Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1α,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3539-3556

  Zhou, Xiaoming ^a   Zhu, Gui Dong ^a   Van Haver, Dirk ^a   Vandewalle, Maurits ^a   De Clercq, Pierre J ^a   Verstuyf, Annemieke ^b   Bouillon, Roger ^b  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL DERIVATIVE; CYCLOHEXANONE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CONFORMATIONAL TRANSITION; DERIVATIZATION; DRUG CONFORMATION; DRUG SYNTHESIS; HORMONE BINDING; HYDROPHOBICITY; HYPERCALCEMIA; MOLECULAR MODEL; STEREOCHEMISTRY;

ANIMALS; BINDING, COMPETITIVE; CELL DIFFERENTIATION; CELL DIVISION; HUMANS; KERATINOCYTES; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RECEPTORS, CALCITRIOL; STEREOISOMERISM; SWINE; TUMOR CELLS, CULTURED; VITAMIN D;

EID: 0033539165     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980736v     Document Type: Article

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