Protective effect of saponins extract from Panax japonicus on myocardial infarction: Involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation

Journal of Pharmacy and Pharmacology

Volumn 66, Issue 11, 2014, Pages 1641-1651

  Wei, Na ^a   Zhang, Changcheng ^a   He, Haibo ^a   Wang, Ting ^a   Liu, Zhaoqi ^a   Liua, Guangyao ^a   Sun, Zhiwei ^b   Zhou, Zhiyong ^a   Bai, Caihong ^a   Yuan, Ding ^a  

^a CHINA THREE GORGES UNIVERSITY   (China)

^b Hubei Three Gorges Career Technical College   (China)

Author keywords

Mitogen activated protein kinases; Myocardial infarction; Nuclear factor kappa B; Saponins from Panax japonicus; Sirtuin1

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BAX; PROTEIN BCL 2; SAPONIN; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CCL2 PROTEIN, RAT; PLANT EXTRACT; SIRT1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; HEART INFARCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART PROTECTION; HISTOPATHOLOGY; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; HEART; INFLAMMATION; LIGATION; METABOLISM; MYOCARDIAL INFARCTION; PANAX; PATHOLOGY; PATHOPHYSIOLOGY; PHYTOTHERAPY; SPRAGUE DAWLEY RAT;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CHEMOKINE CCL2; HEART; INFLAMMATION; LIGATION; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL INFARCTION; NF-KAPPA B; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; RATS, SPRAGUE-DAWLEY; SAPONINS; SIGNAL TRANSDUCTION; SIRTUIN 1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84919387436     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12291     Document Type: Article

References (47)

1. Roger VL et al. Executive summary: heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012; 125: 188-197.
2. Gordon JW et al. Multiple facets of NF-?B in the heart: to be or not to NF-?B. Circ Res 2011; 108: 1122-1132.
3. Van der Heiden K et al. Role of nuclear factor kappa B in cardiovascular health and disease. Clin Sci (Lond) 2010; 118: 593-605.
4. Ren ZH et al. Tanshinone IIA attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression. Phytomedicine 2010; 17: 212-221.
5. Kobusiak-Prokopowicz M et al. Chemokines and left ventricular function in patients with acute myocardial infarction. Eur J Int Med 2007; 18: 288-294.
6. Kohno T et al. Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in postinfarction ventricular remodeling. Circ J 2008; 72: 1685-1692.
7. Fragoso Lona JM et al. Tumor necrosis factor alfa in cardiovascular diseases: molecular biology and genetics. Gac Med Mex 2013; 149: 521-530.
8. Dawson J et al. Targeting monocyte chemoattractant protein-1 signaling in disease. Expert Opin Ther Targets 2003; 7: 35-48.
9. Gupta SC et al. Inhibiting NF-?B activation by small molecules as a therapeutic strategy. Biochim Biophys Acta 2010; 1799: 775-787.
10. Viatour P et al. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005; 30: 43-52.
11. Ishinaga H et al. TGF-beta induces p65 acetylation to enhance bacteriainduced NF-kappaB activation. EMBO J 2007; 26: 1150-1162.
12. Yang XD et al. Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J 2009; 28: 1055-1066.
13. Ghizzoni M et al. Histone acetyltransferases are crucial regulators in NF-?B mediated inflammation. Drug Discov Today 2011; 16: 504-511.
14. Chen LF et al. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 2002; 21: 6539-6548.
15. Yeung F et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23: 2369-2380.
16. Cui YH. Genetic analysis of the SIRT1 gene promoter in myocardial infarction. Biochem Biophys Res Commun 2012; 426: 232-236.
17. Zhao H et al. Effect of total rhizoma panacis japonica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury. Zhongguo Zhong Yao Za Zhi 2008; 33: 557-559.
18. He HB et al. Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats. J Ethnopharmacol 2012; 140: 73-82.
19. Wei N et al. Saponins from Panax japonicus reduces myocardial infarction induced reactive oxygen species production and cardiomyocyte apoptosis via activation of the Nrf-2 pathway. Adv Mater Res 2014; 2014: 881; 339-346.
20. Yuan D et al. Studies on antiinflammatory action of Saponins extract from Panax japonicus. Hubei J Tradit Chin Med 2008; 4: 7-8.
21. Nian M et al. Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res 2004; 94: 1543-1553.
22. Yao YY et al. Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction. Regul Pept 2007; 140: 12-20.
23. Metra M et al. Acute Heart failure: multiple clinical profiles and mechanisms require tailored therapy. Int J Cardiol 2010; 144: 175-179.
24. Hori M, Nishida K. Oxidative stress and left ventricular remodeling after myocardial infarction. Cardiovasc Res 2009; 81: 457-464.
25. Frangogiannis NG. The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol 2004; 2: 163-174.
26. Koch M et al. Immunosuppression with an interleukin-2 fusion protein leads to improved LV function in experimental ischemic cardiomyopathy. Int Immunopharmacol 2010; 10: 207-212.
27. Lu L et al. Activation of nuclear factorkappaB and its proinflammatory mediator cascade in the infarcted rat heart. Biochem Biophys Res Commun 2004; 321: 879-885.
28. Kawano S et al. Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 2006; 291: H1337-H1344.
29. Timmers L et al. Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction. Circ Res 2009; 104: 699-706.
30. Nadtochiy SM et al. Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res 2011; 89: 643-649.
31. Lee SI et al. Role of SIRT1 in heat stress-and lipopolysaccharideinduced immune and defense gene expression in humandental pulp cells. J Endod 2011; 37: 1525-1530.
32. Kim YS et al. SIRT1 modulates highmobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells. J Cell Biochem 2010; 111: 1310-1320.
33. Salminen A et al. SIRT1 longevity factor suppresses NF-kappaB driven immune responses: regulation of aging via NF-kappaB acetylation? Bioessays 2008; 30: 939-942.
34. Cui Y et al. Genetic analysis of the SIRT1 gene promoter in myocardial Infarction. Biochem Biophys Res Commun 2012; 426: 232-236.
35. Alcendor RR et al. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 2004; 95: 971-980.
36. Alcendor RR et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007; 100: 1512-1521.
37. Howitz KT et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-196.
38. Cowan KJ et al. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 2003; 206: 1107-1115.
39. Cai J et al. Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signaling pathway. J Cell MolMed 2009; 13: 909-925.
40. Pan Z et al. Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGF?1 expression and activation of p38-MAPK and ERK1/2. Br J Pharmacol 2011; 162: 688-700.
41. See F et al. p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat. J Am Coll Cardiol 2004; 44: 1679-1689.
42. Wang X et al. Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9. J Mol Histol 2014; 45: 113-120.
43. Tien YC et al. Carthamus tinctorius L. prevents LPS-induced TNF alpha signaling activation and cell apoptosis through JNK1/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells. J Ethnopharmacol 2010; 130: 505-513.
44. von Harsdorf R. ?Fas-ten' your seat belt: anti-apoptotic treatment in heart failure takes off. Circ Res 2004; 95: 554-556.
45. van Empel VP et al. Myocyte hypertrophy and apoptosis: a balancing act. Cardiovasc Res 2004; 63: 487-499.
46. Misao J et al. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation 1996; 94: 1506-1512.
47. Liu S et al. Mitochondrially targeted Bcl-2 and Bcl-X(L) chimeras elicit different apoptotic responses. Mol Cells 2007; 24: 378-387.