메뉴 건너뛰기




Volumn 53, Issue 10, 2014, Pages 919-930

Effect of a Roux-en-Y Gastric Bypass on the Pharmacokinetics of Oral Morphine Using a Population Approach

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE SULFATE; MORPHINE; NARCOTIC ANALGESIC AGENT;

EID: 84918788088     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-014-0163-0     Document Type: Article
Times cited : (58)

References (49)
  • 1
    • 85028157935 scopus 로고    scopus 로고
    • Obesity and overweight. WHO Fact Sheet no. 311. Accessed 8 Aug 2014
    • Obesity and overweight. WHO Fact Sheet no. 311. Available at URL:http://www.who.int/mediacentre/factsheets/fs311/en. Accessed 8 Aug 2014.
  • 2
    • 85028132958 scopus 로고    scopus 로고
    • Media Press Kit
    • American Society for Metabolic and Bariatric Surgery (ASMBS). Final report May 2011. Media Press Kit. Gainesville: American Society for Metabolic and Bariatric Surgery; 2011. http://s3.amazonaws.com/publicASMBS/MediaPressKit/MetabolicBariatricSurgeryOverviewJuly2011.pdf. Accessed 31 Jul 2014.
    • (2011) Gainesville: American Society for Metabolic and Bariatric Surgery , pp. 2011
  • 3
    • 74049144085 scopus 로고    scopus 로고
    • A systematic review of drug absorption following bariatric surgery and its theoretical implications
    • PID: 19493300, COI: 1:CAS:528:DC%2BC3cXhvFSltLs%3D
    • Padwal R, Brocks D, Sharma AM. A systematic review of drug absorption following bariatric surgery and its theoretical implications. Obes Rev. 2010;11:41–50.
    • (2010) Obes Rev , vol.11 , pp. 41-50
    • Padwal, R.1    Brocks, D.2    Sharma, A.M.3
  • 5
    • 80051985491 scopus 로고    scopus 로고
    • Effect of gastric bypass surgery on the absorption and bioavailability of metformin
    • PID: 21478461, COI: 1:CAS:528:DC%2BC3MXos1KmsLo%3D
    • Padwal RS, Gabr RQ, Sharma AM, Langkaas LA, Birch DW, Karmali S, et al. Effect of gastric bypass surgery on the absorption and bioavailability of metformin. Diabetes Care. 2011;34:1295–300.
    • (2011) Diabetes Care , vol.34 , pp. 1295-1300
    • Padwal, R.S.1    Gabr, R.Q.2    Sharma, A.M.3    Langkaas, L.A.4    Birch, D.W.5    Karmali, S.6
  • 6
    • 84858987400 scopus 로고    scopus 로고
    • The effect of gastric bypass on the pharmacokinetics of serotonin reuptake inhibitors
    • PID: 22407114
    • Hamad GG, Helsel JC, Perel JM, Kozak GM, McShea MC, Hughes C, et al. The effect of gastric bypass on the pharmacokinetics of serotonin reuptake inhibitors. Am J Psychiatry. 2012;169:256–63.
    • (2012) Am J Psychiatry , vol.169 , pp. 256-263
    • Hamad, G.G.1    Helsel, J.C.2    Perel, J.M.3    Kozak, G.M.4    McShea, M.C.5    Hughes, C.6
  • 7
    • 84855874150 scopus 로고    scopus 로고
    • Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort
    • PID: 21256091
    • Roerig JL, Steffen K, Zimmerman C, Mitchell JE, Crosby RD, Cao L. Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort. Surg Obes Relat Dis. 2012;8:62–6.
    • (2012) Surg Obes Relat Dis , vol.8 , pp. 62-66
    • Roerig, J.L.1    Steffen, K.2    Zimmerman, C.3    Mitchell, J.E.4    Crosby, R.D.5    Cao, L.6
  • 8
    • 69449099498 scopus 로고    scopus 로고
    • Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients
    • PID: 19494810, COI: 1:CAS:528:DC%2BD1MXhtVGqu7bM
    • Skottheim IB, Stormark K, Christensen H, Jakobsen GS, Hjelmesaeth J, Jenssen T, et al. Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients. Clin Pharmacol Ther. 2009;86:311–8.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 311-318
    • Skottheim, I.B.1    Stormark, K.2    Christensen, H.3    Jakobsen, G.S.4    Hjelmesaeth, J.5    Jenssen, T.6
  • 10
    • 77952583699 scopus 로고    scopus 로고
    • Significant increase in systemic exposure of atorvastatin after biliopancreatic diversion with duodenal switch
    • PID: 20445535, COI: 1:CAS:528:DC%2BC3cXmt1Ojsbg%3D
    • Skottheim IB, Jakobsen GS, Stormark K, Christensen H, Hjelmesaeth J, Jenssen T, et al. Significant increase in systemic exposure of atorvastatin after biliopancreatic diversion with duodenal switch. Clin Pharmacol Ther. 2010;87:699–705.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 699-705
    • Skottheim, I.B.1    Jakobsen, G.S.2    Stormark, K.3    Christensen, H.4    Hjelmesaeth, J.5    Jenssen, T.6
  • 11
    • 74249120678 scopus 로고    scopus 로고
    • Effect of obesity on the pharmacokinetics of drugs in humans
    • PID: 20067334, COI: 1:CAS:528:DC%2BC3cXjtV2isbg%3D
    • Hanley MJ, Abernethy DR, Greenblatt DJ. Effect of obesity on the pharmacokinetics of drugs in humans. Clin Pharmacokinet. 2010;49:71–87.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 71-87
    • Hanley, M.J.1    Abernethy, D.R.2    Greenblatt, D.J.3
  • 13
    • 33845735207 scopus 로고    scopus 로고
    • Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery
    • COI: 1:STN:280:DC%2BD28jjsFGgug%3D%3D
    • Hooper MM, Stellato TA, Hallowell PT, Seitz BA, Moskowitz RW. Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery. Int J Obes (Lond). 2007;31:114–20.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 114-120
    • Hooper, M.M.1    Stellato, T.A.2    Hallowell, P.T.3    Seitz, B.A.4    Moskowitz, R.W.5
  • 14
    • 84884918881 scopus 로고    scopus 로고
    • Chronic use of opioid medications before and after bariatric surgery
    • PID: 24084922, COI: 1:CAS:528:DC%2BC3sXhs1Wmu7nM
    • Raebel MA, Newcomer SR, Reifler LM, Boudreau D, Elliott TE, DeBar L, et al. Chronic use of opioid medications before and after bariatric surgery. JAMA. 2013;310:1369–76.
    • (2013) JAMA , vol.310 , pp. 1369-1376
    • Raebel, M.A.1    Newcomer, S.R.2    Reifler, L.M.3    Boudreau, D.4    Elliott, T.E.5    DeBar, L.6
  • 15
    • 80052314519 scopus 로고    scopus 로고
    • Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population
    • PID: 20411349
    • Lloret Linares C, Hajj A, Poitou C, Simoneau G, Clement K, Laplanche JL, et al. Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population. Obes Surg. 2011;21:1257–64.
    • (2011) Obes Surg , vol.21 , pp. 1257-1264
    • Lloret Linares, C.1    Hajj, A.2    Poitou, C.3    Simoneau, G.4    Clement, K.5    Laplanche, J.L.6
  • 17
    • 34247595372 scopus 로고    scopus 로고
    • Comorbidity of obesity and pain in a general population: results from the Southern Pain Prevalence Study
    • PID: 17337251
    • Hitt HC, McMillen RC, Thornton-Neaves T, Koch K, Cosby AG. Comorbidity of obesity and pain in a general population: results from the Southern Pain Prevalence Study. J Pain. 2007;8:430–6.
    • (2007) J Pain , vol.8 , pp. 430-436
    • Hitt, H.C.1    McMillen, R.C.2    Thornton-Neaves, T.3    Koch, K.4    Cosby, A.G.5
  • 19
    • 79960285690 scopus 로고    scopus 로고
    • Validity of leg-to-leg bioelectrical impedance analysis to estimate body fat in obesity
    • PID: 20936394
    • Lloret Linares C, Ciangura C, Bouillot JL, Coupaye M, Decleves X, Poitou C, et al. Validity of leg-to-leg bioelectrical impedance analysis to estimate body fat in obesity. Obes Surg. 2011;21:917–23.
    • (2011) Obes Surg , vol.21 , pp. 917-923
    • Lloret Linares, C.1    Ciangura, C.2    Bouillot, J.L.3    Coupaye, M.4    Decleves, X.5    Poitou, C.6
  • 20
    • 0015357864 scopus 로고
    • The relation of total body potassium to height, weight, and age in normal adults
    • PID: 4625433, COI: 1:STN:280:DyaE383jtlejsw%3D%3D
    • Boddy K, King PC, Hume R, Weyers E. The relation of total body potassium to height, weight, and age in normal adults. J Clin Pathol. 1972;25:512–7.
    • (1972) J Clin Pathol , vol.25 , pp. 512-517
    • Boddy, K.1    King, P.C.2    Hume, R.3    Weyers, E.4
  • 23
    • 0017081447 scopus 로고
    • Gentamicin serum concentrations: pharmacokinetic predictions
    • PID: 942138, COI: 1:STN:280:DyaE283ltFSquw%3D%3D
    • Hull JH, Sarubbi FA Jr. Gentamicin serum concentrations: pharmacokinetic predictions. Ann Intern Med. 1976;85:183–9.
    • (1976) Ann Intern Med , vol.85 , pp. 183-189
    • Hull, J.H.1    Sarubbi, F.A.2
  • 24
    • 0344839037 scopus 로고    scopus 로고
    • Laparoscopic Roux-en-Y gastric bypass: initial 2-year experience
    • PID: 12582767, COI: 1:STN:280:DC%2BD3s7nvFGrtA%3D%3D
    • Suter M, Giusti V, Heraief E, Zysset F, Calmes JM. Laparoscopic Roux-en-Y gastric bypass: initial 2-year experience. Surg Endosc. 2003;17:603–9.
    • (2003) Surg Endosc , vol.17 , pp. 603-609
    • Suter, M.1    Giusti, V.2    Heraief, E.3    Zysset, F.4    Calmes, J.M.5
  • 25
    • 84871621665 scopus 로고    scopus 로고
    • Sensory impairment in obese patients? sensitivity and pain detection thresholds for electrical stimulation after surgery-induced weight loss, and comparison with a nonobese population
    • PID: 22688605
    • Dodet P, Perrot S, Auvergne L, Hajj A, Simoneau G, Decleves X, et al. Sensory impairment in obese patients? sensitivity and pain detection thresholds for electrical stimulation after surgery-induced weight loss, and comparison with a nonobese population. Clin J Pain. 2013;29:43–9.
    • (2013) Clin J Pain , vol.29 , pp. 43-49
    • Dodet, P.1    Perrot, S.2    Auvergne, L.3    Hajj, A.4    Simoneau, G.5    Decleves, X.6
  • 26
    • 0025954733 scopus 로고
    • Systemic morphine pharmacokinetics after ocular administration
    • PID: 1783997, COI: 1:CAS:528:DyaK3MXmt1aksLk%3D
    • Chast F, Bardin C, Sauvageon-Martre H, Callaert S, Chaumeil JC. Systemic morphine pharmacokinetics after ocular administration. J Pharm Sci. 1991;80:911–7.
    • (1991) J Pharm Sci , vol.80 , pp. 911-917
    • Chast, F.1    Bardin, C.2    Sauvageon-Martre, H.3    Callaert, S.4    Chaumeil, J.C.5
  • 27
    • 58549105374 scopus 로고    scopus 로고
    • Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)
    • PID: 18987623, COI: 1:CAS:528:DC%2BD1MXmt1CrtQ%3D%3D
    • Hirt D, Urien S, Ekouevi DK, Rey E, Arrive E, Blanche S, et al. Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109). Clin Pharmacol Ther. 2009;85:182–9.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 182-189
    • Hirt, D.1    Urien, S.2    Ekouevi, D.K.3    Rey, E.4    Arrive, E.5    Blanche, S.6
  • 28
    • 41849116628 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model
    • PID: 18440921, COI: 1:CAS:528:DC%2BD1cXlvVGqsbk%3D
    • Staahl C, Upton R, Foster DJ, Christrup LL, Kristensen K, Hansen SH, et al. Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model. J Clin Pharmacol. 2008;48:619–31.
    • (2008) J Clin Pharmacol , vol.48 , pp. 619-631
    • Staahl, C.1    Upton, R.2    Foster, D.J.3    Christrup, L.L.4    Kristensen, K.5    Hansen, S.H.6
  • 29
    • 18544402304 scopus 로고    scopus 로고
    • Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers
    • PID: 10201674, COI: 1:CAS:528:DyaK1MXisV2kur4%3D
    • Lotsch J, Weiss M, Ahne G, Kobal G, Geisslinger G. Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers. Anesthesiology. 1999;90:1026–38.
    • (1999) Anesthesiology , vol.90 , pp. 1026-1038
    • Lotsch, J.1    Weiss, M.2    Ahne, G.3    Kobal, G.4    Geisslinger, G.5
  • 30
  • 31
    • 84878548932 scopus 로고    scopus 로고
    • Blood alcohol concentrations rise rapidly and dramatically after Roux-en-Y gastric bypass
    • PID: 23507629
    • Steffen KJ, Engel SG, Pollert GA, Li C, Mitchell JE. Blood alcohol concentrations rise rapidly and dramatically after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2013;9:470–3.
    • (2013) Surg Obes Relat Dis , vol.9 , pp. 470-473
    • Steffen, K.J.1    Engel, S.G.2    Pollert, G.A.3    Li, C.4    Mitchell, J.E.5
  • 32
    • 0027460865 scopus 로고
    • Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations
    • PID: 8491060, COI: 1:STN:280:DyaK3s3lvV2msA%3D%3D
    • Hasselstrom J, Sawe J. Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Clin Pharmacokinet. 1993;24:344–54.
    • (1993) Clin Pharmacokinet , vol.24 , pp. 344-354
    • Hasselstrom, J.1    Sawe, J.2
  • 33
    • 0347504918 scopus 로고    scopus 로고
    • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine
    • PID: 14663457, COI: 1:CAS:528:DC%2BD3sXps1ertbo%3D
    • Kharasch ED, Hoffer C, Whittington D, Sheffels P. Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. Clin Pharmacol Ther. 2003;74:543–54.
    • (2003) Clin Pharmacol Ther , vol.74 , pp. 543-554
    • Kharasch, E.D.1    Hoffer, C.2    Whittington, D.3    Sheffels, P.4
  • 34
    • 84862936370 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis
    • PID: 22031624, COI: 1:CAS:528:DC%2BC38Xjs1ajs7c%3D
    • Xu J, Kulkarni SR, Li L, Slitt AL. UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis. Drug Metab Dispos. 2012;40:259–66.
    • (2012) Drug Metab Dispos , vol.40 , pp. 259-266
    • Xu, J.1    Kulkarni, S.R.2    Li, L.3    Slitt, A.L.4
  • 35
    • 0036146638 scopus 로고    scopus 로고
    • UDP glucuronosyltransferase mRNA levels in human liver disease
    • PID: 11792680, COI: 1:CAS:528:DC%2BD38XosFaiug%3D%3D
    • Congiu M, Mashford ML, Slavin JL, Desmond PV. UDP glucuronosyltransferase mRNA levels in human liver disease. Drug Metab Dispos. 2002;30:129–34.
    • (2002) Drug Metab Dispos , vol.30 , pp. 129-134
    • Congiu, M.1    Mashford, M.L.2    Slavin, J.L.3    Desmond, P.V.4
  • 36
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • PID: 21633179, COI: 1:CAS:528:DC%2BC3MXnsVais7Y%3D
    • Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011;121:2111–7.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 37
    • 0032931896 scopus 로고    scopus 로고
    • Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method
    • COI: 1:CAS:528:DyaK1MXjvVKrsbw%3D
    • Tchernof A, Levesque E, Beaulieu M, Couture P, Despres JP, Hum DW, et al. Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method. Clin Endocrinol (Oxf). 1999;50:637–42.
    • (1999) Clin Endocrinol (Oxf) , vol.50 , pp. 637-642
    • Tchernof, A.1    Levesque, E.2    Beaulieu, M.3    Couture, P.4    Despres, J.P.5    Hum, D.W.6
  • 38
    • 0037133285 scopus 로고    scopus 로고
    • Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    • PID: 11854119, COI: 1:CAS:528:DC%2BD38XitlOls7o%3D
    • Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation. 2002;105:804–9.
    • (2002) Circulation , vol.105 , pp. 804-809
    • Ziccardi, P.1    Nappo, F.2    Giugliano, G.3    Esposito, K.4    Marfella, R.5    Cioffi, M.6
  • 40
    • 36048936308 scopus 로고    scopus 로고
    • Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese
    • PID: 17947717, COI: 1:CAS:528:DC%2BD2sXhtlCgsLjJ
    • Sparreboom A, Wolff AC, Mathijssen RH, Chatelut E, Rowinsky EK, Verweij J, et al. Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese. J Clin Oncol. 2007;25:4707–13.
    • (2007) J Clin Oncol , vol.25 , pp. 4707-4713
    • Sparreboom, A.1    Wolff, A.C.2    Mathijssen, R.H.3    Chatelut, E.4    Rowinsky, E.K.5    Verweij, J.6
  • 41
    • 34547431719 scopus 로고    scopus 로고
    • Antimicrobial dosing considerations in obese adult patients
    • PID: 17655508, COI: 1:CAS:528:DC%2BD2sXptlKqtL4%3D
    • Pai MP, Bearden DT. Antimicrobial dosing considerations in obese adult patients. Pharmacotherapy. 2007;27:1081–91.
    • (2007) Pharmacotherapy , vol.27 , pp. 1081-1091
    • Pai, M.P.1    Bearden, D.T.2
  • 42
    • 3843141820 scopus 로고    scopus 로고
    • What is the best size descriptor to use for pharmacokinetic studies in the obese?
    • PID: 15255794
    • Green B, Duffull SB. What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol. 2004;58:119–33.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 119-133
    • Green, B.1    Duffull, S.B.2
  • 43
    • 84897905004 scopus 로고    scopus 로고
    • The scientific basis of body surface area-based dosing
    • PID: 24646485, COI: 1:CAS:528:DC%2BC2cXltVSqtb4%3D
    • Chatelut E, Puisset F. The scientific basis of body surface area-based dosing. Clin Pharmacol Ther. 2014;95:359–61.
    • (2014) Clin Pharmacol Ther , vol.95 , pp. 359-361
    • Chatelut, E.1    Puisset, F.2
  • 44
    • 0029867902 scopus 로고    scopus 로고
    • Effect of food on the comparative pharmacokinetics of modified-release morphine tablet formulations: oramorph SR and MST Continus
    • PID: 8735684, COI: 1:CAS:528:DyaK28XjsFWiur8%3D
    • Drake J, Kirkpatrick CT, Aliyar CA, Crawford FE, Gibson P, Horth CE. Effect of food on the comparative pharmacokinetics of modified-release morphine tablet formulations: oramorph SR and MST Continus. Br J Clin Pharmacol. 1996;41:417–20.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 417-420
    • Drake, J.1    Kirkpatrick, C.T.2    Aliyar, C.A.3    Crawford, F.E.4    Gibson, P.5    Horth, C.E.6
  • 45
    • 0025755623 scopus 로고
    • Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients—a comparison of two oral formulations
    • PID: 1653145, COI: 1:STN:280:DyaK3MzlslSluw%3D%3D
    • Hasselstrom J, Alexander N, Bringel C, Svensson JO, Sawe J. Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients—a comparison of two oral formulations. Eur J Clin Pharmacol. 1991;40:585–91.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 585-591
    • Hasselstrom, J.1    Alexander, N.2    Bringel, C.3    Svensson, J.O.4    Sawe, J.5
  • 46
    • 0025190756 scopus 로고
    • Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide
    • PID: 2295214, COI: 1:CAS:528:DyaK3cXptFWqtw%3D%3D
    • Osborne R, Joel S, Trew D, Slevin M. Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther. 1990;47:12–9.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 12-19
    • Osborne, R.1    Joel, S.2    Trew, D.3    Slevin, M.4
  • 47
    • 0036792226 scopus 로고    scopus 로고
    • Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
    • PID: 12357145
    • Lotsch J, Zimmermann M, Darimont J, Marx C, Dudziak R, Skarke C, Geisslinger G. Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity? Anesthesiology. 2002;97:814–9.
    • (2002) Anesthesiology , vol.97 , pp. 814-819
    • Lotsch, J.1    Zimmermann, M.2    Darimont, J.3    Marx, C.4    Dudziak, R.5    Skarke, C.6    Geisslinger, G.7
  • 48
    • 0037261291 scopus 로고    scopus 로고
    • Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers
    • PID: 12545149, COI: 1:CAS:528:DC%2BD3sXhtlKgt7g%3D
    • Skarke C, Darimont J, Schmidt H, Geisslinger G, Lotsch J. Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers. Clin Pharmacol Ther. 2003;73:107–21.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 107-121
    • Skarke, C.1    Darimont, J.2    Schmidt, H.3    Geisslinger, G.4    Lotsch, J.5
  • 49
    • 4344639444 scopus 로고    scopus 로고
    • Accuracy of pharmacokinetic models for predicting plasma fentanyl concentrations in lean and obese surgical patients: derivation of dosing weight (“pharmacokinetic mass”)
    • PID: 15329584, COI: 1:CAS:528:DC%2BD2cXntV2itbo%3D
    • Shibutani K, Inchiosa MA Jr, Sawada K, Bairamian M. Accuracy of pharmacokinetic models for predicting plasma fentanyl concentrations in lean and obese surgical patients: derivation of dosing weight (“pharmacokinetic mass”). Anesthesiology. 2004;101:603–13.
    • (2004) Anesthesiology , vol.101 , pp. 603-613
    • Shibutani, K.1    Inchiosa, M.A.2    Sawada, K.3    Bairamian, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.