Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes

American Heart Journal

Volumn 164, Issue 1, 2012, Pages 21-28

  Miner, Martin ^a   Seftel, Allen D ^b   Nehra, Ajay ^c   Ganz, Peter ^d   Kloner, Robert A ^e   Montorsi, Piero ^f   Vlachopoulos, Charalambos ^g   Ramsey, Melinda ^h   Sigman, Mark ^a   Tilkemeier, Peter ^a   Jackson, Graham ⁱ  

^a BROWN UNIVERSITY   (United States)

^b Department of Anesthesiology   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF MILAN   (Italy)

^g UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^h Melinda Ramsey LLC   (United States)

ⁱ ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROTIC PLAQUE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE MARKER; ELECTROCARDIOGRAM; ERECTILE DYSFUNCTION; FRAMINGHAM RISK SCORE; HAZARD RATIO; HEART INFARCTION; HOSPITALIZATION; HUMAN; INCIDENCE; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PHYSICIAN; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK REDUCTION; UNITED STATES;

AGE FACTORS; AGED; CARDIOVASCULAR DISEASES; DIABETIC CARDIOMYOPATHIES; ENDOTHELIUM, VASCULAR; HUMANS; IMPOTENCE, VASCULOGENIC; MALE; MIDDLE AGED; PROGNOSIS; RISK FACTORS; VASCULAR DISEASES;

EID: 84863717553     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2012.04.006     Document Type: Review

References (56)

1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270:83-90.
2. Seftel AD, Sun P, Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J Urol 2004;171(6 Pt 1):2341-5. (Pubitemid 38625466)
3. Krane RJ, Goldstein I, Saenz de Tejada I. Impotence. N Engl J Med 1989;321:1648-59. (Pubitemid 20012916)
4. Rosen RC, Leiblum SR. An overview of historical trends and clinical perspectives. In: RRCLS R, editor. Erectile Disorders: Assessment and Yreatment. New York: Guilford; 1992. p. 3-26.
5. Saigal CS, Wessells H, Pace J, et al. Predictors and prevalence of erectile dysfunction in a racially diverse population. Arch Intern Med 2006;166:207-12. (Pubitemid 43144945)
6. Persu C, Cauni V, Gutue S, et al. Diagnosis and treatment of erectile dysfunction-a practical update. J Med Life 2009;2:394-400.
7. Grover SA, Lowensteyn I, Kaouache M, et al. The prevalence of erectile dysfunction in the primary care setting: importance of risk factors for diabetes and vascular disease. Arch Intern Med 2006;166:213-9. (Pubitemid 43144946)
8. Thompson IM, Tangen CM, Goodman PJ, et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005;294:2996-3002. (Pubitemid 41817661)
9. Bohm M, Baumhakel M, Teo K, et al. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials. Circulation 2010;121:1439-46.
10. Jackson G, Padley S. Erectile dysfunction and silent coronary artery disease: abnormal computed tomography coronary angiogram in the presence of normal exercise ECGs. Int J Clin Pract 2008;62:973-6. (Pubitemid 351691507)
11. Min JK, Williams KA, Okwuosa TM, et al. Prediction of coronary heart disease by erectile dysfunction in men referred for nuclear stress testing. Arch Intern Med 2006;166:201-6. (Pubitemid 43144944)
12. Montorsi P, Ravagnani PM, Galli S, et al. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J 2006;27:2632-9. (Pubitemid 44729861)
13. Montorsi P, Ravagnani PM, Galli S, et al. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005;96:19M-23M. (Pubitemid 43017212)
14. Inman BA, Sauver JL, Jacobson DJ, et al. A population-based, longitudinal study of erectile dysfunction and future coronary artery disease. Mayo Clin Proc 2009;84:108-13.
15. Chew KK, Finn J, Stuckey B, et al. Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: findings from a linked-data study. J Sex Med 2010;7(1 Pt 1):192-202.
16. Riedner CE, Rhoden EL, Fuchs SC, et al. Erectile dysfunction and coronary artery disease: an association of higher risk in younger men. J Sex Med 2011;8:1445-53.
17. Giugliano F, Maiorino M, Bellastella G, et al. Determinants of erectile dysfunction in type 2 diabetes. Int J Impot Res 2010;22:204-9.
18. Gazzaruso C, Solerte SB, Pujia A, et al. Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors. J Am Coll Cardiol 2008;51:2040-4. (Pubitemid 351689055)
19. Ma RC, SoWY, Yang X, et al. Erectile dysfunction predicts coronary heart disease in type 2 diabetes. J Am Coll Cardiol 2008;51:2045-50.
20. Batty GD, Li Q, Czernichow S, et al. Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial. J Am Coll Cardiol 2010;56:1908-13.
21. Jackson G. Prevention of cardiovascular disease by the early identification of erectile dysfunction. Int J Impot Res 2008;20(Suppl 2):S9-14.
22. Kirby M, Jackson G, Simonsen U. Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 2005;59:225-9. (Pubitemid 40331225)
23. Kharbanda RK, Deanfield JE. Functions of the healthy endothelium. Coron Artery Dis 2001;12:485-91. (Pubitemid 32977818)
24. Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation 2003;108:2049-53. (Pubitemid 37337576)
25. Montorsi P, Ravagnani PM, Galli S, et al. Association between erectile dysfunction and coronary artery disease: matching the right target with the right test in the right patient. Eur Urol 2006;50:721-31. (Pubitemid 44332685)
26. Rubinshtein R, Kuvin JT, Soffler M, et al. Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events. Eur Heart J 2010;31:1142-8.
27. Kitta Y, Obata JE, Nakamura T, et al. Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease. J Am Coll Cardiol 2009;53:323-30.
28. Yeboah J, Crouse JR, Hsu FC, et al. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 2007;115:2390-7. (Pubitemid 46717961)
29. Lue TF. Erectile dysfunction. N Engl J Med 2000;342:1802-13. (Pubitemid 30390241)
30. Bivalacqua TJ, Usta MF, Champion HC, et al. Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. J Androl 2003;24(6 Suppl):S17-37. (Pubitemid 37370524)
31. Prieto D. Physiological regulation of penile arteries and veins. Int J Impot Res 2008;20:17-29.
32. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 2002;90:40L-8L. (Pubitemid 35379905)
33. Baumhakel M, Custodis F, Schlimmer N, et al. Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan. J Pharmacol Exp Ther 2008;327:692-8.
34. Schlimmer N, Kratz M, Bohm M, et al. Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol-induced atherosclerosis. Br J Pharmacol 2011;163:804-14.
35. Park K, Shin JW, Oh JK, et al. Restoration of erectile capacity in normotensive aged rats by modulation of angiotensin receptor type 1. J Androl 2005;26:123-8. (Pubitemid 39665285)
36. Yavuzgil O, Altay B, Zoghi M, et al. Endothelial function in patients with vasculogenic erectile dysfunction. Int J Cardiol 2005;103:19-26. (Pubitemid 41074599)
37. Kaya C, Uslu Z, Karaman I. Is endothelial function impaired in erectile dysfunction patients? Int J Impot Res 2006;18:55-60. (Pubitemid 43050962)
38. Kaiser DR, Billups K, Mason C, et al. Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004;43:179-84. (Pubitemid 38201141)
39. Chiurlia E, D'Amico R, Ratti C, et al. Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol 2005;46:1503-6. (Pubitemid 41446186)
40. Betik AC, Luckham VB, Hughson RL. Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions. Am J Physiol Heart Circ Physiol 2004;286:H442-8. (Pubitemid 38049511)
41. De Angelis L, Marfella MA, Siniscalchi M, et al. Erectile and endothelial dysfunction in Type II diabetes: a possible link. Diabetologia 2001;44:1155-60. (Pubitemid 32835508)
42. Schouten BW, Bohnen AM, Bosch JL, et al. Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: results from the Krimpen Study. Int J Impot Res 2008;20:92-9.
43. Araujo AB, Hall SA, Ganz P, et al. Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score? J Am Coll Cardiol 2010;55:350-6.
44. Araujo AB, Travison TG, Ganz P, et al. Erectile dysfunction and mortality. J Sex Med 2009;6:2445-54.
45. Marma AK, Lloyd-Jones DM. Systematic examination of the updated Framingham heart study general cardiovascular risk profile. Circulation 2009;120:384-90.
46. Vlachopoulos C, Ioakeimidis N, Terentes-Printzios D, et al. The triad: erectile dysfunction-endothelial dysfunction-cardiovascular disease. Curr Pharm Des 2008;14:3700-14.
47. Vlachopoulos C, Rokkas K, Ioakeimidis N, et al. Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. Eur Urol 2007;52:1590-600. (Pubitemid 350052419)
48. Vlachopoulos C, Aznaouridis K, Ioakeimidis N, et al. Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease. Eur Heart J 2006;27:2640-8. (Pubitemid 44729862)
49. Billups KL, Kaiser DR, Kelly AS, et al. Relation of C-reactive protein and other cardiovascular risk factors to penile vascular disease in men with erectile dysfunction. Int J Impot Res 2003;15:231-6. (Pubitemid 37101655)
50. Corona G, Rastrelli G, Boddi V, et al. Prolactin levels independently predict major cardiovascular events in patients with erectile dysfunction. Int J Androl 2011;34:217-24.
51. Corona G, Monami M, Boddi V, et al. Low testosterone is associated with an increased risk of MACE lethality in subjects with erectile dysfunction. J Sex Med 2010;7(4 Pt 1):1557-64.
52. Vlachopoulos C. Biomarkers in the evaluation of erectile dysfunction. Princeton III: Cardiometabolic Risks and Sexual Health; 2010 November 8-10, 2010; Miami Beach, FL; 2010.
53. Polonsky TS, Taillon LA, Sheth H, et al. The association between erectile dysfunction and peripheral arterial disease as determined by screening ankle-brachial index testing. Atherosclerosis 2009;207:440-4.
54. Vlachopoulos C, Aznaouridis K, Ioakeimidis N, et al. Arterial function and intima-media thickness in hypertensive patients with erectile dysfunction. J Hypertens 2008;26:1829-36.
55. Achenbach S, Berman D, Budoff M, et al. Prognostic value of coronary CT angiography for the prediction of mortality and non-fatal major adverse cardiac events: Results from the multinational CONFIRM registry. Circulation 2011;124:A14099.
56. Corona G, Monami M, Boddi V, et al. Pulse pressure independently predicts major cardiovascular events in younger but not in older subjects with erectile dysfunction. J Sex Med 2011;8:247-54.