A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices

Archives of General Psychiatry

Volumn 60, Issue 6, 2003, Pages 601-609

  Blumberg, Hilary P ^a,b   Leung, Hoi Chung ^a,b,c   Skudlarski, Pawel ^a   Lacadie, Cheryl M ^a   Fredericks, Carolyn A ^a   Harris, Brent C ^a   Charney, Dennis S ^d   Gore, John C ^e   Krystal, John H ^a,b   Peterson, Bradley S ^f  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f New York State Psychiatric Institute ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ATTENTION; BIPOLAR DISORDER; BRAIN DYSFUNCTION; BRAIN REGION; CINGULATE GYRUS; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; EVENT RELATED POTENTIAL; FEMALE; FUNCTIONAL DISEASE; HANDEDNESS; HEMISPHERIC DOMINANCE; HUMAN; HUMAN EXPERIMENT; IMPULSE CONTROL DISORDER; MALE; MOOD; MOOD DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; RISK FACTOR; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SUPERIOR COLLICULUS; TASK PERFORMANCE;

ADULT; BIPOLAR DISORDER; COGNITION; COLOR PERCEPTION; DEPRESSIVE DISORDER; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; PSYCHIATRIC STATUS RATING SCALES; REACTION TIME; TASK PERFORMANCE AND ANALYSIS; VERBAL BEHAVIOR;

EID: 0038314494     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.60.6.601     Document Type: Article

References (76)

1. Blumer D, Benson DF, eds. Psychiatric Aspects of Neurologic Disease. New York, NY: Grune & Stratton Inc; 1975.
2. Rolls E. The orbitofrontal cortex. Philos Trans R Soc Lond B Biol Sci. 1996;351:1433-1444.
3. Devinsky O, Morrell MJ, Vogt BA. Contributions of the anterior cingulate cortex to behaviour. Brain. 1995;118:279-306.
4. Bechara A, Damasio H, Tranel D, Damasio AR. Deciding advantageously before knowing the advantageous strategy. Science. 1997;275:1293-1295.
5. Davidson RJ. Anterior cerebral asymmetry and the nature of emotion. Brain Cogn. 1992;20:125-151.
6. Sackeim HA, Greenberg MS, Weiman AL, Gur RC, Hungerbuhler JP, Geschwind N. Hemispheric asymmetry in the expression of positive and negative emotions: neurologic evidence. Arch Neurol. 1982;39:210-218.
7. Starkstein SE, Robinson RG. Mechanism of disinhibition after brain lesion. J Nerv Ment Dis. 1997;185:108-114.
8. Baxter LR, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Gerner RH, Sumida RM. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243-250.
9. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RSJ, Dolan RJ. The anatomy of melancholia: focal abnormalities of cerebral blood flow in major depression. Psychol Med. 1992;22:607-615.
10. Cohen RM, Gross M, Nordahl TE, Semple WE, Oren DA. Rosenthal N. Preliminary data on metabolic brain patterns of patients with winter seasonal affective disorder. Arch Gen Psychiatry. 1992;49:545-552.
11. Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Medlewicz J, Lotstra F. Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry. 1994;36:381-388.
12. Drevets WC. Prefrontal-amygdalar metabolism in major depression. Ann N Y Acad Sci. 1999;877:614-637.
13. Blumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, Epstein J, Isenberg N, McBride PA, Kemperman I, Emmerich S, Dhawan V, Eidelberg D, Kocsis H, Silbersweig DA. Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. Am J Psychiatry. 1999;156:1986-1988.
14. Blumberg HP, Stern E, Martinez D, Ricketts S, De Asis J, White T, Epstein J, McBride PA, Eidelberg D, Kocsis JH, Silbersweig DA. Increased anterior cingulate and caudate activity in bipolar mania. Biol Psychiatry. 2000;48:1045-1052.
15. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997; 386:824-827.
16. Rubin E, Sackeim HA, Prohovnik I, Moeller JR, Schnur DB, Mukherlee S. Regional cerebral blood flow in mood disorders, IV: comparison of mania and depression. Psychiatry Res. 1995;61:1-10.
17. Buchsbaum MS, Wu J, Siegel BV, Hackett E, Trenary M, Abel L, Reynolds C. Effect of sertraline on regional metabolic rate in patients with affective disorder. Biol Psychiatry. 1997;41:15-22.
18. Mayberg HS, Brannan SK, Mahurin RK, Jerabek PA, Brickman JS, Tekell JL, Silva JA, McGinnis S, Glass TG, Martin CC, Fox PT. Cingulate function in depression: a potential predictor of treatment response. Neuroreport. 1997;8:1057-1061.
19. Wu J, Buchsbaum MS, Gillin JC, Tang C, Cadwell S, Wiegand M, Najafi A, Klein E, Hazen K, Bunney WE Jr, Fallon JH, Keator D. Prediction of antidepressant effects of sleep deprivation by metabolic rates in ventral anterior cingulate and medial prefrontal cortex. Am J Psychiatry. 1999;156:1149-1158.
20. Brody AL, Saxena S, Stoessel P, Gillie LA, Fairbanks LA, Alborzian S, Phelps ME, Huang S-C, Wu H-M, Ho ML, Ho MK, Au SC, Maidment K, Baxter LR Jr. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Arch Gen Psychiatry. 2001;58:631-640.
21. Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, Dolan RJ, Sahakian BJ. Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychol Med. 1997; 27:931-942.
22. De Asis JM, Stern E, Alexopoulos GS, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig DA. Hippocampal and anterior cingulate activation deficits in patients with geriatric depression. Am J Psychiatry. 2001;158:1321-1323.
23. George MS, Ketter TA, Parekh PI, Rosinsky N, Ring HA, Pazzaglia PJ, Marangell LB, Callahan AM, Post RM. Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). J Neuropsychiatry Clin Neurosci. 1997;9:55-63.
24. 15O PET). Neuropsychiatry Neuropsychol Behav Neurol 1994;7:143-153.
25. Berman KF, Doran AR, Pickar D, Weinberger DR. Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? regional cerebral blood flow during cognitive activation. Br J Psychiatry. 1993;162:183-192.
26. Rubinsztein JS, Fletcher PC, Rogers RD, Ho LW, Aigbirhio FI, Paykel ES, Robbins TW, Sahakian BJ. Decision-making in mania: a PET study. Brain. 2001;124:2550-2563.
27. Ongur D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A. 1998;95:13290-13295.
28. Benes FM, Vincent SL, Todtenkopf M. The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry. 2001;50:395-406.
29. Wolfe J, Granholm E, Butters N, Saunders E, Janowsky D. Verbal memory deficits associated with major affective disorders: a comparison of unipolar and bipolar patients. J Affect Dis. 1987;13:83-92.
30. McGrath J, Scheldt S, Welham J, Clair A. Performance on tests sensitive to impaired executive ability in schizophrenia, mania and well controls: acute and subacute phases. Schizophr Res. 1997;26:127-37.
31. van Gorp WG, Altshuler L, Theberge DC, Wilkins J, Dixon W. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence: a preliminary study. Arch Gen Psychiatry. 1998;55:41-46.
32. Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES. Emotional bias and inhibitory control processes in mania and depression. Psychol Med. 1999;29:1307-1321.
33. Sax KW, Strakowski SM, Zimmerman ME, DelBello M, Keck PE, Hawkins JM. Frontosubcortical neuroanatomy and the continuous performance test in mania. Am J Psychiatry. 1999;156:139-141.
34. Borkowska A, Rybakowski JK. Neuropsychological frontal lobe tests indicate that bipolar depressed patients are more impaired than unipolar. Bipolar Disord. 2001; 3:88-94.
35. Clark L, Iversen SD, Goodwin GM. A neuropsychological investigation of prefrontal involvement in acute mania. Am J Psychiatry. 2001;158:1605-1611.
36. Lebowitz BK, Shear PK, Steed MA, Strakowski SM. Verbal fluency in mania: relationship to number of manic episodes. Neuropsychiatry Neuropsychol Behav Neurol. 2001;14:177-182.
37. Perret E. The left frontal lobe of man and the suppression of habitual responses in verbal categorical behavior. Neuropsychologia. 1974;12:323-330.
38. Cohen JD, Dunbar K, McClelland JL. On the control of automatic processes: a parallel distributed processing account of the Stroop effect. Psychol Rev. 1990; 97:332-361.
39. MacLeod CM. Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991;109:163-203.
40. Pardo JV, Pardo PJ, Janer KW, Raichle ME. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci U S A. 1990;87:256-259.
41. Bench CJ, Frith CD, Grasby PM, Friston KJ, Paulesu E, Frackowiak RSJ, Dolan RJ. Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia. 1993;31:907-922.
42. 15O PET study of Stroop task performance. Neuroimage. 1995;2:264-272.
43. Taylor SF, Kornblum S, Lauber EJ, Minoshima S, Koeppe RA. Isolation of specific interference processing in the Stroop task: PET activation studies. Neuroimage. 1997;6:81-92.
44. Brown GG, Kinderman SS, Siegle GJ, Granholm E, Wong EC, Buxton RB. Brain activation and pupil response during covert performance of the Stroop Color Word task. J Int Neuropsychol Soc. 1999;5:308-319.
45. Peterson BS, Skudlarski P, Gatenby JC, Zhang H, Anderson AW, Gore JC. An fMRI study of Stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biol Psychiatry. 1999; 45:1237-1258.
46. Carter CS, Macdonald AM, Botvinick M, Ross LL, Stenger VA, Noll D, Cohen JD. Parsing executive processes: strategic vs evaluative functions of the anterior cingulate cortex. Proc Natl Acad Sci U S A. 2000;97:1944-1948.
47. Leung H-C, Skudlarski P, Gatenby JC, Peterson BS, Gore JC. An event-related fMRI study of color and word interference. Cereb Cortex. 2000;10:552-560.
48. MacDonald AW III, Cohen JD, Stenger VA, Carter CS. Dissociating the role of the dorsolateral and anterior cingulate cortex in cognitive control. Science. 2000; 288:1835-1838.
49. Gruber SA, Rogowska J, Holcomb P, Soraci S, Yurgelun-Todd D. Stroop performance in normal control subjects: an fMRI study. Neuroimage. 2002;16:349-360.
50. Peterson BS, Kane MJ, Alexander GM, Lacadie C, Skudlarski P, Leung H-C, May J, Gore JC. An event-related functional MRI study comparing interference effects in the Simon and Stroop tasks. Brain Res Cogn Brain Res. 2002;13:427-440.
51. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I & II Disorders (Version 2.0). New York: Biometrics Research, New York State Psychiatric Institute; 1995.
52. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Handedness Inventory. Neuropsychologia. 1971;9:97-113.
53. Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198.
54. Altman EG, Hedeker DR, Janicak PG, Peterson JL, Davis JM. The Clinician-Administered Rating Scale for Mania (CARS-M): development, reliability and validity. Biol Psychiatry. 1994;36:124-134.
55. Williams JBW, Link MJ, Rosenthal NE, Amira L, Terman M. Structured Interview Guide for the Hamilton Depression Rating Scale: Seasonal Affective Disorder Version (SIGH-SAD). New York: New York State Psychiatric Institute; 1994.
56. Cohen JD, MacWhitney B, Flatt M, Provost J. PsyScope: a new graphic interactive environment for designing psychology experiments. Behav Res Methods Instrum Comput. 1993;25:257-271.
57. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York, NY: Thieme Medical Publishers; 1988.
58. Friston KJ, Williams S, Howard R, Frackowiak RSJ, Turner R. Movement-related effects in fMRI time-series. Magn Reson Med. 1996;35:346-355.
59. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of cluster-size threshold. Magn Reson Med. 1995;33:636-647.
60. Posner MI, Peterson SE. The attention system of the human brain. Annu Rev Neurosci. 1990;13:25-42.
61. Freedman M, Black S, Ebert P, Binns M. Orbitofrontal function, object alternation and perseveration. Cereb Cortex. 1998;8:18-27.
62. Nobre AC, Coull JT, Frith CD, Mesulam MM. Orbitofrontal cortex is activated during breaches of expectation in tasks of visual attention. Nat Neurosci. 1999;2:11-12.
63. Jonides J, Smith EE, Marshuetz C, Koeppe RA, Reuter-Lorenz PA. Inhibition in verbal working memory revealed by brain activation. Proc Natl Acad Sci USA. 1998;95:8410-8413.
64. Rolls ET, Hornak J, Wade D, McGrath J. Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry. 1994;57:1518-1524.
65. Morecraft RJ, Geula C, Mesulam M-M. Cytoarchitecture and neural afferents of the orbitofrontal cortex in the brain of the monkey. J Comp Neurol. 1992;323:341-358.
66. Carmichael ST, Price JL. Limbic connections of the orbital and medial prefrontal cortex of macaque monkeys. J Comp Neurol. 1995;363:615-641.
67. Beauregard M, Leroux JM, Bergman S, Arzoumanian Y, Beaudoin G, Bourgouin P, Stip E. The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm. Neuroreport. 1998;9:3253-3258.
68. Pardo JV, Pardo PJ, Raichle ME. Neural correlates of self-induced dysphoria. Am J Psychiatry. 1993;150:713-719.
69. George MS, Ketter TA, Parekh PI, Horowitz B, Herscovitch P, Post RM. Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995;152:341-351.
70. Nobler MS, Oquendo MA, Kegeles LS, Malone KM, Campbell CC, Sackeim HA, Mann JJ. Decreased regional metabolism after ECT. Am J Psychiatry. 2001;158:305-308.
71. Ketter TA, Kimbrell TA, George MS, Willis MW, Benson BE, Danielson A, Frye MA, Herscovitch P, Post RM. Baseline cerebral hypermetabolism associated with carbamazepine response, and hypometabolism with nimodipine response in mood disorders. Biol Psychiatry. 1999;46:1364-1374.
72. Rajkowska G. Cell pathology in mood disorders. Semin Clin Neuropsychiatry. 2002;7:281-292.
73. Kraemer HC, Yesavage JA, Taylor JL, Kupfer D. How can we learn about developmental processes from cross-sectional studies, or can we? Am J Psychiatry. 2000;157:163-171.
74. 15O]H2O PET study during single-trial Stroop task performance. Am J Psychiatry. 1997;154:1670-1675.
75. Barch DM, Sabb FW, Carter CS, Braver TS, Noll DC, Cohen JC. Overt verbal responding during fMRI scanning: empirical investigations of problems and potential solutions. Neuroimage. 1999;10:642-657.
76. Liotti M, Woldorff MG, Perez R, Mayberg HS. An ERP study of the temporal course of the Stroop color-word interference effect. Neuropsychologia. 2000; 38:701-711.