Early Identification and Prevention of Early-Onset Bipolar Disorder

Adolescent Psychopathology and the Developing Brain: Integrating Brain and Prevention Science

Volumn , Issue , 2007, Pages

  Chang, Kiki ^a   Gallelli, Kim ^a   Howe, Meghan ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biological markers; Bipolar disorder development; Genetic risk; Kindling Theory

Indexed keywords

EID: 84918929990     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1093/acprof:oso/9780195306255.003.0014     Document Type: Chapter

References (145)

1. Akiskal, H. S. (1996). The prevalent clinical spectrum of bipolar disorders:Beyond DSM-IV. Journal of Clinical Psychopharmacology, 16(2 Suppl. 1), 4S-14S.
2. Akiskal, H. S., Bourgeois, M. L., Angst, J., Post, R., Moller, H., & Hirschfeld, R. (2000). Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. Journal of Affective Disorders, 59 Suppl 1, S5-S30.
3. Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K., et al. (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48(2), 147-162.
4. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
5. Baumer, F., Howe, M., Gallelli, K., Chang, K.D. (2006). A Pilot Study of antidepressant-induced mania in pediatric bipolar disorder: characteristics, risk factors, and the serotonin transporter gene. Biological Psychiatry, 60, 1005-1012.
6. Bellivier, F., Golmard, J. L., Henry, C., Leboyer, M., & Schurhoff, F. (2001). Admixture analysis of age at onset in bipolar I affective disorder. Archives of General Psychiatry, 58(5), 510-512.
7. Biederman, J., Faraone, S., Mick, E., Wozniak, J., Chen, L., Ouellette, C., et al. (1996). Attention-deficit hyperactivity disorder and juvenile mania: An overlooked comorbidity? Journal of the American Academy of Child and Adolescent Psychiatry, 35(8), 997-1008.
8. Blumberg, H. P., Charney, D. S., & Krystal, J. H. (2002). Frontotemporal neural systems in bipolar disorder. Seminars in Clinical Neuropsychiatry, 7(4), 243-254.
9. Blumberg, H. P., Kaufman, J., Martin, A., Whiteman, R., Zhang, J. H., Gore, J. C., et al. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry, 60(12), 1201-1208.
10. Blumberg, H. P., Leung, H. C., Skudlarski, P., Lacadie, C. M., Fredericks, C. A., Harris, B. C., et al. (2003). A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry, 60(6), 601-609.
11. Blumberg, H. P., Martin, A., Kaufman, J., Leung, H. C., Skudlarski, P., Lacadie, C., et al. (2003). Frontostriatal abnormalities in adolescents with bipolar disorder: Preliminary observations from functional MRI. American Journal of Psychiatry, 160(7), 1345-1347.
12. Calabresi, P., Marti, M., Picconi, B., Saulle, E., Costa, C., Centonze, D., et al. (2003). Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: An electrophysiological study. Experimental Neurology, 182(2), 461-469.
13. Cannon, T. D., Huttunen, M. O., Dahlstrom, M., Larmo, I., Rasanen, P., & Juriloo, A. (2002). Antipsychotic drug treatment in the prodromal phase of schizophrenia. American Journal of Psychiatry, 159(7), 1230-1232.
14. Carlson, G. A., & Weintraub, S. (1993). Childhood behavior problems and bipolar disorder-relationship or coincidence? Journal of Affective Disorders, 28(3), 143-153.
15. Carter, T. D., Mundo, E., Parikh, S. V., & Kennedy, J. L. (2003). Early age at onset as a risk factor for poor outcome of bipolar disorder. Journal of Psychiatric Research, 37(4), 297-303.
16. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389.
17. Chang, K., Adleman, N. E., Dienes, K., Simeonova, D. I., Menon, V., & Reiss, A. (2004). Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: A functional magnetic resonance imaging investigation. Archives of General Psychiatry, 61(8), 781-792.
18. Chang, K., Karchemskiy, A., Barnea-Goraly, N., Garrett, A., Simeonova, D. I., & Reiss, A. (2005). Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44(6), 565-573.
19. Chang, K., Barnea-Goraly, N., Karchemskiy, A., Simeonova, D. I., Barnes, P., Ketter, T., Reiss, A.L. (2005). Cortical MRI findings in pediatric familial bipolar disorder. Biological Psychiatry 58, 197-203.
20. Chang, K.D., Saxena, K., Howe, M., Simeonova, D. (2006). Psychotropic medication exposure and age at onset of bipolar disorder in offspring of parents with bipolar disorder. (In review).
21. Chang, K., & Simeonova, D. (2004). Mood stabilizers: Use in pediatric psychopharma-cology. In H. Steiner, K. Chang, J. Lock & J. Wilson (Eds.), Handbook of mental health interventions in children and adolescents: An integrated developmental approach (pp. 363-412). New York: Jossey-Bass.
22. Chang, K., Steiner, H., Dienes, K., Adleman, N., & Ketter, T. (2003). Bipolar offspring: A window into bipolar disorder evolution. Biological Psychiatry, 53(11), 945-951.
23. Chang, K. D. (2000). Attention-deficit hyperactivity disorder. In D. F. Darko (Ed.), Medicine, ob/gyn, psychiatry, and surgery/psychiatry. St. Petersburg, FL: eMedicine.com.
24. Chang, K. D., Blasey, C. M., Ketter, T. A., & Steiner, H. (2003). Temperament characteristics of child and adolescent bipolar offspring. Journal of Affective Disorders, 77(1), 11-19.
25. Chang, K. D., Chang, M., Garrett, A., Adleman, N., & Reiss, A. L. (2003, December 7-11). Brain activation patterns correlating with positive response to divalproex in children at high risk for bipolar disorder. Paper presented at the 42nd Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico.
26. Chang, K. D., Dienes, K., Blasey, C., Adleman, N., Ketter, T., & Steiner, H. (2003). Divalproex monotherapy in the treatment of bipolar offspring with mood and behavioral disorders and at least mild affective symptoms. Journal of Clinical Psychiatry, 64(8), 936-942.
27. Chang, K. D., & Steiner, H. (2003). Offspring studies in child and early adolescent bipolar disorder. In B. Geller & M. DelBello (Eds.), Bipolar disorder in childhood and early adolescence (pp. 107-129). New York: The Guilford Press.
28. Chang, K. D., Steiner, H., & Ketter, T. A. (2000). Psychiatric phenomenology of child and adolescent bipolar offspring. Journal of the American Academy of Child and Adolescent Psychiatry, 39(4), 453-460.
29. Chen, B. K., Sassi, R., Axelson, D., Hatch, J. P., Sanches, M., Nicoletti, M., et al. (2004). Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biological Psychiatry, 56(6), 399-405.
30. Chen, G., Huang, L. D., Jiang, Y. M., & Manji, H. K. (1999). The moodstabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. Journal of Neurochem-istry, 72(3), 1327-1330.
31. Chen, G., Zeng, W. Z., Yuan, P. X., Huang, L. D., Jiang, Y. M., Zhao, Z. H., et al. (1999). The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. Journal of Neurochemistry, 72(2), 879-882.
32. Chen, Y. W., & Dilsaver, S. C. (1996). Lifetime rates of suicide attempts among participants with bipolar and unipolar disorders relative to participants with other Axis I disorders. Biological Psychiatry, 39(10), 896-899.
33. Chengappa, K. N., Kupfer, D. J., Frank, E., Houck, P. R., Grochocinski, V. J., Cluss, P. A., et al. (2003). Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry. American Journal of Psychiatry, 160(9), 1636-1642.
34. Coppell, A. L., Pei, Q., & Zetterstrom, T. S. (2003). Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology, 44(7), 903-910.
35. D'Sa, C., & Duman, R. S. (2002). Antidepressants and neuroplasticity. Bipolar Disorders, 4(3), 183-194.
36. DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004). Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorders, 6(1), 43-52.
37. Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002). Glucose metabolism in the amygdala in depression:Relationship to diagnostic subtype and plasma cortisol levels. Pharmacology Biochemistry and Behavior, 71(3), 431-447.
38. Drevets, W. C., Price, J. L., Simpson, J. R., Jr., Todd, R. D., Reich, T., Vannier, M., et al. (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386(6627), 824-827.
39. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112(2), 257-269.
40. Egeland, J. A., Hostetter, A. M., Pauls, D. L., & Sussex, J. N. (2000). Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission histories. Journal of the American Academy of Child and Adolescent Psychiatry, 39(10), 1245-1252.
41. Egeland, J. A., Shaw, J. A., Endicott, J., Pauls, D. L., Allen, C. R., Hostetter, A. M., et al. (2003). Prospective study of prodromal features for bipolarity in well Amish children. Journal of the American Academy of Child and Adolescent Psychiatry, 42(7), 786-796.
42. Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., et al. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4(11), 1313-1317.
43. Faedda, G. L., Baldessarini, R. J., Glovinsky, I. P., & Austin, N. B. (2004). Treatment-emergent mania in pediatric bipolar disorder: A retrospective case review. Journal of Affective Disorders, 82(1), 149-158.
44. Faraone, S. V., Biederman, J., Mennin, D., Wozniak, J., & Spencer, T. (1997). Attention-deficit hyperactivity disorder with bipolar disorder: A familial subtype? Journal of the American Academy of Child and Adolescent Psychiatry, 36(10), 1378-1387, discussion 1387-1390.
45. Faraone, S. V., Biederman, J., Wozniak, J., Mundy, E., Mennin, D., & O'Donnell, D. (1997). Is comorbidity with ADHD a marker for juvenile-onset mania? Journal of the American Academy of Child and Adolescent Psychiatry, 36(8), 1046-1055.
46. Faraone, S. V., & Tsuang, M. T. (2003). Heterogeneity and the genetics of bipolar disorder. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 123(1), 1-9.
47. Fergus, E. L., Miller, R. B., Luckenbaugh, D. A., Leverich, G. S., Findling, R. L., Speer, A. M., et al. (2003). Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children. Journal of Affective Disorders, 77(1), 71-78.
48. Findling, R. L. (2002). Combination pharmacotherapy inpediatric bipolar disorders. Paper presented at the Scientific Proceedings of the 49th Annual Meeting of the American Academy of Child and Adolescent Psychiatry, San Francisco, CA.
49. Findling, R. L., Gracious, B. L., McNamara, N. K., & Calabrese, J. R. (2000). The rationale, design, and progress of two novel maintenance treatment studies in pediatric bipolarity. Acta Neuropsychiatrica, 12, 136-138.
50. Findling, R. L., Kowatch, R. A., & Post, R. M. (2003). Pediatric bipolar disorder:A handbook for clinicians. London: Martin Dunitz.
51. Frank, E., Swartz, H. A., & Kupfer, D. J. (2000). Interpersonal and social rhythm therapy: Managing the chaos of bipolar disorder. Biological Psychiatry, 48(6), 593-604.
52. Frazier J.A., Chiu S., Breeze, J.L., Makris, N., Lange, N., Kennedy, D.N., Herbert, M.R., Bent, E.K., Koneru, V.K., Dieterich, M.E., Hodge, S.M., Rauch, S.L., Grant, P.E., Cohen, B.M., Seidman, L.J., Caviness, V.S., Biederman, J. (2005). Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry 162(7):1256-1265.
53. Fristad, M. A., Gavazzi, S. M., & Mackinaw-Koons, B. (2003). Family psychoeducation: An adjunctive intervention for children with bipolar disorder. Biological Psychiatry, 53(11), 1000-1008.
54. Gallelli, K., Wagner, C., Karchemskiy, A., Howe, M., Spielman, D., Reiss, A., et al. (2005). N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder. Bipolar Disorders, 7(6), 589-597.
55. Geller, B., Badner, J. A., Tillman, R., Christian, S. L., Bolhofner, K., & Cook, E. H., Jr. (2004). Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. American Journal of Psychiatry, 161(9), 1698-1700.
56. Geller, B., Cooper, T. B., Zimerman, B., Frazier, J., Williams, M., Heath, J., et al. (1998). Lithium for prepubertal depressed children with family history predictors of future bipolarity: A double-blind, placebo-controlled study. Journal of Affective Disorders, 51(2), 165-175.
57. Geller, B., Fox, L. W., & Clark, K. A. (1994). Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children. Journal of the American Academy of Child and Adolescent Psychiatry, 33(4), 461-468.
58. Geller, B., & Luby, J. (1997). Child and adolescent bipolar disorder: A review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry, 36(9), 1168-1176.
59. Geller, B., Zimerman, B., Williams, M., Bolhofner, K., & Craney, J. L. (2001). Adult psychosocial outcome of prepubertal major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 40(6), 673-677.
60. Goethals, I., Audenaert, K., Van de Wiele, C., & Dierckx, R. (2004). The prefrontal cortex: Insights from functional neuroimaging using cognitive activation tasks. European Journal of Nuclear Medicine and Molecular Imagin, 31(3), 408-416.
61. Goggi, J., Pullar, I. A., Carney, S. L., & Bradford, H. F. (2002). Modulation of neurotrans-mitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain Research, 941(1-2), 34-42.
62. Goodwin, F. K., & Jamison, K. R. (1990). Manic-depressive illness. New York:Oxford University Press.
63. Goossens, D., Del-Favero, J., & Van Broeckhoven, C. (2001). Trinucleotide repeat expansions: Do they contribute to bipolar disorder? Brain Research Bulletin, 56(3-4), 243-257.
64. Gould, T. D., Chen, G., & Manji, H. K. (2004). In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology, 29(1), 32-38.
65. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62(2), 146-152.
66. Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., et al. (2003). Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. Journal fo Neuroscience, 23(17), 6690-6694.
67. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297(5580), 400-403.
68. Hariri, A. R., & Weinberger, D. R. (2003). Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes, Brain and Behavior, 2(6), 341-349.
69. Hashimoto, R., Senatorov, V., Kanai, H., Leeds, P., & Chuang, D. M. (2003). Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience, 117(1), 55-61.
70. Hashimoto, R., Takei, N., Shimazu, K., Christ, L., Lu, B., & Chuang, D. M. (2002). Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity. Neurop-harmacology, 43(7), 1173-1179.
71. Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., et al. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8(1), 20-21.
72. Hodgins, S., Faucher, B., Zarax, A., & Ellenbogen, M. (2002). Children of parents with bipolar disorder: A population at high risk for major affective disorders. Child and Adolescent Psychiatric Clinics of North America, 11(3), 533-53, ix.
73. Honig, A., Hofman, A., Rozendaal, N., & Dingemans, P. (1997). Psycho-education in bipolar disorder: Effect on expressed emotion. Psychiatry Research, 72(1), 17-22.
74. Howe, M. G., Yee, J., Baumer, F., Simeonova, D., Hallmayer, J., & Chang, K. D. (2004, October). Age at onset in familial bipolar disorder. Poster session presented at the 51st Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Washington, DC.
75. Inglefield, J. R., Perry, J. M., & Schwartz, R. D. (1995). Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus. Hippocampus, 5(5), 460-468.
76. Jin, N., Kovacs, A. D., Sui, Z., Dewhurst, S., & Maggirwar, S. B. (2005). Opposite effects of lithium and valproic acid on trophic factor deprivationinduced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death. Neuropharma-cology, 48(4), 576-583.
77. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., et al. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17316-17321.
78. Keller, M. B. (2004). Improving the course of illness and promoting continuation of treatment of bipolar disorder. Journal of Clinical Psychiatry, 65 Suppl 15, 10-14.
79. Kleinman, L., Lowin, A., Flood, E., Gandhi, G., Edgell, E., & Revicki, D. (2003). Costs of bipolar disorder. Pharmacoeconomics, 21(9), 601-622.
80. Kowatch, R. A., Fristad, M., Birmaher, B., Wagner, K. D., Findling, R. L., & Hellander, M. (2005). Treatment guidelines for children and adolescents with bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44(3), 213-235.
81. Kraeplin, E. (1921). Manic-depressive insanity and paranoia. Edinburgh: ES Livingstone.
82. Kudin, A. P., Debska-Vielhaber, G., Vielhaber, S., Elger, C. E., & Kunz, W. S. (2004). The mechanism of neuroprotection by topiramate in an animal model of epilepsy. Epilepsia, 45(12), 1478-1487.
83. Laeng, P., Pitts, R. L., Lemire, A. L., Drabik, C. E., Weiner, A., Tang, H., et al. (2004). The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. Journal of Neurochemistry, 91(1), 238-251.
84. Lam, D. H., Hayward, P., Watkins, E. R., Wright, K., & Sham, P. (2005). Relapse prevention in patients with bipolar disorder: Cognitive therapy outcome after 2 years. American Journal of Psychiatry, 162(2), 324-329.
85. Lapalme, M., Hodgins, S., & LaRoche, C. (1997). Children of parents with bipolar disorder: A meta-analysis of risk for mental disorders. Canadian Journal of Psychiatry, 42(6), 623-631.
86. Lasky-Su, J. A., Faraone, S. V., Glatt, S. J., & Tsuang, M. T. (2004). Metaanalysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 133B(1), 110-115.
87. Leker, R. R., & Neufeld, M. Y. (2003). Anti-epileptic drugs as possible neuroprotectants in cerebral ischemia. Brain Research: Brain Research Reviews, 42(3), 187-203.
88. Lim, K. O., Rosenbloom, M. J., Faustman, W. O., Sullivan, E. V., & Pfefferbaum, A. (1999). Cortical gray matter deficit in patients with bipolar disorder. Schizophrenia Research, 40(3), 219-227.
89. Lish, J. D., Dime-Meenan, S., Whybrow, P. C., Price, R. A., & Hirschfeld, R. M. (1994). The National Depressive and Manic-depressive Association (DMDA) survey of bipolar members. Journal of Affective Disorders, 31(4), 281-294.
90. Lopez-Larson, M. P., DelBello, M. P., Zimmerman, M. E., Schwiers, M. L., & Strakowski, S. M. (2002). Regional prefrontal gray and white matter abnormalities in bipolar disorder. Biological Psychiatry, 52(2), 93-100.
91. Loscher, W., Fisher, J. E., Nau, H., & Honack, D. (1989). Valproic acid in amygdala-kindled rats: Alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment. The Journal of Pharmacology and Experimental Therapeutics, 250(3), 1067-1078.
92. Mamounas, L. A., Altar, C. A., Blue, M. E., Kaplan, D. R., Tessarollo, L., & Lyons, W. E. (2000). BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. Journal of Neuroscience, 20(2), 771-782.
93. Manji, H. K., & Lenox, R. H. (1994). Long-term action of lithium: A role for transcrip-tional and posttranscriptional factors regulated by protein kinase C. Synapse, 16(1), 11-28.
94. Manji, H. K., & Lenox, R. H. (1999). Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: Molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biological Psychiatry, 46(10), 1328-1351.
95. Manji, H. K., Moore, G. J., & Chen, G. (2000a). Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: Implications for the pathophysiology and treatment of manic-depressive illness. Biological Psychiatry, 48(8), 740-754.
96. Manji, H. K., Moore, G. J., & Chen, G. (2000b). Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: A role for neurotrophic and neuroprotective effects in manic depressive illness. Journal of Clinical Psychiatry, 61 Suppl 9, 82-96.
97. Martenyi, F., Brown, E. B., Zhang, H., Prakash, A., & Koke, S. C. (2002, March). Fluoxetine versus placebo in posttraumatic stress disorder. Journal of Clinical Psychiatry, 63(3), 199-206.
98. Mayberg, H. S. (1997). Limbic-cortical dysregulation: A proposed model of depression. Journal of Neuropsychiatry and Clinical Neurosciences, 9(3), 471-481.
99. McInnis, M. G., McMahon, F. J., Chase, G. A., Simpson, S. G., Ross, C. A., & DePaulo, J. R., Jr. (1993). Anticipation in bipolar affective disorder [see comments]. American Journal of Human Genetics, 53(2), 385-390.
100. Miklowitz, D. J., George, E. L., Axelson, D. A., Kim, E. Y., Birmaher, B., Schneck, C., et al. (2004). Family-focused treatment for adolescents with bipolar disorder. Journal of Affective Disorders, 82 Suppl 1, S113-128.
101. Miklowitz, D. J., & Hooley, J. M. (1998). Developing family psychoeducational treatments for patients with bipolar and other severe psychiatric disorders. A pathway from basic research to clinical trials. Journal of Marital and Family Therapy, 24(4), 419-435.
102. Miklowitz, D. J., Simoneau, T. L., George, E. L., Richards, J. A., Kalbag, A., Sachs-Ericsson, N., et al. (2000). Family-focused treatment of bipolar disorder: 1-year effects of a psychoeducational program in conjunction with pharmacotherapy. Biological Psychiatry, 48(6), 582-592.
103. Moore, G. J., Bebchuk, J. M., Hasanat, K., Chen, G., Seraji-Bozorgzad, N., Wilds, I. B., et al. (2000). Lithium increases N-acetyl-aspartate in the human brain: In vivo evidence in support of bcl-2's neurotrophic effects? Biological Psychiatry, 48(1), 1-8.
104. Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., & Manji, H. K. (2000). Lithium-induced increase in human brain grey matter. Lancet, 356(9237), 1241-1242.
105. Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., Manji, H. K., & Menji, H. K. (2000). Lithium-induced increase in human brain grey matter. Lancet, 356(9237), 1241-1242.
106. Nakata, K., Ujike, H., Sakai, A., Uchida, N., Nomura, A., Imamura, T., et al. (2003). Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neuroscience Letters, 337(1), 17-20.
107. Neves-Pereira, M., Mundo, E., Muglia, P., King, N., Macciardi, F., & Kennedy, J. L. (2002). The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study. American Journal of Human Genetics, 71(3), 651-655.
108. Nibuya, M., Nestler, E. J., & Duman, R. S. (1996). Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Journal of Neuroscience, 16(7), 2365-2372.
109. Ongur, D., Drevets, W. C., & Price, J. L. (1998). Glial reduction in the subgenual pre-frontal cortex in mood disorders. Proceedings of the National Academy of Sciences of the United States of America, 95(22), 13290-13295.
110. Otto, M. W., Reilly-Harrington, N., & Sachs, G. S. (2003). Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder. Journal of Affective Disorders, 73(1-2), 171-181.
111. Pavuluri, M. N., Graczyk, P. A., Henry, D. B., Carbray, J. A., Heidenreich, J., & Miklowitz, D. J. (2004). Child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: Development and preliminary results. Journal of the American Academy of Child and Adolescent Psychiatry, 43(5), 528-537.
112. Pearlson, G. D., Barta, P. E., Powers, R. E., Menon, R. R., Richards, S. S., Aylward, E. H., et al. (1997). Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry, 41(1), 1-14.
113. Perlis, R. H., Miyahara, S., Marangell, L. B., Wisniewski, S. R., Ostacher, M., DelBello, M. P., et al. (2004). Long-Term implications of early onset in bipolar disorder: Data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological Psychiatry, 55(9), 875-881.
114. Perry, A., Tarrier, N., Morriss, R., McCarthy, E., & Limb, K. (1999). Randomised controlled trial of efficacy of teaching patients with bipolar disorder to identify early symptoms of relapse and obtain treatment. British Medical Journal, 318(7177), 149-153.
115. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8(6), 828-834.
116. Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., et al. (2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. Journal of Neuroscience, 24(45), 10099-10102.
117. Poo, M. M. (2001). Neurotrophins as synaptic modulators. Nature Reviews Neuroscience, 2(1), 24-32.
118. Post, R. M. (1992). Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. American Journal of Psychiatry, 149(8), 999-1010.
119. Post, R. M. (2002). Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms? Epilepsy Research, 50(1-2), 203-219.
120. Post, R. M., Leverich, G. S., Xing, G., & Weiss, R. B. (2001). Developmental vulnerabilities to the onset and course of bipolar disorder. Development and Psychopathol-ogy, 13(3), 581-598.
121. Post, R. M., & Weiss, S. R. (1996). A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures. Molecular Neurobiology, 13(1), 33-60.
122. Rajkowska, G., Halaris, A., & Selemon, L. D. (2001). Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biological Psychiatry, 49(9), 741-752.
123. Ramnani, N., & Owen, A. M. (2004). Anterior prefrontal cortex:Insights into function from anatomy and neuroimaging. Nature Reviews Neuroscience, 5(3), 184-194.
124. Rana, M., Khanzode, L., Karnik, N., Saxena, K., Chang, K., & Steiner, H. (2005). Dival-proex sodium in the treatment of pediatric psychiatric disorders. Expert Review of Neurotherapeutics, 5(2), 165-176.
125. Reichart, C. G., & Nolen, W. A. (2004). Earlier onset of bipolar disorder in children by antidepressants or stimulants? An hypothesis. Journal of Affective Disorders, 78(1), 81-84.
126. Roy-Byrne, P., Post, R. M., Uhde, T. W., Porcu, T., & Davis, D. (1985). The longitudinal course of recurrent affective illness: Life chart data from research patients at the NIMH. ACTA Psychiatrica Scandinavica. Supplementum, 317, 1-34.
127. Sachs, G. S., Baldassano, C. F., Truman, C. J., & Guille, C. (2000). Comorbidity of attention deficit hyperactivity disorder with early- and late-onset bipolar disorder. American Journal of Psychiatry, 157(3), 466-468.
128. Shuaib, A., Mahmood, R. H., Wishart, T., Kanthan, R., Murabit, M. A., Ijaz, S., et al. (1995). Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histo-logical, in vivo microdialysis and behavioral study. Brain Research, 702(1-2), 199-206.
129. Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002). Can't shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry, 51(9), 693-707.
130. Sklar, P., Gabriel, S. B., McInnis, M. G., Bennett, P., Lim, Y. M., Tsan, G., et al. (2002). Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Molecular Psychiatry, 7(6), 579-593.
131. Smith, G. S., Lotrich, F. E., Malhotra, A. K., Lee, A. T., Ma, Y., Kramer, E., et al. (2004). Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology, 29(12), 2226-2234.
132. Smoller, J. W., & Finn, C. T. (2003). Family, twin, and adoption studies of bipolar disorder. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 123(1), 48-58.
133. Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N., & DelBello, M. P. (2004). A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology, 29(9), 1734-1740.
134. Strakowski, S. M., DelBello, M. P., Adler, C., Cecil, D. M., & Sax, K. W. (2000). Neuroimaging in bipolar disorder. Bipolar Disorders, 2(3 Pt. 1), 148-164.
135. Strakowski, S. M., DelBello, M. P., Sax, K. W., Zimmerman, M. E., Shear, P. K., Hawkins, J. M., et al. (1999). Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry, 56(3), 254-260.
136. Stratton, S. C., Large, C. H., Cox, B., Davies, G., & Hagan, R. M. (2003). Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model. Epilepsy Research, 53(1-2), 95-106.
137. Swayze, V. W., II, Andreasen, N. C., Alliger, R. J., Yuh, W. T., & Ehrhardt, J. C. (1992). Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biological Psychiatry, 31(3), 221-240.
138. Tsuang, M. T., Stone, W. S., & Faraone, S. V. (2002). Understanding predisposition to schizophrenia: Toward intervention and prevention. Canadian Journal of Psychiatry, 47(6), 518-526.
139. Vieta, E., & Colom, F. (2004). Psychological interventions in bipolar disorder: From wishful thinking to an evidence-based approach. ACTA Psychiatrica Scandinavica. Supplementum. (422), 34-38.
140. Wals, M., Hillegers, M. H., Reichart, C. G., Ormel, J., Nolen, W. A., & Verhulst, F. C. (2001). Prevalence of psychopathology in children of a bipolar parent. Journal of the American Academy of Child and Adolescent Psychiatry, 40(9), 1094-1102.
141. Wei, Z., Bai, O., Richardson, J. S., Mousseau, D. D., & Li, X. M. (2003). Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. Journal of Neuroscience Research, 73(3), 364-368.
142. Wozniak, J., Biederman, J., Kiely, K., Ablon, J. S., Faraone, S. V., Mundy, E., et al. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. Journal of the American Academy of Child and Adolescent Psychiatry, 34(7), 867-876.
143. Yang, Y., Li, Q., Wang, C. X., Jeerakathil, T., & Shuaib, A. (2000). Dosedependent neuroprotection with tiagabine in a focal cerebral ischemia model in rat. Neuroreport, 11(10), 2307-2311.
144. Yang, Y., Shuaib, A., Li, Q., & Siddiqui, M. M. (1998). Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization. Brain Research, 804(2), 169-176.
145. Yurgelun-Todd, D. A., Gruber, S. A., Kanayama, G., Killgore, W. D., Baird, A. A., & Young, A. D. (2000). fMRI during affect discrimination in bipolar affective disorder. Bipolar Disorders, 2(3 t. 2), 237-248.