Mudau M, Genis A, Lochner A and Strijdom H: Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc J Afr 23: 222-231, 2012.
    • (2012) Cardiovasc J Afr , vol.23 , pp. 222-231
    • Mudau, M.1    Genis, A.2    Lochner, A.3    Strijdom, H.4
  • 21
    • 57749189130 scopus 로고    scopus 로고
    • Caveolae and transcytosis in endothelial cells: Role in atherosclerosis
    • Frank PG, Pavlides S and Lisanti MP: Caveolae and transcytosis in endothelial cells: role in atherosclerosis. Cell Tissue Res 335: 41-47, 2009.
    • (2009) Cell Tissue Res , vol.335 , pp. 41-47
    • Frank, P.G.1    Pavlides, S.2    Lisanti, M.P.3
  • 22
    • 84866298370 scopus 로고    scopus 로고
    • Caveolae, caveolins, cavins, and endothelial cell function: New insights
    • Sowa G: Caveolae, caveolins, cavins, and endothelial cell function: new insights. Front Physiol 2: 120, 2012.
    • (2012) Front Physiol , vol.2 , pp. 120
    • Sowa, G.1
  • 24
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim VN: MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 6: 376-385, 2005.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 26
    • 84894196759 scopus 로고    scopus 로고
    • Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice
    • Loyer X, Potteaux S, Vion AC, et al: Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice. Circ Res 114: 434-443, 2014.
    • (2014) Circ Res , vol.114 , pp. 434-443
    • Loyer, X.1    Potteaux, S.2    Vion, A.C.3
  • 28
    • 84899957905 scopus 로고    scopus 로고
    • Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: A clinical study
    • Zhang X, Shao S, Geng H, et al: Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study. J Clin Endocrinol Metab 99: E766-774, 2014.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. E766-774
    • Zhang, X.1    Shao, S.2    Geng, H.3
  • 29
    • 79958070445 scopus 로고    scopus 로고
    • Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis
    • Turemen EE, Cetinarslan B, Sahin T, Canturk Z and Tarkun I: Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. Endocr J 58: 349-354, 2011.
    • (2011) Endocr J , vol.58 , pp. 349-354
    • Turemen, E.E.1    Cetinarslan, B.2    Sahin, T.3    Canturk, Z.4    Tarkun, I.5
  • 30
    • 33749575290 scopus 로고    scopus 로고
    • Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma
    • Dardano A, Ghiadoni L, Plantinga Y, et al: Recombinant human thyrotropin reduces endothelium-dependent vasodilation in patients monitored for differentiated thyroid carcinoma. J Clin Endocrinol Metab 91: 4175-4178, 2006.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4175-4178
    • Dardano, A.1    Ghiadoni, L.2    Plantinga, Y.3
  • 31
    • 84873470730 scopus 로고    scopus 로고
    • Carotid intima-media thickness in patients with subclinical hypothyroidism: A meta-analysis
    • Gao N, Zhang W, Zhang YZ, Yang Q and Chen SH: Carotid intima-media thickness in patients with subclinical hypothyroidism: a meta-analysis. Atherosclerosis 227: 18-25, 2013.
    • (2013) Atherosclerosis , vol.227 , pp. 18-25
    • Gao, N.1    Zhang, W.2    Zhang, Y.Z.3    Yang, Q.4    Chen, S.H.5
  • 32
    • 84860743316 scopus 로고    scopus 로고
    • Proangiogenic effect of TSH in human microvascular endothelial cells through its membrane receptor
    • Balzan S, Del Carratore R, Nicolini G, et al: Proangiogenic effect of TSH in human microvascular endothelial cells through its membrane receptor. J Clin Endocrinol Metab 97: 1763-1770, 2012.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1763-1770
    • Balzan, S.1    Del Carratore, R.2    Nicolini, G.3
  • 33
    • 84897838519 scopus 로고    scopus 로고
    • Effects of TSH on the function of human umbilical vein endothelial cells
    • Tian L, Zhang L, Liu J, Guo T, Gao C and Ni J: Effects of TSH on the function of human umbilical vein endothelial cells. J Mol Endocrinol 52: 215-222, 2014.
    • (2014) J Mol Endocrinol , vol.52 , pp. 215-222
    • Tian, L.1    Zhang, L.2    Liu, J.3    Guo, T.4    Gao, C.5    Ni, J.6
  • 34
    • 84155169078 scopus 로고    scopus 로고
    • Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum
    • Wang Y, Zhong J, Wei W, et al: Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum. Biol Trace Elem Res 144: 1039-1049, 2011.
    • (2011) Biol Trace Elem Res , vol.144 , pp. 1039-1049
    • Wang, Y.1    Zhong, J.2    Wei, W.3
  • 35
    • 75449086147 scopus 로고    scopus 로고
    • Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus
    • Gong J, Dong J, Wang Y, et al: Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus. J Neuroendocrinology 22: 129-139, 2010.
    • (2010) J Neuroendocrinology , vol.22 , pp. 129-139
    • Gong, J.1    Dong, J.2    Wang, Y.3
  • 36
    • 84865460335 scopus 로고    scopus 로고
    • Hypothyroidism: Age-related influence on cardiovascular nitric oxide system in rats
    • Sarati LI, Martinez CR, Artés N, et al: Hypothyroidism: age-related influence on cardiovascular nitric oxide system in rats. Metabolism 61: 1301-1311, 2012.
    • (2012) Metabolism , vol.61 , pp. 1301-1311
    • Sarati, L.I.1    Martinez, C.R.2    Artés, N.3
  • 37
    • 34347257788 scopus 로고    scopus 로고
    • Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation
    • Latif R, Ando T and Davies TF: Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology 148: 3164-3175, 2007.
    • (2007) Endocrinology , vol.148 , pp. 3164-3175
    • Latif, R.1    Ando, T.2    Davies, T.F.3
  • 38
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T and Cooke JP: Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99: 3092-3095, 1999.
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 39
    • 11144356028 scopus 로고    scopus 로고
    • HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    • Nofer J-R, van der Giet M, Tölle M, et al: HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest 113: 569-581, 2004.
    • (2004) J Clin Invest , vol.113 , pp. 569-581
    • Nofer, J.-R.1    Van Der Giet, M.2    Tölle, M.3
  • 40
    • 79251621005 scopus 로고    scopus 로고
    • The relationship between serum thyrotropin and components of metabolic syndrome
    • Lai Y, Wang J, Jiang F, et al: The relationship between serum thyrotropin and components of metabolic syndrome. Endocr J 58: 23-30, 2011.
    • (2011) Endocr J , vol.58 , pp. 23-30
    • Lai, Y.1    Wang, J.2    Jiang, F.3
  • 41
    • 33947511989 scopus 로고    scopus 로고
    • The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study
    • Åsvold BO, Vatten LJ, Nilsen TI and Bjøro T: The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. Eur J Endocrinol 156: 181-186, 2007.
    • (2007) Eur J Endocrinol , vol.156 , pp. 181-186
    • Åsvold, B.O.1    Vatten, L.J.2    Nilsen, T.I.3    Bjøro, T.4
  • 42
    • 84919436754 scopus 로고    scopus 로고
    • Even mildly elevated TSH is associated with an atherogenic lipid profile in postmenopausal women with subclinical hypothyroidism
    • Mar 28, Epub ahead of print
    • Geng H, Zhang X, Wang C, et al: Even mildly elevated TSH is associated with an atherogenic lipid profile in postmenopausal women with subclinical hypothyroidism. Endocr Res: Mar 28, 2014 (Epub ahead of print).
    • (2014) Endocr Res
    • Geng, H.1    Zhang, X.2    Wang, C.3
  • 43
    • 84867405480 scopus 로고    scopus 로고
    • Postprandial lipaemia suppresses endothelium-dependent arterial dilation in patients with hypothyroidism
    • Xiang GD, Xiang LW, He HL and Zhao LS: Postprandial lipaemia suppresses endothelium-dependent arterial dilation in patients with hypothyroidism. Endocrine 42: 391-398, 2012.
    • (2012) Endocrine , vol.42 , pp. 391-398
    • Xiang, G.D.1    Xiang, L.W.2    He, H.L.3    Zhao, L.S.4
  • 44
    • 77957944468 scopus 로고    scopus 로고
    • A novel role for thyroid-stimulating hormone: Up-regulation of hepatic 3-hydroxy-3-methy l-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway
    • Tian L, Song Y, Xing M, et al: A novel role for thyroid-stimulating hormone: Up-regulation of hepatic 3-hydroxy-3-methy l-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway. Hepatology 52: 1401-1409, 2010.
    • (2010) Hepatology , vol.52 , pp. 1401-1409
    • Tian, L.1    Song, Y.2    Xing, M.3
  • 45
    • 33845504111 scopus 로고    scopus 로고
    • Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    • Taddei S, Caraccio N, Virdis A, et al: Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis. J Clin Endocrinol Metab 91: 5076-5082, 2006.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 5076-5082
    • Taddei, S.1    Caraccio, N.2    Virdis, A.3
  • 46
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker PM, Rifai N, Stampfer MJ and Hennekens CH: Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101: 1767-1772, 2000.
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3    Hennekens, C.H.4
  • 47
    • 33645060226 scopus 로고    scopus 로고
    • Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway
    • Antunes TT, Gagnon A, Bell A and Sorisky A: Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway. Obes Res 13: 2066-2071, 2005.
    • (2005) Obes Res , vol.13 , pp. 2066-2071
    • Antunes, T.T.1    Gagnon, A.2    Bell, A.3    Sorisky, A.4
  • 48
    • 33646544087 scopus 로고    scopus 로고
    • TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury
    • Zhang C, Xu X, Potter BJ, et al: TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 26: 475-480, 2006.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 475-480
    • Zhang, C.1    Xu, X.2    Potter, B.J.3
  • 49
    • 0033559023 scopus 로고    scopus 로고
    • Neuroendocrine-induced synthesis of bone marrow-derived cytokines with inflammatory immunomodu lating properties
    • Whetsell M, Bagriacik EU, Seetharamaiah GS, Prabhakar BS and Klein JR: Neuroendocrine-induced synthesis of bone marrow-derived cytokines with inflammatory immunomodu lating properties. Cell Immunol 192: 159-166, 1999.
    • (1999) Cell Immunol , vol.192 , pp. 159-166
    • Whetsell, M.1    Bagriacik, E.U.2    Seetharamaiah, G.S.3    Prabhakar, B.S.4    Klein, J.R.5
  • 50
    • 0037300574 scopus 로고    scopus 로고
    • Elevated C-reactive protein and homocysteine values: Cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial
    • Christ-Crain M, Meier C, Guglielmetti M, et al: Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial. Atherosclerosis 166: 379-386, 2003.
    • (2003) Atherosclerosis , vol.166 , pp. 379-386
    • Christ-Crain, M.1    Meier, C.2    Guglielmetti, M.3
  • 51
    • 4143147346 scopus 로고    scopus 로고
    • Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years
    • Kvetny J, Heldgaard PE, Bladbjerg EM and Gram J: Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin Endocrinol (Oxf) 61: 232-238, 2004.
    • (2004) Clin Endocrinol (Oxf) , vol.61 , pp. 232-238
    • Kvetny, J.1    Heldgaard, P.E.2    Bladbjerg, E.M.3    Gram, J.4
  • 52
    • 15744385276 scopus 로고    scopus 로고
    • Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemia
    • Tuzcu A, Bahceci M, Gokalp D, Tuzun Y and Gunes K: Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J 52: 89-94, 2005.
    • (2005) Endocr J , vol.52 , pp. 89-94
    • Tuzcu, A.1    Bahceci, M.2    Gokalp, D.3    Tuzun, Y.4    Gunes, K.5
  • 53
    • 0037161360 scopus 로고    scopus 로고
    • Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein
    • Verma S, Li S-H, Badiwala MV, et al: Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation 105: 1890-1896, 2002.
    • (2002) Circulation , vol.105 , pp. 1890-1896
    • Verma, S.1    Li, S.-H.2    Badiwala, M.V.3
  • 54
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H and Harrison DG: Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844, 2000.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 55
    • 52049099354 scopus 로고    scopus 로고
    • Role of oxidative stress and nitric oxide in atherothrombosis
    • Lubos E, Handy DE and Loscalzo J: Role of oxidative stress and nitric oxide in atherothrombosis. Front Biosci 13: 5323-5344, 2008.
    • (2008) Front Biosci , vol.13 , pp. 5323-5344
    • Lubos, E.1    Handy, D.E.2    Loscalzo, J.3
  • 56
    • 62649123264 scopus 로고    scopus 로고
    • Endothelial function and oxidative stress in cardiovascular diseases
    • Higashi Y, Noma K, Yoshizumi M and Kihara Y: Endothelial function and oxidative stress in cardiovascular diseases. Circ J 73: 411-418, 2009.
    • (2009) Circ J , vol.73 , pp. 411-418
    • Higashi, Y.1    Noma, K.2    Yoshizumi, M.3    Kihara, Y.4
  • 57
    • 73349127833 scopus 로고    scopus 로고
    • Serum oxidative stress parameters of women with hypothyroidism
    • Coria MJ, Pastran AI and Gimenez MS: Serum oxidative stress parameters of women with hypothyroidism. Acta Biomed 80: 135-139, 2009.
    • (2009) Acta Biomed , vol.80 , pp. 135-139
    • Coria, M.J.1    Pastran, A.I.2    Gimenez, M.S.3
  • 58
    • 60349094682 scopus 로고    scopus 로고
    • Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism
    • Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk BO, Isbilen E and Tutuncu NB: Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clin Endocrinol (Oxf) 70: 469-474, 2009.
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 469-474
    • Torun, A.N.1    Kulaksizoglu, S.2    Kulaksizoglu, M.3    Pamuk, B.O.4    Isbilen, E.5    Tutuncu, N.B.6
  • 59
    • 84856710414 scopus 로고    scopus 로고
    • Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism
    • Cebeci E, Alibaz-Oner F, Usta M, Yurdakul S and Erguney M: Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism. J Investig Med 60: 23-28, 2012.
    • (2012) J Investig Med , vol.60 , pp. 23-28
    • Cebeci, E.1    Alibaz-Oner, F.2    Usta, M.3    Yurdakul, S.4    Erguney, M.5
  • 60
    • 84866722099 scopus 로고    scopus 로고
    • Oxidative stress parameters in serum and low density lipoproteins of Hashimoto's thyroiditis patients with subclinical and overt hypothyroidism
    • Ozturk U, Vural P, Ozderya A, Karadag B, Dogru-Abbasoglu S and Uysal M: Oxidative stress parameters in serum and low density lipoproteins of Hashimoto's thyroiditis patients with subclinical and overt hypothyroidism. Int Immunopharmacol 14: 349-352, 2012.
    • (2012) Int Immunopharmacol , vol.14 , pp. 349-352
    • Ozturk, U.1    Vural, P.2    Ozderya, A.3    Karadag, B.4    Dogru-Abbasoglu, S.5    Uysal, M.6
  • 61
    • 77958139810 scopus 로고    scopus 로고
    • Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism
    • G DX, J HP, H LS and L SZ: Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism. Exp Clin Endocrinol Diabetes 118: 625-629, 2010.
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 625-629
    • G Dx, J.H.1    Ls, H.2    Sz, L.3
  • 62
    • 39549120887 scopus 로고    scopus 로고
    • Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients
    • Fujii N, Tsuchihashi K, Sasao H, et al: Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients. Heart Vessels 23: 9-15, 2008.
    • (2008) Heart Vessels , vol.23 , pp. 9-15
    • Fujii, N.1    Tsuchihashi, K.2    Sasao, H.3
  • 63
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction molecular and pathophysiological mechanisms
    • Kim J-a, Montagnani M, Koh KK and Quon MJ: Reciprocal relationships between insulin resistance and endothelial dysfunction molecular and pathophysiological mechanisms. Circulation 113: 1888-1904, 2006.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.-A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 64
    • 77952414200 scopus 로고    scopus 로고
    • Insulin resistance and cardiovascular risk factors in patients with mild and severe subclinical hypothyroidism
    • Gen R, Akbay E and Sezer K: Insulin resistance and cardiovascular risk factors in patients with mild and severe subclinical hypothyroidism. The Endocrinologist 20: 128-130, 2010.
    • (2010) The Endocrinologist , vol.20 , pp. 128-130
    • Gen, R.1    Akbay, E.2    Sezer, K.3
  • 65
    • 65549135659 scopus 로고    scopus 로고
    • Studies of insulin resistance in patients with clinical and subclinical hypothyroidism
    • Maratou E, Hadjidakis DJ, Kollias A, et al: Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol 160: 785-790, 2009.
    • (2009) Eur J Endocrinol , vol.160 , pp. 785-790
    • Maratou, E.1    Hadjidakis, D.J.2    Kollias, A.3
  • 66
    • 33750633204 scopus 로고    scopus 로고
    • Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women
    • Al Sayed A, Al Ali N and Alfadhli E: Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocr J 53: 653-657, 2006.
    • (2006) Endocr J , vol.53 , pp. 653-657
    • Al Sayed, A.1    Al Ali, N.2    Alfadhli, E.3
  • 67
    • 34347402634 scopus 로고    scopus 로고
    • The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men
    • Peeters RP, Van Der Deure WM, Van Den Beld AW, et al: The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Clin Endocrinol (Oxf) 66: 808-815, 2007.
    • (2007) Clin Endocrinol (Oxf) , vol.66 , pp. 808-815
    • Peeters, R.P.1    Van Der Deure, W.M.2    Van Den Beld, A.W.3
  • 68
    • 0041883173 scopus 로고    scopus 로고
    • Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: Beneficial effect of levothyroxine therapy
    • Taddei S, Caraccio N, Virdis A, et al: Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 88: 3731-3737, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3731-3737
    • Taddei, S.1    Caraccio, N.2    Virdis, A.3
  • 69
    • 2442442844 scopus 로고    scopus 로고
    • Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: A double-blind, placebo-controlled study
    • Monzani F, Caraccio N, Kozakowa M, et al: Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 89: 2099-2106, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2099-2106
    • Monzani, F.1    Caraccio, N.2    Kozakowa, M.3
  • 70
    • 85027945198 scopus 로고    scopus 로고
    • Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism
    • Oner FA, Yurdakul S, Oner E, Uzum AK and Erguney M: Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism. Endocrine 40: 280-284, 2011.
    • (2011) Endocrine , vol.40 , pp. 280-284
    • Oner, F.A.1    Yurdakul, S.2    Oner, E.3    Uzum, A.K.4    Erguney, M.5
  • 71
    • 34249854618 scopus 로고    scopus 로고
    • The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: Randomized, crossover trial
    • Razvi S, Ingoe L, Keeka G, Oates C, McMillan C and Weaver JU: The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 92: 1715-1723, 2007.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1715-1723
    • Razvi, S.1    Ingoe, L.2    Keeka, G.3    Oates, C.4    McMillan, C.5    Weaver, J.U.6
  • 72
    • 67650302288 scopus 로고    scopus 로고
    • Effects of 18 months of l-T4 replacement in women with subclinical hypothyroidism
    • Adrees M, Gibney J, El-Saeity N and Boran G: Effects of 18 months of l-T4 replacement in women with subclinical hypothyroidism. Clin Endocrinol (Oxf) 71: 298-303, 2009.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 298-303
    • Adrees, M.1    Gibney, J.2    El-Saeity, N.3    Boran, G.4
  • 73
    • 80052704064 scopus 로고    scopus 로고
    • Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism
    • Cabral MD, Teixeira P, Soares D, Leite S, Salles E and Waisman M: Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism. Clinics (Sao Paulo) 66: 1321-1328, 2011.
    • (2011) Clinics (Sao Paulo) , vol.66 , pp. 1321-1328
    • Cabral, M.D.1    Teixeira, P.2    Soares, D.3    Leite, S.4    Salles, E.5    Waisman, M.6
  • 75
    • 84861715746 scopus 로고    scopus 로고
    • Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality
    • Razvi S, Weaver JU, Butler TJ and Pearce SH: Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality. Arch Intern Med 178: 811-817, 2012.
    • (2012) Arch Intern Med , vol.178 , pp. 811-817
    • Razvi, S.1    Weaver, J.U.2    Butler, T.J.3    Pearce, S.H.4
  • 76
    • 0035954660 scopus 로고    scopus 로고
    • Clinical practice. Subclinical hypothyroidism
    • Cooper DS: Clinical practice. Subclinical hypothyroidism. N Engl J Med 345: 260-265, 2001.
    • (2001) N Engl J Med , vol.345 , pp. 260-265
    • Cooper, D.S.1


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