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Volumn 13, Issue 5, 2012, Pages 640-644

Psoromic Acid Derivatives: A New Family of Small-Molecule Pre-mRNA Splicing Inhibitors Discovered by a Stage-Specific High-Throughput in Vitro Splicing Assay

(8) Samatov, Timur R a Wolf, Alexander b Odenwälder, Peter a,e Bessonov, Sergey a Deraeve, Céline c,f Bon, Robin S c,g Waldmann, Herbert c,d Lührmann, Reinhard a

a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY (Germany)

b Lead Discovery Center GmbH (Germany)

c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY (Germany)

d TU DORTMUND UNIVERSITY (Germany)

e MCKINSEY AND COMPANY (United States)

f LCC LABORATOIRE DE CHIMIE DE COORDINATION (France)

g UNIVERSITY OF LEEDS (United Kingdom)

Author keywords

High throughput screening; Inhibitors; Pre mRNA splicing; RNA; Spliceosome assembly

Indexed keywords

BUTYROLACTONE; CHEMICAL COMPOUND; DEAD BOX PROTEIN; DIHYDROCOUMARIN; GARCINOL; MESSENGER RNA; PROTEIN INHIBITOR; PSOROMIC ACID DERIVATIVE; SPLICEOSTATIN A; SPLITOMICIN; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ALTERNATIVE RNA SPLICING; APOPTOSIS; ARTICLE; CATALYSIS; CYTOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; SPLICEOSOME; STRUCTURE ANALYSIS;

BENZOXEPINS; BIOLOGICAL ASSAY; CARBOXYLIC ACIDS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; LACTONES; MOLECULAR STRUCTURE; RNA SPLICING; RNA, MESSENGER; SALICYLIC ACIDS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858322656 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.201100790 Document Type: Article

Times cited : (11)

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