Identification of small molecule inhibitors of pre-mRNA splicing

Journal of Biological Chemistry

Volumn 289, Issue 50, 2014, Pages 34683-34698

  Pawellek, Andrea ^a   McElroy, Stuart ^a   Samatov, Timur ^b   Mitchell, Lee ^a   Woodland, Andrew ^a   Ryder, Ursula ^a   Gray, David ^a   Lührmann, Reinhard ^b   Lamond, Angus I ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; TRANSCRIPTION;

CELL-CYCLE ARREST; CHEMICAL INHIBITORS; HIGH THROUGHPUT; PRE-MRNA SPLICING; PROTEIN LOCALIZATION; SMALL MOLECULE INHIBITOR; SMALL MOLECULES; THERAPEUTIC APPLICATION;

MOLECULES;

AGENTS AFFECTING PROTEIN METABOLISM; MADRASIN; SMALL MOLECULE SPLICING INHIBITOR; UNCLASSIFIED DRUG; MESSENGER RNA; MOLECULAR LIBRARY; QUINAZOLINE DERIVATIVE; RNA PRECURSOR;

ARTICLE; CELL CYCLE ARREST; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; GENETIC REGULATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN LOCALIZATION; RNA SPLICING; RNA STRUCTURE; SPLICEOSOME; CELL NUCLEUS; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HELA CELL LINE; MOLECULAR LIBRARY; PHARMACOLOGY;

EUKARYOTA;

CELL NUCLEUS; DRUG EVALUATION, PRECLINICAL; HEK293 CELLS; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; QUINAZOLINES; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; SMALL MOLECULE LIBRARIES;

EID: 84918515101     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.590976     Document Type: Article

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51. 1 peak. Cytometry 8, 1-8