Pharmacokinetics and protein binding of cefazolin in morbidly obese patients

European Journal of Clinical Pharmacology

Volumn 67, Issue 10, 2011, Pages 985-992

  Van Kralingen, Simone ^a,c   Taks, Margot ^a   Diepstraten, Jeroen ^a   Van De Garde, Ewoudt M ^a   Van Dongen, Eric P ^a   Wiezer, Marinus J ^a   Van Ramshorst, Bert ^a   Vlaminckx, Bart ^a   Deneer, Vera H ^a   Knibbe, Catherijne A ^a,b  

^a ST ANTONIUS HOSPITAL   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

Author keywords

Antibiotics; Bariatric surgery; Cefazolin; Morbid; Obesity

Indexed keywords

CEFAZOLIN;

ADULT; AGE; ARTICLE; BARIATRIC SURGERY; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL TRIAL; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG PROTEIN BINDING; FEMALE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MORBID OBESITY; PRIORITY JOURNAL; SURGICAL INFECTION;

ADULT; AGE FACTORS; ANTI-BACTERIAL AGENTS; BARIATRIC SURGERY; CEFAZOLIN; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; OBESITY, MORBID; PROSPECTIVE STUDIES; PROTEIN BINDING;

EID: 80054740906     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1048-x     Document Type: Article

References (28)

1. PG Kopelman 2000 Obesity as a medical problem Nature 404 635 643 10766250 1:CAS:528:DC%2BD3cXis1Grtb8%3D (Pubitemid 30205068)
2. AH Mokdad ES Ford BA Bowman WH Dietz F Vinicor VS Bales JS Marks 2003 Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 JAMA 289 76 79 12503980 10.1001/jama.289.1.76 (Pubitemid 36026281)
3. JW Greve IM Janssen B van Ramshorst 2007 Gastric reduction in morbidly obese adults in the Netherlands Ned Tijdschr Geneeskd 151 1116 1120 17557667 1:STN:280:DC%2BD2szksFChtA%3D%3D (Pubitemid 47040762)
4. EJ DeMaria 2007 Bariatric surgery for morbid obesity N Engl J Med 356 2176 2183 17522401 10.1056/NEJMct067019 1:CAS:528:DC%2BD2sXlvVChu7k%3D (Pubitemid 47010843)
5. PS Choban R Heckler JC Burge L Flancbaum 1995 Increased incidence of nosocomial infections in obese surgical patients Am Surg 61 1001 1005 7486411 1:STN:280:DyaK28%2FivFGltg%3D%3D (Pubitemid 26166662)
6. GT Lesser S Deutsch 1967 Measurement of adipose tissue blood flow and perfusion in man by uptake of 85Kr J Appl Physiol 23 621 630 6061376 1:STN:280:DyaF1c%2FlsVOguw%3D%3D
7. WJ Pories AM van Rij BT Burlingham RS Fulghum D Meelheim 1981 Prophylactic cefazolin in gastric bypass surgery Surgery 90 426 432 7020141 1:STN:280:DyaL3M3kvFynug%3D%3D (Pubitemid 11047258)
8. RA Forse B Karam LD MacLean NV Christou 1989 Antibiotic prophylaxis for surgery in morbidly obese patients Surgery 106 750 756 2799651 1:STN:280:DyaK3c%2FhvF2ktg%3D%3D discussion 756-7
9. CE Edmiston C Krepel H Kelly J Larson D Andris C Hennen A Nakeeb JR Wallace 2004 Perioperative antibiotic prophylaxis in the gastric bypass patient: do we achieve therapeutic levels? Surgery 136 738 747 15467657 10.1016/j.surg.2004.06.022 (Pubitemid 39311298)
10. ME Falagas DE Karageorgopoulos 2010 Adjustment of dosing of antimicrobial agents for bodyweight in adults Lancet 375 248 251 19875163 10.1016/S0140-6736(09)60743-1
11. Kahlmeter GBD, Canton T European committee on antimicrobial susceptibility testing. Available at: www.eucast.org. Assessed 22 Mar 2011
12. http://www.prezies.nl/zkh/publicaties/20080100-praktijkgids-powi.pdf. Accessed 22 Mar 2011
13. MJ Ahsman ED Wildschut D Tibboel RA Mathot 2009 Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates Antimicrob Agents Chemother 53 75 80 18955527 10.1128/AAC.00636-08 1:CAS:528:DC%2BD1MXhs1Kksrg%3D
14. C Kamani 1998 HPLC determination of cefazolin in plasma, urine and dialysis fluid J Pharm Pharmacol 50 118 10.1111/j.2042-7158.1998.tb02318.x 1:CAS:528:DyaK1cXmtlKltbo%3D
15. JW Vella-Brincat EJ Begg CM Kirkpatrick M Zhang ST Chambers K Gallagher 2007 Protein binding of cefazolin is saturable in vivo both between and within patients Br J Clin Pharmacol 63 753 757 17223858 10.1111/j.1365-2125.2006.02827. x 1:CAS:528:DC%2BD2sXntl2rs7s%3D (Pubitemid 46753567)
16. JH Proost DKF Meijer 1992 MW/PHARM, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring Comput Biol Med 22 155 163 1617949 10.1016/0010-4825(92)90011-B 1:CAS:528:DyaK38XkvVarsrg%3D
17. Website for Mediware software. Available at: http://www.mediware.nl/ downloads/documentation/UK-315-VOL3.PDF. Accessed 22 Mar 2011
18. JH Proost 1985 Wagner's exact Loo-Riegelman equation: the need for a criterion to choose between the linear and logarithmic trapezoidal rule J Pharm Sci 74 793 794 4032259 10.1002/jps.2600740724 1:STN:280:DyaL2M3pt1KjsA%3D%3D
19. PY Han SB Duffull CM Kirkpatrick B Green 2007 Dosing in obesity: a simple solution to a big problem Clin Pharmacol Ther 82 505 508 17952107 10.1038/sj.clpt.6100381 1:CAS:528:DC%2BD2sXhtF2qs7bI (Pubitemid 47622534)
20. S Schmidt R Banks V Kumar KH Rand H Derendorf 2008 Clinical microdialysis in skin and soft tissues: an update J Clin Pharmacol 48 351 364 18285620 10.1177/0091270007312152 1:CAS:528:DC%2BD1cXjs1ektLw%3D (Pubitemid 351257772)
21. P Delanaye EP Cohen 2008 Formula-based estimates of the GFR: equations variable and uncertain Nephron Clin Pract 110 c48 c53 18708727 10.1159/000151436 1:CAS:528:DC%2BD1cXhtFCis7vO discussion c54
22. JK Alexander EW Dennis WG Smith KH Amad WC Duncan RC Austin 1962 Blood volume, cardiac output, and distribution of systemic blood flow in extreme obesity Cardiovasc Res Cent Bull 1 39 44 14011956
23. Marshall BEWH (ed) (1980) The pharmacological basis of therapeutics, vol. 285. MacMillan, New York
24. WD Welch JP Jantzen K Johnson RE Bawdon 1985 Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery Antimicrob Agents Chemother 27 874 875 4015078 1:STN:280:DyaL2M3ltVemtw%3D%3D (Pubitemid 15122010)
25. DW Polly Jr JJ Meter R Brueckner L Asplund BE van Dam 1996 The effect of intraoperative blood loss on serum cefazolin level in patients undergoing instrumented spinal fusion. A prospective, controlled study Spine (Phila Pa 1976) 21 2363 2367 10.1097/00007632-199610150-00011 (Pubitemid 26362119)
26. D Sue TA Salazar K Turley BJ Guglielmo 1989 Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics Ann Thorac Surg 47 857 859 2757440 10.1016/0003-4975(89)90020-9 1:STN:280:DyaL1MzjsVCnug%3D%3D (Pubitemid 19182526)
27. SM Swoboda C Merz J Kostuik B Trentler PA Lipsett 1996 Does intraoperative blood loss affect antibiotic serum and tissue concentrations? Arch Surg 131 1165 1171 8911256 1:STN:280:DyaK2s%2Fmsl2hug%3D%3D discussion 1171-2
28. H Ohge Y Takesue T Yokoyama Y Murakami E Hiyama Y Yokoyama T Kanehiro H Itaha Y Matsuura 1999 An additional dose of cefazolin for intraoperative prophylaxis Surg Today 29 1233 1236 10639702 10.1007/BF02482213 1:CAS:528:DC%2BD3cXptlWruw%3D%3D (Pubitemid 30026613)