The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: Reanalysis of the Whickham survey cohort

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 4, 2010, Pages 1734-1740

  Razvi, Salman ^a,b   Weaver, Jola U ^a,b   Vanderpump, Mark P ^c   Pearce, Simon H S ^b  

^a GATESHEAD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; THYROID HORMONE; CHOLESTEROL; THYROID STIMULATING IMMUNOGLOBULIN; THYROTROPIN;

ADULT; ARTICLE; CLINICAL ASSESSMENT; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HEALTH SURVEY; HUMAN; HYPOTHYROIDISM; INCIDENCE; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PRIORITY JOURNAL; RISK FACTOR; SUBCLINICAL HYPOTHYROIDISM; SYSTOLIC BLOOD PRESSURE; ADOLESCENT; AGED; BLOOD; BLOOD PRESSURE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; HEART MUSCLE ISCHEMIA; MIDDLE AGED; PHENOTYPE; SOCIOECONOMICS; THYROID FUNCTION TEST;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOOD PRESSURE; CHOLESTEROL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HEALTH SURVEYS; HUMANS; HYPOTHYROIDISM; IMMUNOGLOBULINS, THYROID-STIMULATING; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PHENOTYPE; SOCIOECONOMIC FACTORS; THYROID FUNCTION TESTS; THYROID HORMONES; THYROTROPIN; YOUNG ADULT;

EID: 77951640269     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1749     Document Type: Article

References (23)

1. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE 2002 Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489-499
2. Tunbridge WMG, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Grimley Evans J, Young E, Bird T, Smith PA 1977 The spectrum of thyroid disease in a community: the Whickham Survey. Clin Endocrinol (Oxf) 7:481-493 (Pubitemid 8235965)
3. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC 2000 Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 132:270-278
4. Walsh JP, Bremner AP, Bulsara MK, O'Leary P, Leedman PJ, Feddema P, Michelangeli V 2005 Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med 165:2467-2472
5. Cappola AR, Fried LP, Arnold AM, Danese MD, Kuller LH, Burke GL, Tracy RP, Ladenson PW 2006 Thyroid status, cardiovascular risk, and mortality in older adults. JAMA 295:1033-1041
6. Rodondi N, Newman AB, Vittinghoff E, de Rekeneire N, Satterfield S, Harris TB, Bauer DC 2005 Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 165:2460-2466
7. Imaizumi M, Akahoshi M, Ichimaru S, Nakashima E, Hida A, Soda M, Usa T, Ashizawa K, Yokoyama N, Maeda R, Nagataki S, Eguchi K 2004 Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism. J Clin Endocrinol Metab 89:3365-3370
8. Vanderpump MPJ, Tunbridge WMG, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Hasan DM, Rodgers H, Tunbridge F, Young ET 1995 The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 43:55-68
9. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Rodgers H, Tunbridge F, Young ET 1996 The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community. Thyroid 6:155-160
10. Helfand M; U.S. Preventive Services Task Force 2004 Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 140:128-141
11. Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J 2004 Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin Endocrinol (Oxf) 61:232-238 (Pubitemid 39093119)
12. Nicoloff JT, Spencer CA 1990 The use and misuse of the sensitive thyrotropin assays. J Clin Endocrinol Metab 71:553-558
13. Rodondi N, Bauer DC, Cappola AR, Cornuz J, Robbins J, Fried LP, Ladenson PW, Vittinghoff E, Gottdiener JS, Newman AB 2008 Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health study. J Am Coll Cardiol 52:1152-1159
14. Rodondi N, Aujesky D, Vittinghoff E, Cornuz J, Bauer DC 2006 Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. Am J Med 119:541-551 (Pubitemid 44041257)
15. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH 2008 The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a meta-analysis. J Clin Endocrinol Metab 93:2998-3007
16. Biondi B, Cooper DS 2008 The clinical significance of subclinical thyroid dysfunction. Endocr Rev 29:76-131
17. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, Salvetti A, Ferrannini E, Monzani F 2003 Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 88:3731-3737
18. Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub JJ, Müller B 2003 Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial. Atherosclerosis 166:379-386
19. Haentjens P, Van Meerhaeghe A, Poppe K, Velkeniers B 2008 Subclinical thyroid dysfunction and mortality: an estimate of relative and absolute excess all-cause mortality based on time-to-event data from cohort studies. Eur J Endocrinol 159:329-341
20. Caraccio N, Ferrannini E, Monzani F 2002 Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab 87:1533-1538
21. Monzani F, Carracio N, Kozàkowà M, Dardano A, Vittone F, Virdis A, Taddei S, Palombo C, Ferrannini E 2004 Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 89:2099-2106
22. Meier C, Staub JJ, Roth CB, Guglielmetti M, Kunz M, Miserez AR, Drewe J, Huber P, Herzog R, Müller B 2001 TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study). J Clin Endocrinol Metab 86:4860-4866
23. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU 2007 The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 92:1715-1723