Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain

Brain, Behavior, and Immunity

Volumn 44, Issue , 2015, Pages 128-136

  Lewis, Susannah S ^a   Hutchinson, Mark R ^b   Frick, Morin M ^a   Zhang, Yingning ^a   Maier, Steven F ^a   Sammakia, Tarek ^a   Rice, Kenner C ^c   Watkins, Linda R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

(+) Naloxone; Corticosterone; Corticosterone 21 glucuronide; Estradiol; Estradiol 17 glucuronide; Estradiol 3 glucuronide; TLR4

Indexed keywords

CORTICOSTERONE; ESTRADIOL; ESTRADIOL 17 GLUCURONIDE; ESTROGEN; ETHYL GLUCURONIDE; GLUCURONIC ACID; GLUCURONIDE; LIPOPOLYSACCHARIDE; MORPHINE 3 GLUCURONIDE; NALOXONE; TOLL LIKE RECEPTOR 4; TRICYCLIC ANTIDEPRESSANT AGENT; ALKALINE PHOSPHATASE; SEX HORMONE; TLR4 PROTEIN, HUMAN;

ADULT; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC PAIN; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; GENETIC TRANSFECTION; GLUCURONIDATION; HEK293 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPORTER GENE; RHODOBACTER SPHAEROIDES; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; HUMAN; HYPERALGESIA; METABOLISM; MOLECULAR DOCKING; PAIN; SPRAGUE DAWLEY RAT; STIMULATION;

ALKALINE PHOSPHATASE; ANIMALS; CORTICOSTERONE; ESTRADIOL; GLUCURONIDES; GONADAL STEROID HORMONES; HEK293 CELLS; HUMANS; HYPERALGESIA; MALE; MOLECULAR DOCKING SIMULATION; NALOXONE; PAIN; PHYSICAL STIMULATION; RATS, SPRAGUE-DAWLEY; TOLL-LIKE RECEPTOR 4;

EID: 84918587962     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.09.004     Document Type: Article

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