The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts

Immunology

Volumn 144, Issue 1, 2015, Pages 91-106

  Urbanellis, Peter ^a   Shyu, Wendy ^a,b   Khattar, Ramzi ^a   Wang, Jihong ^a   Zakharova, Anna ^b   He, Wei ^a   Sadozai, Hassan ^a   Amir, Achiya Z ^c   Shalev, Itay ^a   Phillips, M James ^c   Adeyi, Oyedele ^a   Ross, Heather ^a   Grant, David ^a   Levy, Gary A ^a,b   Chruscinski, Andrzej ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Fgl2; Regulatory T cell; Tolerance; Transplantation

Indexed keywords

CD223 ANTIGEN; FGL2 PROTEIN, MOUSE; FIBRINOGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GAMMA INTERFERON; GRANZYME; GZMB PROTEIN, MOUSE; IMMUNOSUPPRESSIVE AGENT; LEUKOCYTE ANTIGEN; RAPAMYCIN; TRANSFORMING GROWTH FACTOR BETA;

ALLOGRAFT; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE DEPLETION; MOUSE; PATHOLOGY; PROCEDURES; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE;

ALLOGRAFTS; ANIMALS; ANTIGENS, CD; FIBRINOGEN; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GRAFT REJECTION; GRANZYMES; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; SIROLIMUS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION TOLERANCE;

EID: 84918788141     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12354     Document Type: Article

References (46)

1. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation - how much of the promise has been realized? Nat Med 2005; 11:605-13.
2. + regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006; 177:8338-47.
3. + regulatory T cells. Blood 2005; 105:4743-8.
4. Thomson AW, Turnquist HR, Raimondi G. Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol 2009; 9:324-37.
5. + T cells via a CD30-dependent mechanism. J Clin Invest 2004; 113:310-7.
6. + regulatory T cells. Transplantation 2006; 82:1749-55.
7. Powell JD, Pollizzi KN, Heikamp EB, Horton MR. Regulation of immune responses by mTOR. Annu Rev Immunol 2012; 30:39-68.
8. Strauss L, Czystowska M, Szajnik M, Mandapathil M, Whiteside TL. Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin. PLoS ONE 2009; 4:e5994.
9. Huang CT, Workman CJ, Flies D et al. Role of LAG-3 in regulatory T cells. Immunity 2004; 21:503-13.
10. + regulatory cells that control intestinal inflammation. J Exp Med 2000; 192:295-302.
11. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008; 8:523-32.
12. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 2005; 174:1783-6.
13. + T cells. Nat Immunol 2007; 8:1353-62.
14. Li XL, Menoret S, Bezie S et al. Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance. J Immunol 2010; 185:823-33.
15. Liu H, Shalev I, Manuel J et al. The FGL2-FcγRIIB pathway: a novel mechanism leading to immunosuppression. Eur J Immunol 2008; 38:3114-26.
16. Shalev I, Liu H, Koscik C et al. Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J Immunol 2008; 180:249-60.
17. Kurian SM, Heilman R, Mondala TS et al. Biomarkers for early and late stage chronic allograft nephropathy by proteogenomic profiling of peripheral blood. PLoS ONE 2009; 4:e6212.
18. Turka LA, Lechler RI. Towards the identification of biomarkers of transplantation tolerance. Nat Rev Immunol 2009; 9:521-6.
19. Xie L, Ichimaru N, Morita M et al. Identification of a novel biomarker gene set with sensitivity and specificity for distinguishing between allograft rejection and tolerance. Liver Transpl 2012; 18:444-54.
20. Deng MC, Eisen HJ, Mehra MR et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant 2006; 6:150-60.
21. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16:343-50.
22. Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5:1298-302.
23. Braun M, Kirsten R, Rupp NJ, Moch H, Fend F, Wernert N, Kristiansen G, Perner S. Quantification of protein expression in cells and cellular subcompartments on immunohistochemical sections using a computer supported image analysis system. Histol Histopathol 2013; 28:605-10.
24. Lawrence BP. Measuring the activity of cytolytic lymphocytes. Curr Protoc Toxicol. 2005;Chapter 18:Unit18 6.
25. Khattar R, Luft O, Yavorska N et al. Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis caused by LCMV WE. PLoS ONE 2013; 8:e72309.
26. + regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis. Hepatology 2009; 49:387-97.
27. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005; 6:1142-51.
28. Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282:2085-8.
29. Joller N, Lozano E, Burkett PR et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014; 40:569-81.
30. Gagliani N, Gregori S, Jofra T et al. Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation. PLoS ONE 2011; 6:e28434.
31. + T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol 2006; 176:5988-94.
32. Pascher A, Proesch S, Pratschke J et al. Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage. Am J Transplant 2006; 6:2035-45.
33. + T cells is associated with latent infection-mediated resistance to transplantation tolerance. J Immunol 2008; 180:3190-200.
34. Chong AS, Alegre ML. The impact of infection and tissue damage in solid-organ transplantation. Nat Rev Immunol 2012; 12:459-71.
35. Levitsky J, Mathew JM, Abecassis M et al. Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. Hepatology 2013; 57:239-48.
36. + regulatory T cells cultured with rapamycin. J Immunol 2007; 178:320-9.
37. Koyama T, Hall LR, Haser WG, Tonegawa S, Saito H. Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen β and γ chains. Proc Natl Acad Sci U S A 1987; 84:1609-13.
38. Marazzi S, Blum S, Hartmann R et al. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. J Immunol 1998; 161:138-47.
39. + regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009; 326:986-91.
40. Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206:3015-29.
41. Mu J, Qu D, Bartczak A et al. Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiol Genomics 2007; 31:53-62.
42. Sagoo P, Perucha E, Sawitzki B et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120:1848-61.
43. Lande JD, Patil J, Li N, Berryman TR, King RA, Hertz MI. Novel insights into lung transplant rejection by microarray analysis. Proc Am Thorac Soc 2007; 4:44-51.
44. Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007; 445:936-40.
45. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007; 7:610-21.
46. Foerster K, Helmy A, Zhu Y et al. The novel immunoregulatory molecule FGL2: a potential biomarker for severity of chronic hepatitis C virus infection. J Hepatol 2010; 53:608-15.