Vascular action of cocoa flavanols in humans: The roots of the story

Journal of Cardiovascular Pharmacology

Volumn 47, Issue SUPPL. 2, 2006, Pages

  K Hollenberg, Norman ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cocoa; Endothelial function; Flavanols; Flavonoids; Hypertension; Nitric oxide

Indexed keywords

ALCOHOL; ARGININE DERIVATIVE; CALCIUM; FLAVANOL DERIVATIVE; FLAVONOID; MAGNESIUM; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; OMEGA 3 FATTY ACID; POTASSIUM; PROTEIN; SODIUM; VASODILATOR AGENT;

ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; CACAO; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DIET; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ESSENTIAL HYPERTENSION; HEALTH STATUS; HUMAN; HYPERTENSION; KIDNEY FAILURE; MULTIINFARCT DEMENTIA; PANAMA; PATHOPHYSIOLOGY; POTASSIUM INTAKE; PREECLAMPSIA; PRIORITY JOURNAL; SODIUM INTAKE; URINALYSIS;

AGING; BLOOD PRESSURE; BLOOD VESSELS; CACAO; ENZYME ACTIVATION; FLAVONOIDS; HUMANS; HYPERTENSION; INDIANS, CENTRAL AMERICAN; NITRIC OXIDE SYNTHASE; PANAMA;

EID: 33750300165     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200606001-00002     Document Type: Article

References (17)

1. Howe J. The Kuna Gathering. Contemporary Village Politics in Panama. Austin, TX: University of Texas Press; 1986.
2. Kean BH. The BP of the Kuna Indians. Am J Trop Med Hyg. 1944;24:341-343.
3. James GD, Baker PT. Human population biology and blood pressure: evolutional and ecological considerations and interpretations of population studies. In: Laragh JH, Brenner BM, eds. Hypertension, Pathophysiology, Diagnosis, and Management. New York: Raven Press; 1995:115-125.
4. Hollenberg NK, Williams GH. Abnormal renal function, sodium-volume homeostasis and renin system hypertension: the evolution of the nonmodulator concept. In: Laragh JH, Brenner BM, eds. Hypertension: Pathophysiology, Diagnosis, and Management. New York: Raven Press; 1995:1837-1856.
5. Koshachuhanan N, Hunt SC, Hopkins PN, et al. Genetic determinants of nonmodulating hypertension. Hypertension. 2003;42:901-908.
6. Williams GH, Hollenberg NK, Hopkins PM, et al. The role of intermediate phenotypes in essential hypertension: non-modulation as a model. Endocrine Res. 1996;22:675-680.
7. Hollenberg NK, Martinez G, McCullough M, et al. Aging, acculturation, salt intake, and hypertension. Hypertension. 1997;29:171-176.
8. Hollenberg NK, Rivera A, Meinking T, et al. Age, renal perfusion, and function in island-dwelling indigenous Kuna Amerinds of Panama. Nephron. 1999;82:131-138.
9. Herrera M, Garvin JL. Recent advances in the regulation of nitric oxide in the kidney. Hypertension. 2005;45:1062-1067.
10. Chevaux KA, Jackson L, Villar ME, et al. Proximate mineral and procyandin content of certain foods and beverages consumed by Kuna Amerinds of Panama. J Food Composit Anal. 2001;14:553-563.
11. Fisher NDL, Hollenberg NKH. Flavanols for cardiovascular health: the science behind the sweetness. J Hypertension. 2005;23:1453-1459.
12. Fisher NDL, Hughes M, Gerhard-Herman M, et al. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertension. 2003;21:2281-2286.
13. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005;308:1592-1594.
14. Takase B, Goto T, Hamabe A, et al. Flow-mediated dilation in brachial artery in the second half of pregnancy and pre-eclampsia. J Hum Hypertension. 2003;17:697-704.
15. Savvidou MD, Hingorani AD, Tsikas D, et al. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet. 2003;361:1511-1517.
16. Schramm DD, Wang JF, Holt RR, et al. Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am J Clin Nutr. 2001;73:36-40.
17. Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr. 2000;130:2105S-2108S.