A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes

Journal of Biomolecular Screening

Volumn 18, Issue 9, 2013, Pages 1110-1120

  Effenberger, Kerstin A ^a   Perriman, Rhonda J ^a   Bray, Walter M ^a   Lokey, R Scott ^a   Ares, Manuel ^a   Jurica, Melissa S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

high throughput assay; inhibitor; pre mRNA splicing; RT qPCR; spliceosome

Indexed keywords

INDOLE DERIVATIVE; MESSENGER RNA; NAPHTHAZARIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GEL ELECTROPHORESIS; GENE EXPRESSION; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HYDROLYSIS; IN VITRO STUDY; NONHUMAN; OXIDATION REDUCTION POTENTIAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; RNA DEGRADATION; RNA SPLICING; SACCHAROMYCES CEREVISIAE; SPLICEOSOME; YEAST;

HIGH-THROUGHPUT ASSAY; INHIBITOR; PRE-MRNA SPLICING; RT-QPCR; SPLICEOSOME;

HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA PRECURSORS; RNA SPLICING; SACCHAROMYCES CEREVISIAE; SMALL MOLECULE LIBRARIES; SPLICEOSOMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884658099     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113493117     Document Type: Article

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