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Volumn 58, Issue 2, 2004, Pages 119-133

What is the best size descriptor to use for pharmacokinetic studies in the obese?

Author keywords

Body mass index; Body surface area; Body weight; Obesity; Pharmacokinetics

Indexed keywords

BODY FAT; BODY MASS; BODY SIZE; BODY SURFACE; BODY WEIGHT; CHRONIC DRUG ADMINISTRATION; DISTRIBUTION VOLUME; DOSE CALCULATION; DRUG CLEARANCE; HUMAN; INDIVIDUALITY; LEAN BODY WEIGHT; LIPOPHILICITY; MEDICAL LITERATURE; OBESITY; PHARMACOKINETICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW;

EID: 3843141820     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2004.02157.x     Document Type: Review
Times cited : (296)

References (81)
  • 1
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-43.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 3
    • 0035207420 scopus 로고    scopus 로고
    • Obesity, body fat distribution, and ambulatory blood pressure in children and adolescents
    • Lurbe E, Alvarez V, Redon J. Obesity, body fat distribution, and ambulatory blood pressure in children and adolescents. J Clin Hypertens 2001; 3: 362-7.
    • (2001) J Clin Hypertens , vol.3 , pp. 362-367
    • Lurbe, E.1    Alvarez, V.2    Redon, J.3
  • 4
    • 0035514956 scopus 로고    scopus 로고
    • Obesity and disease management: Effects of weight loss on comorbid conditions
    • Anderson JW, Konz EC. Obesity and disease management: effects of weight loss on comorbid conditions. Obes Res 2001; 9: 326S-334S.
    • (2001) Obes Res , vol.9
    • Anderson, J.W.1    Konz, E.C.2
  • 6
    • 0032956432 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in obesity
    • Blouin RA, Warren GW. Pharmacokinetic considerations in obesity. J Pharm Sci 1999; 88: 1-7.
    • (1999) J Pharm Sci , vol.88 , pp. 1-7
    • Blouin, R.A.1    Warren, G.W.2
  • 7
    • 0034043474 scopus 로고    scopus 로고
    • Glomerular filtration rate in severely overweight normotensive humans
    • Anastasio P, Spitali L, Frangiosa A et al. Glomerular filtration rate in severely overweight normotensive humans. Am J Kidney Dis 2000; 35: 1144-8.
    • (2000) Am J Kidney Dis , vol.35 , pp. 1144-1148
    • Anastasio, P.1    Spitali, L.2    Frangiosa, A.3
  • 8
    • 0026738042 scopus 로고
    • Renal hemodynamics in recent-onset type II diabetes
    • Nowack R, Raum E, Blum W, Ritz E. Renal hemodynamics in recent-onset type II diabetes. Am J Kidney Dis 1992; 20: 342-7.
    • (1992) Am J Kidney Dis , vol.20 , pp. 342-347
    • Nowack, R.1    Raum, E.2    Blum, W.3    Ritz, E.4
  • 9
    • 0016916438 scopus 로고
    • Prediction of creatinine clearance from serum creatinine
    • Cockroft DW, Gault H. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.
    • (1976) Nephron , vol.16 , pp. 31-41
    • Cockroft, D.W.1    Gault, H.2
  • 12
    • 0027223897 scopus 로고
    • Clinical pharmacokietics of drugs in obesity
    • Cheymol G. Clinical pharmacokietics of drugs in obesity. Clin Pharmacokinet 1993; 25: 103-14.
    • (1993) Clin Pharmacokinet , vol.25 , pp. 103-114
    • Cheymol, G.1
  • 13
    • 0033800745 scopus 로고    scopus 로고
    • Effects of obesity on pharmacokinetics
    • Cheymol G. Effects of obesity on pharmacokinetics. Clin Pharmacokinet 2000; 39: 215-31.
    • (2000) Clin Pharmacokinet , vol.39 , pp. 215-231
    • Cheymol, G.1
  • 14
  • 16
    • 0002051622 scopus 로고
    • The composition of adipose tissue and the nonadipose body of obese and nonobese man
    • Morse W, Soeldner JS. The composition of adipose tissue and the nonadipose body of obese and nonobese man. Metabolism 1963; 12: 99-107.
    • (1963) Metabolism , vol.12 , pp. 99-107
    • Morse, W.1    Soeldner, J.S.2
  • 17
    • 33744839368 scopus 로고
    • Clinical calorimetry. Tenth paper. A formula to estimate the approximate surface area if height and weight be known
    • Du Bois D, Du Bois EF. Clinical calorimetry. Tenth paper. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916; 17: 863.
    • (1916) Arch Intern Med , vol.17 , pp. 863
    • Du Bois, D.1    Du Bois, E.F.2
  • 18
    • 0001192085 scopus 로고
    • Oberflächenmessungen des menschlichen körpers
    • Meeh K., Oberflächenmessungen des menschlichen körpers. Ztschr f Biol, München, 1879; 15: 425-58.
    • (1879) Ztschr F Biol, München , vol.15 , pp. 425-458
    • Meeh, K.1
  • 19
    • 0023662620 scopus 로고
    • Simplified calculation of body surfaced area
    • Mosteller RD. Simplified calculation of body surfaced area. N Eng J Med 1987; 317: 1098.
    • (1987) N Eng J Med , vol.317 , pp. 1098
    • Mosteller, R.D.1
  • 20
    • 3843151696 scopus 로고    scopus 로고
    • Distribution and discordance of body surface area (BSA) and body mass index (BMI) in 4514 patients with malignancy. The utility of BMI to identify obese patients and its implications in BSA adjusted dosing of cytotoxics
    • Dooley M, Singh S, Poole S, Toner G, Michael M. Distribution and discordance of body surface area (BSA) and body mass index (BMI) in 4514 patients with malignancy. The utility of BMI to identify obese patients and its implications in BSA adjusted dosing of cytotoxics. Proc Am Soc Clin Oncol 2002; 21: 356.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 356
    • Dooley, M.1    Singh, S.2    Poole, S.3    Toner, G.4    Michael, M.5
  • 21
    • 0018783843 scopus 로고
    • Erroneous nomograms for body-surface area
    • Turcotte G. Erroneous nomograms for body-surface area. N Eng J Med 1979; 300: 1339.
    • (1979) N Eng J Med , vol.300 , pp. 1339
    • Turcotte, G.1
  • 22
    • 3843083039 scopus 로고
    • Stat Bull Metropolitan Life Insurance Co October
    • Ideal Weights for Women. Stat Bull Metropolitan Life Insurance Co October 1942.
    • (1942) Ideal Weights for Women
  • 23
    • 3843148462 scopus 로고
    • Stat Bull Metropolitan Life Insurance Co June
    • Ideal Weights for Men. Stat Bull Metropolitan Life Insurance Co June 1943.
    • (1943) Ideal Weights for Men
  • 24
    • 3843072195 scopus 로고
    • Stat Bull Metropolitan Life Insurance Co Nov-Dec
    • New Weight Standards for Men and Women. Stat Bull Metropolitan Life Insurance Co Nov-Dec 1959; 40: 1-4.
    • (1959) New Weight Standards for Men and Women , vol.40 , pp. 1-4
  • 25
    • 3843071143 scopus 로고
    • Stat Bull Metropolitan Life Insurance Co
    • Mortality among overweight men and women. Stat Bull Metropolitan Life Insurance Co 1960; 41: 6.
    • (1960) Mortality among Overweight Men and Women , vol.41 , pp. 6
  • 26
    • 0004329301 scopus 로고
    • New York; Peter Mallon
    • Society of Actuaries. Build and Blood Pressure Study. New York; Peter Mallon, 1959.
    • (1959) Build and Blood Pressure Study
  • 28
    • 0016278917 scopus 로고
    • Case study number 25 gentamicin therapy
    • Devine D. Case study number 25 gentamicin therapy. Drug Intell Clin Pharm 1974; 8: 650-5.
    • (1974) Drug Intell Clin Pharm , vol.8 , pp. 650-655
    • Devine, D.1
  • 29
    • 0001049153 scopus 로고
    • The determination of total body fat by means of the body specific gravity
    • Rathbun EN, Pace N. The determination of total body fat by means of the body specific gravity. J Biol Chem 1945; 158: 667-76.
    • (1945) J Biol Chem , vol.158 , pp. 667-676
    • Rathbun, E.N.1    Pace, N.2
  • 30
    • 0015040524 scopus 로고
    • Relationship between total body water and surface area in normal and obese subjects
    • Hume R, Weyers E. Relationship between total body water and surface area in normal and obese subjects. J Clin Pathol 1971; 24: 234-8.
    • (1971) J Clin Pathol , vol.24 , pp. 234-238
    • Hume, R.1    Weyers, E.2
  • 31
    • 0014115757 scopus 로고
    • The assessment of the amount of fat in the human body from measurements of skinfold thickness
    • Durnin JVGA, Rahaman MM. The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr 1967; 21: 681-9.
    • (1967) Br J Nutr , vol.21 , pp. 681-689
    • Durnin, J.V.G.A.1    Rahaman, M.M.2
  • 32
    • 18844478413 scopus 로고
    • Estimation of the fat-free mass of twenty subjects from measurements of total body potassium, body density, skinfold thickness, and height and weight
    • Boddy K, King PC, Hume R, Weyers E. Estimation of the fat-free mass of twenty subjects from measurements of total body potassium, body density, skinfold thickness, and height and weight. Proc Nutr Soc 1972; 31: 35A.
    • (1972) Proc Nutr Soc , vol.31
    • Boddy, K.1    King, P.C.2    Hume, R.3    Weyers, E.4
  • 33
    • 0022553636 scopus 로고
    • Validation of tetrapolar bioelectrical impedance method to assess human body composition
    • Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 1986; 60: 1327-32.
    • (1986) J Appl Physiol , vol.60 , pp. 1327-1332
    • Lukaski, H.C.1    Bolonchuk, W.W.2    Hall, C.B.3    Siders, W.A.4
  • 34
    • 0023881187 scopus 로고
    • Lean body mass estimation by bioelectrical impedance analysis: A four-site cross-validation study
    • Segal KR, Van Loan M, Fitzgerald PI, Hodgdon JA, Van Itallie TB. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin Nutr 1988; 47: 7-14.
    • (1988) Am J Clin Nutr , vol.47 , pp. 7-14
    • Segal, K.R.1    Van Loan, M.2    Fitzgerald, P.I.3    Hodgdon, J.A.4    Van Itallie, T.B.5
  • 37
    • 0027372614 scopus 로고
    • The pharmacokinetics and pharmacodynamics of 12 weeks of glyburide therapy in obese diabetics
    • Jaber LA, Antal EJ, Slaughter RL, Welshman IR. The pharmacokinetics and pharmacodynamics of 12 weeks of glyburide therapy in obese diabetics. Eur J Clin Pharmacol 1993; 45: 459-63.
    • (1993) Eur J Clin Pharmacol , vol.45 , pp. 459-463
    • Jaber, L.A.1    Antal, E.J.2    Slaughter, R.L.3    Welshman, I.R.4
  • 38
    • 0004245626 scopus 로고
    • London: Her Majesty's Stationery Office
    • James W. Research on Obesity. London: Her Majesty's Stationery Office, 1976.
    • (1976) Research on Obesity
    • James, W.1
  • 39
    • 0028281786 scopus 로고
    • Lean body mass as a predictor of drug dosage
    • Morgan DJ, Bray KM. Lean body mass as a predictor of drug dosage. Clin Pharmacokinet 1994; 26: 292-307.
    • (1994) Clin Pharmacokinet , vol.26 , pp. 292-307
    • Morgan, D.J.1    Bray, K.M.2
  • 40
    • 0036908986 scopus 로고    scopus 로고
    • Caution when lean body weight is used as a size descriptor for obese subjects
    • Green B, Duffull S. Caution when lean body weight is used as a size descriptor for obese subjects. Clin Pharmacol Ther 2002; 72: 743-4.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 743-744
    • Green, B.1    Duffull, S.2
  • 41
    • 0020625997 scopus 로고
    • Influence of weight on aminoglycoside pharmacokinetics in normal weight and morbidly obese patients
    • Bauer LA, Edwards WA, Dellinger EP, Simonowitz DA. Influence of weight on aminoglycoside pharmacokinetics in normal weight and morbidly obese patients. Eur J Clin Pharmacol 1983; 24: 643-7.
    • (1983) Eur J Clin Pharmacol , vol.24 , pp. 643-647
    • Bauer, L.A.1    Edwards, W.A.2    Dellinger, E.P.3    Simonowitz, D.A.4
  • 44
    • 0034947990 scopus 로고    scopus 로고
    • Efficient screening of covariates in population models using Wald's approximation to the liklihood ratio test
    • Kowalski KC, Hutmacher MM. Efficient screening of covariates in population models using Wald's approximation to the liklihood ratio test. J Pharmacokinet Pharmacodynam 2001; 28: 253-75.
    • (2001) J Pharmacokinet Pharmacodynam , vol.28 , pp. 253-275
    • Kowalski, K.C.1    Hutmacher, M.M.2
  • 45
    • 0027049043 scopus 로고
    • Building population pharmacokinetic-pharmacodynamic models. I. Models for covariate effects
    • Mandema JW, Verotta D, Sheiner LB. Building population pharmacokinetic-pharmacodynamic models. I. Models for covariate effects. J Pharmacokinet Biopharm 1992; 20: 511-28.
    • (1992) J Pharmacokinet Biopharm , vol.20 , pp. 511-528
    • Mandema, J.W.1    Verotta, D.2    Sheiner, L.B.3
  • 46
    • 0028031207 scopus 로고
    • Interaction between structural, statistical, and covariate models in population pharmacokinetic analysis
    • Wade JR, Beal SL, Sambol NC. Interaction between structural, statistical, and covariate models in population pharmacokinetic analysis. J Pharmacokinet Biopharm 1994; 22: 165-77.
    • (1994) J Pharmacokinet Biopharm , vol.22 , pp. 165-177
    • Wade, J.R.1    Beal, S.L.2    Sambol, N.C.3
  • 47
    • 85046914570 scopus 로고    scopus 로고
    • Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis
    • Wahlby U, Jonsson EN, Karlsson MO. Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis. MPS Pharm Sci 2002; 4: 27.
    • (2002) MPS Pharm Sci , vol.4 , pp. 27
    • Wahlby, U.1    Jonsson, E.N.2    Karlsson, M.O.3
  • 48
    • 0034954242 scopus 로고    scopus 로고
    • Assessment of actual significance levels for covariate effects in NONMEM
    • Wahlby U, Jonsson EN, Karlsson MO. Assessment of actual significance levels for covariate effects in NONMEM. J Pharmacokinet Pharmacodyn 2001; 28: 231-52.
    • (2001) J Pharmacokinet Pharmacodyn , vol.28 , pp. 231-252
    • Wahlby, U.1    Jonsson, E.N.2    Karlsson, M.O.3
  • 49
    • 0015357864 scopus 로고
    • The relationship of total body potassium to height, weight and age in normal subjects
    • Boddy K, King PC, Hume R, Weyers E. The relationship of total body potassium to height, weight and age in normal subjects. J Clin Pathol 1972; 25: 512-7.
    • (1972) J Clin Pathol , vol.25 , pp. 512-517
    • Boddy, K.1    King, P.C.2    Hume, R.3    Weyers, E.4
  • 50
    • 0015401903 scopus 로고
    • A comparison of the fat free mass of young adults estimated by anthropometry, body density and total potassium content
    • Womersley J, Boddy K, King PC, Durnin JVGA. A comparison of the fat free mass of young adults estimated by anthropometry, body density and total potassium content. Clin Sci 1972; 43: 469-75.
    • (1972) Clin Sci , vol.43 , pp. 469-475
    • Womersley, J.1    Boddy, K.2    King, P.C.3    Durnin, J.V.G.A.4
  • 52
    • 0033926129 scopus 로고    scopus 로고
    • The effect of body weight on dalteparin pharmacokinetics. A preliminary study
    • Yee JY, Duffull SB. The effect of body weight on dalteparin pharmacokinetics. A preliminary study. Eur J Clin Pharmacol 2000; 56: 293-7.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 293-297
    • Yee, J.Y.1    Duffull, S.B.2
  • 53
    • 0027401831 scopus 로고
    • Effect of obesity on vancomycin pharmacokinetic parameters as determined by using a Bayesian forecasting technique
    • Vance-Bryan K, Guay DR, Gilliland SS, Rodvold KA, Rotschafer JC. Effect of obesity on vancomycin pharmacokinetic parameters as determined by using a Bayesian forecasting technique. Antimicrob Agents Chemother 1993; 37: 436-40.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 436-440
    • Vance-Bryan, K.1    Guay, D.R.2    Gilliland, S.S.3    Rodvold, K.A.4    Rotschafer, J.C.5
  • 54
    • 0033564364 scopus 로고    scopus 로고
    • The impact of obesity and disease on busulfan oral clearance in adults
    • Gibbs JP, Gooley T, Corneau B et al. The impact of obesity and disease on busulfan oral clearance in adults. Blood 1999; 93: 4436-40.
    • (1999) Blood , vol.93 , pp. 4436-4440
    • Gibbs, J.P.1    Gooley, T.2    Corneau, B.3
  • 56
    • 0024367984 scopus 로고
    • Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution
    • Lind MJ, Margison JM, Cerny T, Thatcher N, Wilkinson PM. Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution. Cancer Chemother Pharmacol 1989; 25: 139-42.
    • (1989) Cancer Chemother Pharmacol , vol.25 , pp. 139-142
    • Lind, M.J.1    Margison, J.M.2    Cerny, T.3    Thatcher, N.4    Wilkinson, P.M.5
  • 57
    • 0028916829 scopus 로고
    • Caffeine pharmacokinetics in obesity and following significant weight reduction
    • Caraco Y, Zylber-Katz E, Berry EM, Levy M. Caffeine pharmacokinetics in obesity and following significant weight reduction. Int J Obes Relat Metab Disord 1995; 19: 234-9.
    • (1995) Int J Obes Relat Metab Disord , vol.19 , pp. 234-239
    • Caraco, Y.1    Zylber-Katz, E.2    Berry, E.M.3    Levy, M.4
  • 62
    • 0036738186 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers
    • Sanderink GJ, Le Liboux A, Jariwala N et al. The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers. Clin Pharmacol Ther 2002; 72: 308-18.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 308-318
    • Sanderink, G.J.1    Le Liboux, A.2    Jariwala, N.3
  • 63
    • 0038115062 scopus 로고    scopus 로고
    • Development of a dosing strategy for enoxaparin in obese patients
    • Green B, Duffull S. Development of a dosing strategy for enoxaparin in obese patients. Br J Clin Pharmacol 2002; 56: 96-103.
    • (2002) Br J Clin Pharmacol , vol.56 , pp. 96-103
    • Green, B.1    Duffull, S.2
  • 65
    • 0031155476 scopus 로고    scopus 로고
    • How to predict carboplatin clearance from standard morphological and biological characteristics in obese patients
    • Benezet S, Guimbaud R, Chatelut E, Chevreau C, Bugat R, Canal P. How to predict carboplatin clearance from standard morphological and biological characteristics in obese patients. Ann Oncol 1997; 8: 607-9.
    • (1997) Ann Oncol , vol.8 , pp. 607-609
    • Benezet, S.1    Guimbaud, R.2    Chatelut, E.3    Chevreau, C.4    Bugat, R.5    Canal, P.6
  • 66
    • 0034809384 scopus 로고    scopus 로고
    • Population pharmacodynamics in patients receiving tinzaparin for the prevention and treatment of deep vein thrombosis
    • Barrett JS, Gibiansky E, Hull RD et al. Population pharmacodynamics in patients receiving tinzaparin for the prevention and treatment of deep vein thrombosis. Int J Clin Pharmacol Ther 2001; 39: 431-46.
    • (2001) Int J Clin Pharmacol Ther , vol.39 , pp. 431-446
    • Barrett, J.S.1    Gibiansky, E.2    Hull, R.D.3
  • 67
    • 0031696064 scopus 로고    scopus 로고
    • Remifentanil pharmacokinetics in obese versus lean patients
    • Egan TD, Huizinga B, Gupta SK et al. Remifentanil pharmacokinetics in obese versus lean patients. Anesthesiology 1998; 89: 562-73.
    • (1998) Anesthesiology , vol.89 , pp. 562-573
    • Egan, T.D.1    Huizinga, B.2    Gupta, S.K.3
  • 68
    • 0028960340 scopus 로고
    • Bayesian estimation of p-aminohippurate clearance by a limited sampling strategy
    • Kinowski JM, Rodier M, Bressolle F et al. Bayesian estimation of p-aminohippurate clearance by a limited sampling strategy. J Pharm Sci 1995; 84: 307-11.
    • (1995) J Pharm Sci , vol.84 , pp. 307-311
    • Kinowski, J.M.1    Rodier, M.2    Bressolle, F.3
  • 70
    • 0032822884 scopus 로고    scopus 로고
    • The influence of renal function on the pharmacokinetics and pharmacodynamics and simulated time course of doxacurium
    • Fisher D, Schoolar Reynolds K, Schmith VD et al. The influence of renal function on the pharmacokinetics and pharmacodynamics and simulated time course of doxacurium. Anesth Analg 1999; 89: 789-95.
    • (1999) Anesth Analg , vol.89 , pp. 789-795
    • Fisher, D.1    Schoolar Reynolds, K.2    Schmith, V.D.3
  • 71
    • 0035999631 scopus 로고    scopus 로고
    • Population pharmacokinetics model and limited sampling strategy for intravenous vinorelbine derived from phase I clinical trials
    • Nguyen L, Tranchand B, Puozzo C, Variol P. Population pharmacokinetics model and limited sampling strategy for intravenous vinorelbine derived from phase I clinical trials. Br J Clin Pharmacol 2002; 53: 459-68.
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 459-468
    • Nguyen, L.1    Tranchand, B.2    Puozzo, C.3    Variol, P.4
  • 72
    • 6844250116 scopus 로고    scopus 로고
    • Population pharmacokinetics of total and unbound etoposide
    • Nguyen L, Chatelut E, Chevreau C et al. Population pharmacokinetics of total and unbound etoposide. Cancer Chemother Pharmacol 1998; 41: 125-32.
    • (1998) Cancer Chemother Pharmacol , vol.41 , pp. 125-132
    • Nguyen, L.1    Chatelut, E.2    Chevreau, C.3
  • 78
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 1992; 41: 368-77.
    • (1992) Diabetes , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 79
    • 0020317168 scopus 로고
    • Prolongation of drug half-life due to obesity: Studies of desmethyldiazepam (clorazepate)
    • Abernethy DR, Greenblatt DJ, Divoll M, Shader RI. Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate). J Pharm Sci 1982; 71: 942-4.
    • (1982) J Pharm Sci , vol.71 , pp. 942-944
    • Abernethy, D.R.1    Greenblatt, D.J.2    Divoll, M.3    Shader, R.I.4
  • 80
    • 0023805638 scopus 로고
    • Effect of body weight on the volume of distribution of theophylline
    • Rizzo A, Mirabella A, Bonanno A. Effect of body weight on the volume of distribution of theophylline. Lung 1988; 166: 269-76.
    • (1988) Lung , vol.166 , pp. 269-276
    • Rizzo, A.1    Mirabella, A.2    Bonanno, A.3
  • 81
    • 0021943575 scopus 로고
    • Phenytoin disposition in obesity. Determination of loading dose
    • Abernethy DR, Greenblatt DJ. Phenytoin disposition in obesity. Determination of loading dose. Arch Neurol 1985; 42: 468-71.
    • (1985) Arch Neurol , vol.42 , pp. 468-471
    • Abernethy, D.R.1    Greenblatt, D.J.2


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