Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 30, 2012, Pages 12105-12110

  Xiao, Sheng ^a   Brooks, Craig R ^a   Zhu, Chen ^a   Wu, Chuan ^a   Sweere, Johanna M ^a   Petecka, Sonia ^a   Yeste, Ada ^a   Quintana, Francisco J ^a   Ichimura, Takaharu ^a   Sobel, Raymond A ^b,c   Bonventre, Joseph V ^a   Kuchroo, Vijay K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatitis A virus cellular receptor 1; Inflammation; Kidney injury molecule 1

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; DOUBLE STRANDED DNA ANTIBODY; GAMMA INTERFERON; GLYCOPROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 17; MESSENGER RNA; T LYMPHOCYTE IMMUNOGLOBULIN MUCIN 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL TOLERANCE; IMMUNOPHENOTYPING; LYMPHOCYTE FUNCTION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DOMAIN; REGULATORY T LYMPHOCYTE; SYSTEMIC DISEASE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE IMMUNOGLOBULIN MUCIN 1 MUCIN DOMAIN;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES, REGULATORY; BLOTTING, WESTERN; CROSSES, GENETIC; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; INTERFERON-GAMMA; INTERLEUKIN-10; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUCINS; MUTAGENESIS; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

HEPATITIS A VIRUS; MUS;

EID: 84864373441     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120914109     Document Type: Article

References (40)

1. Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJ (2003) The TIM gene family: Emerging roles in immunity and disease. Nat Rev Immunol 3:454-462. (Pubitemid 37339185)
2. Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH (2006) TIM family of genes in immunity and tolerance. Adv Immunol 91:227-249. (Pubitemid 44286997)
3. Kuchroo VK, Dardalhon V, Xiao S, Anderson AC (2008) New roles for TIM family members in immune regulation. Nat Rev Immunol 8:577-580.
4. Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH (2010) TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 235:172-189.
5. RennertPD(2011)Novel roles for TIM-1 in immunity and infection.Immunol Lett 141:28-35.
6. McIntire JJ, Umetsu DT, DeKruyff RH (2004) TIM-1, a novel allergy and asthma susceptibility gene. Springer Semin Immunopathol 25:335-348.
7. Silberstein E, et al. (2003) Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin-and mucin-like regions. J Virol 77:8765-8774. (Pubitemid 36936088)
8. Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol 72:6621-6628. (Pubitemid 28323979)
9. Thompson P, Lu J, Kaplan GG (1998) The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4. J Virol 72:3751-3761. (Pubitemid 28188673)
10. McIntire JJ, et al. (2001) Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2:1109-1116. (Pubitemid 33130144)
11. McIntire JJ, et al. (2003) Immunology: Hepatitis A virus link to atopic disease. Nature 425:576. (Pubitemid 37280135)
12. Umetsu DT, Dekruyff RH (2004) Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment. Ann N Y Acad Sci 1029:88-93. (Pubitemid 40298520)
13. Umetsu DT, Umetsu SE, Freeman GJ, DeKruyff RH (2008) TIM gene family and their role in atopic diseases. Curr Top Microbiol Immunol 321:201-215.
14. Kim HY, et al. (2011) A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest 121:1111-1118.
15. Barlow JL, Wong SH, Ballantyne SJ, Jolin HE, McKenzie AN (2011) Tim1 and Tim3 are not essential for experimental allergic asthma. Clin Exp Allergy 41:1012-1021.
16. Wong SH, Barlow JL, Nabarro S, Fallon PG, McKenzie AN (2010) Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response. Immunology 131:77-88.
17. Yamanishi Y, et al. (2010) TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med 207:1501-1511.
18. Meyers JH, et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 6:455-464. (Pubitemid 41716758)
19. Rodriguez-Manzanet R, et al. (2008) TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol 180:4706-4713.
20. Ichimura T, et al. (2008) Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 118:1657-1668. (Pubitemid 351632370)
21. Kobayashi N, et al. (2007) TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27:927-940. (Pubitemid 50014866)
22. Miyanishi M, et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450:435-439. (Pubitemid 350126753)
23. Santiago C, et al. (2007) Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. Immunity 27:941-951. (Pubitemid 50013979)
24. Umetsu SE, et al. (2005) TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol 6:447-454. (Pubitemid 41716757)
25. Xiao S, et al. (2007) Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 204:1691-1702. (Pubitemid 47048034)
26. Crispín JC, et al. (2008) Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 181:8761-8766.
27. Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC (2010) Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol 184:4605-4609.
28. Rudensky AY (2011) Regulatory T cells and Foxp3. Immunol Rev 241:260-268.
29. Bettelli E, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
30. Bouaziz JD, Yanaba K, Tedder TF (2008) Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 224:201-214.
31. Maynard CL, et al. (2007) Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol 8: 931-941. (Pubitemid 47300007)
32. Ding Q, et al. (2011) Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest 121: 3645-3656.
33. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF (2009) The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182:7459-7472.
34. Cohen PL, Eisenberg RA (1991) Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 9:243-269.
35. Wu HY, Quintana FJ, Weiner HL (2008) Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol 181:6038-6050.
36. Xiao S, et al. (2011) Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells. Eur J Immunol 41:1539-1549.
37. Watanabe R, et al. (2010) Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol 184:4801-4809.
38. Voll RE, et al. (1997) Immunosuppressive effects of apoptotic cells. Nature 390:350-351.
39. Gray M, Miles K, Salter D, Gray D, Savill J (2007) Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc Natl Acad Sci USA 104:14080-14085. (Pubitemid 350003338)
40. Chakravarti S, et al. (2005) Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med 202:437-444. (Pubitemid 41126961)