Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model

Journal of Clinical Pharmacology

Volumn 48, Issue 5, 2008, Pages 619-631

  Staahl, Camilla ^a,b   Upton, Richard ^c   Foster, David J R ^d   Christrup, Lona Louring ^e   Kristensen, Kim ^f   Hansen, Steen Honoré ^e   Arendt Nielsen, Lars ^b   Drewes, Asbjørn Mohr ^a,b  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f ASTRAZENECA R AND D   (Sweden)

Author keywords

Experimental pain; Morphine; Oxycodone; Pharmaco kinetics; Pharmacodynamics

Indexed keywords

MORPHINE; OXYCODONE; OXYNORM; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ANALGESIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; ELECTROSTIMULATION; ESOPHAGUS; FEMALE; HUMAN; MALE; MECHANICAL STIMULATION; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; RANDOMIZED CONTROLLED TRIAL; SKIN; THERMAL STIMULATION;

ADMINISTRATION, ORAL; ADULT; ALGORITHMS; ANALGESICS, OPIOID; AREA UNDER CURVE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTRIC STIMULATION; FEMALE; HEAT; HUMANS; INFUSIONS, PARENTERAL; MALE; MODELS, BIOLOGICAL; MORPHINE; OXYCODONE; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION;

EID: 41849116628     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270008314465     Document Type: Article

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