Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter

Toxicology and Applied Pharmacology

Volumn 273, Issue 1, 2013, Pages 172-179

  Schwartz, Justin ^a   Holmuhamedov, Ekhson ^a   Zhang, Xun ^a   Lovelace, Gregory L ^a   Smith, Charles D ^a   Lemasters, John J ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Calcium; Doxycycline; Minocycline; Mitochondria; MPT; Uniporter

Indexed keywords

DOXYCYCLINE; MINOCYCLINE; TETRACYCLINE DERIVATIVE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL KILLING; CELL MEMBRANE DEPOLARIZATION; CELL PROTECTION; HYPOXIA; LIVER CELL; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; RAT; REPERFUSION INJURY;

CALCIUM; CIS-9-OCTADECONYL-N-HYDROXYLAMIDE; CSA; CYCLOSPORIN A; DOXYCYCLINE; I/R; IAA; IODOACETIC ACID; ISCHEMIA/REPERFUSION; KREBS-RINGER-HEPES; KRH; MATRIX METALLOPROTEASE; MCU; MINOCYCLINE; MITOCHONDRIA; MITOCHONDRIAL CALCIUM UNIPORTER; MITOCHONDRIAL PERMEABILITY TRANSITION; MMP; MPT; OA-HY; PI; PROPIDIUM IODIDE; REACTIVE OXYGEN SPECIES; RH123; RHODAMINE 123; ROS; UNIPORTER;

ANIMALS; ANOXIA; ANTI-BACTERIAL AGENTS; CALCIUM; CALCIUM CHANNELS; DOXYCYCLINE; HEPATOCYTES; IRON; MALE; MINOCYCLINE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TETRACYCLINE;

EID: 84884717492     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.08.027     Document Type: Article

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