-
1
-
-
0036598644
-
Dealing with the data deluge
-
Lanfear J (2002) Dealing with the data deluge. Nat Rev Drug Discov 1: 479.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 479
-
-
Lanfear, J.1
-
2
-
-
80053448367
-
Linked open drug data for pharmaceutical research and development
-
Samwald M, Jentzsch A, Bouton C, Kallesoe CS, Willighagen E, et al. (2011) Linked open drug data for pharmaceutical research and development. J Cheminform 3: 19-2946-3-19.
-
(2011)
J Cheminform
, vol.3
-
-
Samwald, M.1
Jentzsch, A.2
Bouton, C.3
Kallesoe, C.S.4
Willighagen, E.5
-
3
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, et al. (2009) Predicting new molecular targets for known drugs. Nature 462: 175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
-
4
-
-
36048992504
-
Chemogenomic data analysis: Prediction of small-molecule targets and the advent of biological fingerprint
-
Bender A, Young DW, Jenkins JL, Serrano M, Mikhailov D, et al. (2007) Chemogenomic data analysis: Prediction of small-molecule targets and the advent of biological fingerprint. Comb Chem High Throughput Screen 10: 719-731.
-
(2007)
Comb Chem High Throughput Screen
, vol.10
, pp. 719-731
-
-
Bender, A.1
Young, D.W.2
Jenkins, J.L.3
Serrano, M.4
Mikhailov, D.5
-
5
-
-
84863889195
-
Identifying mechanism-ofaction targets for drugs and probes
-
Gregori-Puigjane E, Setola V, Hert J, Crews BA, Irwin JJ, et al. (2012) Identifying mechanism-ofaction targets for drugs and probes. Proc Natl Acad Sci U S A 109: 11178-11183.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 11178-11183
-
-
Gregori-Puigjane, E.1
Setola, V.2
Hert, J.3
Crews, B.A.4
Irwin, J.J.5
-
6
-
-
84868138829
-
Open PHACTS: Semantic interoperability for drug discovery
-
Williams AJ, Harland L, Groth P, Pettifer S, Chichester C, et al. (2012) Open PHACTS: Semantic interoperability for drug discovery. Drug Discov Today 17: 1188-1198.
-
(2012)
Drug Discov Today
, vol.17
, pp. 1188-1198
-
-
Williams, A.J.1
Harland, L.2
Groth, P.3
Pettifer, S.4
Chichester, C.5
-
7
-
-
84908353448
-
Applying Linked Data Approaches to Pharmacology: Architectural Decisions and Implementation
-
Gray AJ, Groth P, Loizou A, Askjaer S, Brenninkmeijer C, et al. (2014) Applying Linked Data Approaches to Pharmacology: Architectural Decisions and Implementation. Semantic Web Journal 10.3233/SW-2012-0088
-
(2014)
Semantic Web Journal
-
-
Gray, A.J.1
Groth, P.2
Loizou, A.3
Askjaer, S.4
Brenninkmeijer, C.5
-
8
-
-
48249158190
-
Bio2RDF: Towards a mashup to build bioinformatics knowledge systems
-
Belleau F, Nolin MA, Tourigny N, Rigault P, Morissette J (2008) Bio2RDF: Towards a mashup to build bioinformatics knowledge systems. J Biomed Inform 41: 706-716.
-
(2008)
J Biomed Inform
, vol.41
, pp. 706-716
-
-
Belleau, F.1
Nolin, M.A.2
Tourigny, N.3
Rigault, P.4
Morissette, J.5
-
9
-
-
77953907294
-
Chem2Bio2RDF: A semantic framework for linking and data mining chemogenomic and systems chemical biology data
-
Chen B, Dong X, Jiao D, Wang H, Zhu Q, et al. (2010) Chem2Bio2RDF: A semantic framework for linking and data mining chemogenomic and systems chemical biology data. BMC Bioinformatics 11: 255-2105-11-255.
-
(2010)
BMC Bioinformatics
, vol.11
-
-
Chen, B.1
Dong, X.2
Jiao, D.3
Wang, H.4
Zhu, Q.5
-
10
-
-
79957469242
-
Collaborative development of predictive toxicology applications
-
Hardy B, Douglas N, Helma C, Rautenberg M, Jeliazkova N, et al. (2010) Collaborative development of predictive toxicology applications. J Cheminform 2: 7-2946-2-7.
-
(2010)
J Cheminform
, vol.2
-
-
Hardy, B.1
Douglas, N.2
Helma, C.3
Rautenberg, M.4
Jeliazkova, N.5
-
11
-
-
84883246246
-
Scientific competency questions as the basis for semantically enriched open pharmacological space development
-
Azzaoui K, Jacoby E, Senger S, Rodriguez EC, Loza M, et al. (2013) Scientific competency questions as the basis for semantically enriched open pharmacological space development. Drug Discov Today 18: 843-852.
-
(2013)
Drug Discov Today
, vol.18
, pp. 843-852
-
-
Azzaoui, K.1
Jacoby, E.2
Senger, S.3
Rodriguez, E.C.4
Loza, M.5
-
12
-
-
84862203775
-
WikiPathways: Building research communities on biological pathways
-
Kelder T, van Iersel MP, Hanspers K, Kutmon M, Conklin BR, et al. (2012) WikiPathways: Building research communities on biological pathways. Nucleic Acids Res 40: D1301-7.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D1301-D1307
-
-
Kelder, T.1
Van Iersel, M.P.2
Hanspers, K.3
Kutmon, M.4
Conklin, B.R.5
-
13
-
-
84879557098
-
-
Preisach C, Burkhardt H, Schmidt-Thieme L, Decker R, editors.: Springer Berlin Heidelberg
-
Berthold M, Cebron N, Dill F, Gabriel T, Kötter T, et al. (2008) KNIME: The konstanz information miner. In: Preisach C, Burkhardt H, Schmidt-Thieme L, Decker R, editors.: Springer Berlin Heidelberg. pp.319-326.
-
(2008)
KNIME: The Konstanz Information Miner.
, pp. 319-326
-
-
Berthold, M.1
Cebron, N.2
Dill, F.3
Gabriel, T.4
Kötter, T.5
-
14
-
-
33646855259
-
-
Availble: Accessed 2014 Nov 30
-
Accelrys (2010) Pipeline pilot. Availble: http://accelrys.com/products/pipeline-pilot/. Accessed 2014 Nov 30.
-
(2010)
Pipeline Pilot
-
-
-
15
-
-
84862192766
-
ChEMBL: A large-scale bioactivity database for drug discovery
-
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, et al. (2012) ChEMBL: A large-scale bioactivity database for drug discovery. Nucleic Acids Res 40: D1100-7.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D1100-7
-
-
Gaulton, A.1
Bellis, L.J.2
Bento, A.P.3
Chambers, J.4
Davies, M.5
-
16
-
-
84891762026
-
The ChEMBL bioactivity database: An update
-
Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, et al. (2014) The ChEMBL bioactivity database: An update. Nucleic Acids Res 42: D1083-90.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D1083-D1090
-
-
Bento, A.P.1
Gaulton, A.2
Hersey, A.3
Bellis, L.J.4
Chambers, J.5
-
17
-
-
38549127678
-
ChEBI: A database and ontology for chemical entities of biological interest
-
Degtyarenko K, de Matos P, Ennis M, Hastings J, Zbinden M, et al. (2008) ChEBI: A database and ontology for chemical entities of biological interest. Nucleic Acids Res 36: D344-50.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. D344-D350
-
-
Degtyarenko, K.1
De Matos, P.2
Ennis, M.3
Hastings, J.4
Zbinden, M.5
-
18
-
-
75549092202
-
Chemical entities of biological interest: An update
-
de Matos P, Alcantara R, Dekker A, Ennis M, Hastings J, et al. (2010) Chemical entities of biological interest: An update. Nucleic Acids Res 38: D249-54.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. D249-D254
-
-
De Matos, P.1
Alcantara, R.2
Dekker, A.3
Ennis, M.4
Hastings, J.5
-
19
-
-
84876560358
-
The ChEBI reference database and ontology for biologically relevant chemistry: Enhancements for 2013
-
Hastings J, de Matos P, Dekker A, Ennis M, Harsha B, et al. (2013) The ChEBI reference database and ontology for biologically relevant chemistry: Enhancements for 2013. Nucleic Acids Res 41: D456-63.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D456-D463
-
-
Hastings, J.1
De Matos, P.2
Dekker, A.3
Ennis, M.4
Harsha, B.5
-
20
-
-
78651287426
-
DrugBank 3.0: A comprehensive resource for 'omics' research on drugs
-
Knox C, Law V, Jewison T, Liu P, Ly S, et al. (2011) DrugBank 3.0: A comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39: D1035-41.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D1035-D1041
-
-
Knox, C.1
Law, V.2
Jewison, T.3
Liu, P.4
Ly, S.5
-
21
-
-
84869114811
-
ChemSpider - Building a foundation for the semantic web by hosting a crowd sourced databasing platform for chemistry
-
Williams AJ, Tkachenko V, Golotvin S, Kidd R, McCann G (2010) ChemSpider - building a foundation for the semantic web by hosting a crowd sourced databasing platform for chemistry. Journal of Cheminformatics 2: O16-O16. doi: 10.1186/1758-2946-2-s1-o16
-
(2010)
Journal of Cheminformatics
, vol.2
, pp. O16-O16
-
-
Williams, A.J.1
Tkachenko, V.2
Golotvin, S.3
Kidd, R.4
McCann, G.5
-
22
-
-
0034069495
-
Gene ontology: Tool for the unification of biology
-
the gene ontology consortium
-
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: Tool for the unification of biology. the gene ontology consortium. Nat Genet 25: 25-29.
-
(2000)
Nat Genet
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
Ball, C.A.2
Blake, J.A.3
Botstein, D.4
Butler, H.5
-
24
-
-
9144232912
-
UniProt: The universal protein knowledgebase
-
Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, et al. (2004) UniProt: The universal protein knowledgebase. Nucleic Acids Res 32: D115-9.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. D115-D119
-
-
Apweiler, R.1
Bairoch, A.2
Wu, C.H.3
Barker, W.C.4
Boeckmann, B.5
-
25
-
-
0033963089
-
The ENZYME database in 2000
-
Bairoch A (2000) The ENZYME database in 2000. Nucleic Acids Res 28: 304-305.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 304-305
-
-
Bairoch, A.1
-
26
-
-
84885817238
-
Collaboration and the Semantic Web
-
Ekins S, Hupcey MAZ, Williams AJ editors. John Wiley & Sons, Inc. New Jersey
-
Chichester C, Mons B (2011) Collaboration and the Semantic Web. In: Collaborative Computational Technologies for Biomedical Research. Ekins S, Hupcey MAZ, Williams AJ editors. John Wiley & Sons, Inc. New Jersey. pp453-465
-
(2011)
Collaborative Computational Technologies for Biomedical Research
, pp. 453-465
-
-
Chichester, C.1
Mons, B.2
-
27
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schäffer, A.A.3
Zhang, J.4
Zhang, Z.5
-
28
-
-
33847634405
-
The debate over dopamine's role in reward: The case for incentive salience
-
Berridge KC (2007) The debate over dopamine's role in reward: The case for incentive salience. Psychopharmacology (Berl) 191: 391-431.
-
(2007)
Psychopharmacology (Berl)
, vol.191
, pp. 391-431
-
-
Berridge, K.C.1
-
29
-
-
79952032110
-
The physiology, signaling, and pharmacology of dopamine receptors
-
Beaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63: 182-217.
-
(2011)
Pharmacol Rev
, vol.63
, pp. 182-217
-
-
Beaulieu, J.M.1
Gainetdinov, R.R.2
-
30
-
-
0026543545
-
Molecular biology of dopamine receptors
-
Sibley DR, Monsma FJ Jr (1992) Molecular biology of dopamine receptors. Trends Pharmacol Sci 13: 61-69.
-
(1992)
Trends Pharmacol Sci
, vol.13
, pp. 61-69
-
-
Sibley, D.R.1
Monsma, F.J.2
-
32
-
-
77950581269
-
Dopamine D2 receptors as treatment targets in schizophrenia
-
Seeman P (2010) Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses 4: 56-73.
-
(2010)
Clin Schizophr Relat Psychoses
, vol.4
, pp. 56-73
-
-
Seeman, P.1
-
33
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
Hynes NE, Lane HA (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
34
-
-
69449106154
-
MMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts
-
Gondi CS, Dinh DH, Klopfenstein JD, Gujrati M, Rao JS (2009) MMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts. Int J Oncol 35: 257-263.
-
(2009)
Int J Oncol
, vol.35
, pp. 257-263
-
-
Gondi, C.S.1
Dinh, D.H.2
Klopfenstein, J.D.3
Gujrati, M.4
Rao, J.S.5
-
36
-
-
84864367360
-
The ERBB network: At last, cancer therapy meets systems biology
-
Yarden Y, Pines G (2012) The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer 12: 553-563.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 553-563
-
-
Yarden, Y.1
Pines, G.2
-
37
-
-
33750456519
-
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
-
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127: 635-648.
-
(2006)
Cell
, vol.127
, pp. 635-648
-
-
Olsen, J.V.1
Blagoev, B.2
Gnad, F.3
Macek, B.4
Kumar, C.5
-
38
-
-
84881524358
-
The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: An eye on microglia
-
Ridolfi E, Barone C, Scarpini E, Galimberti D (2013) The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia. Clin Dev Immunol 2013: 939786.
-
(2013)
Clin Dev Immunol
, vol.2013
, pp. 939786
-
-
Ridolfi, E.1
Barone, C.2
Scarpini, E.3
Galimberti, D.4
-
39
-
-
34547678667
-
Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders
-
Blach-Olszewska Z, Leszek J (2007) Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders. Neuropsychiatr Dis Treat 3: 365-372.
-
(2007)
Neuropsychiatr Dis Treat
, vol.3
, pp. 365-372
-
-
Blach-Olszewska, Z.1
Leszek, J.2
-
40
-
-
0015042430
-
Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine
-
Holick MF, Schnoes HK, DeLuca HF (1971) Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A 68: 803-804.
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, pp. 803-804
-
-
Holick, M.F.1
Schnoes, H.K.2
DeLuca, H.F.3
-
41
-
-
33846187147
-
Molecular regulation of calcium and bone metabolism through the vitamin D receptor
-
Fleet JC (2006) Molecular regulation of calcium and bone metabolism through the vitamin D receptor. J Musculoskelet Neuronal Interact 6: 336-337.
-
(2006)
J Musculoskelet Neuronal Interact
, vol.6
, pp. 336-337
-
-
Fleet, J.C.1
-
42
-
-
0031892913
-
The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
-
Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, et al. (1998) The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. J Bone Miner Res 13: 325-349.
-
(1998)
J Bone Miner Res
, vol.13
, pp. 325-349
-
-
Haussler, M.R.1
Whitfield, G.K.2
Haussler, C.A.3
Hsieh, J.C.4
Thompson, P.D.5
-
43
-
-
0035204814
-
Vitamin D: Its role and uses in immunology
-
Deluca HF, Cantorna MT (2001) Vitamin D: Its role and uses in immunology. FASEB J 15: 2579-2585.
-
(2001)
FASEB J
, vol.15
, pp. 2579-2585
-
-
Deluca, H.F.1
Cantorna, M.T.2
-
44
-
-
0036220629
-
The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents
-
Mathieu C, Adorini L (2002) The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med 8: 174-179.
-
(2002)
Trends Mol Med
, vol.8
, pp. 174-179
-
-
Mathieu, C.1
Adorini, L.2
-
45
-
-
27544499686
-
Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
-
van Etten E, Mathieu C (2005) Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol 97: 93-101.
-
(2005)
J Steroid Biochem Mol Biol
, vol.97
, pp. 93-101
-
-
Van Etten, E.1
Mathieu, C.2
-
46
-
-
34250880148
-
Vitamin D3 and the immune system: Maintaining the balance in health and disease
-
Baeke F, Etten EV, Overbergh L, Mathieu C (2007) Vitamin D3 and the immune system: Maintaining the balance in health and disease. Nutr Res Rev 20: 106-118.
-
(2007)
Nutr Res Rev
, vol.20
, pp. 106-118
-
-
Baeke, F.1
Etten, E.V.2
Overbergh, L.3
Mathieu, C.4
-
47
-
-
56049110628
-
Vitamin D analogs: Therapeutic applications and mechanisms for selectivity
-
Brown AJ, Slatopolsky E (2008) Vitamin D analogs: Therapeutic applications and mechanisms for selectivity. Mol Aspects Med 29: 433-452.
-
(2008)
Mol Aspects Med
, vol.29
, pp. 433-452
-
-
Brown, A.J.1
Slatopolsky, E.2
-
48
-
-
56049098150
-
Molecular actions of vitamin D contributing to cancer prevention
-
Fleet JC (2008) Molecular actions of vitamin D contributing to cancer prevention. Mol Aspects Med 29: 388-396.
-
(2008)
Mol Aspects Med
, vol.29
, pp. 388-396
-
-
Fleet, J.C.1
-
49
-
-
4043057256
-
Molecular characterization of the microsomal tamoxifen binding site
-
Kedjouar B, de Medina P, Oulad-Abdelghani M, Payre B, Silvente-Poirot S, et al. (2004) Molecular characterization of the microsomal tamoxifen binding site. J Biol Chem 279: 34048-34061.
-
(2004)
J Biol Chem
, vol.279
, pp. 34048-34061
-
-
Kedjouar, B.1
De Medina, P.2
Oulad-Abdelghani, M.3
Payre, B.4
Silvente-Poirot, S.5
-
50
-
-
84861577327
-
25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D
-
Jones G, Prosser DE, Kaufmann M (2012) 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys 523: 9-18.
-
(2012)
Arch Biochem Biophys
, vol.523
, pp. 9-18
-
-
Jones, G.1
Prosser, D.E.2
Kaufmann, M.3
-
51
-
-
3042784114
-
Therapeutic potential of vitamin D-binding protein
-
Gomme PT, Bertolini J (2004) Therapeutic potential of vitamin D-binding protein. Trends Biotechnol 22: 340-345.
-
(2004)
Trends Biotechnol
, vol.22
, pp. 340-345
-
-
Gomme, P.T.1
Bertolini, J.2
-
52
-
-
8544284075
-
Enzymes involved in the activation and inactivation of vitamin D
-
Prosser DE, Jones G (2004) Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 29: 664-673.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 664-673
-
-
Prosser, D.E.1
Jones, G.2
-
54
-
-
66449103103
-
Synthesis of 2alpha-propoxy-1alpha,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1
-
Saito N, Suhara Y, Abe D, Kusudo T, Ohta M, et al. (2009) Synthesis of 2alpha-propoxy-1alpha,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1. Bioorg Med Chem 17: 4296-4301.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 4296-4301
-
-
Saito, N.1
Suhara, Y.2
Abe, D.3
Kusudo, T.4
Ohta, M.5
-
55
-
-
0033539165
-
Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1alpha,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20
-
Zhou X, Zhu GD, Van Haver D, Vandewalle M, De Clercq PJ, et al. (1999) Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1alpha,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20. J Med Chem 42: 3539-3556.
-
(1999)
J Med Chem
, vol.42
, pp. 3539-3556
-
-
Zhou, X.1
Zhu, G.D.2
Van Haver, D.3
Vandewalle, M.4
De Clercq, P.J.5
-
56
-
-
0033133943
-
Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3
-
Boehm MF, Fitzgerald P, Zou A, Elgort MG, Bischoff ED, et al. (1999) Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3. Chem Biol 6: 265-275.
-
(1999)
Chem Biol
, vol.6
, pp. 265-275
-
-
Boehm, M.F.1
Fitzgerald, P.2
Zou, A.3
Elgort, M.G.4
Bischoff, E.D.5
-
57
-
-
2242435340
-
Structure-based design of selective agonists for a rickets-associated mutant of the vitamin d receptor
-
Swann SL, Bergh J, Farach-Carson MC, Ocasio CA, Koh JT (2002) Structure-based design of selective agonists for a rickets-associated mutant of the vitamin d receptor. J Am Chem Soc 124: 13795-13805.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 13795-13805
-
-
Swann, S.L.1
Bergh, J.2
Farach-Carson, M.C.3
Ocasio, C.A.4
Koh, J.T.5
-
58
-
-
23744438917
-
Gene regulatory potential of nonsteroidal vitamin D receptor ligands
-
Perakyla M, Malinen M, Herzig KH, Carlberg C (2005) Gene regulatory potential of nonsteroidal vitamin D receptor ligands. Mol Endocrinol 19: 2060-2073.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 2060-2073
-
-
Perakyla, M.1
Malinen, M.2
Herzig, K.H.3
Carlberg, C.4
-
59
-
-
33645511267
-
Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators
-
Ma Y, Khalifa B, Yee YK, Lu J, Memezawa A, et al. (2006) Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators. J Clin Invest 116: 892-904.
-
(2006)
J Clin Invest
, vol.116
, pp. 892-904
-
-
Ma, Y.1
Khalifa, B.2
Yee, Y.K.3
Lu, J.4
Memezawa, A.5
-
60
-
-
84875269056
-
Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands
-
Asano L, Ito I, Kuwabara N, Waku T, Yanagisawa J, et al. (2013) Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands. FEBS Lett 587: 957-963.
-
(2013)
FEBS Lett
, vol.587
, pp. 957-963
-
-
Asano, L.1
Ito, I.2
Kuwabara, N.3
Waku, T.4
Yanagisawa, J.5
-
61
-
-
34748860260
-
Early lethality in Hyp mice with targeted deletion of Pth gene
-
Bai X, Miao D, Goltzman D, Karaplis AC (2007) Early lethality in Hyp mice with targeted deletion of Pth gene Endocrinology, 148 (10). pp.4974-4983
-
(2007)
Endocrinology
, vol.148
, Issue.10
, pp. 4974-4983
-
-
Bai, X.1
Miao, D.2
Goltzman, D.3
Karaplis, A.C.4
-
62
-
-
0028218006
-
Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived hyp mice: A mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets
-
Roy S, Martel J, Ma S, Tenenhouse HS (1994) Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived hyp mice: A mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets. Endocrinology 134: 1761-1767.
-
(1994)
Endocrinology
, vol.134
, pp. 1761-1767
-
-
Roy, S.1
Martel, J.2
Ma, S.3
Tenenhouse, H.S.4
-
63
-
-
28844507235
-
Expression of VDR and CYP24A1 mRNA in human tumors
-
Anderson MG, Nakane M, Ruan X, Kroeger PE, Wu-Wong JR. (2006) Expression of VDR and CYP24A1 mRNA in human tumors. Cancer Chemother Pharmacol 57: 234-240.
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, pp. 234-240
-
-
Anderson, M.G.1
Nakane, M.2
Ruan, X.3
Kroeger, P.E.4
Wu-Wong, J.R.5
-
64
-
-
69449084716
-
SNAIL2 cooperates with SNAIL1 in the repression of vitamin D receptor in colon cancer
-
Larriba MJ, Martin-Villar E, Garcia JM, Pereira F, Pena C, et al. (2009) SNAIL2 cooperates with SNAIL1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis 30: 1459-1468.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1459-1468
-
-
Larriba, M.J.1
Martin-Villar, E.2
Garcia, J.M.3
Pereira, F.4
Pena, C.5
-
65
-
-
77956297936
-
Novel SNAIL1 target proteins in human colon cancer identified by proteomic analysis
-
Larriba MJ, Casado-Vela J, Pendas-Franco N, Pena R, Garcia de Herreros A, et al. (2010) Novel SNAIL1 target proteins in human colon cancer identified by proteomic analysis. PLoS One 5: e10221.
-
(2010)
PLoS One
, vol.5
, pp. e10221
-
-
Larriba, M.J.1
Casado-Vela, J.2
Pendas-Franco, N.3
Pena, R.4
Garcia De Herreros, A.5
-
66
-
-
4644229397
-
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
-
Palmer HG, Larriba MJ, Garcia JM, Ordonez-Moran P, Pena C, et al. (2004) The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med 10: 917-919.
-
(2004)
Nat Med
, vol.10
, pp. 917-919
-
-
Palmer, H.G.1
Larriba, M.J.2
Garcia, J.M.3
Ordonez-Moran, P.4
Pena, C.5
-
67
-
-
77954760117
-
The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression
-
Larriba MJ, Bonilla F, Munoz A (2010) The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression. J Steroid Biochem Mol Biol 121: 106-109.
-
(2010)
J Steroid Biochem Mol Biol
, vol.121
, pp. 106-109
-
-
Larriba, M.J.1
Bonilla, F.2
Munoz, A.3
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