Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect

Journal of Cardiovascular Electrophysiology

Volumn 24, Issue 8, 2013, Pages 914-918

  Sobrado, Lucas F ^a   Varone, Bruno B ^a,b   Machado, Ananda D ^a,c   Nearing, Bruce D ^a   Zeng, Dewan ^d   Belardinelli, Luiz ^d   Verrier, Richard L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c HARVARD MEDICAL SCHOOL   (United States)

^d GILEAD SCIENCES   (United States)

Author keywords

contractility; dronedarone; heart rate; hemodynamics; If current

Indexed keywords

DILTIAZEM; DRONEDARONE; ISOPRENALINE; IVABRADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD SAMPLING; BRADYCARDIA; CHRONOTROPISM; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG MECHANISM; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE CONTRACTILITY; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; SINUS TACHYCARDIA; SWINE;

CONTRACTILITY; DRONEDARONE; HEART RATE; HEMODYNAMICS; IF CURRENT;

AMIODARONE; ANALYSIS OF VARIANCE; ANIMALS; ARTERIAL PRESSURE; BENZAZEPINES; BLOOD PRESSURE; BRADYCARDIA; DILTIAZEM; ISOPROTERENOL; MYOCARDIAL CONTRACTION; SWINE;

EID: 84880596838     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12155     Document Type: Article

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