-
2
-
-
35549003579
-
Regulation of interferon-gamma during innate and adaptive immune responses
-
Schoenborn JR, Wilson CB. Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 2007;96:41-101
-
(2007)
Adv Immunol
, vol.96
, pp. 41-101
-
-
Schoenborn, J.R.1
Wilson, C.B.2
-
3
-
-
0842266786
-
Interferon- gamma: An overview of signals, mechanisms and functions
-
Schroder K, Hertzog PJ, Ravasi T, et al. Interferon- gamma: An overview of signals, mechanisms and functions. J Leukoc Biol 2004;75:163-89
-
(2004)
J Leukoc Biol
, vol.75
, pp. 163-189
-
-
Schroder, K.1
Hertzog, P.J.2
Ravasi, T.3
-
4
-
-
0032526840
-
Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation
-
Munder M, Mallo M, Eichmann K, et al. Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med 1998;187:2103-8
-
(1998)
J Exp Med
, vol.187
, pp. 2103-2108
-
-
Munder, M.1
Mallo, M.2
Eichmann, K.3
-
6
-
-
0021045038
-
Activation of human monocyte cytotoxicity by natural and recombinant immune interferon
-
Le J, Prensky W, Yip YK, et al. Activation of human monocyte cytotoxicity by natural and recombinant immune interferon. J Immunol 1983;131:2821-6
-
(1983)
J Immunol
, vol.131
, pp. 2821-2826
-
-
Le Prensky, J.W.1
Yip, Y.K.2
-
7
-
-
0020539090
-
Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing
-
Pace JL, Russell SW, Torres BA, et al. Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing. J Immunol 1983;130:2011-3
-
(1983)
J Immunol
, vol.130
, pp. 2011-2013
-
-
Pace, J.L.1
Russell, S.W.2
Torres, B.A.3
-
8
-
-
0020502358
-
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity
-
Nathan CF, Murray HW, Wiebe ME, et al. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983;158:670-89
-
(1983)
J Exp Med
, vol.158
, pp. 670-689
-
-
Nathan, C.F.1
Murray, H.W.2
Wiebe, M.E.3
-
9
-
-
0023793266
-
Modulation of major histocompatibility complex (MHC) expression by interferons and microbial agents. Independent regulation of MHC class II expression and induction of tumoricidal activity in bone marrow-derived mononuclear phagocytes
-
Keller R, Joller P, Keist R, et al. Modulation of major histocompatibility complex (MHC) expression by interferons and microbial agents. Independent regulation of MHC class II expression and induction of tumoricidal activity in bone marrow-derived mononuclear phagocytes. Scand J Immunol 1988;28:113-21
-
(1988)
Scand J Immunol
, vol.28
, pp. 113-121
-
-
Keller, R.1
Joller, P.2
Keist, R.3
-
10
-
-
0027409771
-
Interferon gamma inhibits interleukin 10 production by monocytes
-
Chomarat P, RissoanMC, Banchereau J, et al. Interferon gamma inhibits interleukin 10 production by monocytes. J ExpMed 1993;177:523-7
-
(1993)
J ExpMed
, vol.177
, pp. 523-527
-
-
Chomarat, P.1
Rissoan, M.C.2
Banchereau, J.3
-
11
-
-
0022982147
-
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by shortlived repressors
-
Collart MA, Belin D, Vassalli JD, et al. Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by shortlived repressors. J Exp Med 1986;164:2113-8
-
(1986)
J Exp Med
, vol.164
, pp. 2113-2118
-
-
Collart, M.A.1
Belin, D.2
Vassalli, J.D.3
-
12
-
-
0025076370
-
Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4
-
Donnelly RP, Fenton MJ, Finbloom DS, et al. Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4. J Immunol 1990;145:569-75
-
(1990)
J Immunol
, vol.145
, pp. 569-575
-
-
Donnelly, R.P.1
Fenton, M.J.2
Finbloom, D.S.3
-
13
-
-
0029970931
-
Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: Requirement of gamma interferon for IL-12 secretion
-
Fantuzzi L, Gessani S, Borghi P, et al. Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: Requirement of gamma interferon for IL-12 secretion. J Virol 1996;70:4121-4
-
(1996)
J Virol
, vol.70
, pp. 4121-4124
-
-
Fantuzzi, L.1
Gessani, S.2
Borghi, P.3
-
14
-
-
0027320142
-
IL-2 upregulates but IFN-gamma suppresses IL-8 expression in human monocytes
-
Gusella GL, Musso T, Bosco MC, et al. IL-2 upregulates but IFN-gamma suppresses IL-8 expression in human monocytes. J Immunol 1993;151: 2725-32
-
(1993)
J Immunol
, vol.151
, pp. 2725-2732
-
-
Gusella, G.L.1
Musso, T.2
Bosco, M.C.3
-
16
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 2004;4:937-47
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
17
-
-
77949887017
-
Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux
-
Zhou X, Yin Z, Guo X, et al. Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux. J Biol Chem 2010;285:6316-26
-
(2010)
J Biol Chem
, vol.285
, pp. 6316-6326
-
-
Zhou, X.1
Yin, Z.2
Guo, X.3
-
18
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocrine Rev 2001;22:153-83
-
(2001)
Endocrine Rev
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
-
19
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007;26:3291-310
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
20
-
-
77949464718
-
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
-
Fremin C, Meloche S. From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol 2010;3:8
-
(2010)
J Hematol Oncol
, vol.3
, pp. 8
-
-
Fremin, C.1
Meloche, S.2
-
21
-
-
79951928689
-
Novel mitogenactivated protein kinase kinase inhibitors
-
Chapman MS, Miner JN. Novel mitogenactivated protein kinase kinase inhibitors. Expert Opin Invest Drugs 2011;20:209-20
-
(2011)
Expert Opin Invest Drugs
, vol.20
, pp. 209-220
-
-
Chapman, M.S.1
Miner, J.N.2
-
22
-
-
84897490281
-
Identification of interferon-gamma as a new molecular target of liver X receptor
-
Wang Q, Ma X, Chen Y, et al. Identification of interferon-gamma as a new molecular target of liver X receptor. Biochem J 2014;459:345-54
-
(2014)
Biochem J
, vol.459
, pp. 345-354
-
-
Wang, Q.1
Ma, X.2
Chen, Y.3
-
23
-
-
84871549478
-
Activation of liver X receptor induces macrophage interleukin- 5 expression
-
Chen Y, Duan Y, Kang Y, et al. Activation of liver X receptor induces macrophage interleukin- 5 expression. J Biol Chem 2012;287:43340-50
-
(2012)
J Biol Chem
, vol.287
, pp. 43340-43350
-
-
Chen, Y.1
Duan, Y.2
Kang, Y.3
-
24
-
-
34248563290
-
The ERK1/2 mitogenactivated protein kinase pathway as a master regulator of the G1-to S-phase transition
-
Meloche S, Pouyssegur J. The ERK1/2 mitogenactivated protein kinase pathway as a master regulator of the G1-to S-phase transition. Oncogene 2007;26:3227-39
-
(2007)
Oncogene
, vol.26
, pp. 3227-3239
-
-
Meloche, S.1
Pouyssegur, J.2
-
25
-
-
34047129136
-
Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia
-
Scholl FA, Dumesic PA, Barragan DI, et al. Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia. Dev Cell 2007;12:615-29
-
(2007)
Dev Cell
, vol.12
, pp. 615-629
-
-
Scholl, F.A.1
Dumesic, P.A.2
Barragan, D.I.3
-
27
-
-
38849139580
-
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2- mediated degradation
-
Yang JY, Zong CS, XiaW, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2- mediated degradation. Nat Cell Biol 2008;10:138-48
-
(2008)
Nat Cell Biol
, vol.10
, pp. 138-148
-
-
Yang, J.Y.1
Zong, C.S.2
Xia, W.3
-
28
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007;7:295-308
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
29
-
-
0032984348
-
Blockade of theMAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold JS,Dudley DT,Herrera R, et al. Blockade of theMAP kinase pathway suppresses growth of colon tumors in vivo. NatMed 1999;5:810-6
-
(1999)
NatMed
, vol.5
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
-
30
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pages G, Guerin S, Grall D, et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 1999;286:1374-7
-
(1999)
Science
, vol.286
, pp. 1374-1377
-
-
Pages, G.1
Guerin, S.2
Grall, D.3
-
31
-
-
0034170871
-
Mechanisms of interferon-induced cell cycle arrest
-
Sangfelt O, Erickson S, Grander D. Mechanisms of interferon-induced cell cycle arrest. Front Biosci 2000;5:D479-87
-
(2000)
Front Biosci
, vol.5
, pp. D479-D487
-
-
Sangfelt, O.1
Erickson, S.2
Grander, D.3
-
32
-
-
0031010127
-
Interleukin- 6 overcomes p21WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-gamma in multiple myeloma cells
-
Urashima M, Teoh G, Chauhan D, et al. Interleukin- 6 overcomes p21WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-gamma in multiple myeloma cells. Blood 1997;90:279-89
-
(1997)
Blood
, vol.90
, pp. 279-289
-
-
Urashima, M.1
Teoh, G.2
Chauhan, D.3
-
33
-
-
33745938818
-
Interferon-gamma in combination with carboplatin and paclitaxel as a safe and effective first-line treatment option for advanced ovarian cancer: Results of a phase I/II study
-
Marth C, Windbichler GH, Hausmaninger H, et al. Interferon-gamma in combination with carboplatin and paclitaxel as a safe and effective first-line treatment option for advanced ovarian cancer: Results of a phase I/II study. Int J Gynecol Cancer 2006;16:1522-8
-
(2006)
Int J Gynecol Cancer
, vol.16
, pp. 1522-1528
-
-
Marth, C.1
Windbichler, G.H.2
Hausmaninger, H.3
-
34
-
-
42749083267
-
Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: Results from a prospectively designed analysis of progressionfree survival
-
GRACES Clinical Trial Consortium
-
Alberts DS, Marth C, Alvarez RD, et al. GRACES Clinical Trial Consortium. Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: Results from a prospectively designed analysis of progressionfree survival. Gynecol Oncol 2008;109:174-81
-
(2008)
Gynecol Oncol
, vol.109
, pp. 174-181
-
-
Alberts, D.S.1
Marth, C.2
Alvarez, R.D.3
-
35
-
-
0344198121
-
The immunomodulating effect of interferon-gamma intravesical instillations in preventing bladder cancer recurrence
-
Giannopoulos A, Constantinides C, Fokaeas E, et al. The immunomodulating effect of interferon-gamma intravesical instillations in preventing bladder cancer recurrence. Clin Cancer Res 2003;9:5550-8
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5550-5558
-
-
Giannopoulos, A.1
Constantinides, C.2
Fokaeas, E.3
-
36
-
-
0023155285
-
Recombinant interferon beta and gamma in the treatment of adult T-cell leukemia
-
Tamura K, Makino S, Araki Y, et al. Recombinant interferon beta and gamma in the treatment of adult T-cell leukemia. Cancer 1987;59:1059-62
-
(1987)
Cancer
, vol.59
, pp. 1059-1062
-
-
Tamura, K.1
Makino, S.2
Araki, Y.3
-
37
-
-
16844379776
-
Interferon gamma induces neurite outgrowth by upregulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway
-
Song JH, Wang CX, Song DK, et al. Interferon gamma induces neurite outgrowth by upregulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway. J Biol Chem 2005;280:12896-901
-
(2005)
J Biol Chem
, vol.280
, pp. 12896-12901
-
-
Song, J.H.1
Wang, C.X.2
Song, D.K.3
-
38
-
-
79959949690
-
Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNgamma-induced apoptosis
-
Burova EB, Smirnova IS, Gonchar IV, et al. Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNgamma-induced apoptosis. Cell Cycle 2011;10:2197-205
-
(2011)
Cell Cycle
, vol.10
, pp. 2197-2205
-
-
Burova, E.B.1
Smirnova, I.S.2
Gonchar, I.V.3
-
39
-
-
33847740720
-
A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes
-
Gough DJ, Sabapathy K, Ko EY, et al. A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. J Biol Chem 2007;282:938-46
-
(2007)
J Biol Chem
, vol.282
, pp. 938-946
-
-
Gough, D.J.1
Sabapathy, K.2
Ko, E.Y.3
-
40
-
-
77949536564
-
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents
-
Zhou B, He Y, Zhang X, et al. Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents. Proc Natl Acad Sci USA 2010;107:4573-8
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4573-4578
-
-
Zhou, B.1
He, Y.2
Zhang, X.3
-
41
-
-
42249089079
-
A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor necrosis factor-alpha and interferon-gamma inflammatory effects in human endothelial cells
-
Lombardi A, Cantini G, Piscitelli E, et al. A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor necrosis factor-alpha and interferon-gamma inflammatory effects in human endothelial cells. Arterioscler Thromb Vasc Biol 2008;28:718-24
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 718-724
-
-
Lombardi, A.1
Cantini, G.2
Piscitelli, E.3
-
42
-
-
0034662145
-
Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kinase C-dependent mechanism
-
Nguyen VA, Chen J, Hong F, et al. Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kinase C-dependent mechanism. Biochem J 2000;349: 427-34
-
(2000)
Biochem J
, vol.349
, pp. 427-434
-
-
Nguyen, V.A.1
Chen, J.2
Hong, F.3
-
43
-
-
77954697899
-
Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli
-
Töröcsik D, Baráth M, Benko S, et al. Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli. J Immunol 2010; 184:5456-65.
-
(2010)
J Immunol
, vol.184
, pp. 5456-5465
-
-
Töröcsik, D.1
Baráth, M.2
Benko, S.3
|