If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation

Heart Rhythm

Volumn 11, Issue 12, 2014, Pages 2288-2296

  Verrier, Richard L ^a   Bonatti, Rodolfo ^a,b   Silva, Ana F G ^a,b   Batatinha, Julio A P ^a,b   Nearing, Bruce D ^a   Liu, Gongxin ^c   Rajamani, Sridharan ^c   Zeng, Dewan ^c   Belardinelli, Luiz ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c GILEAD SCIENCES   (United States)

Author keywords

Atrial fibrillation; Atrioventricular node; If current; Ivabradine; Ventricular rate

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL I F; IVABRADINE; UNCLASSIFIED DRUG; ZATEBRADINE; BENZAZEPINE DERIVATIVE; CARDIOVASCULAR AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ELECTROCARDIOGRAM; GUINEA PIG; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART CONDUCTION; HEART LEFT VENTRICLE DP-DT; HEART PACING; HEART RATE; HEART VENTRICLE; HIS BUNDLE ELECTROGRAM; ISOLATED HEART; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PR INTERVAL; SINUS RHYTHM; YORKSHIRE PIG; ANALYSIS OF VARIANCE; ANIMAL; ATRIAL FIBRILLATION; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; DRUG PULSE THERAPY; ELECTROCARDIOGRAPHY; FLUOROSCOPY; HEART CATHETERIZATION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONDUCTION SYSTEM; INTRAVENOUS DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PIG; PROCEDURES; RANDOMIZATION; REFERENCE VALUE;

ANALYSIS OF VARIANCE; ANIMALS; ATRIAL FIBRILLATION; ATRIOVENTRICULAR NODE; BENZAZEPINES; CARDIAC CATHETERIZATION; CARDIOVASCULAR AGENTS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FLUOROSCOPY; GUINEA PIGS; HEART CONDUCTION SYSTEM; HEART RATE; INFUSIONS, INTRAVENOUS; MALE; PULSE THERAPY, DRUG; RANDOM ALLOCATION; REFERENCE VALUES; SUS SCROFA; SWINE; VENTRICULAR FUNCTION, LEFT;

EID: 84919402748     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.08.007     Document Type: Article

References (28)

1. A.A. Munk, R.A. Adjemian, J. Zhao, A. Ogbaghebriel, and A. Shrier Electrophysiological properties of morphologically distinct cells isolated from the rabbit atrioventricular node J Physiol 493 1996 801 818
2. W. Shi, R. Wymore, H. Yu, J. Wu, R.T. Wymore, Z. Pan, R.B. Robinson, J.E. Dixon, D. McKinnon, and I.S. Cohen Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues Circ Res 85 1999 e1 e6
3. H. Dobrzynski, V.P. Nikolski, A.T. Sambelashvili, I.D. Greener, M. Yamamoto, M.R. Boyett, and I.R. Efimov Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart Circ Res 93 2003 1102 1110
4. D. Di Francesco The role of the funny current in pacemaker activity Circ Res 106 2010 434 446
5. f inhibitor, in the anesthetized dog heart J Cardiovasc Pharmacol 26 1995 957 964
6. V. Chiamvimonvat, D. Newman, A. Tang, M. Green, J. Mitchell, Z. Wulffhart, and P. Doran A double-blind placebo-controlled evaluation of the human electrophysiologic effects of zatebradine, a sinus node inhibitor J Cardiovasc Pharmacol 32 1998 516 520
7. A.J. Camm, and C.-P. Lau Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology Drugs R & D 4 2003 83 89
8. K. Fox, I. Ford, P.G. Steg, M. Tendera, and R. Ferrari Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial Lancet 372 2008 807 816
9. M. Baruscotti, A. Barbuti, and A. Bucchi The cardiac pacemaker current J Mol Cell Cardiol 48 2010 55 64
10. B.N. Singh, S.J. Connolly, H.J. Crijns, D. Roy, P.R. Kowey, A. Capucci, D. Radzik, E.M. Aliot, and S.H. Hohnloser Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter N Engl J Med 357 2007 987 999
11. S.H. Hohnloser, H.J.G.M. Crijns, M. van Eickels, C. Gaudin, R.L. Page, C. Torp-Pedersen, and S.J. Connolly for the ATHENA Investigators. Effect of dronedarone on cardiovascular events in atrial fibrillation N Engl J Med 360 2009 668 678
12. R.L. Page, S.J. Connolly, H.J. Crijns, M. van Eickels, C. Gaudin, C. Torp-Pedersen, and S.H. Hohnloser for the ATHENA Investigators. Rhythm- and rate-controlling effects of dronedarone in patients with atrial fibrillation (from the ATHENA trial) Am J Cardiol 107 2011 1019 1022
13. J.M. Davy, M. Herold, C. Hoglund, A. Timmermans, A. Alings, D. Radzik, and L. Van Kempen Dronedarone for the control of ventricular rate in permanent atrial fibrillation: the Efficacy and safety of dRonedArone for the cOntrol of ventricular rate during atrial fibrillation (ERATO) study Am Heart J 156 2008 527 529
14. f current J Cardiac Electrophysiol 24 2013 914 918
15. f in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation Heart Rhythm 10 2013 1692 1697
16. 2+ and HCN channels Naunyn Schmiedebergs Arch Pharmacol 383 2011 347 356
17. G.M. DeFerrari, A. Mazzuero, L. Agnesin, A. Bertoletti, M. Lettino, C. Campana, P.J. Schwartz, and L. Tavazzi Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure Eur J Heart Fail 10 2008 550 555
18. f inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction Cardiology 100 2003 149 155
19. K. Kumar, B.D. Nearing, M. Carvas, B.C.G. Nascimento, M. Acar, L. Belardinelli, and R.L. Verrier Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart J Cardiovasc Electrophysiol 20 2009 796 802
20. T.H. Everett, L.C. Kok, R.H. Vaughn, J.R. Moorman, and D.E. Haines Frequency domain algorithm for quantifying atrial fibrillation organization to increase defibrillation efficacy IEEE Trans Biomed Eng 48 2001 969 978
21. J.C. Hancox, A.J. Levi, C.O. Lee, and P. Heap A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and function Am J Physiol 265 1993 H755 H766
22. K.H. Yuill, and J.C. Hancox Characteristics of single cells isolated from the atrioventricular node of the adult guinea-pig heart Pflugers Arch 445 2002 311 320
23. C. Marionneau, B. Couette, J. Liu, H. Li, M.E. Mangoni, J. Nargeot, M. Lei, D. Escande, and S. Demolombe Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart J Physiol 562 2005 223 234
24. J. Liu, P.J. Noble, G. Xiao, M. Abdelrahman, H. Dobrzynski, M.R. Boyett, M. Lei, and D. Noble Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node Prog Biophys Mol Biol 96 2008 294 304
25. X.J. Du, X. Feng, X.M. Gao, T.P. Tan, H. Kiriazis, and A.M. Dart I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities Br J Pharmacol 142 2004 107 112
26. f inhibition with ivabradine: electrophysiological effects and safety Drug Safety 31 2008 95 107
27. Servier. Procorlan: summary of product characteristics. Available at: http://www.servier.com/sites/default/files/Summary%20of%20Product%20Characteristics%20Procoralan%209-2-2012.pdf. Accessed November 4, 2013
28. L.P. Lai, M.J. Su, J.L. Lin, C.H. Tsai, F.Y. Lin, Y.S. Chen, J.-J. Hwang, S.K.S. Huang, Y.-Z. Tseng, and W.-P. Lien Measurement of funny current (I(f)) channel mRNA in human atrial tissue: correlation with left atrial filling pressure and atrial fibrillation J Cardiovasc Electrophysiol 10 1999 947 953