Activation of the mitogen-activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells

Journal of Neurochemistry

Volumn 79, Issue 1, 2001, Pages 45-54

  Yamazaki, Matsumi ^a   Chiba, Kenzo ^a   Mohri, Tetsuro ^a   Hatanaka, Hiroshi ^b  

^a HOKURIKU UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Genipin; Mitogen activated protein kinase; Nerve growth factor; Neurite outgrowth; Nitric oxide; PC12h cells

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; CYCLIC GMP; GENIPIN; GUANYLATE CYCLASE; IRIDOID; MITOGEN ACTIVATED PROTEIN KINASE; N(G) NITROARGININE METHYL ESTER; NERVE GROWTH FACTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; NERVE CELL CULTURE; NERVE FIBER GROWTH; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GUANYLATE CYCLASE; IRIDOIDS; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NEURITES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PC12 CELLS; PHOSPHORYLATION; PYRANS; RATS;

EID: 0034785360     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00533.x     Document Type: Article

References (29)

1. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor-NO through a radical reaction
2. Gases as biological messengers: Nitric oxide and carbon monoxide in the brain
3. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues
4. A synthetic inhibitor of the mitogen-activated protein kinase cascade
5. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
6. Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines
7. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
8. Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line
9. Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism
10. Neurotransmitter release regulated by nitric oxide in PC-12 cells and brain synaptosomes
11. Evidence that endogenous nitric oxide modulates oedema formation induced by substance P
12. Effects of iridoids on sex- and learning-behaviours in chronic stressed mice
13. Counteraction of genipin to the trauma- and scopolamine-induced impairment of memory in mice
14. FR144420, a novel, slow, nitric oxide-releasing agent
15. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle
16. Nerve growth factor increases the cyclic GMP level and activates the cyclic GMP phosphodiesterase in PC12 cells
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
19. Involvement of the NO-cGMP signaling pathway in the neuritogenesis of PC12h cells
20. G-nitro arginine methyl ester exhibits antinociceptive activity in the mouse
21. Neuronal nitric oxide synthase expression in neuronal cell differentiation
22. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
23. 1/2 activation in postcapillary endothelium
24. Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells
25. Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: A cGMP independent pathway
26. WAF1 regulates neuronal differentiation of PC12 cells
27. The guanylate cyclase/receptor family of proteins
28. Growth factor induction of nitric oxide synthase in rat pheochromocytoma cells
29. Neuritogenic effect of natural iridoid compounds on PC12h cells and its possible relation to signaling protein kinases