Effect of chitosan and thiolated chitosan coating on the inhibition behaviour of PIBCA nanoparticles against intestinal metallopeptidases

Journal of Nanoparticle Research

Volumn 10, Issue 8, 2008, Pages 1293-1301

  Bravo Osuna, Irene ^a   Vauthier, Christine ^a   Farabollini, Alessandra ^a   Millotti, Gioconda ^a   Ponchel, Gilles ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Chitosan; Core shell nanoparticles; Intestinal metallopeptidases; Nanomedicine; Poly(isobutylcyanoacrylate); Thiolated chitosan; Zinc binding capacity

Indexed keywords

AMINO ACIDS; ARSENIC COMPOUNDS; BIOMOLECULES; BIOPOLYMERS; CHITIN; CHITOSAN; CLADDING (COATING); COLLOIDS; GELATION; GELS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES; PEPTIDES; POLYMERS; PROTEINS; SHELLS (STRUCTURES); ZINC; ZINC SULFIDE;

ACTIVE PEPTIDES; BINDING CAPACITIES; BIOPOLYMER CHAINS; BUSINESS MEDIA; CARBOXYPEPTIDASE A (CPA); CORE SHELL NANOPARTICLES; DISULPHIDE BONDS; GASTROINTESTINAL (GI); GASTROINTESTINAL TRACT (GIT); GEL LAYERS; IN-VITRO; ISOBUTYLCYANOACRYLATE (IBCA); LEUCINE AMINOPEPTIDASE (LAP); METALLOPEPTIDASES; NANOCARRIERS; NANOPARTICLE SURFACES; ORAL ADMINISTRATION; ORAL ROUTE; POLYMERIC SHELLS; THIOL GROUPS; THIOLATED CHITOSAN; ZINC BINDING;

AMINES;

BIOPOLYMER; BUCRILATE; CARBOXYPEPTIDASE A; CHITOSAN; CYTOSOL AMINOPEPTIDASE; METALLOPROTEINASE; NANOCARRIER; NANOPARTICLE; THIOL DERIVATIVE; ZINC BINDING PROTEIN;

ARTICLE; COATED PARTICLE; CROSS LINKING; DISULFIDE BOND; ENZYME INHIBITION; GASTROINTESTINAL TRACT; GEL; IN VITRO STUDY; MATERIAL COATING; NANOMEDICINE; PRIORITY JOURNAL; SURFACE PROPERTY;

EID: 48749093701     PISSN: 13880764     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11051-008-9364-5     Document Type: Article

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