메뉴 건너뛰기




Volumn 5, Issue NOV, 2014, Pages

Contribution of defective PS recognition and efferocytosis to chronic inflammation and autoimmunity

Author keywords

Apoptotic cells; Apoptotic versus non apoptotic PS externalization; Autoimmunity; Phosphatidylserine; Scramblases

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMINOPHOSPHOLIPID; BAVITUXIMAB; CASPASE 3; CD14 ANTIGEN; CD36 ANTIGEN; CD68 ANTIGEN; CELL MEMBRANE PROTEIN; CXCL16 CHEMOKINE; FAS LIGAND; INTERLEUKIN 10; KIDNEY INJURY MOLECULE 1; LACTADHERIN; LIPOCORTIN 2; LIPOCORTIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEMBRANE PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; SCAVENGER RECEPTOR F; SCAVENGER RECEPTOR F1; SCRAMBLASE; T CELL MEMBRANE PROTEIN 4; TRANSFORMING GROWTH FACTOR BETA; TRANSMEMBRANE PROTEIN 16F; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; UNINDEXED DRUG; XKR8 PROTEIN;

EID: 84919400992     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00566     Document Type: Article
Times cited : (56)

References (104)
  • 1
    • 0242577378 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells and the resolution of inflammation
    • Maderna P, Godson C. Phagocytosis of apoptotic cells and the resolution of inflammation. Biochim Biophys Acta (2003) 1639:141-51. doi: 10.1016/j.bbadis.2003.09.004
    • (2003) Biochim Biophys Acta , vol.1639 , pp. 141-151
    • Maderna, P.1    Godson, C.2
  • 2
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: clearance of apoptotic cells regulates immune responses
    • Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol (2002) 2:965-75. doi:10.1038/nri957
    • (2002) Nat Rev Immunol , vol.2 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 3
    • 0034641931 scopus 로고    scopus 로고
    • Corpse clearance defines the meaning of cell death
    • Savill J, Fadok V. Corpse clearance defines the meaning of cell death. Nature (2000) 407:784-8. doi:10.1038/35037722
    • (2000) Nature , vol.407 , pp. 784-788
    • Savill, J.1    Fadok, V.2
  • 5
    • 77951971046 scopus 로고    scopus 로고
    • The role of defective clearance of apoptotic cells in systemic autoimmunity
    • Munoz LE, Lauber K, Schiller M, Manfredi AA, Herrmann M. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol (2010) 6:280-9. doi:10.1038/nrrheum.2010.46
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 280-289
    • Munoz, L.E.1    Lauber, K.2    Schiller, M.3    Manfredi, A.A.4    Herrmann, M.5
  • 6
    • 0036164008 scopus 로고    scopus 로고
    • Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus
    • Baumann I, Kolowos W, Voll RE, Manger B, Gaipl U, Neuhuber WL, et al. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum (2002) 46:191-201. doi:10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO;2-K
    • (2002) Arthritis Rheum , vol.46 , pp. 191-201
    • Baumann, I.1    Kolowos, W.2    Voll, R.E.3    Manger, B.4    Gaipl, U.5    Neuhuber, W.L.6
  • 7
    • 79961086472 scopus 로고    scopus 로고
    • Disturbances of apoptotic cell clearance in systemic lupus erythematosus
    • Shao WH, Cohen PL. Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther (2011) 13:202. doi:10.1186/ar3206
    • (2011) Arthritis Res Ther , vol.13 , pp. 202
    • Shao, W.H.1    Cohen, P.L.2
  • 8
    • 0026508561 scopus 로고
    • Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
    • Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol (1992) 148:2207-16.
    • (1992) J Immunol , vol.148 , pp. 2207-2216
    • Fadok, V.A.1    Voelker, D.R.2    Campbell, P.A.3    Cohen, J.J.4    Bratton, D.L.5    Henson, P.M.6
  • 9
    • 0028800947 scopus 로고
    • Early redistribution of plasma-membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus - inhibition by overexpression of Bcl-2 and Abl
    • Martin SJ, Reutelingsperger CPM, Mcgahon AJ, Rader JA, Vanschie RCAA, Laface DM, et al. Early redistribution of plasma-membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus - inhibition by overexpression of Bcl-2 and Abl. J Exp Med (1995) 182:1545-56. doi:10.1084/jem.182.5.1545
    • (1995) J Exp Med , vol.182 , pp. 1545-1556
    • Martin, S.J.1    Reutelingsperger, C.P.M.2    Mcgahon, A.J.3    Rader, J.A.4    Vanschie, Rcaa5    Laface, D.M.6
  • 10
    • 33645845142 scopus 로고    scopus 로고
    • Phosphatidylserine recognition by phagocytes: a view to a kill
    • Wu Y, Tibrewal N, Birge RB. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol (2006) 16:189-97. doi:10.1016/j.tcb.2006.02.003
    • (2006) Trends Cell Biol , vol.16 , pp. 189-197
    • Wu, Y.1    Tibrewal, N.2    Birge, R.B.3
  • 11
    • 84939215881 scopus 로고    scopus 로고
    • Loading of nuclear autoantigens prototypically recognized by SLE sera into late apoptotic vesicles requires intact microtubules and MLCK activity
    • Zirngibl M, Furnrohr BG, Janko C, Munoz LE, Voll RE, Gregory CD, et al. Loading of nuclear autoantigens prototypically recognized by SLE sera into late apoptotic vesicles requires intact microtubules and MLCK activity. Clin Exp Immunol (2014). doi:10.1111/cei.12342
    • (2014) Clin Exp Immunol
    • Zirngibl, M.1    Furnrohr, B.G.2    Janko, C.3    Munoz, L.E.4    Voll, R.E.5    Gregory, C.D.6
  • 14
    • 0037236025 scopus 로고    scopus 로고
    • Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages
    • Bijl M, Horst G, Bijzet J, Bootsma H, Limburg PC, Kallenberg CG. Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages. Arthritis Rheum (2003) 48:248-54. doi:10.1002/art.10737
    • (2003) Arthritis Rheum , vol.48 , pp. 248-254
    • Bijl, M.1    Horst, G.2    Bijzet, J.3    Bootsma, H.4    Limburg, P.C.5    Kallenberg, C.G.6
  • 15
    • 84859064901 scopus 로고    scopus 로고
    • CRP/anti-CRP antibodies assembly on the surfaces of cell remnants switches their phagocytic clearance toward inflammation
    • Janko C, Franz S, Munoz LE, Siebig S, Winkler S, Schett G, et al. CRP/anti-CRP antibodies assembly on the surfaces of cell remnants switches their phagocytic clearance toward inflammation. Front Immunol (2011) 2:70. doi:10.3389/fimmu.2011.00070
    • (2011) Front Immunol , vol.2 , pp. 70
    • Janko, C.1    Franz, S.2    Munoz, L.E.3    Siebig, S.4    Winkler, S.5    Schett, G.6
  • 16
    • 4043075014 scopus 로고    scopus 로고
    • The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages
    • van Rossum AP, Fazzini F, Limburg PC, Manfredi AA, Rovere-Querini P, Mantovani A, et al. The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages. Arthritis Rheum (2004) 50:2667-74. doi:10.1002/art.20370
    • (2004) Arthritis Rheum , vol.50 , pp. 2667-2674
    • van Rossum, A.P.1    Fazzini, F.2    Limburg, P.C.3    Manfredi, A.A.4    Rovere-Querini, P.5    Mantovani, A.6
  • 17
    • 33947386301 scopus 로고    scopus 로고
    • After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes
    • Franz S, Herrmann K, Furnrohr BG, Sheriff A, Frey B, Gaipl US, et al. After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes. Cell Death Differ (2007) 14:733-42. doi:10.1038/sj.cdd.4402066
    • (2007) Cell Death Differ , vol.14 , pp. 733-742
    • Franz, S.1    Herrmann, K.2    Furnrohr, B.G.3    Sheriff, A.4    Frey, B.5    Gaipl, U.S.6
  • 18
    • 0842330365 scopus 로고    scopus 로고
    • Phagocytosis of opsonized apoptotic cells: roles for 'old-fashioned' receptors for antibody and complement
    • Hart SP, Smith JR, Dransfield I. Phagocytosis of opsonized apoptotic cells: roles for 'old-fashioned' receptors for antibody and complement. Clin Exp Immunol (2004) 135:181-5. doi:10.1111/j.1365-2249.2003.02330.x
    • (2004) Clin Exp Immunol , vol.135 , pp. 181-185
    • Hart, S.P.1    Smith, J.R.2    Dransfield, I.3
  • 20
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    • Huynh ML, Fadok VA, Henson PM. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest (2002) 109:41-50. doi:10.1172/JCI200211638
    • (2002) J Clin Invest , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 21
    • 0035126319 scopus 로고    scopus 로고
    • Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
    • Angelillo-Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, et al. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med (2001) 7:215-21. doi:10.1038/84667
    • (2001) Nat Med , vol.7 , pp. 215-221
    • Angelillo-Scherrer, A.1    de Frutos, P.2    Aparicio, C.3    Melis, E.4    Savi, P.5    Lupu, F.6
  • 22
    • 84872136694 scopus 로고    scopus 로고
    • Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus
    • Wu CS, Hu CY, Chan CJ, Chang SK, Hsu PN. Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus. Clin Rheumatol (2012) 31:1443-8. doi:10.1007/s10067-012-2027-z
    • (2012) Clin Rheumatol , vol.31 , pp. 1443-1448
    • Wu, C.S.1    Hu, C.Y.2    Chan, C.J.3    Chang, S.K.4    Hsu, P.N.5
  • 23
    • 70349656483 scopus 로고    scopus 로고
    • Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
    • Burstyn-Cohen T, Heeb MJ, Lemke G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest (2009) 119:2942-53. doi:10.1172/JCI39325
    • (2009) J Clin Invest , vol.119 , pp. 2942-2953
    • Burstyn-Cohen, T.1    Heeb, M.J.2    Lemke, G.3
  • 24
    • 0142124287 scopus 로고    scopus 로고
    • Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance
    • Bertolaccini ML, Sanna G, Ralhan S, Gennari LC, Merrill JT, Khamashta MA, et al. Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance. Thromb Haemost (2003) 90:636-41. doi:10.1160/TH03-03-0151
    • (2003) Thromb Haemost , vol.90 , pp. 636-641
    • Bertolaccini, M.L.1    Sanna, G.2    Ralhan, S.3    Gennari, L.C.4    Merrill, J.T.5    Khamashta, M.A.6
  • 25
    • 0344002703 scopus 로고    scopus 로고
    • Prevalence of anti-protein S antibodies in patients with systemic lupus erythematosus
    • Song KS, Park YS, Kim HK. Prevalence of anti-protein S antibodies in patients with systemic lupus erythematosus. Arthritis Rheum (2000) 43:557-60. doi:10.1002/1529-0131(200003)43:3<557::AID-ANR11>3.0.CO;2-O
    • (2000) Arthritis Rheum , vol.43 , pp. 557-560
    • Song, K.S.1    Park, Y.S.2    Kim, H.K.3
  • 26
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science (2004) 304:1147-50. doi:10.1126/science.1094359
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3    Aozasa, K.4    Koike, M.5    Uchiyama, Y.6
  • 27
    • 67049160855 scopus 로고    scopus 로고
    • Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human
    • Hu CY, Wu CS, Tsai HF, Chang SK, Tsai WI, Hsu PN. Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human. Lupus (2009) 18:676-81. doi:10.1177/0961203309103027
    • (2009) Lupus , vol.18 , pp. 676-681
    • Hu, C.Y.1    Wu, C.S.2    Tsai, H.F.3    Chang, S.K.4    Tsai, W.I.5    Hsu, P.N.6
  • 28
    • 77953312484 scopus 로고    scopus 로고
    • Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus
    • Yamaguchi H, Fujimoto T, Nakamura S, Ohmura K, Mimori T, Matsuda F, et al. Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus. Eur J Immunol (2010) 40:1778-85. doi:10.1002/eji.200940096
    • (2010) Eur J Immunol , vol.40 , pp. 1778-1785
    • Yamaguchi, H.1    Fujimoto, T.2    Nakamura, S.3    Ohmura, K.4    Mimori, T.5    Matsuda, F.6
  • 29
    • 0031778836 scopus 로고    scopus 로고
    • Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    • Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet (1998) 19:56-9. doi:10.1038/ng0598-56
    • (1998) Nat Genet , vol.19 , pp. 56-59
    • Botto, M.1    Dell'Agnola, C.2    Bygrave, A.E.3    Thompson, E.M.4    Cook, H.T.5    Petry, F.6
  • 30
    • 0031697215 scopus 로고    scopus 로고
    • C1q and systemic lupus erythematosus
    • Walport MJ, Davies KA, Botto M. C1q and systemic lupus erythematosus. Immunobiology (1998) 199:265-85. doi:10.1016/S0171-2985(98)80032-6
    • (1998) Immunobiology , vol.199 , pp. 265-285
    • Walport, M.J.1    Davies, K.A.2    Botto, M.3
  • 31
    • 14844363449 scopus 로고    scopus 로고
    • Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    • Stuart LM, Takahashi K, Shi L, Savill J, Ezekowitz RAB. Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol (2005) 174:3220-6. doi:10.4049/jimmunol.174.6.3220
    • (2005) J Immunol , vol.174 , pp. 3220-3226
    • Stuart, L.M.1    Takahashi, K.2    Shi, L.3    Savill, J.4    Ezekowitz, R.A.B.5
  • 33
    • 0031682102 scopus 로고    scopus 로고
    • Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene
    • Ip WK, Chan SY, Lau CS, Lau YL. Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene. Arthritis Rheum (1998) 41:1663-8.
    • (1998) Arthritis Rheum , vol.41 , pp. 1663-1668
    • Ip, W.K.1    Chan, S.Y.2    Lau, C.S.3    Lau, Y.L.4
  • 35
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science (2001) 293:306-11. doi:10.1126/science.1061663
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 36
    • 0036645294 scopus 로고    scopus 로고
    • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    • Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, et al. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med (2002) 196:135-40. doi:10.1084/jem.20012094
    • (2002) J Exp Med , vol.196 , pp. 135-140
    • Cohen, P.L.1    Caricchio, R.2    Abraham, V.3    Camenisch, T.D.4    Jennette, J.C.5    Roubey, R.A.6
  • 37
    • 79951563979 scopus 로고    scopus 로고
    • Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Kilpatrick TJ, Binder MD, Field J. Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility
    • Ma GZ, Stankovich J, Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Kilpatrick TJ, Binder MD, Field J. Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility. PLoS One (2011) 6:e16964. doi:10.1371/journal.pone.0016964
    • (2011) PLoS One , vol.6
    • Ma, G.Z.1    Stankovich, J.2
  • 38
    • 70350731272 scopus 로고    scopus 로고
    • Mechanisms and consequences of efferocytosis in advanced atherosclerosis
    • Thorp E, Tabas I. Mechanisms and consequences of efferocytosis in advanced atherosclerosis. J Leukoc Biol (2009) 86:1089-95. doi:10.1189/jlb.0209115
    • (2009) J Leukoc Biol , vol.86 , pp. 1089-1095
    • Thorp, E.1    Tabas, I.2
  • 39
    • 84891418230 scopus 로고    scopus 로고
    • Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity
    • Zizzo G, Guerrieri J, Dittman LM, Merri JT, Cohen PL. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther (2013) 15:R212. doi:10.1186/ar4407
    • (2013) Arthritis Res Ther , vol.15 , pp. R212
    • Zizzo, G.1    Guerrieri, J.2    Dittman, L.M.3    Merri, J.T.4    Cohen, P.L.5
  • 41
    • 84907376415 scopus 로고    scopus 로고
    • p85alpha recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression
    • Tian L, Choi SC, Murakami Y, Allen J, Morse HC III, Qi CF, et al. p85alpha recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression. Nat Commun (2014) 5:3146. doi:10.1038/ncomms4146
    • (2014) Nat Commun , vol.5 , pp. 3146
    • Tian, L.1    Choi, S.C.2    Murakami, Y.3    Allen, J.4    Morse III, H.C.5    Qi, C.F.6
  • 42
  • 43
    • 79551552424 scopus 로고    scopus 로고
    • Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors
    • Schledzewski K, Geraud C, Arnold B, Wang S, Grone HJ, Kempf T, et al. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest (2011) 121:703-14. doi:10.1172/JCI44740
    • (2011) J Clin Invest , vol.121 , pp. 703-714
    • Schledzewski, K.1    Geraud, C.2    Arnold, B.3    Wang, S.4    Grone, H.J.5    Kempf, T.6
  • 44
    • 79953316593 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
    • He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahasi T, et al. Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells. EMBO Rep (2011) 12:358-64. doi:10.1038/embor.2011.28
    • (2011) EMBO Rep , vol.12 , pp. 358-364
    • He, M.1    Kubo, H.2    Morimoto, K.3    Fujino, N.4    Suzuki, T.5    Takahasi, T.6
  • 45
    • 84863893585 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis
    • Martens HA, Nienhuis HL, Gross S, van der Steege G, Brouwer E, Berden JH, et al. Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis. Lupus (2012) 21:959-68. doi:10.1177/0961203312444495
    • (2012) Lupus , vol.21 , pp. 959-968
    • Martens, H.A.1    Nienhuis, H.L.2    Gross, S.3    van der Steege, G.4    Brouwer, E.5    Berden, J.H.6
  • 46
    • 0026439778 scopus 로고
    • Ldl receptor-related protein internalizes and degrades Upa-Pai-1 complexes and is essential for embryo implantation
    • Herz J, Clouthier DE, Hammer RE. Ldl receptor-related protein internalizes and degrades Upa-Pai-1 complexes and is essential for embryo implantation. Cell (1992) 71:411-21. doi:10.1016/0092-8674(92)90511-A
    • (1992) Cell , vol.71 , pp. 411-421
    • Herz, J.1    Clouthier, D.E.2    Hammer, R.E.3
  • 47
    • 77957866595 scopus 로고    scopus 로고
    • Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages
    • Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol (2010) 88:769-78. doi:10.1189/jlb.0410220
    • (2010) J Leukoc Biol , vol.88 , pp. 769-778
    • Gorovoy, M.1    Gaultier, A.2    Campana, W.M.3    Firestein, G.S.4    Gonias, S.L.5
  • 48
    • 38149064475 scopus 로고    scopus 로고
    • Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up?
    • Bratton DL, Henson PM. Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol (2008) 18:R76-9. doi:10.1016/j.cub.2007.11.024
    • (2008) Curr Biol , vol.18 , pp. R76-R79
    • Bratton, D.L.1    Henson, P.M.2
  • 49
    • 84872027397 scopus 로고    scopus 로고
    • Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion
    • Hochreiter-Hufford A, Ravichandran KS. Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion. Cold Spring Harb Perspect Biol (2013) 5:a008748. doi:10.1101/cshperspect.a008748
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , pp. a008748
    • Hochreiter-Hufford, A.1    Ravichandran, K.S.2
  • 50
    • 84896690342 scopus 로고    scopus 로고
    • Apoptotic cell clearance: basic biology and therapeutic potential
    • Poon IKH, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol (2014) 14:166-80. doi:10.1038/nri3607
    • (2014) Nat Rev Immunol , vol.14 , pp. 166-180
    • Poon, I.K.H.1    Lucas, C.D.2    Rossi, A.G.3    Ravichandran, K.S.4
  • 51
    • 84864373441 scopus 로고    scopus 로고
    • Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice
    • Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, et al. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A (2012) 109:12105-10. doi:10.1073/pnas.1120914109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 12105-12110
    • Xiao, S.1    Brooks, C.R.2    Zhu, C.3    Wu, C.4    Sweere, J.M.5    Petecka, S.6
  • 52
    • 84865559140 scopus 로고    scopus 로고
    • Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity
    • Miyanishi M, Segawa K, Nagata S. Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity. Int Immunol (2012) 24:551-9. doi:10.1093/intimm/dxs064
    • (2012) Int Immunol , vol.24 , pp. 551-559
    • Miyanishi, M.1    Segawa, K.2    Nagata, S.3
  • 53
    • 45249094514 scopus 로고    scopus 로고
    • Phagocytic signaling: you can touch, but you can't eat
    • Kinchen JM, Ravichandran KS. Phagocytic signaling: you can touch, but you can't eat. Curr Biol (2008) 18:R521-4. doi:10.1016/j.cub.2008.04.058
    • (2008) Curr Biol , vol.18 , pp. R521-R524
    • Kinchen, J.M.1    Ravichandran, K.S.2
  • 54
    • 2342584674 scopus 로고    scopus 로고
    • Clearance of apoptotic cells: getting rid of the corpses
    • Lauber K, Blumenthal SG, Waibel M, Wesselborg S. Clearance of apoptotic cells: getting rid of the corpses. Mol Cell (2004) 14:277-87. doi:10.1016/S1097-2765(04)00237-0
    • (2004) Mol Cell , vol.14 , pp. 277-287
    • Lauber, K.1    Blumenthal, S.G.2    Waibel, M.3    Wesselborg, S.4
  • 55
    • 33747410914 scopus 로고    scopus 로고
    • MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin
    • Finnemann SC, Nandrot EF. MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin. Adv Exp Med Biol (2006) 572:499-503. doi:10.1007/0-387-32442-9_69
    • (2006) Adv Exp Med Biol , vol.572 , pp. 499-503
    • Finnemann, S.C.1    Nandrot, E.F.2
  • 56
    • 14644411712 scopus 로고    scopus 로고
    • A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells
    • Wu Y, Singh S, Georgescu MM, Birge RB. A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci (2005) 118:539-53. doi:10.1242/jcs.01632
    • (2005) J Cell Sci , vol.118 , pp. 539-553
    • Wu, Y.1    Singh, S.2    Georgescu, M.M.3    Birge, R.B.4
  • 57
    • 79955100531 scopus 로고    scopus 로고
    • Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
    • Wu J, Ekman C, Jonsen A, Sturfelt G, Bengtsson AA, Gottsater A, et al. Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis. Arthritis Res Ther (2011) 13:R62. doi:10.1186/ar3316
    • (2011) Arthritis Res Ther , vol.13 , pp. R62
    • Wu, J.1    Ekman, C.2    Jonsen, A.3    Sturfelt, G.4    Bengtsson, A.A.5    Gottsater, A.6
  • 58
    • 84897557376 scopus 로고    scopus 로고
    • The expression and clinical significance of different forms of mer receptor tyrosine kinase in systemic lupus erythematosus
    • Zhu H, Sun X, Zhu L, Hu F, Shi L, Li Z, et al. The expression and clinical significance of different forms of mer receptor tyrosine kinase in systemic lupus erythematosus. J Immunol Res (2014). doi:10.1155/2014/431896
    • (2014) J Immunol Res
    • Zhu, H.1    Sun, X.2    Zhu, L.3    Hu, F.4    Shi, L.5    Li, Z.6
  • 59
    • 84897550342 scopus 로고    scopus 로고
    • Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy
    • Hilliard BA, Zizzo G, Ulas M, Linan MK, Schreiter J, Cohen PL. Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy. Arthritis Res Ther (2014) 16:R76. doi:10.1186/ar4517
    • (2014) Arthritis Res Ther , vol.16 , pp. R76
    • Hilliard, B.A.1    Zizzo, G.2    Ulas, M.3    Linan, M.K.4    Schreiter, J.5    Cohen, P.L.6
  • 60
    • 84892565880 scopus 로고    scopus 로고
    • Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients
    • Majai G, Kiss E, Tarr T, Zahuczky G, Hartman Z, Szegedi G, et al. Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients. Lupus (2014) 23:133-45. doi:10.1177/0961203313511557
    • (2014) Lupus , vol.23 , pp. 133-145
    • Majai, G.1    Kiss, E.2    Tarr, T.3    Zahuczky, G.4    Hartman, Z.5    Szegedi, G.6
  • 61
    • 77954554268 scopus 로고    scopus 로고
    • TAM receptor ligands in lupus: protein S but not gas6 levels reflect disease activity in systemic lupus erythematosus
    • Suh CH, Hilliard B, Li S, Merrill JT, Cohen PL. TAM receptor ligands in lupus: protein S but not gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res Ther (2010) 12:R146. doi:10.1186/ar3088
    • (2010) Arthritis Res Ther , vol.12 , pp. R146
    • Suh, C.H.1    Hilliard, B.2    Li, S.3    Merrill, J.T.4    Cohen, P.L.5
  • 62
    • 79952663868 scopus 로고    scopus 로고
    • Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition
    • Paidassi H, Tacnet-Delorme P, Verneret M, Gaboriaud C, Houen G, Duus K, et al. Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition. J Mol Biol (2011) 408:277-90. doi:10.1016/j.jmb.2011.02.029
    • (2011) J Mol Biol , vol.408 , pp. 277-290
    • Paidassi, H.1    Tacnet-Delorme, P.2    Verneret, M.3    Gaboriaud, C.4    Houen, G.5    Duus, K.6
  • 63
    • 84866914816 scopus 로고    scopus 로고
    • Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells
    • Martin M, Leffler J, Blom AM. Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells. J Biol Chem (2012) 287:33733-44. doi:10.1074/jbc.M112.341339
    • (2012) J Biol Chem , vol.287 , pp. 33733-33744
    • Martin, M.1    Leffler, J.2    Blom, A.M.3
  • 64
    • 84909641212 scopus 로고    scopus 로고
    • Characterization of the impairment of the uptake of apoptotic polymorphonuclear cells by monocyte subpopulations in systemic lupus erythematosus
    • Mikolajczyk T, Skiba D, Batko B, Krezelok M, Wilk G, Osmenda G, et al. Characterization of the impairment of the uptake of apoptotic polymorphonuclear cells by monocyte subpopulations in systemic lupus erythematosus. Lupus (2014):1-12. doi:10.1177/0961203314541316
    • (2014) Lupus , pp. 1-12
    • Mikolajczyk, T.1    Skiba, D.2    Batko, B.3    Krezelok, M.4    Wilk, G.5    Osmenda, G.6
  • 65
    • 31144439799 scopus 로고    scopus 로고
    • Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells
    • Tas SW, Quartier P, Botto M, Fossati-Jimack L. Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann Rheum Dis (2006) 65:216-21. doi:10.1136/ard.2005.037143
    • (2006) Ann Rheum Dis , vol.65 , pp. 216-221
    • Tas, S.W.1    Quartier, P.2    Botto, M.3    Fossati-Jimack, L.4
  • 66
    • 33646477412 scopus 로고    scopus 로고
    • Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus
    • Donnelly S, Roake W, Brown S, Young P, Naik H, Wordsworth P, et al. Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis Rheum (2006) 54:1543-56. doi:10.1002/art.21783
    • (2006) Arthritis Rheum , vol.54 , pp. 1543-1556
    • Donnelly, S.1    Roake, W.2    Brown, S.3    Young, P.4    Naik, H.5    Wordsworth, P.6
  • 67
    • 84882281876 scopus 로고    scopus 로고
    • Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids
    • Lauber K, Keppeler H, Munoz LE, Koppe U, Schroder K, Yamaguchi H, et al. Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids. Cell Death Differ (2013) 20:1230-40. doi:10.1038/cdd.2013.82
    • (2013) Cell Death Differ , vol.20 , pp. 1230-1240
    • Lauber, K.1    Keppeler, H.2    Munoz, L.E.3    Koppe, U.4    Schroder, K.5    Yamaguchi, H.6
  • 69
    • 68949145931 scopus 로고    scopus 로고
    • Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    • A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity (2009) 31:245-58. doi:10.1016/j.immuni.2009.06.018
    • (2009) Immunity , vol.31 , pp. 245-258
    • A-Gonzalez, N.1    Bensinger, S.J.2    Hong, C.3    Beceiro, S.4    Bradley, M.N.5    Zelcer, N.6
  • 70
    • 79959588042 scopus 로고    scopus 로고
    • Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosis
    • Zahuczky G, Kristof E, Majai G, Fesus L. Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosis. PLoS One (2011) 6:e21349. doi:10.1371/journal.pone.0021349
    • (2011) PLoS One , vol.6
    • Zahuczky, G.1    Kristof, E.2    Majai, G.3    Fesus, L.4
  • 71
    • 77952944942 scopus 로고    scopus 로고
    • The distribution and function of phosphatidylserine in cellular membranes
    • Leventis PA, Grinstein S. The distribution and function of phosphatidylserine in cellular membranes. Annu Rev Biophys (2010) 39:407-27. doi:10.1146/annurev.biophys.093008.131234
    • (2010) Annu Rev Biophys , vol.39 , pp. 407-427
    • Leventis, P.A.1    Grinstein, S.2
  • 72
    • 0142218366 scopus 로고    scopus 로고
    • Regulation of transbilayer plasma membrane phospholipid asymmetry
    • Daleke DL. Regulation of transbilayer plasma membrane phospholipid asymmetry. J Lipid Res (2003) 44:233-42. doi:10.1194/jlr.R200019-JLR200
    • (2003) J Lipid Res , vol.44 , pp. 233-242
    • Daleke, D.L.1
  • 73
    • 84887246316 scopus 로고    scopus 로고
    • Mechanisms of apoptotic phosphatidylserine exposure
    • Marino G, Kroemer G. Mechanisms of apoptotic phosphatidylserine exposure. Cell Res (2013) 23:1247-8. doi:10.1038/cr.2013.115
    • (2013) Cell Res , vol.23 , pp. 1247-1248
    • Marino, G.1    Kroemer, G.2
  • 74
    • 78650172970 scopus 로고    scopus 로고
    • Calcium-dependent phospholipid scrambling by TMEM16F
    • Suzuki J, Umeda M, Sims PJ, Nagata S. Calcium-dependent phospholipid scrambling by TMEM16F. Nature (2010) 468:834-8. doi:10.1038/nature09583
    • (2010) Nature , vol.468 , pp. 834-838
    • Suzuki, J.1    Umeda, M.2    Sims, P.J.3    Nagata, S.4
  • 75
    • 84871860558 scopus 로고    scopus 로고
    • TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation
    • Yang H, Kim A, David T, Palmer D, Jin T, Tien J, et al. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell (2012) 151:111-22. doi:10.1016/j.cell.2012.07.036
    • (2012) Cell , vol.151 , pp. 111-122
    • Yang, H.1    Kim, A.2    David, T.3    Palmer, D.4    Jin, T.5    Tien, J.6
  • 76
    • 84880758440 scopus 로고    scopus 로고
    • Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells
    • Suzuki J, Denning DP, Imanishi E, Horvitz HR, Nagata S. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science (2013) 341:403-6. doi:10.1126/science.1236758
    • (2013) Science , vol.341 , pp. 403-406
    • Suzuki, J.1    Denning, D.P.2    Imanishi, E.3    Horvitz, H.R.4    Nagata, S.5
  • 77
    • 84877709762 scopus 로고    scopus 로고
    • Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members
    • Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem (2013) 288:13305-16. doi:10.1074/jbc.M113.457937
    • (2013) J Biol Chem , vol.288 , pp. 13305-13316
    • Suzuki, J.1    Fujii, T.2    Imao, T.3    Ishihara, K.4    Kuba, H.5    Nagata, S.6
  • 78
    • 82755163551 scopus 로고    scopus 로고
    • Constitutive exposure of phosphatidylserine on viable cells
    • Segawa K, Suzuki J, Nagata S. Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci U S A (2011) 108:19246-51. doi:10.1073/pnas.1114799108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 19246-19251
    • Segawa, K.1    Suzuki, J.2    Nagata, S.3
  • 79
    • 0033680282 scopus 로고    scopus 로고
    • The ced-8 gene controls the timing of programmed cell deaths in C. elegans
    • Stanfield GM, Horvitz HR. The ced-8 gene controls the timing of programmed cell deaths in C. elegans. Mol Cell (2000) 5:423-33. doi:10.1016/S1097-2765(00)80437-2
    • (2000) Mol Cell , vol.5 , pp. 423-433
    • Stanfield, G.M.1    Horvitz, H.R.2
  • 80
    • 84901849205 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
    • Segawa K, Kurata S, Yanagihashi Y, Brummelkamp TR, Matsuda F, Nagata S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science (2014) 344:1164-8. doi:10.1126/science.1252809
    • (2014) Science , vol.344 , pp. 1164-1168
    • Segawa, K.1    Kurata, S.2    Yanagihashi, Y.3    Brummelkamp, T.R.4    Matsuda, F.5    Nagata, S.6
  • 81
    • 84876014848 scopus 로고    scopus 로고
    • Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation
    • Clark SR, Thomas CP, Hammond VJ, Aldrovandi M, Wilkinson GW, Hart KW, et al. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proc Natl Acad Sci U S A (2013) 110:5875-80. doi:10.1073/pnas.1222419110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 5875-5880
    • Clark, S.R.1    Thomas, C.P.2    Hammond, V.J.3    Aldrovandi, M.4    Wilkinson, G.W.5    Hart, K.W.6
  • 82
    • 84870540393 scopus 로고    scopus 로고
    • Specificity of lipoprotein-associated phospholipase A(2) toward oxidized phosphatidylserines: liquid chromatography-electrospray ionization mass spectrometry characterization of products and computer modeling of interactions
    • Tyurin VA, Yanamala N, Tyurina YY, Klein-Seetharaman J, Macphee CH, Kagan VE. Specificity of lipoprotein-associated phospholipase A(2) toward oxidized phosphatidylserines: liquid chromatography-electrospray ionization mass spectrometry characterization of products and computer modeling of interactions. Biochemistry (2012) 51:9736-50. doi:10.1021/bi301024e
    • (2012) Biochemistry , vol.51 , pp. 9736-9750
    • Tyurin, V.A.1    Yanamala, N.2    Tyurina, Y.Y.3    Klein-Seetharaman, J.4    Macphee, C.H.5    Kagan, V.E.6
  • 83
    • 84907164891 scopus 로고    scopus 로고
    • Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation
    • Tsou WI, Nguyen KQ, Calarese DA, Garforth SJ, Antes AL, Smirnov SV, et al. Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation. J Biol Chem (2014) 289:25750-63. doi:10.1074/jbc.M114.569020
    • (2014) J Biol Chem , vol.289 , pp. 25750-25763
    • Tsou, W.I.1    Nguyen, K.Q.2    Calarese, D.A.3    Garforth, S.J.4    Antes, A.L.5    Smirnov, S.V.6
  • 84
    • 0034795821 scopus 로고    scopus 로고
    • Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences
    • Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest (2001) 108:957-62. doi:10.1172/JCI200114122
    • (2001) J Clin Invest , vol.108 , pp. 957-962
    • Fadok, V.A.1    Bratton, D.L.2    Henson, P.M.3
  • 85
    • 8544226228 scopus 로고    scopus 로고
    • Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine
    • Kagan VE, Borisenko GG, Tyurina YY, Tyurin VA, Jiang J, Potapovich AI, et al. Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic Biol Med (2004) 37:1963-85. doi:10.1016/j.freeradbiomed.2004.08.016
    • (2004) Free Radic Biol Med , vol.37 , pp. 1963-1985
    • Kagan, V.E.1    Borisenko, G.G.2    Tyurina, Y.Y.3    Tyurin, V.A.4    Jiang, J.5    Potapovich, A.I.6
  • 86
    • 0036644558 scopus 로고    scopus 로고
    • A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis
    • Kagan VE, Gleiss B, Tyurina YY, Tyurin VA, Elenström-Magnusson C, Liu S-X, et al. A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol (2002) 169:487-99. doi:10.4049/jimmunol.169.1.487
    • (2002) J Immunol , vol.169 , pp. 487-499
    • Kagan, V.E.1    Gleiss, B.2    Tyurina, Y.Y.3    Tyurin, V.A.4    Elenström-Magnusson, C.5    Liu, S.-X.6
  • 87
    • 0032989435 scopus 로고    scopus 로고
    • Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition
    • Chang MK, Bergmark C, Laurila A, Horkko S, Han KH, Friedman P, et al. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc Natl Acad Sci U S A (1999) 96:6353-8. doi:10.1073/pnas.96.11.6353
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6353-6358
    • Chang, M.K.1    Bergmark, C.2    Laurila, A.3    Horkko, S.4    Han, K.H.5    Friedman, P.6
  • 88
    • 33751519372 scopus 로고    scopus 로고
    • Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells
    • Greenberg ME, Sun M, Zhang R, Febbraio M, Silverstein R, Hazen SL. Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med (2006) 203:2613-25. doi:10.1084/jem.20060370
    • (2006) J Exp Med , vol.203 , pp. 2613-2625
    • Greenberg, M.E.1    Sun, M.2    Zhang, R.3    Febbraio, M.4    Silverstein, R.5    Hazen, S.L.6
  • 89
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig LP, Henson PM. Clearance of apoptotic cells by phagocytes. Cell Death Differ (2008) 15:243-50. doi:10.1038/sj.cdd.4402184
    • (2008) Cell Death Differ , vol.15 , pp. 243-250
    • Erwig, L.P.1    Henson, P.M.2
  • 90
    • 84898053295 scopus 로고    scopus 로고
    • Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2
    • Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Vikulina AS, He RR, et al. Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2. Cell Death Differ (2014) 21:825-35. doi:10.1038/cdd.2014.1
    • (2014) Cell Death Differ , vol.21 , pp. 825-835
    • Tyurin, V.A.1    Balasubramanian, K.2    Winnica, D.3    Tyurina, Y.Y.4    Vikulina, A.S.5    He, R.R.6
  • 92
    • 79251561239 scopus 로고    scopus 로고
    • Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency
    • Roszer T, Menendez-Gutierrez MP, Lefterova MI, Alameda D, Nunez V, Lazar MA, et al. Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. J Immunol (2011) 186:621-31. doi:10.4049/jimmunol.1002230
    • (2011) J Immunol , vol.186 , pp. 621-631
    • Roszer, T.1    Menendez-Gutierrez, M.P.2    Lefterova, M.I.3    Alameda, D.4    Nunez, V.5    Lazar, M.A.6
  • 93
    • 84859701003 scopus 로고    scopus 로고
    • Emerging roles for lysophosphatidylserine in resolution of inflammation
    • Frasch SC, Bratton DL. Emerging roles for lysophosphatidylserine in resolution of inflammation. Prog Lipid Res (2012) 51:199-207. doi:10.1016/j.plipres.2012.03.001
    • (2012) Prog Lipid Res , vol.51 , pp. 199-207
    • Frasch, S.C.1    Bratton, D.L.2
  • 94
    • 84874090688 scopus 로고    scopus 로고
    • Neutrophils regulate tissue neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine
    • Frasch SC, Fernandez-Boyanapalli RF, Berry KAZ, Murphy RC, Leslie CC, Nick JA, et al. Neutrophils regulate tissue neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine. J Biol Chem (2013) 288:4583-93. doi:10.1074/jbc.M112.438507
    • (2013) J Biol Chem , vol.288 , pp. 4583-4593
    • Frasch, S.C.1    Fernandez-Boyanapalli, R.F.2    Berry, K.A.Z.3    Murphy, R.C.4    Leslie, C.C.5    Nick, J.A.6
  • 95
    • 84860492147 scopus 로고    scopus 로고
    • GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position
    • Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, et al. GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. J Biochem (2012) 151:511-8. doi:10.1093/jb/mvs011
    • (2012) J Biochem , vol.151 , pp. 511-518
    • Kitamura, H.1    Makide, K.2    Shuto, A.3    Ikubo, M.4    Inoue, A.5    Suzuki, K.6
  • 96
    • 84875749991 scopus 로고    scopus 로고
    • GPR34 as a lysophosphatidylserine receptor
    • Makide K, Aoki J. GPR34 as a lysophosphatidylserine receptor. J Biochem (2013) 153:327-9. doi:10.1093/jb/mvt010
    • (2013) J Biochem , vol.153 , pp. 327-329
    • Makide, K.1    Aoki, J.2
  • 97
    • 57749122043 scopus 로고    scopus 로고
    • NADPH Oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A
    • Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin H-S, Leslie C, Henson PM, et al. NADPH Oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem (2008) 283:33736-49. doi:10.1074/jbc.M807047200
    • (2008) J Biol Chem , vol.283 , pp. 33736-33749
    • Frasch, S.C.1    Berry, K.Z.2    Fernandez-Boyanapalli, R.3    Jin, H.-S.4    Leslie, C.5    Henson, P.M.6
  • 98
    • 84890933692 scopus 로고    scopus 로고
    • Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation
    • Yin Y, Huang X, Lynn KD, Thorpe PE. Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation. Cancer Immunol Res (2013) 1:256-68. doi:10.1158/2326-6066.CIR-13-0073
    • (2013) Cancer Immunol Res , vol.1 , pp. 256-268
    • Yin, Y.1    Huang, X.2    Lynn, K.D.3    Thorpe, P.E.4
  • 99
    • 80455127305 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors
    • Gerber DE, Stopeck AT, Wong L, Rosen LS, Thorpe PE, Shan JS, et al. Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res (2011) 17:6888-96. doi:10.1158/1078-0432.CCR-11-1074
    • (2011) Clin Cancer Res , vol.17 , pp. 6888-6896
    • Gerber, D.E.1    Stopeck, A.T.2    Wong, L.3    Rosen, L.S.4    Thorpe, P.E.5    Shan, J.S.6
  • 100
    • 8644274867 scopus 로고    scopus 로고
    • Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo
    • Bondanza A, Zimmermann VS, Rovere-Querini P, Turnay J, Dumitriu IE, Stach CM, et al. Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. J Exp Med (2004) 200:1157-65. doi:10.1084/jem.20040327
    • (2004) J Exp Med , vol.200 , pp. 1157-1165
    • Bondanza, A.1    Zimmermann, V.S.2    Rovere-Querini, P.3    Turnay, J.4    Dumitriu, I.E.5    Stach, C.M.6
  • 101
  • 102
    • 84867647748 scopus 로고    scopus 로고
    • The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry
    • Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, et al. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe (2012) 12:544-57. doi:10.1016/j.chom.2012.08.009
    • (2012) Cell Host Microbe , vol.12 , pp. 544-557
    • Meertens, L.1    Carnec, X.2    Lecoin, M.P.3    Ramdasi, R.4    Guivel-Benhassine, F.5    Lew, E.6
  • 103
    • 84880594815 scopus 로고    scopus 로고
    • Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry
    • Moller-Tank S, Kondratowicz AS, Davey RA, Rennert PD, Maury W. Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J Virol (2013) 87:8327-41. doi:10.1128/JVI.01025-13
    • (2013) J Virol , vol.87 , pp. 8327-8341
    • Moller-Tank, S.1    Kondratowicz, A.S.2    Davey, R.A.3    Rennert, P.D.4    Maury, W.5
  • 104
    • 84896955320 scopus 로고    scopus 로고
    • Role of phosphatidylserine receptors in enveloped virus infection
    • Morizono K, Chen IS. Role of phosphatidylserine receptors in enveloped virus infection. J Virol (2014) 88:4275-90. doi:10.1128/JVI.03287-13
    • (2014) J Virol , vol.88 , pp. 4275-4290
    • Morizono, K.1    Chen, I.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.