Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure

European Journal of Heart Failure

Volumn 10, Issue 6, 2008, Pages 550-555

  De Ferrari, Gaetano M ^a   Mazzuero, Antonio ^a   Agnesina, Laura ^a   Bertoletti, Alessandra ^a   Lettino, Maddalena ^a   Campana, Carlo ^a   Schwartz, Peter J ^a,b,c   Tavazzi, Luigi ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c ISTITUTO AUXOLOGICO ITALIANO   (Italy)

Author keywords

Haemodynamics; Heart failure; Heart rate; Sinoatrial node

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; IVABRADINE; METOPROLOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG MECHANISM; FEMALE; HEART FAILURE; HEART INDEX; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE TACHYCARDIA; HEMODYNAMICS; HUMAN; HYPERTHERMIA; HYPOKALEMIA; MALE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SINUS BRADYCARDIA; VISUAL DISORDER;

ADULT; BENZAZEPINES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART FAILURE; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PILOT PROJECTS; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 44649184945     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2008.04.005     Document Type: Article

References (26)

1. Opasich C., Rapezzi C., Lucci D., et al. Italian Network on Congestive Heart Failure (IN-CHF) investigators. Precipitating factors and decision-making processes of short-term worsening heart failure despite "optimal" treatment (from the IN-CHF Registry). Am J Cardiol 88 (2001) 382-387
2. Metra M., Torp-Pedersen C., Swedberg K., et al. Influence of heart rate, blood pressure, and beta-blocker dose on outcome and the differences in outcome between carvedilol and metoprolol tartrate in patients with chronic heart failure: results from the COMET trial. Eur Heart J 26 (2005) 2259-2268
3. Lechat P., Hulot J.S., Escolano S., et al. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II trial. Circulation 103 (2001) 1428-1433
4. Nagatsu M., Spinale F.G., Koide M., et al. Bradycardia and the role of beta-blockade in the amelioration of left ventricular dysfunction. Circulation 101 (2000) 653-659
5. Thackray S.D.R., Ghosh J.M., Wright G.A., et al. The effect of altering heart rate on ventricular function in patients with heart failure treated with β-blockers. Am Heart J 152 (2006) 713.e9-713.e13
6. f) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J Physiol 434 (1991) 23-40
7. Simon L., Ghaleh B., Puybasset L., Giudicelli J.F., and Berdeaux A. Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. J Pharmacol Exp Ther 275 (1995) 659-666
8. Mulder P., Barbier S., Chagraoui A., et al. Long-term heart rate reduction induced by the selective If current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation 109 (2004) 1674-1679
9. Dedkov E., Zheng W., Christensen L., Weiss R., Mahlberg-Gaudin F., and Tomanek R.J. Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen. Am J Physiol Heart Circ Physiol 293 (2007) H590-H598
10. f inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) Study. Am Heart J 152 (2006) 860-866
11. f inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction. Cardiology 100 (2003) 149-155
12. Camm A.J., and Lau C.P. Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology. Drugs R&D 4 (2003) 83-89
13. De Ferrari G.M., Vanoli E., and Schwartz P.J. Cardiac vagal activity, myocardial ischemia and sudden death. In: Zipes D., and Jalife J. (Eds). Cardiac electrophysiology. From cell to bedside. II Edition (1995), WB Saunders Co, Philadelphia 422-434
14. De Ferrari G.M., Ajmone-Marsan N., Revera M., et al. Long term vagal stimulation in patients with advanced heart failure. First human experience. Eur Heart J 28 (2007) 143 (Abstract Supplement)
15. f inhibitor, in stable angina. A randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107 (2003) 817-823
16. f inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J 26 (2005) 2529-2536
17. Brown H.F., DiFrancesco D., and Noble S.J. How does adrenaline accelerate the heart?. Nature 280 (1979) 235-236
18. f) by cAMP in the rabbit sino-atrial node. J Physiol 474 (1994) 473-482
19. Moroni A., Barbuti A., Altomare C., et al. Kinetic and ionic properties of the human HCN2 pacemaker channel. Pflugers Arch 439 (2000) 618-626
20. 1-adenosine receptor stimulation. Br J Pharmacol 122 (1997) 963-969
21. Mulieri L.A., Hasenfuss G., Leavitt B., Allen P.D., and Alpert N.R. Altered myocardial force-frequency relation in human heart failure. Circulation 85 (1992) 1743-1750
22. Hasenfuss G., Holubarsch C., Hermann H.P., Astheimer K., Pieske B., and Just H. Influence of the force-frequency relationship on hemodynamics and left ventricular function in patients with non-failing hearts and in patients with dilated cardiomyopathy. Eur Heart J 15 (1994) 164-170
23. Ragueneau I., Laveille C., Jochemsen R., Resplandy G., Funck-Brentano C., and Jaillon P. Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers. Clin Pharmacol Ther 64 (1998) 192-203
24. Demontis G.C., Longoni B., Barcaro U., and Cervetto L. Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods. J Phisiol 515 (1999) 813-828
25. h) in retinal rod photoreceptors. Neuropharmacology 39 (2000) 1284-1291
26. f, in ventricular myocytes from human failing heart. Circulation 95 (1997) 568-571