-
2
-
-
0028492040
-
The mitogen-activated protein kinases, ERK1 and ERK2
-
Cobb M.H., Hepler J.E., Cheng M., and Robbins D. The mitogen-activated protein kinases, ERK1 and ERK2. Semin. Cancer Biol. 5 (1994) 261-268
-
(1994)
Semin. Cancer Biol.
, vol.5
, pp. 261-268
-
-
Cobb, M.H.1
Hepler, J.E.2
Cheng, M.3
Robbins, D.4
-
3
-
-
34248563299
-
Role of mitogen-activated protein kinase kinase kinases in signal integration
-
Cuevas B.D., Abell A.N., and Johnson G.L. Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26 (2007) 3159-3171
-
(2007)
Oncogene
, vol.26
, pp. 3159-3171
-
-
Cuevas, B.D.1
Abell, A.N.2
Johnson, G.L.3
-
4
-
-
34248563290
-
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
-
Meloche S., and Pouyssegur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26 (2007) 3227-3239
-
(2007)
Oncogene
, vol.26
, pp. 3227-3239
-
-
Meloche, S.1
Pouyssegur, J.2
-
5
-
-
14944350982
-
Regulatory mechanisms and function of ERK MAP kinases
-
Torii S., Nakayama K., Yamamoto T., and Nishida E. Regulatory mechanisms and function of ERK MAP kinases. J. Biochem. 136 (2004) 557-561
-
(2004)
J. Biochem.
, vol.136
, pp. 557-561
-
-
Torii, S.1
Nakayama, K.2
Yamamoto, T.3
Nishida, E.4
-
6
-
-
20444418706
-
MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression
-
Johnson G.L., Dohlman H.G., and Graves L.M. MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression. Curr. Opin. Chem. Biol. 9 (2005) 325-331
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 325-331
-
-
Johnson, G.L.1
Dohlman, H.G.2
Graves, L.M.3
-
7
-
-
0028103004
-
RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2
-
Jelinek T., Catling A.D., Reuter C.W., Moodie S.A., Wolfman A., and Weber M.J. RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2. Mol. Cell. Biol. 14 (1994) 8212-8218
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 8212-8218
-
-
Jelinek, T.1
Catling, A.D.2
Reuter, C.W.3
Moodie, S.A.4
Wolfman, A.5
Weber, M.J.6
-
8
-
-
0027428530
-
Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation
-
Huang W., Alessandrini A., Crews C.M., and Erikson R.L. Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. Proc. Natl. Acad. Sci. USA 90 (1993) 10947-10951
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10947-10951
-
-
Huang, W.1
Alessandrini, A.2
Crews, C.M.3
Erikson, R.L.4
-
9
-
-
0034704153
-
MEKK1 binds raf-1 and the ERK2 cascade components
-
Karandikar M., Xu S., and Cobb M.H. MEKK1 binds raf-1 and the ERK2 cascade components. J. Biol. Chem. 275 (2000) 40120-40127
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40120-40127
-
-
Karandikar, M.1
Xu, S.2
Cobb, M.H.3
-
10
-
-
0024324790
-
Phosphorylation of microtubule-associated protein 2 by MAP kinase primarily involves the projection domain
-
Silliman C.C., and Sturgill T.W. Phosphorylation of microtubule-associated protein 2 by MAP kinase primarily involves the projection domain. Biochem. Biophys. Res. Commun. 160 (1989) 993-998
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.160
, pp. 993-998
-
-
Silliman, C.C.1
Sturgill, T.W.2
-
11
-
-
0022213027
-
Major substrate for growth factor-activated protein-tyrosine kinases is a low-abundance protein
-
Cooper J.A., and Hunter T. Major substrate for growth factor-activated protein-tyrosine kinases is a low-abundance protein. Mol. Cell. Biol. 5 (1985) 3304-3309
-
(1985)
Mol. Cell. Biol.
, vol.5
, pp. 3304-3309
-
-
Cooper, J.A.1
Hunter, T.2
-
12
-
-
0141611211
-
Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase
-
Rossomando A.J., Payne D.M., Weber M.J., and Sturgill T.W. Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc. Natl. Acad. Sci. USA 86 (1989) 6940-6943
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 6940-6943
-
-
Rossomando, A.J.1
Payne, D.M.2
Weber, M.J.3
Sturgill, T.W.4
-
13
-
-
0021911948
-
Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells
-
Kohno M. Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells. J. Biol. Chem. 260 (1985) 1771-1779
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 1771-1779
-
-
Kohno, M.1
-
14
-
-
0032720680
-
MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells
-
Rivard N., Boucher M.J., Asselin C., and L'Allemain G. MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells. Am. J. Physiol. 277 (1999) C652-C664
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Rivard, N.1
Boucher, M.J.2
Asselin, C.3
L'Allemain, G.4
-
15
-
-
0029786329
-
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
-
Lavoie J.N., L'Allemain G., Brunet A., Muller R., and Pouyssegur J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271 (1996) 20608-20616
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20608-20616
-
-
Lavoie, J.N.1
L'Allemain, G.2
Brunet, A.3
Muller, R.4
Pouyssegur, J.5
-
16
-
-
0034634574
-
Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner
-
Casanovas O., Miro F., Estanyol J.M., Itarte E., Agell N., and Bachs O. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J. Biol. Chem. 275 (2000) 35091-35097
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35091-35097
-
-
Casanovas, O.1
Miro, F.2
Estanyol, J.M.3
Itarte, E.4
Agell, N.5
Bachs, O.6
-
17
-
-
0036169078
-
Targeted inactivation of p53 in human cells does not result in aneuploidy
-
Bunz F., Fauth C., Speicher M.R., Dutriaux A., Sedivy J.M., Kinzler K.W., Vogelstein B., and Lengauer C. Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res. 62 (2002) 1129-1133
-
(2002)
Cancer Res.
, vol.62
, pp. 1129-1133
-
-
Bunz, F.1
Fauth, C.2
Speicher, M.R.3
Dutriaux, A.4
Sedivy, J.M.5
Kinzler, K.W.6
Vogelstein, B.7
Lengauer, C.8
-
18
-
-
0032495589
-
The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells
-
Alblas J., Slager-Davidov R., Steenbergh P.H., Sussenbach J.S., and van der Burg B. The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells. Oncogene 16 (1998) 131-139
-
(1998)
Oncogene
, vol.16
, pp. 131-139
-
-
Alblas, J.1
Slager-Davidov, R.2
Steenbergh, P.H.3
Sussenbach, J.S.4
van der Burg, B.5
-
19
-
-
24744438238
-
Hepatocyte growth factor induces redistribution of p21(CIP1) p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells
-
Han J., Tsukada Y., Hara E., Kitamura N., and Tanaka T. Hepatocyte growth factor induces redistribution of p21(CIP1) p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J. Biol. Chem. 280 (2005) 31548-31556
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31548-31556
-
-
Han, J.1
Tsukada, Y.2
Hara, E.3
Kitamura, N.4
Tanaka, T.5
-
20
-
-
0032192153
-
Senescence of human fibroblasts induced by oncogenic Raf
-
Zhu J., Woods D., McMahon M., and Bishop J.M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12 (1998) 2997-3007
-
(1998)
Genes Dev.
, vol.12
, pp. 2997-3007
-
-
Zhu, J.1
Woods, D.2
McMahon, M.3
Bishop, J.M.4
-
21
-
-
0033543549
-
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
-
Kamakura S., Moriguchi T., and Nishida E. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J. Biol. Chem. 274 (1999) 26563-26571
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26563-26571
-
-
Kamakura, S.1
Moriguchi, T.2
Nishida, E.3
-
22
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M., Lin A.W., McCurrach M.E., Beach D., and Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 (1997) 593-602
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
23
-
-
0031985094
-
Activated Raf-1 causes growth arrest in human small cell lung cancer cells
-
Ravi R.K., Weber E., McMahon M., Williams J.R., Baylin S., Mal A., Harter M.L., Dillehay L.E., Claudio P.P., Giordano A., Nelkin B.D., and Mabry M. Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J. Clin. Invest. 101 (1998) 153-159
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 153-159
-
-
Ravi, R.K.1
Weber, E.2
McMahon, M.3
Williams, J.R.4
Baylin, S.5
Mal, A.6
Harter, M.L.7
Dillehay, L.E.8
Claudio, P.P.9
Giordano, A.10
Nelkin, B.D.11
Mabry, M.12
-
24
-
-
36549068158
-
Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways
-
discussion 959-64
-
dKunnimalaiyaan M., Ndiaye M., and Chen H. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery 142 (2007) 959-964 discussion 959-64
-
(2007)
Surgery
, vol.142
, pp. 959-964
-
-
dKunnimalaiyaan, M.1
Ndiaye, M.2
Chen, H.3
-
25
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
Wang W., Chen J.X., Liao R., Deng Q., Zhou J.J., Huang S., and Sun P. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol. Cell. Biol. 22 (2002) 3389-3403
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
Deng, Q.4
Zhou, J.J.5
Huang, S.6
Sun, P.7
-
26
-
-
0036237039
-
Oncogenic ras and p53 cooperate to induce cellular senescence
-
Ferbeyre G., de Stanchina E., Lin A.W., Querido E., McCurrach M.E., Hannon G.J., and Lowe S.W. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol. 22 (2002) 3497-3508
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3497-3508
-
-
Ferbeyre, G.1
de Stanchina, E.2
Lin, A.W.3
Querido, E.4
McCurrach, M.E.5
Hannon, G.J.6
Lowe, S.W.7
-
27
-
-
0032504784
-
p19ARF links the tumour suppressor p53 to Ras
-
Palmero I., Pantoja C., and Serrano M. p19ARF links the tumour suppressor p53 to Ras. Nature 395 (1998) 125-126
-
(1998)
Nature
, vol.395
, pp. 125-126
-
-
Palmero, I.1
Pantoja, C.2
Serrano, M.3
-
28
-
-
27144478655
-
Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling
-
Cammarano M.S., Nekrasova T., Noel B., and Minden A. Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling. Mol. Cell. Biol. 25 (2005) 9532-9542
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 9532-9542
-
-
Cammarano, M.S.1
Nekrasova, T.2
Noel, B.3
Minden, A.4
-
29
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin A.W., Barradas M., Stone J.C., van Aelst L., Serrano M., and Lowe S.W. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12 (1998) 3008-3019
-
(1998)
Genes Dev.
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
30
-
-
26644461205
-
Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21
-
Nakagawa M., Oliva J.L., Kothapalli D., Fournier A., Assoian R.K., and Kazanietz M.G. Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21. J. Biol. Chem. 280 (2005) 33926-33934
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33926-33934
-
-
Nakagawa, M.1
Oliva, J.L.2
Kothapalli, D.3
Fournier, A.4
Assoian, R.K.5
Kazanietz, M.G.6
-
31
-
-
2442675270
-
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest
-
Todd D.E., Densham R.M., Molton S.A., Balmanno K., Newson C., Weston C.R., Garner A.P., Scott L., and Cook S.J. ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest. Oncogene 23 (2004) 3284-3295
-
(2004)
Oncogene
, vol.23
, pp. 3284-3295
-
-
Todd, D.E.1
Densham, R.M.2
Molton, S.A.3
Balmanno, K.4
Newson, C.5
Weston, C.R.6
Garner, A.P.7
Scott, L.8
Cook, S.J.9
-
32
-
-
0842346437
-
Principles of tumor suppression
-
Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
-
(2004)
Cell
, vol.116
, pp. 235-246
-
-
Sherr, C.J.1
-
33
-
-
0036714366
-
Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1
-
Squires M.S., Nixon P.M., and Cook S.J. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem. J. 366 (2002) 673-680
-
(2002)
Biochem. J.
, vol.366
, pp. 673-680
-
-
Squires, M.S.1
Nixon, P.M.2
Cook, S.J.3
-
34
-
-
0033613250
-
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts
-
Wright J.H., Munar E., Jameson D.R., Andreassen P.R., Margolis R.L., Seger R., and Krebs E.G. Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc. Natl. Acad. Sci. USA 96 (1999) 11335-11340
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11335-11340
-
-
Wright, J.H.1
Munar, E.2
Jameson, D.R.3
Andreassen, P.R.4
Margolis, R.L.5
Seger, R.6
Krebs, E.G.7
-
35
-
-
6344235546
-
MEK1 and MEK2, different regulators of the G1/S transition
-
Ussar S., and Voss T. MEK1 and MEK2, different regulators of the G1/S transition. J. Biol. Chem. 279 (2004) 43861-43869
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 43861-43869
-
-
Ussar, S.1
Voss, T.2
-
36
-
-
0033848878
-
Integrating the MAP kinase signal into the G1 phase cell cycle machinery
-
Roovers K., and Assoian R.K. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22 (2000) 818-826
-
(2000)
Bioessays
, vol.22
, pp. 818-826
-
-
Roovers, K.1
Assoian, R.K.2
-
37
-
-
0033613944
-
Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
-
Abbott D.W., and Holt J.T. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J. Biol. Chem. 274 (1999) 2732-2742
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2732-2742
-
-
Abbott, D.W.1
Holt, J.T.2
-
38
-
-
1242272924
-
The MAP kinase pathway is required for entry into mitosis and cell survival
-
Liu X., Yan S., Zhou T., Terada Y., and Erikson R.L. The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 23 (2004) 763-776
-
(2004)
Oncogene
, vol.23
, pp. 763-776
-
-
Liu, X.1
Yan, S.2
Zhou, T.3
Terada, Y.4
Erikson, R.L.5
-
39
-
-
2942615282
-
Polo-like kinases and the orchestration of cell division
-
Barr F.A., Sillje H.H., and Nigg E.A. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5 (2004) 429-440
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 429-440
-
-
Barr, F.A.1
Sillje, H.H.2
Nigg, E.A.3
-
40
-
-
1242290740
-
Mek2 is dispensable for mouse growth and development
-
Belanger L.F., Roy S., Tremblay M., Brott B., Steff A.M., Mourad W., Hugo P., Erikson R., and Charron J. Mek2 is dispensable for mouse growth and development. Mol. Cell. Biol. 23 (2003) 4778-4787
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4778-4787
-
-
Belanger, L.F.1
Roy, S.2
Tremblay, M.3
Brott, B.4
Steff, A.M.5
Mourad, W.6
Hugo, P.7
Erikson, R.8
Charron, J.9
-
41
-
-
0033535584
-
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
-
Giroux S., Tremblay M., Bernard D., Cardin-Girard J.F., Aubry S., Larouche L., Rousseau S., Huot J., Landry J., Jeannotte L., and Charron J. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9 (1999) 369-372
-
(1999)
Curr. Biol.
, vol.9
, pp. 369-372
-
-
Giroux, S.1
Tremblay, M.2
Bernard, D.3
Cardin-Girard, J.F.4
Aubry, S.5
Larouche, L.6
Rousseau, S.7
Huot, J.8
Landry, J.9
Jeannotte, L.10
Charron, J.11
-
42
-
-
0030760981
-
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism
-
Xu S., Khoo S., Dang A., Witt S., Do V., Zhen E., Schaefer E.M., and Cobb M.H. Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism. Mol. Endocrinol. 11 (1997) 1618-1625
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 1618-1625
-
-
Xu, S.1
Khoo, S.2
Dang, A.3
Witt, S.4
Do, V.5
Zhen, E.6
Schaefer, E.M.7
Cobb, M.H.8
-
43
-
-
0027397368
-
Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase
-
Wu J., Harrison J.K., Vincent L.A., Haystead C., Haystead T.A., Michel H., Hunt D.F., Lynch K.R., and Sturgill T.W. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. Proc. Natl. Acad. Sci. USA 90 (1993) 173-177
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 173-177
-
-
Wu, J.1
Harrison, J.K.2
Vincent, L.A.3
Haystead, C.4
Haystead, T.A.5
Michel, H.6
Hunt, D.F.7
Lynch, K.R.8
Sturgill, T.W.9
-
44
-
-
0028219853
-
Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation
-
Rossomando A.J., Dent P., Sturgill T.W., and Marshak D.R. Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation. Mol. Cell. Biol. 14 (1994) 1594-1602
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1594-1602
-
-
Rossomando, A.J.1
Dent, P.2
Sturgill, T.W.3
Marshak, D.R.4
-
45
-
-
0038269059
-
Mechanism of mitosis-specific activation of MEK1
-
Harding A., Giles N., Burgess A., Hancock J.F., and Gabrielli B.G. Mechanism of mitosis-specific activation of MEK1. J. Biol. Chem. 278 (2003) 16747-16754
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16747-16754
-
-
Harding, A.1
Giles, N.2
Burgess, A.3
Hancock, J.F.4
Gabrielli, B.G.5
-
46
-
-
0037016678
-
Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway
-
Sharma P., Veeranna, Sharma M., Amin N.D., Sihag R.K., Grant P., Ahn N., Kulkarni A.B., and Pant H.C. Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J. Biol. Chem. 277 (2002) 528-534
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 528-534
-
-
Sharma, P.1
Veeranna2
Sharma, M.3
Amin, N.D.4
Sihag, R.K.5
Grant, P.6
Ahn, N.7
Kulkarni, A.B.8
Pant, H.C.9
-
47
-
-
0028276218
-
Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)
-
Brunet A., Pages G., and Pouyssegur J. Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1). FEBS Lett. 346 (1994) 299-303
-
(1994)
FEBS Lett.
, vol.346
, pp. 299-303
-
-
Brunet, A.1
Pages, G.2
Pouyssegur, J.3
-
48
-
-
0036333485
-
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
-
Eblen S.T., Slack J.K., Weber M.J., and Catling A.D. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol. Cell. Biol. 22 (2002) 6023-6033
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6023-6033
-
-
Eblen, S.T.1
Slack, J.K.2
Weber, M.J.3
Catling, A.D.4
-
49
-
-
37549016809
-
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels
-
Lefloch R., Pouyssegur J., and Lenormand P. Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol. Cell. Biol. 28 (2008) 511-527
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 511-527
-
-
Lefloch, R.1
Pouyssegur, J.2
Lenormand, P.3
-
50
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pages G., Guerin S., Grall D., Bonino F., Smith A., Anjuere F., Auberger P., and Pouyssegur J. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286 (1999) 1374-1377
-
(1999)
Science
, vol.286
, pp. 1374-1377
-
-
Pages, G.1
Guerin, S.2
Grall, D.3
Bonino, F.4
Smith, A.5
Anjuere, F.6
Auberger, P.7
Pouyssegur, J.8
-
51
-
-
10744228332
-
Essential role for ERK2 mitogen-activated protein kinase in placental development
-
Hatano N., Mori Y., Oh-hora M., Kosugi A., Fujikawa T., Nakai N., Niwa H., Miyazaki J., Hamaoka T., and Ogata M. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8 (2003) 847-856
-
(2003)
Genes Cells
, vol.8
, pp. 847-856
-
-
Hatano, N.1
Mori, Y.2
Oh-hora, M.3
Kosugi, A.4
Fujikawa, T.5
Nakai, N.6
Niwa, H.7
Miyazaki, J.8
Hamaoka, T.9
Ogata, M.10
-
52
-
-
0242607637
-
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
-
Saba-El-Leil M.K., Vella F.D., Vernay B., Voisin L., Chen L., Labrecque N., Ang S.L., and Meloche S. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4 (2003) 964-968
-
(2003)
EMBO Rep.
, vol.4
, pp. 964-968
-
-
Saba-El-Leil, M.K.1
Vella, F.D.2
Vernay, B.3
Voisin, L.4
Chen, L.5
Labrecque, N.6
Ang, S.L.7
Meloche, S.8
-
53
-
-
0027331491
-
Investigation of the role of G1/S cell cycle mediators in cellular senescence
-
Afshari C.A., Vojta P.J., Annab L.A., Futreal P.A., Willard T.B., and Barrett J.C. Investigation of the role of G1/S cell cycle mediators in cellular senescence. Exp. Cell Res. 209 (1993) 231-237
-
(1993)
Exp. Cell Res.
, vol.209
, pp. 231-237
-
-
Afshari, C.A.1
Vojta, P.J.2
Annab, L.A.3
Futreal, P.A.4
Willard, T.B.5
Barrett, J.C.6
-
54
-
-
0028225705
-
Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors
-
Chuang C.F., and Ng S.Y. Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors. FEBS Lett. 346 (1994) 229-234
-
(1994)
FEBS Lett.
, vol.346
, pp. 229-234
-
-
Chuang, C.F.1
Ng, S.Y.2
-
55
-
-
0026464922
-
Signal transduction within the nucleus by mitogen-activated protein kinase
-
Seth A., Gonzalez F.A., Gupta S., Raden D.L., and Davis R.J. Signal transduction within the nucleus by mitogen-activated protein kinase. J. Biol. Chem. 267 (1992) 24796-24804
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 24796-24804
-
-
Seth, A.1
Gonzalez, F.A.2
Gupta, S.3
Raden, D.L.4
Davis, R.J.5
-
56
-
-
33845904217
-
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
-
Vantaggiato C., Formentini I., Bondanza A., Bonini C., Naldini L., and Brambilla R. ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J. Biol. 5 (2006) 14
-
(2006)
J. Biol.
, vol.5
, pp. 14
-
-
Vantaggiato, C.1
Formentini, I.2
Bondanza, A.3
Bonini, C.4
Naldini, L.5
Brambilla, R.6
-
57
-
-
33947511318
-
MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines
-
Chrestensen C.A., Shuman J.K., Eschenroeder A., Worthington M., Gram H., and Sturgill T.W. MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines. J. Biol. Chem. 282 (2007) 4243-4252
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 4243-4252
-
-
Chrestensen, C.A.1
Shuman, J.K.2
Eschenroeder, A.3
Worthington, M.4
Gram, H.5
Sturgill, T.W.6
-
58
-
-
0029029894
-
The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle
-
Rana B., Xie Y., Mischoulon D., Bucher N.L., and Farmer S.R. The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle. J. Biol. Chem. 270 (1995) 18123-18132
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18123-18132
-
-
Rana, B.1
Xie, Y.2
Mischoulon, D.3
Bucher, N.L.4
Farmer, S.R.5
-
59
-
-
0035914307
-
ERK2- and p90(Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor
-
Hanlon M., Sturgill T.W., and Sealy L. ERK2- and p90(Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor. J. Biol. Chem. 276 (2001) 38449-38456
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38449-38456
-
-
Hanlon, M.1
Sturgill, T.W.2
Sealy, L.3
-
60
-
-
0028866816
-
Raf-1 kinase and ERK2 uncoupled from mitogenic signals in rat fibroblasts
-
Kortenjann M., and Shaw P.E. Raf-1 kinase and ERK2 uncoupled from mitogenic signals in rat fibroblasts. Oncogene 11 (1995) 2105-2112
-
(1995)
Oncogene
, vol.11
, pp. 2105-2112
-
-
Kortenjann, M.1
Shaw, P.E.2
-
61
-
-
33744543239
-
ERK2 is required for efficient terminal differentiation of skeletal myoblasts
-
Li J., and Johnson S.E. ERK2 is required for efficient terminal differentiation of skeletal myoblasts. Biochem. Biophys. Res. Commun. (2006)
-
(2006)
Biochem. Biophys. Res. Commun.
-
-
Li, J.1
Johnson, S.E.2
-
62
-
-
0036312641
-
Downregulation of ERK2 is essential for the inhibition of radiation-induced cell death in HSP25 overexpressed L929 cells
-
Cho H.N., Lee Y.J., Cho C.K., Lee S.J., and Lee Y.S. Downregulation of ERK2 is essential for the inhibition of radiation-induced cell death in HSP25 overexpressed L929 cells. Cell Death Differ. 9 (2002) 448-456
-
(2002)
Cell Death Differ.
, vol.9
, pp. 448-456
-
-
Cho, H.N.1
Lee, Y.J.2
Cho, C.K.3
Lee, S.J.4
Lee, Y.S.5
-
63
-
-
17844395484
-
Atorvastatin induces T cell anergy via phosphorylation of ERK1
-
Waiczies S., Prozorovski T., Infante-Duarte C., Hahner A., Aktas O., Ullrich O., and Zipp F. Atorvastatin induces T cell anergy via phosphorylation of ERK1. J. Immunol. 174 (2005) 5630-5635
-
(2005)
J. Immunol.
, vol.174
, pp. 5630-5635
-
-
Waiczies, S.1
Prozorovski, T.2
Infante-Duarte, C.3
Hahner, A.4
Aktas, O.5
Ullrich, O.6
Zipp, F.7
-
64
-
-
0037449749
-
ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin
-
Roberts M.S., Woods A.J., Shaw P.E., and Norman J.C. ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin. J. Biol. Chem. 278 (2003) 1975-1985
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1975-1985
-
-
Roberts, M.S.1
Woods, A.J.2
Shaw, P.E.3
Norman, J.C.4
|