Accurate determination of tissue steroid hormones, precursors and conjugates in adult male rat

Journal of Biochemistry

Volumn 153, Issue 1, 2013, Pages 63-71

  Maeda, Naoyuki ^a,b   Tanaka, Emi ^b   Suzuki, Tomokazu ^b   Okumura, Kanako ^a   Nomura, Sachiko ^a   Miyasho, Taku ^a   Haeno, Satoko ^a   Yokota, Hiroshi ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b Association of Meat Science and Technology Institute   (Japan)

Author keywords

accurate determination; conjugation; LC MS analysis; metabolism; tissue steroids

Indexed keywords

CORTICOSTERONE; GLUCURONIDE; PREGNENOLONE; STEROID HORMONE; TESTOSTERONE; TISSUE STEROID HORMONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ELECTROSPRAY; HORMONE DETERMINATION; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; MALE; MOUSE; NONHUMAN; PRECURSOR; SOLID PHASE EXTRACTION; TIME OF FLIGHT MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ADRENAL GLANDS; ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORTICOSTERONE; ESTRADIOL CONGENERS; GLUCURONIDES; KIDNEY; LIMIT OF DETECTION; LIVER; MALE; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFATES; TANDEM MASS SPECTROMETRY; TESTIS; TESTOSTERONE CONGENERS;

RATTUS;

EID: 84871628522     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvs121     Document Type: Article

References (39)

1. Holst, J.P., Soldin, O.P., Guo, T., and Soldin, S.J. (2004) Steroid hormones: relevance and measurement in the clinical laboratory. Clin. Lab. Med. 24, 105-118
2. Funderburgh, L.J., Zipf, W.B., and Sotos, J.F. (1983) Direct measurement of testosterone in a pediatric center, with use of a radioimmunoassay kit and unextracted serum. Clin. Chem. 29, 1796-1798
3. Turpeinen, U., Linko, S., Itkonen, O., and Hama la inen, E. (2008) Determination of testosterone in serum by liquid chromatography-tandem mass spectrometry. Scand. J. Clin. Lab. Invest. 68, 50-57
4. Cawood, M.L., Field, H.P., Ford, C.G., Gillingwater, S., Kicman, A., Cowan, D., and Barth, J.H. (2005) Testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry: validation of a method for routine clinical practice. Clin. Chem. 51, 1472-1479
5. Taieb, J., Mathian, B., Millot, F., Patricot, M.C., Mathieu, E., Queyrel, N., Lacroix, I., Somma-Delpero, C., and Boudou, P. (2003) Testosterone measured by 10 immunoassays and by isotope dilution-gas chromatography-mass spectrometry in sera from 116 men, women, and children. Clin. Chem. 49, 1381-1395
6. Kumar, V., Nakada, N., Yasojima, M., Yamashita, N., Johnson, A.C., and Tanaka, H. (2009) Rapid determination of free and conjugated estrogen in different water matrices by liquid chromatography-tandem mass spectrometry. Chemosphere 77, 1440-1446
7. Weng, Y., Xie, F., Xu, L., Zagorevski, D., Spink, D.C., and Ding, X. (2010) Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal. Biochem. 402, 121-128
8. Pozo, O.J., Deventer, K., Eenoo, P.V., and Delbeke, F.T. (2008) Efficient approach for the comprehensive detection of unknown anabolic steroids and metabolites in human urine by liquid chromatographyelectrospray-tandem mass spectrometry. Anal. Chem. 80, 1709-1720
9. Faupel-badger, J.M., Fuhrman, B.J., Xu, X., Falk, R.T., Keefer, L.K., Veenstra, T.D., Hoover, R.N., and Ziegler, R.G. (2010) Comparison of liquid chromatographytandem mass spectrometry, RIA,and ELISA methods for measurement of urinary estrogens. Cancer Epidemiol. Biomarkers Prev. 19, 292-300
10. Buiarelli, F., Coccioli, F., Merolle, M., Neri, B., and Terracciano, A. (2004) Development of a liquid chromatography-tandem mass spectrometry method for the identification of natural androgen steroids and their conjugates in urine samples. Anal. Chim. Acta 526, 113-120
11. Kumar, V., Nakada, N., Yasojima, M., Yamashita, N., Johnson, A.C., and Tanaka, H. (2009) Rapid determination of free and conjugated estrogen in different water matrices by liquid chromatography-tandem mass spectrometry. Chemosphere 77, 1440-1446
12. Hernande z, F., Sancho, J.V., and Pozo, O.J. (2005) Critical review of the application of liquid chro matography/mass spectrometry to the determination of pesticide residues in biological samples. Anal. Bioanal. Chem. 382, 934-946
13. Taylor, P.J. (2005) Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin. Biochem. 38, 328-334
14. Honour, J.W. (2010) Steroid assays in paediatric endocrinology. J. Clin. Res. Pediatr. Endocrinol. 2, 1-16
15. Yamashita, K., Miyashiro, Y., Maekubo, H., Okuyama, M., Honma, S., Takahashi, M., and Numazawa, M. (2009) Development of highly sensitive quantification method for testosterone and dihydrotestosterone in human serum and prostate tissue by liquid chromatography electrospray ionization tandem mass spectrometry. Steroids 74, 920-926
16. Pelander, A., Ojanpera, I., Laks, S., Rasanen, I., and Vuori, E. (2003) Toxicological screening with formulabased metabolite identification by liquid chromatography/time-of-flight mass spectrometry. Anal. Chem. 75, 5710-5718
17. Gergov, M., Boucher, B., Ojanpera, I., and Vuori, E. (2001) Toxicological screening of urine for drugs by liquid chromatography/time-of-flight mass spectrometry with automated target library search based on elemental formulas. Rapid Commun. Mass Spectrom. 15, 521-526
18. Ojanpera , S., Pelander, A., Pelzing, M., Krebs, I., Vuori, E., and Ojanpera , I. (2006) Isotopic pattern and accurate mass determination in urine drug screening by liquid chromatography/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 20, 1161-1167
19. FDA Draft Guidance (2001) Bioanalytical Methods Validation for Human Studies
20. Stuber, M. and Reemtsma, T. (2004) Evaluation of three calibration methods to compensate matrix effects in environmental analysis with LC-ESI-MS. Anal. Bioanal. Chem. 378, 910-916
21. Polettini, A., Gottardo, R., Pascali, J.P., and Tagliaro, F. (2008) Implementation and performance evaluation of a database of chemical formulas for the screening of pharmaco/toxicologically relevant compounds in biological samples using electrospray ionization-time-of-flight mass spectrometry. Anal. Chem. 80, 3050-3057
22. Peters, R.J., Bolck, Y.J., Rutgers, P., Stolker, A.A., and Nielen, M.W. (2009) Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry. J. Chromatogr. A. 1216, 8206-8216
23. Weng, Y., Xie, F., Xu, L., Zagorevski, D., Spink, D.C., and Ding, X. (2010) Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal. Biochem. 402, 121-128
24. Ebner, M.J., Corol, D.I., Havlkova , H., Honour, J.W., and Fry, J.P. (2006) Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain. Endocrinology 147, 179-190
25. Faupel-badger, J.M., Fuhrman, B.J., Xu, X., Falk, R.T., Keefer, L.K., Veenstra, T.D., Hoover, R.N., and Ziegler, R.G. (2010) Comparison of liquid chromatographytandem mass spectrometry, RIA, and ELISA methods for measurement of urinary estrogens. Cancer Epidemiol. Biomarkers Prev. 19, 292-300
26. Zhao, M., Baker, S.D., Yan, X., Zhao, Y., Wright, W.W., Zirkin, B.R., and Jarow, J.P. (2004) Simultaneous determination of steroid composition of human testicular fluid using liquid chromatography tandem mass spectrometry. Steroids 69, 721-726
27. Turgeon, J.L., Carr, M.C., Maki, P.M., Mendelsohn, M.E., and Wise, P.M. (2006) Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies. Endocr. Rev. 27, 575-605
28. Hojo, Y., Hattori, T.A., Enami, T., Furukawa, A., Suzuki, K., Ishii, H.T., Mukai, H., Morrison, J.H., Janssen, W.G., Kominami, S., Harada, N., Kimoto, T., and Kawato, S. (2004) Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc. Natl Acad. Sci. USA 101, 865-870
29. Kretz, O., Fester, L., Wehrenberg, U., Zhou, L., Brauckmann, S., Zhao, S., Prange-Kiel, J., Naumann, T., Jarry, H., Frotscher, M., and Rune, G.M. (2004) Hippocampal synapses depend on hippocampal estrogen synthesis. J. Neuro. Sci. 24, 5913-5921
30. Wang, G.M., Ge, R.S., Latif, S.A., Morris, D.J., and Hardy, M.P. (2002) Expression of 11beta-hydroxylase in rat Leydig cells. Endocrinology 143, 621-626
31. Monder, C., Miroff, Y., Marandici, A., and Hardy, M.P. (1994) 11beta-Hydroxysteroid dehydrogenase alleviates glucocorticoid-mediated inhibition of steroidogenesis in rat Leydig cells. Endocrinology 134, 1199-1204
32. Monder, C., Hardy, M.P., Blanchard, R.J., and Blanchard, D.C. (1994) Comparative aspects of 11beta-hydroxysteroid dehydrogenase-Testicular 11beta-hydroxysteroid dehydrogenase: development of a model for the mediation of Leydig cell function by corticosteroids. Steroids 59, 69-73
33. Higo, S., Hojo, Y., Ishii, H., Komatsuzaki, Y., Ooishi, Y., Murakami, G., Mukai, H., Yamazaki, T., Nakahara, D., Barron, A., Kimoto, T., and Kawato, S. (2011) Endogenous synthesis of corticosteroids in the hippocampus. PLoS One 6, e21631
34. Kallonen, S.E., Tammima ki, A., Piepponen, P., Raattamaa, H., Ketola, R.A., and Kostiainen, R. (2009) Discovery of neurosteroid glucuronides in mouse brain. Anal. Chim. Acta 651, 69-74
35. Liu, S., Sjo vall, J., and Griffiths, W.J. (2003) Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatographyelectrospray mass spectrometry. Anal. Chem. 75, 5835-5846
36. Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Liu, S., Griffiths, W., Schumacher, M., Sjo vall, J., and Baulieu, E.E. (2004) Novel lipoidal derivatives of pregnenolone and dehydro-epiandrosterone and absence of their sulfated counterparts in rodent brain. J. Lipid Res. 45, 2287
37. Corpechot, C., Synguelakis, M., Talha, S., Axelson, M., Sjo vall, J., Vihko, R., Baulieu, E.E., and Robel, P. (1983) Pregnenolone and its sulfate ester in the rat brain. Brain Res. 270, 119-125
38. Corpechot, C., Robel, P., Axelson, M., Sjo vall, J., and Baulieu, E.E. (1981) Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc. Natl Acad. Sci. USA 78, 4704-4707
39. Wood, C.E. (2011) Fetal hypothalamus-pituitaryadrenal responses to estradiol sulfate. Endocrinology 152, 4966-4973