Simultaneous effect of thiolation and carboxylation of chitosan particles towards mucoadhesive oral insulin delivery applications: An in vitro and in vivo evaluation

Journal of Biomedical Nanotechnology

Volumn 11, Issue 1, 2015, Pages 165-176

  Rekha, M R ^a   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Chitosan; Insulin; Mucoadhesion; Oral delivery; Submicroparticles; Thiolation

Indexed keywords

CARBOXYLATION; CHITOSAN; FUNCTIONAL GROUPS; INSULIN; PEPTIDES;

MUCOADHESION; NEGATIVE ZETA POTENTIALS; ORAL DELIVERY; PERMEATION ENHANCEMENT; PROTECTIVE PROPERTIES; RELEASE CHARACTERISTICS; SUBMICRO-PARTICLES; THIOLATION;

MULTILAYERS;

CHITOSAN; CHITOSAN DERIVATIVE; INSULIN; PANCREAS ENZYME; PEPSIN A; THIOMALYL CHITOSAN; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG; DELAYED RELEASE FORMULATION; GLUCOSE BLOOD LEVEL; NANOCAPSULE; STOMACH MUCIN; STREPTOZOCIN; THIOMALIC ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACO 2 CELL LINE; CARBOXYLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; INTESTINE WALL; MALE; MUCOADHESION; NONHUMAN; PH; RAT; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANALYSIS; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DELAYED RELEASE FORMULATION; DIABETES MELLITUS, EXPERIMENTAL; DIFFUSION; GLUCOSE BLOOD LEVEL; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; TREATMENT OUTCOME; ULTRASTRUCTURE; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CACO-2 CELLS; CHITOSAN; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DIFFUSION; GASTRIC MUCINS; HUMANS; INSULIN; MALE; NANOCAPSULES; PARTICLE SIZE; RATS; RATS, WISTAR; STREPTOZOCIN; THIOMALATES; TREATMENT OUTCOME;

EID: 84918525769     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2015.1904     Document Type: Article

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