Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling

European Journal of Pharmacology

Volumn 744, Issue , 2015, Pages 76-82

  Ortiz Vilchis, Pilar ^a   Yamazaki, Katrina Go ^b   Rubio Gayosso, Ivan ^a   Ramirez Sanchez, Israel ^a   Calzada, Claudia ^a   Romero Perez, Diego ^c   Ortiz, Alicia ^a   Meaney, Eduardo ^a   Taub, Pam ^b   Villarreal, Francisco ^b   Ceballos, Guillermo ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSIDAD AUTÓNOMA DE BAJA CALIFORNIA   (Mexico)

Author keywords

Doxycycline; Epicatechin; Ischemia reperfusion; Mitochondrial swelling

Indexed keywords

DOXYCYCLINE; EPICATECHIN; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; QUERCETIN; CARDIOTONIC AGENT; CATECHIN; FLAVONOID;

ADULT; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; EC30; EC40; EC50; HEART INFARCTION SIZE; HEART PROTECTION; MALE; MITOCHONDRION SWELLING; NONHUMAN; RAT; REPERFUSION INJURY; ANIMAL; CORONARY BLOOD VESSEL; DRUG EFFECTS; HEART MITOCHONDRION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; CARDIOTONIC AGENTS; CATECHIN; CORONARY VESSELS; DOXYCYCLINE; DRUG SYNERGISM; FLAVONOIDS; MALE; MITOCHONDRIA, HEART; MITOCHONDRIAL SWELLING; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84918801034     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.09.042     Document Type: Article

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